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2021 Vol. 18, No. 14
Published: 2021-05-15
 
 
4 Effect of paeoniflorin on vascular endothelial growth factor induced tubule formation of human umbilical vein endothelial cells
CHI Xiaowei1 CHEN Gangling2
Objective To study the effects of paeoniflorin (PF) on vascular endothelial growth factor (VEGF) induced tubule formation of human umbilical vein endothelial cells (HUVECs). Methods The HUVECs cell lines were resuscitated and cultured. MTT assay was used to determine the effects of different concentrations of PF (1, 3, 10, 30, 100 μmol/L) on HUVECs cell viability and the increase of cell viability induced by VEGF. Tubule formation experiments were conducted to evaluate the effect of different concentrations of PF (1, 3, 10, 30, 100 μmol/L) on VEGF induced tubule formation of HUVECs. The effect of PF (1, 3, 10, 30, 100 μmol/L) on VEGF induced HUVECs migration was evaluated by cell scratch test. Results Compared with blank group, there was no statistical significance in the effect of different concentrations of PF (1, 3, 10, 30, 100 μmol/L) on HUVECs cell viability (P ＞ 0.05). Compared with model group (VEGF was given 10 ng/mL, the same as below), there was no statistical significance in the effect of different concentrations of PF (1, 3, 10, 30, 100 μmol/L) on VEGF induced increased HUVECs cell viability (P ＞ 0.05). Compared with model group, different concentrations of PF (1, 3, 10, 30, 100 μmol/L) could inhibit the tubule formation of HUVECs induced by VEGF in vitro. Compared with model group, the scratch width ratio of 24 h/0 h in 10, 30 and 100 μmol/L PF dosage groups were all significantly higher than that in model group, with highly statistical significance (all P ＜ 0.01). Conclusion PF inhibits VEGF induced tubule formation of HUVECs in vitro, and this effect may be realized by inhibiting VEGF induced HUVECs migration.
2021 Vol. 18 (14): 4-8 [Abstract] ( 170 ) HTML (1 KB)  PDF (973 KB)  ( 80 )
9 Effect of Osimertinib on blood-cord barrier permeability after spinal cord injury in rats
LI Zaiwang1 CAO Tingting2 WANG Qian1 TU Jingmei1 HAN Jing1
Objective To investigate the effects of epidermal growth factor receptor (EGFR) inhibitor Osimertinib on blood-cord barrier permeability after spinal cord injury (SCI) in rats. Methods A total of sixty eight week-old female SD rats (200 to 250 g) were divided into sham operation group (n = 20) and SCI model group (n = 40) according to random number table method. The 40 SCI model rats were divided into injury group and Osimertinib group by random number table method, with 20 rats in each group. The Osimertinib group was gavaged with 0.4 mg/mL Osimertinib solution (2 mL/d), and the sham operation group and the injury group were gavaged with normal saline (2 mL/d). All the three groups were treated for 3 days. The water content of spinal cord tissue was determined 3 days after SCI, the expression of aquaporin-4 (AQP-4) protein was detected by Western blot, the evans blue (EB) dye leakage test and the albumin content of spinal cord were determined by immunofluorescence technique to evaluate the changes of blood and spinal cord barrier permeability. Basso-Beattie-Bresnahan (BBB) score was used to evaluate the motor function of rats. Results The water content of spinal cord in Osimertinib group at 3 days after SCI was significantly lower than that in injury group (P ＜ 0.05). The expression of AQP-4 protein in Osimertinib group was significantly lower than that in injury group (P ＜ 0.01). The concentration of EB dye in spinal cord tissue in Osimertinib group was less than that in injury group, and the fluorescence intensity of EB was weaker than that in injury group (P ＜ 0.05). The immunofluorescence intensity of albumin in Osimertinib group was weaker than that in injury group. The overall BBB score of Osimertinib group was significantly higher than that of injury group (P ＜ 0.05). Conclusion The EGFR inhibitor Osimertinib can improve the damage of the blood-cord barrier after SCI and alleviate the secondary injury of the spinal cord, and promote the recovery of neurological function.
2021 Vol. 18 (14): 9-12,26 [Abstract] ( 58 ) HTML (1 KB)  PDF (703 KB)  ( 95 )
13 Clinicopathological significance of hMSH2 and FHIT expression in Kazakh esophageal squamous cell carcinoma
Dannier·Duolikun1,2 Kawuli·Jumai3 ZHANG Haiping3 Madiniyet·Niyaz1 Edris·Awut2,3
Objective To investigate the expression of hMSH2 and FHIT genes in Kazakh esophageal squamous cell carcinoma, and analyze the correlation between gene expression and its clinicopathological significance. Methods Esophageal cancer and its adjacent normal tissue specimens were selected from 43 patients who underwent radical resection of esophageal cancer in the First Affiliated Hospital of Xinjiang Medical University from May 2013 to May 2017. qRT-PCR method was used on 30 cases, while immunohistochemistry was conducted on 43 cases to study their clinicopathological characteristics. Results The mRNA expression levels of both hMSH2 and FHIT genes in esophageal squamous cell carcinoma tissues were significantly lower than those in adjacent normal tissues, and the differences were statistically significant (P ＜ 0.05). Results of immunohistochemistry showed that the positive expression rate of hMSH2 and FHIT protein in esophageal squamous cell carcinoma tissues was significantly lower than that in adjacent normal tissues, and the difference was statistically significant (P ＜ 0.05). The expression level of HMSH2 protein was related to the degree of tumor differentiation, lymph node metastasis and postoperative pathological stage (P ＜ 0.05), while it had nothing to do with the age, sex and tumor location of the patients with esophageal cancer (P ＞ 0.05). The expression level of FHIT was only related to the depth of infiltration (P ＜ 0.05). Kaplan-Meier survival analysis found that the expression level of HMSH2 in esophageal cancer was correlated with survival rate (P ＜ 0.05). The results of COX multivariate survival analysis showed that the loss of hMSH2 gene expression and the degree of tumor differentiation were independent risk factors for poor prognosis in Kazakh patients with esophageal squamous cell carcinoma (P ＜ 0.05). Conclusion hMSH2 and FHIT may be involved in the occurrence and development of Kazakh esophageal cancer, so the detection of co-expression could be used as an important indicator for prognosis.
2021 Vol. 18 (14): 13-17 [Abstract] ( 63 ) HTML (1 KB)  PDF (706 KB)  ( 87 )
18 Establishment of non-small cell lung cancer HCC827 Osimertinib-resistant cell line and exploration of the resistance mechanism
HUANG Jiali CHEN Zhenyao LEI Tianyao WANG Zhaoxia CHENG Zhixiang
Objective To construct human non-small cell lung cancer (NSCLC) Osimertinib-resistant cells HCC827OR in vitro, and to explore its resistance mechanism. Methods Using the NSCLC cell line HCC827, the Osimertinib-resistant cell line HCC827OR was constructed by the concentration-increasing method, and the differences in morphology, proliferation, apoptosis, and cell protein expression between the two cell lines were compared. Results Half-inhibitory concentration (IC50) and resistance index (RI) results showed that HCC827OR was highly resistant to Osimertinib, and the morphology of HCC827OR and HCC827 cells were significantly different. On the first day of the CCK8 proliferation experiment, the cell viability of HCC827OR was higher than that of HCC827 (P ＜ 0.05), and on the second, third and fourth days, the cell viability of HCC827OR was significantly higher than that of HCC827 (P ＜ 0.01). In the clone formation experiment result showed that, the colony formation number of HCC827OR was higher than that of HCC827 (P ＜ 0.01). After EdU staining, the number of EdU-positive cells in HCC827OR was higher than that in HCC827 (P ＜ 0.01). In the apoptosis experiment result showed that, compared with HCC827, the apoptosis of HCC827OR cells was reduced (P ＜ 0.01). In Western blot experiment, compared with HCC827, the expression of EGFR and p-EGFR in HCC827OR cells decreased, and the expression of p-AKT, p-ERK and Vimentin increased. Conclusion The NSCLC osimertinib-resistant cell line HCC827OR is successfully constructed. It is speculated that the resistance mechanism is related to the decreased expression of EGFR and p-EGFR, and the increased expression of p-AKT, p-ERK and Vimentin.
2021 Vol. 18 (14): 18-21,31 [Abstract] ( 161 ) HTML (1 KB)  PDF (1194 KB)  ( 394 )
22 Bibliometric analysis on the treatment of Hashimoto thyroiditis with traditional Chinese medicine in the past 40 years
ZHAO Xueru1 CHEN Jidong2 MA Li1
Objective To understand the research status and development trend of Hashimoto thyroiditis treated by traditional Chinese medicine in China, and to provide reference for related scientific research in this field in the future. Methods The literatures related to the treatment of Hashimoto thyroiditis with traditional Chinese medicine in the past 40 years was selected, and the retrieval time was limited from January 1979 to December 2019. CiteSpace software was used for literature visualization analysis. Results A total of 403 literatures were included in the analysis. Four core clusters were formed by the co-author network. Two core organization teams, namely Shanghai and Nanjing, were formed by institutional clustering knowledge graph. The co-occurrence map was formed by 12 keywords with centrality above 0.1, such as “high iodine area”, “integrated treatment of traditional Chinese and Western medicine” and “preventive treatment of disease”. Conclusion The core author team in this field has gradually formed, and the research organization team has typical regional characteristics. The integrated treatment of traditional Chinese and Western medicine has become the mainstream treatment scheme. The prevention of disease and the inheritance of the experience of famous and veteran Chinese medicine will be the key research directions in the treatment of Hashimoto thyroiditis with traditional Chinese medicine in the future.
2021 Vol. 18 (14): 22-26 [Abstract] ( 170 ) HTML (1 KB)  PDF (1663 KB)  ( 134 )
27 Visual analysis of research on radiation enteritis treated by traditional Chinese medicine based on CiteSpace
XU Jingxuan1,2 FU Qiuju3 LI Liang1 QIAN Xiaoping4
Objective To analyze the research situation of traditional Chinese medicine in the treatment of radiation enteritis in recent 10 years by visualization method. Methods Articles related to the treatment of radiation enteritis with traditional Chinese medicine were collected in China national knowledge infrastructure (CNKI) from January 2010 to January 2020. CiteSpace was used to perform co-occurrence analysis and visualize the collaboration networks of the authors, institutes, keywords, in order to understand the research status, hotspots and trends in this field. Results A total of 193 articles were included. The annual number of published articles on the whole showed a trend of increasing first and then decreasing slightly. The author who published the most articles was Wang Yuguo, among whom Li Mei’s team and Wang Lei’s team worked closely together. Seven institutions were the main bases for the study of traditional Chinese medicine treatment of radioactive enteritis. Research institutions were independent and scattered, and no obvious cooperative network had been formed. The keyword co-occurrence network formed five clusters. When the keywords related to the subject words were removed, the top two keywords in frequency were “retention enema” and  “Chinese medicine enema” respectively. The top three keywords with high mediating centrality were “cervical cancer” “retention enema” and “Chinese medicine enema”. Conclusion In the past ten years, the number of related studies on traditional Chinese medicine treatment of radiation enteritis with is not large, with relatively few researchers involved, scattered research institutions and lack of cooperation. There are few studies on the mechanism of action and the research depth is not enough. Therefore, high-quality studies should be carried out to provide evidence support for clinical practice. The clinical effect of traditional Chinese medicine retention enema on radiation enteritis is the focus of research.
2021 Vol. 18 (14): 27-31 [Abstract] ( 147 ) HTML (1 KB)  PDF (1065 KB)  ( 168 )
32 New progress of sodium-glucose cotransporter 2 inhibitors in the treatment of diabetic nephropathy
REN Yanrong1,2 YU Lei2▲
Diabetic nephropathy (DN) is a common and serious microvascular complication of diabetes mellitus, and it is the leading cause of end-stage renal disease (ESRD). Despite the use of various drugs such as renin-angiotensin system inhibitors, DN often continues to progress, and patients are at great risk of progressing to ESRD. Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are a novel class of target drugs that have been extensively investigated in type 2 diabetes mellitus (T2DM). The inhibitors block sodium and glucose reabsorption in the renal proximal tubule, leading to glycosuria for the treatment of hyperglycemia. Recent large scale clinical trials in T2DM patients have shown that SGLT-2i exhibit cardiorenal protective propertiesin in addition to its hypoglycemic effects. Especially in the patients complicated with DN, SGLT-2i are found to protect renal function and reduce urinary albumin excretion through various mechanisms. Therefore, the latest studies have discovered that SGLT-2i can significantly improve the prognosis of patients with DN. This article reviews the recent progress on SGLT-2i for renal protective effects and mechanisms in DN.
2021 Vol. 18 (14): 32-35 [Abstract] ( 267 ) HTML (1 KB)  PDF (433 KB)  ( 124 )
36 Research progress on the relationship between estrogen receptor-α36 and breast cancer
HOU Mengyue HUANG Zhaoquan
Estrogen receptor (ER) -α36 is a 36 kD variant of ER-α66, a subtype of ER-α. ER-α36 is mainly expressed in cytoplasm and cell membrane. Compared with ER-α66, it lacks the transcriptional activation domain (AF) -1 and AF-2, and retains the DNA binding domain, partial dimerization domain, and partial distributive binding domain of ER-α66. It can cooperate with various signaling factors such as protein kinase A, protein kinase C and Ca2+, and can rapidly activate non-genomic estrogen signaling pathway in a short period of time to regulate the biological behavior of tumors. Current studies have found that ER-α36 is expressed in human breast cancer, endometrial cancer and other estrogen-related tumor cells. Therefore, the relationship between ER-α36 and malignant tumor is worth studying.
2021 Vol. 18 (14): 36-38,50 [Abstract] ( 69 ) HTML (1 KB)  PDF (707 KB)  ( 177 )
39 Progress in the treatment of dyskinesia in Parkinson’s disease
ZHONG Zhe XU Min CHEN Weijie GAO Huan YE Min
Levodopa-induced dyskinesia is a complication caused by long-term treatment of Levodopa in patients with Parkinson’s disease. The treatment of Levodopa-induced dyskinesia is mainly divided into two parts, drug therapy and non-drug therapy. In non-drug therapy, deep brain stimulation and unilateral pallidotomy is considered to be effective. Drug therapy focuses on providing continuous dopaminergic stimulation, such as the development of new Dopamine preparations, catechol-O-methyltransferase inhibitors, Subcutaneous Apomorphine and Levodopa-carbidopa enteral gel continuous jejunal infusion, the second is the use of non-dopaminergic drugs such as Amantadine, Clozapine and Levetiracetam. Although the preclinical results of most non-dopaminergic drugs are encouraging, however, due to the uncertainty of its effect and its side effects, at present, the transformation to clinical practice is still challenging. This article describes in detail the latest treatment of Levodopa-induced dyskinesia at home and abroad, so as to provide reference for daily clinical work.
2021 Vol. 18 (14): 39-42 [Abstract] ( 134 ) HTML (1 KB)  PDF (470 KB)  ( 106 )
43 Analysis of participation degree of traditional Chinese medicine in lung malignant tumor cases from 30 hospitals in Beijing
LIU Liming1 CHENG Wei1,2 MAN Xiaowei1,2 ZHAO Liying1,2 YANG Hong1 XU Yue1 MA Lin1 JIANG Yan1,2
Objective To explore the main factors that affect patients’ participation in traditional Chinese medicine, and to provide references for traditional Chinese medicine to participate in the treatment of lung malignant tumors. Methods Taking socio-demographic factors into consideration, a total of 30 hospitals in Beijing from January to December, 2016 were selected. The information of patients with lung malignant tumors was extracted from them, and the basic information, hospitalization status, and participation in traditional Chinese medicine were extracted. The factors affecting participation were analyzed statistically. Results A total of 12 163 hospitalized patients with lung malignant tumors were collected, and the effective number of cases was 12 099 cases. Among them, the proportion of male patients was higher than that of females, and the proportion of patients aged >60-80 years was the largest. The payment method was mainly urban employee basic medical insurance, and the proportion of patients in tertiary hospitals was much higher. In a secondary hospital, the average hospital stay was (11.62±9.39) days. The overall participation rate of traditional Chinese medicine in patients with lung malignant tumors was 69.30%. The single-factor analysis showed that the participation rate of traditional Chinese medicine was statistically significant in different genders, ages, payment methods, hospital levels and length of stay in hospital (P ＜ 0.05). The logistic regression results showed that payment method (OR = 1.864), hospital level (OR = 1.435) and hospital stay (OR = 1.047) were the main factors affecting the participation of traditional Chinese medicine in patients with lung malignant tumors (P ＜ 0.05). Conclusion The participation of traditional Chinese medicine in the treatment of lung malignant tumors can be further enhanced by rationally guiding the flow of medical treatment, exploring the characteristics of traditional Chinese medicine diagnosis and treatment methods, and improving the price system of traditional Chinese medicine services, which can reduce the cost burden of lung cancer while exerting the advantages of traditional Chinese medicine.
2021 Vol. 18 (14): 43-46 [Abstract] ( 128 ) HTML (1 KB)  PDF (425 KB)  ( 86 )
47 Analysis of humanistic care needs of patients with myelodysplastic syndrome and its influencing factors
WU Yujuan SUN Yu TANG Juying▲
Objective To observe the status quo of humanistic care needs of patients with myelodysplastic syndrome (MDS), and to analyze the factors that affect the humanistic care needs of patients. Methods A total of 92 patients with myelodysplastic syndrome admitted to Chinese People’s Liberation Army General Hospital from April 2018 to December 2019 were prospectively selected as the research subjects, the self-made humanistic care demand questionnaire was used to investigate the current situation of patients’ humanistic care needs, and the patients were divided in to higher-demand group and lower-demand group, taken all possible factors into consideration, through single factor and multi factor, the influencing factors of humanistic care demand were searched. Results This study included 92 patients with MDS. There were 24 cases in the higher-demand group and 68 cases in the lower-demand group. The proportion of women in the group, their children being the main caregivers, and education level (high school and above) were higher than those of the lower-demand group, while the number of hospitalizations was more than that of the lower-demand group, and the differences were statistically significant (P ＜ 0.05). The results of logistic regression analysis showed that females, children as the main caregivers, higher education level, and more hospitalizations were factors influenced the high demand for humanistic care in MDS patients (OR ＞ 1, P ＜ 0.05). Conclusion MDS patients with females and children as the main caregivers, higher education level, and frequent hospitalizations may have a high demand for humanistic care. The clinic should pay attention to the assessment of humanistic care needs of such patients and early intervention.
2021 Vol. 18 (14): 47-50 [Abstract] ( 64 ) HTML (1 KB)  PDF (455 KB)  ( 51 )
51 Analysis of related researches on mitral valve replacement based on bibliometrics
XU Rongrong HU Yuanhui SHI Jingjing WANG Dandan
Objective To analyze related researches on mitral valve replacement based on bibliometrics. Methods Literatures related to mitral valve replacement were retrieved from the Web of Science Core Collection database from January 2010 to December 2019. CiteSpace V software was used for visual analysis of countries, institutions, authors and keywords in the research field. Results A total of 1794 literatures were included. The major research forces were from the United States, including Mayo Clinic, Columbia University and University of Pennsylvania. Research focuses on related diseases, surgical experience and methods, surgical risk, postoperative survival and recovery, etc. Conclusion This paper reveals the research strength, development context, hot spots and frontiers of this field in the past ten years, and provides reference for future related research.
2021 Vol. 18 (14): 51-54,62 [Abstract] ( 161 ) HTML (1 KB)  PDF (1230 KB)  ( 81 )
55 Effect of different treatment protocols in illness perception and medical coping modes of patients with rapid ventricular rate of persistent atrial fibrillation
ZHOU Jiali1 LIANG Jingyu1 YU Xiaomei1 LIU Huafen2
Objective To analyze the effects of different treatment protocols in illness perception and medical coping modes of patients with rapid ventricular rate of persistent atrial fibrillation. Methods A total of 129 patients with rapid ventricular rate of persistent atrial fibrillation admitted to Renmin Hospital of Wuhan University from September 2017 to September 2019 were recruited. The brief illness perception questionnaire (BIPQ) and the medical coping modes questionnaire (MCMQ) were used to conduct the investigation. A total of 127 patients were collected. According to different treatment methods, they were divided into operation group (radiofrequency ablation, 58 cases) and drug group (69 cases). The results of the questionnaires in two groups were compared, as well as the correlation between the scores of each dimension. Results The scores of cognitive representation, total score of illness perception and face dimension in the operation group were higher than those in the drug group, while the scores of emotional representation, avoidance dimension and yield dimension were lower than those in the drug group, with statistical significance (all P ＜ 0.05). There was no significant difference in illness comprehension scores between the two groups (P ＞ 0.05). The scores of cognitive representation and understanding of illness were positively correlated with the scores of face dimension (r ＞ 0, P ＜ 0.01), and negatively correlated with the scores of avoidance and yield dimension (r ＜ 0, P ＜ 0.05). There was a positive correlation between the score of emotional representation and the score of yield dimension in the two groups (r ＞ 0, P ＜ 0.05). In the operation group, the emotional representation score was positively correlated with the avoidance dimension score (r ＞ 0, P ＜ 0.05), and negatively correlated with the face dimension score (r ＜ 0, P ＜ 0.05). Conclusion Patients with rapid ventricular rate of persistent atrial fibrillation who are treated with operation have a more severe awareness of their illness and are more likely to adopt a face to face approach. Patients who are treaded with medication are more emotionally affected by the illness and are more likely to adopt avoidance and submission coping styles.
2021 Vol. 18 (14): 55-58 [Abstract] ( 99 ) HTML (1 KB)  PDF (465 KB)  ( 72 )
59 Correlation of exercise and detection rate of supraventricular tachycardia in patients with transesophageal atrial pacing
GAO Jie1,2 WANG Xinkang1,2▲
Objective To investigate the correlation of exercise and detection rate of supraventricular tachycardia (SVT) in patients with transesophageal atrial pacing (TEAP). Methods A total of 126 patients who suspected paropathic SVT due to palpitation and with indications of TEAP admitted to Fujian Provincial Hospital from October 2019 to October 2020 were selected and they were divided into conventional TEAP group (63 cases) and post exercise TEAP group (63 cases) according to the random number table method. The detection rate of SVT and induction mode were compared between the two groups. Results The detection rates of SVT and atrioventricular node reentrant tachycardia in the post exercise TEAP group were higher than those in the conventional TEAP group, and the differences were statistically significant (all P ＜ 0.05). The difference of induction mode between two groups was  statistically significant (P ＜ 0.05). Conclusion Exercise can improve the detection rate of SVT by TEAP.
2021 Vol. 18 (14): 59-62 [Abstract] ( 51 ) HTML (1 KB)  PDF (469 KB)  ( 71 )
63 Risk factors analysis of anxiety, depression and cognitive impairment associated with Parkinson’s disease
CHAI Bin MA Huizi▲ FENG Tao
Objective To observe and analyze the related influencing factors of anxiety, depression and cognitive impairment in Parkinson’s disease (PD) patients. Methods A total of 92 PD patients diagnosed in the Department of Movement Disorders, Neurology Center, Beijing Tiantan Hospital, Capital Medical University from January to October 2016 were selected. The unified Parkinson’s disease rating scale (UPDRS), modified Hoehn-Yahr staging scale, Hamilton anxiety scale, Hamilton depression scale, and the Montreal cognitive assessment scale (MoCA) were evaluated. The incidence of anxiety, depression and cognitive dysfunction in PD patients was understood, and the risk factors associated with anxiety, depression and cognitive dysfunction in PD patients were analyzed and discussed. Results In this group, 92 PD patients with anxiety accounted for 77.17%. The patients with depression accounted for 69.57%. Logistic regression results showed that male was a protective factor for PD patients with anxiety (OR = 0.24, P = 0.048), the long course of disease was a risk factor for PD patients with anxiety (OR = 1.36, P = 0.019), male (OR = 0.22, P = 0.013) and advanced age (OR = 0.95, P = 0.041) were protective factors for PD patients with depression (OR = 0.22, P = 0.013), high UPDRS score was a risk factor for PD patients with depression (OR = 1.08, P = 0.007). MoCA score showed that 78.26% of the patients had cognitive dysfunction. Logistic regression results showed that long years of education was a protective factor for cognitive dysfunction in PD patients (OR = 0.70, P < 0.003). Conclusion Anxiety, depression and cognitive impairment are all common non-exercise symptoms of PD patients with a high incidence and are easily affected by age, gender, course of disease, years of education and other factors, while non-exercise symptoms have a significant impact on the overall treatment effect and quality of life of patients.
2021 Vol. 18 (14): 63-66,71 [Abstract] ( 163 ) HTML (1 KB)  PDF (642 KB)  ( 56 )
67 Predictive value of serum soluble intercellular adhesion molecule 1 and cysteine aspartate proteolytic enzyme 3 levels in cerebral vasospasm after intracranial ruptured aneurysm surgery
YIN Hang FENG Lijun XIAO Longhai LI Changge QIN Hao
Objective To investigate the predictive value of serum soluble intercellular adhesion molecule 1 (SICAM-1) and cysteine aspartate proteolytic enzyme 3 (caspase-3) levels in cerebral vasospasm (CVS) after intracranial ruptured aneurysm surgery. Methods A total of 203 patients with ruptured intracranial aneurysm subarachnoid hemorrhage (SAH) admitted to Zaozhuang Municipal Hospital, Shandong Province from January 2016 to December 2019 were selected. All of them received craniotomy clipping or interventional embolization treatment, and underwent digital subtraction angiography four days after surgery. According to different degrees of postoperative CVS, they were divided into severe CVS group (19 cases), moderate CVS group (44 cases), mild CVS group (23 cases) and no CVS group (117 cases). Serum levels of caspase-3 and SICAM-1 were detected before and 3, 7 days after surgery. The serum levels of SICAM-1 and caspase-3 in the four groups were compared before and after intracranial ruptured aneurysm. The correlation between serum SICAM-1 and caspase-3 after intracranial ruptured aneurysm was analyzed by Pearson correlation coefficient. Receiver operating characteristic (ROC) curve was drawn to determine the predictive value of serum SICAM-1 and caspase-3 on postoperative CVS of ruptured intracranial aneurysm three days after surgery. Results Serum levels of SICAM-1 and caspase-3 in the four groups 3 and 7 days after surgery were higher than those before surgery, and serum levels of SICAM-1 and caspase-3 seven days after surgery were lower than those three days after surgery (P < 0.05). Pearson correlation andlysisshowed that there was a positive correlation between serum SICAM-1 and caspase-3 levels of ruptured intracranial aneurysm 3 and 7 days after surgery (r = 0.493, 0.585, P < 0.05). The ROC curve showed that the area under the curve, sensitivity and specificity of SICAM-1 + caspase-3 in the diagnosis of postoperative CVS of ruptured intracranial aneurysm 3 days after surgery were higher than those of SICAM-1 and caspase-3 alone. Conclusion Serum levels of SICAM-1 and caspase-3 in patients with intracranial ruptured aneurysm after surgery are significantly increased, and combined detection can effectively predict the occurrence of CVS.
2021 Vol. 18 (14): 67-71 [Abstract] ( 131 ) HTML (1 KB)  PDF (692 KB)  ( 48 )
72 Clinical study of Jianshi Lishui Granules combined with Furosemide in the treatment of secondary cerebral edema after cerebral hemorrhage
TAN Lulu1 HUANG Rongsen2 ZHOU Guan2 CHEN Xinghua1 LIU Yonghui1
Objective To investigate the clinical effect of Jianshi Lishui Granules combined with Furosemide in the treatment of secondary cerebral edema after cerebral hemorrhage. Methods A total of 100 patients with secondary cerebral edema after cerebral hemorrhage admitted to the First Affiliated Hospital of Guangxi University of Chinese Medicine from April 2017 to April 2020 were selected and they were divided into control group and study group according to random number table method, with 50 cases in each group. The control group was treated with Furosemide, and the study group was treated with Jianshi Lishui Granules on the basis of the control group. Both groups were treated for 14 days. The efficacy, the United States national institutes of health stroke scale (NIHSS) score, hypersensitive C-reactive protein (hs-CRP), S-100β protein, interleukin-1β (IL-1β), hematoma volume, cerebral edema volume, peak systolic blood flow velocity, average blood flow velocity, cerebral blood flow and incidence of adverse reactions were compared between the two groups. Results The clinical total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, NIHSS scores in both groups were decreased compared with before treatment, and those in the study group were lower than those in the control group, with statistical significance (all P ＜ 0.05). After treatment, average blood flow velocity, peak systolic blood flow velocity and cerebral blood flow in both groups were increased compared with before treatment, and those in the study group were higher than those in the control group, with statistical significance (all P ＜ 0.05). After treatment, hs-CRP, S-100β protein and IL-1β were decreased in both groups compared with before treatment, and those in the study group were lower than those in the control group, with statistical significance (all P ＜ 0.05). After treatment, hematoma volume and cerebral edema volume in both groups were decreased compared with before treatment, and the those in the study group were smaller than those in the control group, with statistical significance (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion In the treatment of secondary cerebral edema after cerebral hemorrhage, Jianshi Lishui Granules combined with Furosemide can promote the reduction of hematoma volume and cerebral edema volume, improve cerebral blood flow, reduce the inflammatory response and peroxidation damage of brain tissue, and reduce the injury of brain tissue, with definite curative effect.
2021 Vol. 18 (14): 72-75,80 [Abstract] ( 139 ) HTML (1 KB)  PDF (594 KB)  ( 57 )
76 Analysis of risk factors for severity of pulmonary thromboembolism after craniocerebral tumor operation under cluster intervention measure
YANG Yakun1 HAN Song1 LIU Ning1 ZHANG Xufei2 ZHANG Linpeng1 HAN Mingyang1 ZHANG Yunxin3 YAN Changxiang1▲
Objective To analyze the risk factors of pulmonary thromboembolism with different severity after craniocerebral tumor operation under cluster intervention measures, and to provide reference for early clinical intervention of pulmonary thromboembolism. Methods The clinical information of 56 patients with pulmonary thromboembolism diagnosed by CT pulmonary angiography after craniocerebral tumor operation in the Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University from June 2016 to June 2019 was retrospectively analyzed. The patients were divided into low risk group (36 cases) and high risk group (20 cases) according to the diagnosis and treatment guidelines of pulmonary thromboembolism. Clinical phenotypes, coagulation function and perioperative related factors were compared between the two groups, and multivariate logistic regression was used to analyze the risk factors of pulmonary thromboembolism with different severity. Results Among the 56 patients, 35 were male and 21 were female. The mean age was (46.23±18.12) years old. Postoperative pathology showed malignant tumor in 20 cases, accounting for 35.71%; benign tumors in 36 cases, accounting for 64.29%. Tumor site classification showed sellar region tumors in 26 cases, accounting for 46.43%; supratentorial tumor in 21 cases, accounting for 37.50%; skull base tumor in 7 cases, accounting for 12.5%; infratentorial tumor in 2 cases, accounting for 3.57%. There were no significant differences in clinical phenotype and coagulation function between the two groups (P ＞ 0.05). There was no significant difference in perioperative related factors between the two groups except the time of water fasting before operation (P ＞ 0.05). Multivariate logistic regression analysis showed that the presence of postoperative limb mobility disorder was a risk factor for pulmonary thromboembolism after craniocerebral tumor operation (OR = 9.574, P = 0.02). Conclusion Pulmonary thromboembolism after craniocerebral tumor operation has complex underlying causes and no specific clinical manifestations. The identification of the risk factors of pulmonary thromboembolism combined with the results of laboratory examination is helpful for the early diagnosis and treatment of  pulmonary thromboembolism.
2021 Vol. 18 (14): 76-80 [Abstract] ( 105 ) HTML (1 KB)  PDF (623 KB)  ( 86 )
81 Analysis of influencing factors of the formation of postoperative acute pressure ulcers in patients with subarachnoid hemorrhage
SHEN Jie1 WANG Jing2▲
 Objective To investigate the influencing factors of the formation of postoperative acute pressure ulcers in patients with subarachnoid hemorrhage (SAH). Methods The data of 80 patients with SAH who completed surgery in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January to October 2020 were retrospective analyzed. According to whether postoperative acute pressure ulcers occurred, they were divided into acute pressure ulcers group (10 cases) and no acute pressure ulcers group (70 cases). The general data of the two groups were compared, and the influencing factors of the formation of postoperative acute pressure ulcers in SAH patients were analyzed by univariate and multivariate analysis. Results The intraoperative body temperature of the acute pressure ulcers group was lower than that of the no acute pressure ulcers group, the preoperative fasting blood glucose level was higher than that of no acute pressure ulcers group, and the stress response degree was worse than that of the no acute pressure ulcers group, with statistical significant differences (all P < 0.05). The results of univariate and multivariate logistic regression analysis showed that high intraoperative body temperature were the protective factors for the formation of postoperative acute pressure ulcers in SAH patients (OR ＜ 1, P ＜ 0.05); high level of preoperative fasting blood glucose and severe stress response degree might be risk factors for postoperative acute pressure ulcers in SAH patients (OR ＞ 1, P ＜ 0.05). Conclusion Some patients with SAH are still at risk of postoperative acute pressure ulcers, which may be related to the high level of preoperative fasting blood glucose and severe stress response degree, and the high intraoperative body temperature may be helpful to prevent the formation of postoperative pressure ulcers. Patients at high risk should be actively intervened in early stage.
2021 Vol. 18 (14): 81-84 [Abstract] ( 136 ) HTML (1 KB)  PDF (609 KB)  ( 76 )
85 Risk factors analysis of patent ductus arteriosus with hemodynamic significance in preterm infants
WAN Yuan LI Yalin WANG Dandan
Objective To analyze the risk factors of patent ductus arteriosus with hemodynamic significance (hsPDA) in premature infants. Methods From January 2018 to June 2020, 80 cases of preterm infants with hsPDA admitted to Department of Neonatology, Xuancheng People’s Hospital, Anhui Province (“our hospital” for short) were selected as the observation group, and 80 cases of preterm infants without hsPDA delivered in our hospital during the same period were selected as the control group. The platelet (PLT) count, mean platelet volume (MPV), platelet distribution width (PDW), platelet hematocrit (PCT) and platelet large cell ratio (P-LCR) were compared between the two groups within 24 hours after birth; risk factors of hsPDA preterm infants were analyzed by logistic regression analysis. Results There were highly significant differences in gestational age, birth weight, neonatal 1 min Apgar score, neonatal respiratory distress syndrome, arterial duct diameter, left atrial diameter / aortic diameter between the two groups (all P < 0.01). There were significance differences in the ratio of cesarean section and gestational hypertension between the two groups (all P < 0.05). There were no significant differences in PLT and P-LCR between the two groups (P > 0.05); MPV, PDW and PCT in the observation group were lower than those in the control group, and the differences were highly statistically significant (all P < 0.01). Logistic regression analysis results showed that gestational age (OR = 0.721, 95%CI:0.270-0.932), cesarean section (OR = 0.601, 95%CI:0.168-0.970), gestational hypertension (OR = 0.699, 95%CI:0.231-0.807), MPV (OR = 1.669, 95%CI:1.217-2.288), PDW(OR = 1.906, 95%CI:1.460-2.488） and PCT(OR = 1.636, 95%CI:1.243-2.152) were influnce factors of hsPDA in preterm infants (P ＜ 0.05). Conclusion In preterm infants with hsPDA, the expression of MPV, PDW and PCT are significantly reduced, the gestational age, cesarean section, gestational hypertension, MPV, PDW and PCT are independent risk factors for the disease, and have high clinical application value.
2021 Vol. 18 (14): 85-88 [Abstract] ( 229 ) HTML (1 KB)  PDF (374 KB)  ( 116 )
89 Detection of serum interleukin and immunoglobulin levels in patients with esophageal cancer and its clinical significance
LI Rizhu1 GAO Jie2 NONG Feng1 WANG Juping2 TANG Renguang3
Objective To investigate the expression levels of serum interleukin (IL) and immunoglobulin in patients with esophageal cancer and its clinical significance. Methods A total of 150 patients with esophageal cancer admitted to Affiliated Hospital of Youjiang Medical University for Nationalities (hereinafter referred to as “our hospital”) from January 2016 to December 2018 were selected as esophageal cancer group. A total of 130 healthy subjects were selected as control group as the same period. The expression levels of IL-6, IL-10, IL-18, IgG, IgA and IgM were compared between two groups. At the same time, the expression levels of IL-6, IL-10, IL-18, IgG, IgA and IgM in esophageal cancer patients with different stages and metastasis or non-metastatic were compared. Results The levels of IL-6, IL-18 and IgA in esophageal cancer group were higher than those in control group, and the level of IL-10 was lower than that in control group (all P < 0.05). There were no significant differences in IgG and IgM levels between the two groups (P > 0.05). The levels of IL-6, IL-18 and IgA in stage Ⅲ-Ⅳ group were higher than those in stage Ⅰ-Ⅱ group, and the level of IL-10 was lower than that in stage Ⅰ-Ⅱ group (all P < 0.05). The levels of IL-6, IL-18 and IgA in metastatic esophageal cancer group were higher than those in non-metastatic esophageal cancer group, and the level of IL-10 was lower than that in non-metastatic esophageal cancer group (all P < 0.05). Conclusion The levels of IL-6, IL-18 and IgA in patients with esophageal cancer, stage Ⅲ-Ⅳ and metastasis are significantly increased, while IL-10 is significantly decreased. These indexes may provide basis for the diagnosis, treatment and prognosis of esophageal cancer.
2021 Vol. 18 (14): 89-92,110 [Abstract] ( 106 ) HTML (1 KB)  PDF (586 KB)  ( 108 )
93 Meta-analysis of the predictive value of systemic immune inflammatory index in the prognosis of patients with breast cancer
GU Jingjing1 ZHANG Weidong2 CHEN Dandan1 ZHANG Jianguo1 HUANG Guanhong3
Objective To investigated the predictive value of systemic immune inflammatory index (SII) in the prognosis of patients with breast cancer. Methods PubMed, Cochrane Library, Embase, and Web of Science databases were searched by computer, all the studies on SII and prognosis of patients with breast cancer were collected from January 2015 to July 2020. Stata 12.0 and Review Manager 5.3 software were used for data analysis. Results A total of eight studies were included in this study, including 2642 cases patients with breast cancer. Meta-analysis results showed that the proportion of tumor diameter > 2.0 cm in high SII patients with breast cancer was higher than that in low SII patients with breast cancer (OR = 1.49, 95%CI: 1.19-1.85, P = 0.0004). The proportion of lymph node metastases in high SII patients with breast cancer was higher than that in low SII patients with breast cancer (OR = 1.38, 95%CI: 1.12-1.69, P = 0.002). Overal survival in high SII patients with breast cancer was shorter than those with low SII breast cancer (HR = 2.06, 95%CI: 1.55-2.74, P < 0.000 01). Distase free survival in high SII patients with breast cancer was shorter than that in low SII patients with breast cancer (HR = 1.93, 95%CI: 1.63-2.30, P < 0.000 01). Conclusion SII can be used as a reliable indicator to predict the prognosis of patients of breast cancer.
2021 Vol. 18 (14): 93-97 [Abstract] ( 61 ) HTML (1 KB)  PDF (1263 KB)  ( 46 )
98 Correlation analysis of pelvic floor dysfunction and self-efficacy of pelvic floor muscle exercise in young postoperative survivors with cervical cancer
MA Lili1 XIN Chunyan2 MA Jing1 YE Jinchan1 SU Jianping1
Objective To investigate the self-efficacy of pelvic floor muscle exercise in young postoperative survivors of cervical cancer and to analyze its influencing factors, in order to provide a reference for the further formulation of accurate pelvic floor muscle rehabilitation. Methods A total of 105 young postoperative survivors who underwent radical resection of cervical cancer in a grade 3A cancer hospital in Xinjiang region from January to July 2020 were selected as the research subjects. The self-designed general information questionnaire, broome pelvic muscle self-efficacy scale (BPMSES) and pelvic floor distress inventory short form (PFDI-20) were used to investigate the current situation of the subjects. The correlation between pelvic floor dysfunction and self-efficacy of pelvic floor muscle exercise in young postoperative survivors with cervical cancer were analyzed. Results The total score of self-efficacy of pelvic floor muscle exercise in 105 young postoperative survivors of cervical cancer were (103.11±26.06) points, and pelvic floor dysfunction were 12.50(4.17, 22.40) points. There were statistically significant differences in scores of the self-efficacy of pelvic floor muscle exercise among young postoperative survivors with cervical cancer in different age, residence, occupation and marital status (all P < 0.05). The expected self-efficacy and total scores of pelvic floor muscle exercise in young postoperative survivors with cervical cancer were positively correlated with urination, defecation, pelvic organ prolapse and pelvic floor dysfunction total score. The expected results were positively correlated with urination, pelvic organ prolapse and pelvic floor dysfunction total score (all P < 0.05). The results of multiple stepwise linear regression analysis showed that pelvic organ prolapse, marital status, residence and defecation were the influencing factors of pelvic floor muscle exercise self-efficacy in young postoperative survivors with cervical cancer (P < 0.05), which cumulative explanatory self-efficacy score of pelvic floor muscle exercise was 18.3%. Conclusion Young postoperative survivors with cervical cancer of self-efficacy pelvic floor muscle exercise scores are generally high, medical staff should be combined with young postoperative survivors with cervical cancer pelvic floor of common complications and unique psychological characteristics to develop targeted nursing intervention measures, by guiding the active coping ways to prevent or reduce the occurrence of pelvic floor dysfunction, improve patient quality of life after surgery.
2021 Vol. 18 (14): 98-102 [Abstract] ( 282 ) HTML (1 KB)  PDF (607 KB)  ( 120 )
103 Comparison of the detection rate and safety of transrectal and transperineal puncture biopsy for prostate cancer
JIANG Ke HANG Zhenyu MA Hongxiang WU Ming
Objective To investigate the detection rate and safety of transrectal and transperineal puncture biopsy for prostate cancer. Methods Retrospective analysis was performed on 80 patients undergoing transrectal prostate puncture biopsy (transrectal group) and 80 patients undergoing transperineal prostate puncture biopsy (transperineal group) admitted to the Department of Urology, Liyang Branch of Jiangsu Provincial People’s Hospital from May 2015 to January 2020 were selected. The general data, the detection rate of prostate cancer, the occurrence of complications, and the perioperative conditions of prostate cancer patients undergoing radical resection were compared between two groups. Results There were no significant differences in age, body mass index, longest nodules meridian, number of nodules, prostate volume, total prostate specific antigen, Gleason score, number of puncture needles, number of positive puncture needles and number of unqualified samples between two groups (P > 0.05). The puncture time in transperineal group was longer than that in transrectal group (P < 0.01). There was no significant difference in the detection rate of prostate cancer between two groups (P ＞ 0.05). The incidence of total complications in transperineal group was lower than that in transrectal group (P < 0.01). The interval of puncture to radical operation, radical operation time in transperineal group were shorter than those in transrectal group, and intraoperative blood loss, intraoperative prostate tissue adhesion rate were lower than those in transrectal group (P < 0.05 or P < 0.01). Conclusion Compared with transrectal prostate cancer puncture biopsy, transperineal puncture biopsy has higher safety and less negative impact on radical surgery.
2021 Vol. 18 (14): 103-106 [Abstract] ( 122 ) HTML (1 KB)  PDF (599 KB)  ( 108 )
107 Application effect and safety of Docetaxel in postoperative chemotherapy after radical mastectomy
YUAN Le WAN Xin’an ZHOU Qin
Objective To investigate the application effect and safety of Docetaxel in chemotherapy after radical mastectomy. Methods Sixty patients with breast cancer who underwent radical mastectomy in the Second People’s Hospital of Wuhu City, Anhui Province from January 2015 to January 2017 were selected as research subjects. They were divided into two groups according to random number table method, with 30 cases in each group. Control group was given Epirubicin combined with Cyclophosphamide, and observation group was given Docetaxel on the basis of control group. The clinical efficacy and the occurrence degree of toxic side effects were compared between two groups. After treatment, the patients were followed up for three years by telephone. If the patients died, the follow-up was stopped. The survival rates of one to three years after treatment were observed between two groups. Results The total effective rate and disease control rate of observation group were higher than those of the control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the occurrence degree of toxic side effects in digestive system between two groups after treatment (P > 0.05). One and two years after treatment, there were no differences in survival rates between two groups (P > 0.05); three years after treatment, the survival rate of observation group was higher than that of control group, and the difference was statistically significant (P < 0.05). Conclusion Docetaxel chemotherapy after radical mastectomy has significant effect, high safety and good prognosis.
2021 Vol. 18 (14): 107-110 [Abstract] ( 115 ) HTML (1 KB)  PDF (562 KB)  ( 50 )
111 Effect of endoscopic EMR resection of gastrointestinal polyps and changes of gastrointestinal hormone levels
YANG Shenglan XIANG Zhengguo▲ CHEN Xufeng ZHENG Yang TANG Xiaolong
Objective To investigate the effect of endoscopic mucosal resection (EMR) on the treatment of gastrointestinal polyps and its effect on gastrointestinal hormone levels. Methods A total of 300 patients with gastrointestinal polyps admitted to No.904 th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army from October 2016 to October 2018 were selected and they were divided into EMR group and control group (high-frequency electrocoagulation ligation) by random number table method, with 150 cases in each group. The rate of complete polyp resection, operative time, intraoperative bleeding rate, delayed bleeding rate, changes of serum motilin, gastrin and vasoactive intestinal peptide levels before and after surgery and the incidence of complications in two groups were compared. Results The rate of intact polyp removal in EMR group was higher than that in control group (P < 0.05). There was no significant difference in operation time between EMR group and control group (P ＞ 0.05). The intraoperative bleeding rate and delayed bleeding rate in EMR group were significantly lower than those in control group (P ＜ 0.05). Twenty-four hours after surgery, the levels of motilin and gastrin in both groups were lower than those before surgery (P ＜ 0.05), but those in EMR group were higher than those in control group (P ＜ 0.05). Twenty-four hours after operation, vasoactive intestinal peptide in both groups was increased (P ＜ 0.05), but EMR group was lower than control group (P ＜ 0.05). Conclusion EMR treatment of gastrointestinal polyps is superior to high-frequency electrocoagulation ligation and has less effect on gastrointestinal hormone levels.
2021 Vol. 18 (14): 111-114 [Abstract] ( 86 ) HTML (1 KB)  PDF (591 KB)  ( 142 )
115 A study on the relationship between the use of online social network and mild cognitive impairment in the middle-aged and elderly in the community
FENG Tengyu1,2 WU Jingsong1,2,3 YIN Lianhua4 HAN Mengyu1,2 YANG Ting1,2 HUANG Jia1,2,3 LIU Zhizhen2,3
Objective To explore the relationship between online social network use and social isolation and mild cognitive impairment (MCI) among older adults in the community. Methods From June 2019 to January 2020, 758 middle-aged and elderly people in Fuzhou community were selected as the research subjects. According to the diagnostic criteria of MCI, they were divided into MCI group (179 cases) and cognitive normal group (579 cases). According to the Lubben scale score, a total score of <12 score was divided into the social isolation group (125 cases), ≥12 score was divided into the non-social isolation group (633 cases). The montreal cognitive assessment scale, the instrumental daily living competence scale, the simplified geriatric depression scale (GDS-15), the social network scale, and the online social network use questionnaire were used to evaluate the participants. Results Compared with the cognitively normal group, the MCI group had lower educational level (P ＜ 0.01); GDS-15 score was higher (P ＜ 0.01). There were no significant differences in age, gender, marriage, living status, life style and disease history between the two groups (P ＞ 0.05). The use of online social network in the cognitive normal group was longer than that in the MCI group (P ＜ 0.01). The daily duration of the cognitive normal group was longer than that of the MCI group, but the difference was not statistically significant (P ＞ 0.05). The social isolation group was lower than the non-social isolation group in terms of the number of years of online social network use and the daily length, with highly statistical significance (all P ＜ 0.01). Logistic regression analysis showed that the service life of online social network was related to MCI (OR = 0.181, 95%CI: 0.086, 0.384). Online social network use over 10 years significantly reduced the risk of MCI (OR = 0.263, 95%CI: 0.117, 0.591). There was no connection between the daily time of online social network and MCI (P ＞ 0.05). Conclusion The use of online social networks can reduce the occurrence of social isolation in middle-aged and elderly people and have a protective effect on cognitive function. The longer the use of online social networks, the lower the risk of MCI.
2021 Vol. 18 (14): 115-118,127 [Abstract] ( 97 ) HTML (1 KB)  PDF (611 KB)  ( 112 )
119 Study on correlation between generalized anxiety disorder and thyroid hormone level
YANG Zhihui1 PEI Qinghua2 LU Meimei1 WANG Chenxi1
Objective To investigate the relationship and correlation between generalized anxiety disorder (GAD) and thyroid hormone level. Methods With the cross-sectional study method, a total of 62 patients with generalized anxiety disorder who visited the Department of Encephalopathy of the Third Affiliated Hospital of Beijing University of Chinese Medicine (“our hospital” for short) from June 2019 to January 2020 were selected as study group, a total of 60 healthy adults who take a physical examination in the physical examination center of our hospital during the same period were selected as the control group. Serum thyroid hormone levels were measured in all subjects, including thyroid stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4) and free thyroxine (FT4). Hamilton anxiety scale (HAMA) was used to evaluate the anxiety level of all members of the study group, there were 20 cases in the mild anxiety group, 32 cases in the moderate anxiety group and 10 cases in the severe anxiety group. The differences of thyroid hormone levels between the study group and the control group and among the groups with different degrees of generalized anxiety disorder were compared. The relationship between generalized anxiety disorder and thyroid hormone levels was analyzed, the correlation between the groups with different degrees of generalized anxiety disorder and thyroid hormone levels was explored. Results The levels of T3 and T4 in the study group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in FT3, TSH and FT4 levels between the two groups (P ＞ 0.05). There were significant differences in T4 level among groups with different anxiety levels (P ＜ 0.05), and T4 level in severe anxiety group was higher than that in mild anxiety group and moderate anxiety group, respectively, with statistical significance (P ＞ 0.05). There were no significant differences in TSH, T3, FT3 and FT4 levels among the three groups (P ＞ 0.05). The anxiety level of GAD patients was positively correlated with T4 level (r = 0.332, P ＜ 0.01), and had no significant correlation with FT3, TSH, T3 and FT4. Conclusion Patients with GAD have abnormal thyroid hormone level, that is abnormal thyroid hormone level is correlated with the occurrence of GAD to a certain extent. Reasonable regulation of thyroid hormone level can reduce the risk of GAD to a certain extent.
2021 Vol. 18 (14): 119-122 [Abstract] ( 144 ) HTML (1 KB)  PDF (551 KB)  ( 66 )
123 Correlation research of diagnostic value of fractional exhaled nitric oxide in bronchial asthma and its correlation with bronchial provocation test by Astograph
CHEN Bin CHEN Fang▲
Objective To investigate the diagnostic value of fractional exhaled nitric oxide (FeNO) test for bronchial asthma and the correlation between the bronchial provocation test. Methods From June 2016 to April 2017, 162 patients with suspected asthma underwent bronchial provocation test in the First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine were selected, and the receiver operating characteristic (ROC) curves of FeNO for the diagnosis of bronchial asthma were drawn according to the medical history, physical signs, clinical symptoms, laboratory tests and the results of bronchial provocation test. The correlation between FeNO and the forced oscillation continuous tracing respiratory resistance method (Astograph) bronchial excitation test indexes was compared. Results A total of 162 patients with suspected bronchial asthma were divided into asthma group (78 patients) and non-asthma group (84 patients), and the FeNO value of asthma group was significantly higher than that of non-asthma group (P ＜ 0.001). The optimal threshold for diagnosis was 19.5 ppb, the sensitivity was 82.05%, the specificity was 65.48%, the positive predictive value was 68.1%, and the negative predictive value was 79.7%. FeNO was negatively correlated with response threshold of bronchial provocation test by astograph and minimum concentration at the beginning of resistance rise (r = -0.263, -0.253, all P ＜ 0.05). Conclusion The increase of FeNO level has a certain guiding effect on the diagnosis of asthma.
2021 Vol. 18 (14): 123-127 [Abstract] ( 89 ) HTML (1 KB)  PDF (755 KB)  ( 112 )
128 Analysis of clinical characteristics of pyogenic liver abscess patients with diabetes mellitus
XIAO Juan XIN Xiaojun▲
Objective To analyze the clinical characteristics of pyogenic liver abscess (PLA) patients with diabetes mellitus in order to guide the clinical diagnosis and treatment. Methods A total of 225 patients with PLA treated in the First Affiliated Hospital of Chongqing Medical University from January 2015 to December 2019 were selected, they were divided into diabetic group (109 cases) and non-diabetic group (116 cases) according to whether they had diabetes or not. The general data, basic diseases, clinical manifestation, laboratory findings, pathogenic results, complications, treatment and prognosis of the two groups were analyzed retrospectively. Results The mean age of diabetic group was higher than that of non-diabetic group (P ＜ 0.05). The probability of hypertension and cerebral infarction in diabetic group was higher than that in non-diabetic group (P ＜ 0.05). The probability of fever and fatigue in diabetic group was higher than that in non-diabetic group (P ＜ 0.05), and the prealbumin level was lower than that in non-diabetic group (P ＜ 0.05). Abdominal distension, abdominal pain, vomiting, chills and abdominal tenderness, tap pain, white blood cell count, liver area percentage granulocyte, hemoglobin, platelet count, albumin, alanine aminotransferase, aspartate aminotransferase, total bilirubin, activated clotting time live enzymes, prothrombin time, blood urea nitrogen, serum creatinine, calcitonin original differences between groups were no statistical significance (all P ＞ 0.05). The infection rate of total negative bacteria and Klebsiella Pneumoniae (KP) in diabetic group was higher than that in non-diabetic group, and the infection rate of streptococcus mueller group was lower than that in non-diabetic group (P ＜ 0.05). The proportion of pneumonia, sepsis and septic shock in DM group was higher than that in non-diabetic group (P ＜ 0.05), and there was no significant difference in antibiotic use and prognosis between the two groups (P ＞ 0.05). Conclusion PLA complicated with diabetes is common in middle-aged and elderly men with atypical clinical manifestations, easy to be complicated with KP infection, and more prone to complications such as pneumonia, sepsis, septic shock.
2021 Vol. 18 (14): 128-131 [Abstract] ( 117 ) HTML (1 KB)  PDF (555 KB)  ( 69 )
132 Analysis on medication rule of Professor Mao Dexi in treating chest arthralgia and heartache based on data mining technology
ZHAO Chuang1 LU Yongping2 SHI Ruoyu1
Objective To analyze the medication rule of Professor Mao Dexi in the treatment of chest arthralgia and heartache based on data mining technology. Methods The outpatient medical records of Professor Mao Dexi in treating chest arthralgia and heartache in the Famous Medical Hall of He’nan Hospital of Traditional Chinese Medicine from February 2018 to January 2020 were collected and collated. Professor Mao Dexi’s prescription for chest arthralgia and heartache was analyzed by using traditional Chinese medicine inheritance assistant system (V2.5) through data mining method, such as frequency analysis, association rules, complex entropy clustering analysis, and so on. Results There were 128 prescriptions for chest arthralgia and heartache, involving 145 traditional Chinese medicine, of which, cold and warm were the main ones, and pungent, bitter and sweet medicines accounted for a large proportion. The lung, spleen, stomach, heart and liver meridians appeared more frequently. The top five drugs used frequently were Salviae Miltiorrhizae Radix et Rhizoma, Paeoniae Radix Rubra, Chuanxiong Rhizoma, Dalbergiae Odoriferae Lignum, Allii Macrostemonis Bulbus. The most frequently used drug combinations were Paeoniae Radix Rubra-Salviae Miltiorrhizae Radix et Rhizoma, Chuanxiong Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma, Dalbergiae Odoriferae Lignum-Salviae Miltiorrhizae Radix et Rhizoma, Dalbergiae Odoriferae Lignum-Paeoniae Radix Rubra, Dalbergiae Odoriferae Lignum-Paeoniae Radix Rubra-Salviae Miltiorrhizae Radix et Rhizoma. Eight core drug combinations and four potential new prescriptions were found. Conclusion Professor Mao Dexi is good at promoting blood circulation and removing blood stasis, regulating qi and resolving phlegm, tonifying qi and nourishing yin, consolidating the root, combining cold and heat, reinforcing and reducing, and treating both symptoms and root causes.
2021 Vol. 18 (14): 132-135,144 [Abstract] ( 136 ) HTML (1 KB)  PDF (700 KB)  ( 86 )
136 Clinical study of Xuanjin Jiangni Decoction combined with Zuojin Pills in the treatment of reflux esophagitis
WANG Kun1 WANG Juan2 SUI Xin3 LIU Xiaojin1 MA Aiwen4
Objective To explore clinical effect of Xuanjin Jiangni Decoction combined with Zuojin Pills in the treatment of reflux esophagitis (RE). Methods Eighty patients with newly diagnosed RE in Dezhou People’s Hospital of Shandong Province from December 2018 to December 2019 were selected and divided into control group and study group according to random number table method, with 100 cases in each group. Control group was treated with conventional Western medicine, and study group was treated with Xuanjin Jiangni Decoction combined with Zuojin Pills. Clinical efficacy, Chinese medicine syndrome score, serological indicators and adverse reactions were compared between two groups. Results Total effective rate of study group was higher than that of control group (P < 0.05). After treatment, the scores of acid regurgitation, poststernal burning, irritability, upset, dry mouth and bitter mouth and constipation in two groups were lower than those before treatment, and the scores in study group were lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, the levels of motilin (MOT) and gastrin (GAS) in two groups were higher than those before treatment, the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in two groups were lower than those before treatment, and the levels of MOT and GAS in study group were higher than those in control group, and the levels of TNF-α and IL-6 in study group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence rate of adverse reactions between two groups (P > 0.05). Conclusion Xuanjin Jiangni Decoction combined with Zuojin Pills is safe and effective in the treatment of RE, which can effectively improve the clinical symptoms. Its mechanism may be related to the improvement of serum GAS, TNF-α, MOT and IL-6 levels.
2021 Vol. 18 (14): 136-139 [Abstract] ( 88 ) HTML (1 KB)  PDF (667 KB)  ( 23 )
140 Clinical effect of Bushen Huoxue Decoction combined with electroacupuncture and ear-point pressing beans in the treatment of patients with tinnitus
LYU Kun1 SUN Qinguo1 LUO Meng1 WU Longjun2
Objective To observe clinical effect of Bushen Huoxue Decoction combined with electroacupuncture and ear-point pressing beans in the treatment of patients with tinnitus and insomnia. Methods A total of 90 patients with tinnitus and insomnia treated in Outpatient Department of Traditional Chinese Medicine and Department of Ophthalmology in the Third Hospital of Wuhan City from May 2018 to October 2019 were selected and divided into Chinese medicine group, Chinese medicine + electroacupuncture group and Chinese medicine + electroacupuncture + auricular point pressing group according to random number table method, with 30 cases in each group. Seven days was as a course of treatment, a total of four courses. Clinical efficacy, tinnitus handicap inventory (THI) score, Pittsburgh sleep quality index (FSQI) score and total score of three groups were observed. Results Total effective rate of Chinese medicine + electroacupuncture + auricular point pressing group was significantly higher than that of Chinese medicine group and Chinese medicine + electroacupuncture group (P ＜ 0.0167). After treatment, THI scores of three groups were lower than those before treatment, and the scores of Chinese medicine + electroacupuncture + auricular point pressing group were lower than those of Chinese medicine group and Chinese medicine + electroacupuncture group (P < 0.05), and the scores of Chinese medicine + electroacupuncture group were lower than those of Chinese medicine group (P < 0.05). After treatment, all items FSQI scores of three groups were lower than those before treatment, and the scores of Chinese medicine + electroacupuncture + auricular point pressing group were lower than those of Chinese medicine group and Chinese medicine + electroacupuncture group (P < 0.05). After treatment, total FSQI scores of three groups were lower than those before treatment, and the scores of Chinese medicine + electroacupuncture + auricular point pressing group were lower than those of Chinese medicine group and Chinese medicine + electroacupuncture group (P < 0.05). Conclusion Bushen Huoxue Decoction combined with electroacupuncture and ear-point pressing beans in the treatment of tinnitus with insomnia has definite effect, which is worthy of clinical application.
2021 Vol. 18 (14): 140-144 [Abstract] ( 166 ) HTML (1 KB)  PDF (723 KB)  ( 93 )
145 Clinical observation of millifire needle combined with liming tendon manipulation in the treatment of knee osteoarthritis
LIU Haiyong1 ZHANG Jin2 LIU Fubiao3 WANG Yanying4 WU Xiaojian5 ZHANG Rui6 YANG Lisheng7
Objective To observe clinical effect of millifire needle combined with liming tendon manipulation in the treatment of knee osteoarthritis. Methods Eighty patients with knee osteoarthritis treated in Sanhe Hospital of Hebei Province from October 2019 to August 2020 were selected as research objects and they were divided into treatment group and control group according to random number table method, with 40 cases in each group. Treatment group was treated with millifire needle and liming tendon manipulation combined with oral Diclofenac Sodium Sustained Release Tablets, while control group was treated with liming tendon manipulation combined with oral Diclofenac Sodium Sustained Release Tablets. Western Ontario and McMaster University osteoarthritis index (WOMAC) score, visual analogue scale (VAS) and curative effect were compared between two groups. Results After treatment, WOMAC scores of two groups were lower than those before treatment, and treatment group was lower than that of control group, the differences were statistically significant (P < 0.05). After treatment, VAS of two groups were lower than those before treatment, and treatment group was lower than that of control group, the differences were statistically significant (P < 0.05). Total effective rate of treatment group was higher than that of control group, the difference was statistically significant (P < 0.05). Conclusion The effect of millifire needle combined with liming tendon manipulation in the treatment of knee osteoarthritis is significant and safe, which is suitable for clinical application.
2021 Vol. 18 (14): 145-148 [Abstract] ( 162 ) HTML (1 KB)  PDF (711 KB)  ( 91 )
149 Exploration on the innovation of integrated construction path of disciplines and specialties in traditional Chinese medicine colleges and universities under the new background
WANG Chunyan1 ZHU Shu2 LIU Hongyan3 SHANG Qingxin2 WU Wei2 REN Jian2 LYU Yingyu2 ZHAO Lu2
Both disciplines and specialties have undertaken the important task of personnel training in colleges and universities, the two are closely related and complementary. The coordinated development of disciplines and specialties will be extremely helpful to improve the quality and level of colleges and universities and become an important measure to realize the connotative development. This paper analyzes the research progress in the integration of disciplines and specialties in traditional Chinese medicine colleges and universities, summarizes the problems, combines the construction practice, takes the discipline of traditional Chinese medicine as an example, to innovate and explore the integrated construction path of disciplines and specialties in traditional Chinese medicine, strengthen the intersection of disciplines and industries, promote the benign interaction between scientific research and teaching, perfect the system of scientific research innovation and achievement transformation, realize the “co-cultivation + co-research + win-win” integrated construction of disciplines and specialties under the new background, and explore effective strategies for the coordinated development of disciplines and specialties to improve the quality of traditional Chinese medicine personnel training.
2021 Vol. 18 (14): 149-151,155 [Abstract] ( 76 ) HTML (1 KB)  PDF (714 KB)  ( 195 )
152 Summary of Professor Yang Zhihong’s experience in treating insomnia with phlegm-fire disturbing heart syndrome
YU Huan1 YANG Zhihong2 ZHU Xiaona2 GUAN Yu1
This article aims to introduce etiology, pathogenesis and experience of Professor Yang Zhihong in treating insomnia with phlegm-heat disturbing heart syndrome. Professor Yang Zhihong thinks that location of insomnia of phlegm-fire disturbing heart syndrome is mainly in the heart, liver and spleen. Most of clinical symptoms belong to the excess of phlegm fire, which is the deficiency of liver and spleen. Its treatment is not only clearing heart fire and resolving phlegm turbidity to dispel excess evil, but also soothing liver, strengthening spleen and nourishing heart. Therefore, in the process of disease progression, we often do not forget to invigorate spleen to help the earth and cultivate the yuan, and we are good at selecting the classic famous Huanglian Wendan Decoction. This article summarizes Professor Yang Zhihong’s treatment of insomnia of phlegm-fire disturbing heart syndrome from the definition, syndrome differentiation, treatment and clinical cases of insomnia, in order to better combine the experience and theory of famous traditional Chinese medicine, and provide ideas for the treatment of insomnia in the future.
2021 Vol. 18 (14): 152-155 [Abstract] ( 135 ) HTML (1 KB)  PDF (664 KB)  ( 156 )
156 Retrospective analysis of adverse drug reaction induced by antipsychotics drug
SHAO Qing ZHANG Xiaohong QUAN Wei DAI Zunxiao LIU Fei
Objective To analyze the characteristics of incidence of adverse drug reactions (ADR) induced by antipsychotics drug, and to provide the basis for rational use of drugs in clinic. Methods A total of 897 patients with ADR reported by Xi’an Mental Health Center (hereinafter referred to as “our hospital”) in the national adverse drug reactions monitoring system from January 2009 to December 2019 were collected. Among them, 775 cases developed ADRs caused by antipsychotics drug, and the time of ADRs, clinical manifestations, drug types, systems or organs involved were analyzed statistically. Results Seven hundred and seventy-five cases of ADRs caused by antipsychotic drugs involved 16 items gauge. Among them, the top ten drugs in the list of ADR incidence were Olanzapine Tablets, Amsulapride Tablets, Clozapine Tablets, Quetiapine Fumarate Tablets, Risperidone Tablets, Risperidone Dispersible Tablets, Haloperidol Injection, Aripiprazole Orally Disintegrated Tablets, Hydrochloride Ziprasidone Capsules, and Hydrochloride Ziprasidone Tablets. The nervous system was the most involved system (221 cases, 26.53%), followed by the cardiovascular system (202 cases, 24.25%). In addition, the incidence of ADR within 15 days after medication accounted for 52.38%. Conclusion The type and proportion of ADR of antipsychotics drug reported by our hospital were consistent with the key requirements of drug administration department. ADR can occur at all stages, and attention should be paid to drugs with a high incidence of ADR, especially monitoring and laboratory examination within 15 days after administration.
2021 Vol. 18 (14): 156-159 [Abstract] ( 110 ) HTML (1 KB)  PDF (370 KB)  ( 168 )
160 Influence of responsibility system grouping management mode on the quality and satisfaction of cardiology nursing
JIA Yuanyuan XU Huaiyu▲ JI Shanshan
Objective To explore the impact of responsibility system group management on the quality and satisfaction of cardiology care. Methods A total of 11 nurses from the Department of Cardiology, Huai’an First People’s Hospital, Jiangsu Province were selected as the research objects. The traditional nursing system was implemented from January to December 2017, and the responsibility system group management model was used for intervention from January to December 2018. At the same time, 100 patients and 20 doctors were included before and after the implementation, Patients and doctors’ satisfaction with nursing care, nursing quality scores, and the incidence of nursing accidents in the past year under different management models were analyzed. Results After the implementation of the responsibility system grouping mode management, doctors’ satisfaction scores for nursing work were significantly higher than before implementation, and the difference was statistically significant （P ＜ 0.05）. After the implementation of the responsibility system group management, the patient satisfaction score was significantly higher than before the implementation, the difference was statistically significant（P ＜ 0.05）. After the implementation of the responsibility system grouping mode management, the nursing quality score was significantly higher than that before the implementation, and the difference was statistically significant （P ＜ 0.05）. The total incidence of nursing accidents among nursing staff in the past year was significantly lower than before implementation, and the difference was statistically significant （P ＜ 0.05）. Conclusion The establishment of a responsibility system group management model will help improve the quality of cardiology care, increase the satisfaction of patients and doctors with nursing services, and effectively prevent the incidence of nursing accidents.
2021 Vol. 18 (14): 160-163 [Abstract] ( 83 ) HTML (1 KB)  PDF (621 KB)  ( 57 )
164 Reconstruction of health education program for elderly female patients with stress urinary incontinence based on Delphi method
GAO Yan1 YE Meng1 SHEN Xiaoping1 XU Fanglei2
Objective To construct a health education program for elderly female patients with stress urinary incontinence by applying Delphi method. Methods Form July to December 2019, the literature research method was used by research team to draft the contents of the health education program for elderly women with stress urinary incontinence. A total of 11 specialists were selected from Changzheng Hospital Affiliated to Naval Military Medical University, Huadong Hospital affiliated to Fudan University, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Tongji Hospital of Tongji University, People’s Hospital of Putuo District in Shanghai. Delphi method was used by specialists to construct a health education program for elderly women with stress urinary incontinence in two rounds. Results The return rate of the two rounds of expert consultation questionnaires was 100%, and the expert authority coefficient was 0.928. The plan was revised based on expert opinions, and 3 first-level items, 15 second-level items, and 61 third-level items were finally determined. Conclusion This research program is scientific and practical, and can provide theoretical guidance for clinical nurses to implement health education for elderly female patients with stress urinary incontinence.
2021 Vol. 18 (14): 164-168 [Abstract] ( 65 ) HTML (1 KB)  PDF (673 KB)  ( 57 )
169 Application of based on CICARE communication mode in patients with fracture of tibial plateau surgery
SUN Jingming FENG Qiuyan▲
Objective To explore the application effect of based on CICARE communication mode nursing in patients with fracture of tibial plateau (FTP) surgery. Methods A prospective study of 107 FTP patients admitted to Hainan Hospital of Traditional Chinese Medicine from July 2018 to March 2020 was included, according to the odd-even number of hospitalized patients, 53 patients with even number were included in group A and 54 patients with single number were included in group B; group A were received routine care and group B were received based on CICARE communication mode care. Before surgery and on the day of discharge, negative emotions, nursing satisfaction was compared between the two groups; the knee function of the two groups was compared before and after six months of follow-up. Results There was no significant difference in the scores of hamilton anxiety (HAMA) and hamilton depression (HAMD) scale between the two groups (P ＞ 0.05); the scores of HAMA and HAMD in the two groups on the day of discharge were lower than those before operation, and the scores of HAMA and HAMD in group B were lower than those in group A, with statistical significance (P ＜ 0.05); the nursing satisfaction of group B was higher than group A, and the difference was statistically significant (P ＜ 0.05); the knee function scores of both groups six months after surgery were higher than those before surgery, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in knee function between the two groups (P ＞ 0.05). Conclusion FTP patients adopt CICARE communication mode nursing, which is beneficial to reduce patients’ negative emotions and improve nursing satisfaction.
2021 Vol. 18 (14): 169-172 [Abstract] ( 145 ) HTML (1 KB)  PDF (671 KB)  ( 107 )
173 Application of strengthening rehabilitation nursing multidisciplinary combined with virtual reality training in severe patients with multiple fractures
MO Yuzhu1 WANG Haiyan1▲ YE Ping2
Objective To explore the application effect of strengthening rehabilitation nursing multidisciplinary combined with virtual reality training in severe patients with multiple fractures. Methods A total of 92 severe patients with multiple fractures who completed surgical treatment from June 2019 to June 2020 in Hainan West Central Hospital were selected as the research subjects, they were divided into observation group and control group in each group by the random number table method, with 46 case in each group, the multidisciplinary nursing mode of intensive rehabilitation nursing was adopted in control group, intensive rehabilitation nursing multidisciplinary combined virtual reality training nursing mode was adopted in observation group, both were received three months of continuous nursing. Before and three months after nursing, the balance function, motor function of both groups were evaluated and compared; after three months of nursing, the walking function and compliance of the two groups were evaluated and compared; the incidence of postoperative complications was compared between the two groups. Results After three months of nursing, the Berg balance scale (BBS) score, simplified Fugl-Meyer motor function assessment (FMA) score of both groups were higher than those before nursing, and the observation group was higher than the control group, with statistical significant differences (P ＜ 0.05); the lower limb walking ability grading of the observation group was better than that of the control group, and the exercise compliance of the observation group was better than that of the control group, the difference was statistically significant (P ＜ 0.05), there was no significant difference in the incidence of postoperative complications between the two groups (P ＞ 0.05). Conclusion Strengthening rehabilitation nursing multidisciplinary combined with virtual reality training can improve the exercise compliance of severe patients with multiple fractures, and promote the improvement of balance function, motor function and walking function.
2021 Vol. 18 (14): 173-176 [Abstract] ( 84 ) HTML (1 KB)  PDF (664 KB)  ( 25 )
177 Application effect of FMEA model in optimizing the first aid process of patients with severe craniocerebral injury
WU Yao1 ZHOU Zhengwu1 YIN Huiling2
Objective To explore the effect of failure mode and effect analysis (FMEA) on optimizing emergency nursing process of severe craniocerebral injury patients. Methods A total of 100 patients with severe craniocerebral injury in the Department of Emergency Lu’an Hospital of Anhui Medical University from April to October 2019 were selected as the research subjects, 50 patients treated from April to October 2019 were treated as the control group and received routine emergency care were given, patients treated from November 2019 to April 2020 were treated as the observation group and optimized care based on FMEA mode were given. The rescue effect and complications were compared. The national Institute of health stroke (NIHSS) score, glasgow coma score (GCS) and nursing satisfaction were recorded. Results The total effective rate of the observation group was higher than the control group (P ＜ 0.05); after nursing, NIHSS scores of both groups were decreased, and observation group was lower than control group; GCS scores of both groups were increased, the GCS score of observation group was higher than that of control group (P ＜ 0.05); the inspection return time, consultation arrival time and rescue room stay time of the observation group were shorter than those of the control group (P ＜ 0.05); the emergency nursing operation evaluation and nursing care of the observation group were significantly lower than those of the control group (P ＜ 0.05), the evaluation of emergency nursing operation, nursing service attitude and nursing effect in the observation group were significantly higher than those in the control group (P ＜ 0.05). Conclusion The optimized emergency nursing process based on FMEA model can effectively improve the emergency rescue effect and neurological function of patients with severe craniocerebral injury, reduce adverse reactions during nursing, and improve the satisfaction, which can be widely used in clinical practice.
2021 Vol. 18 (14): 177-180 [Abstract] ( 118 ) HTML (1 KB)  PDF (664 KB)  ( 95 )
181 Application of disease awareness nursing based on self-regulation model in dialysis patients with acute lymphoblastic leukemia
ZHANG Yang ZHANG Ling▲ XU Jing
Objective To explore the application effect of self-regulation model (SRM)-based illness perceptionness (IP) nursing in patients with acute lymphocytic leukemia (ALL) and dialysis. Methods A total of 99 ALL dialysis patients treated in the Department of Hematology, the First Affiliated Hospital of Hebei North University from April 2018 to November 2019 were selected as subjects. According to the random number table, they were divided into group A 49 cases, routine care were adopt and group B 50 cases, IP nursing based on SRM care were adopted. Before nursing and two months after nursing, the brief illness perception questionnaire (BIPQ) was used to assess the IP abilities of both groups, the herth hope inventory (HHI) was used to evaluate the hope levels of both groups, the connor-davidson resilience scale (CD-RISC) was used to assess the psychological resilience of both groups; after two months of nursing, a self-made compliance scale was used to evaluate the treatment compliance of the two groups. Results After two months of nursing, BIPQ score, HHI score and CD-RISC score were higher in both groups than before, and the BIPQ score, HHI score and CD-RISC scores in all dimensions of group B were higher than those of group A, with statistical significant differences (all P ＜ 0.05); the scores of treatment compliance in both groups were higher than before, and the treatment compliance of group B was higher than that of group A, with a statistical significant difference (P ＜ 0.05). Conclusion SRM based IP nursing for ALL dialysis patients is beneficial to improve their IP ability and hope level, improve their psychological flexibility, and improve treatment compliance of them after nursing.
2021 Vol. 18 (14): 181-184 [Abstract] ( 96 ) HTML (1 KB)  PDF (671 KB)  ( 79 )
185 Study on improving strategy of emergency department nurses’ disaster nursing ability
FENG Xiumin1 LI Jing1 LI Fan2▲ LI Shuya3
Objective To understand the current situation of disaster nursing ability of nurses in emergency department, and formulate strategies to improve disaster nursing ability. Methods One-on-one interviews with 15 domestic disaster relief experts from June to July 2018, colaizzi seven-step analysis method was adopted the data were analyzed. Results Nurses in emergency department have advantages in disaster rescue; emergency department nurses should have diversified disaster nursing capabilities; emergency department nurses’ disaster rescue ability needs to be improved, and the training system needs to be improved. Conclusion Hospital administrators and medical educators can build a domestic disaster nursing training management system, train disaster rescue teams, and improve the core competence of emergency nurses in disaster nursing.
2021 Vol. 18 (14): 185-188 [Abstract] ( 212 ) HTML (1 KB)  PDF (614 KB)  ( 28 )
189 Question and resolution on the qualification management system of Chinese physicians in double track system
ZHANG Yuan1,2 BAI Simin1,2 OUYANG Jing1,2 LI Xiuqin1,2 YUAN Ruihua3
Law of the People’s Republic of China on Traditional Chinese Medicine and Pharmacy advocates the qualification examination system of traditional Chinese medicine doctors, and breaks the single qualification examination system of Law of the People’s Republic of China on Medical Practitioners. At present, the two kinds of physician qualification management systems are both legal and effective, which are separated and parallel, forming a operation mode of double track system. By comparing the two systems, it is found that they are quite different. In operation, it is easy to cause disputes of fairness and risk, and the scope of practice of traditional Chinese medicine practitioners is not clearly stipulated by the two systems. The implementation of the new policy will bring more staff and clinics, which will also bring pressure to grass-roots supervision. In addition, the different interpretation and implementation of the new policy will not be conducive to the unity of legal construction and policy implementation. This paper proposes and approves the following four suggestions: It is suggested that the access system should be strictly enforced to ensure fairness. It is suggested to perfect the regulation of the scope of practice of traditional Chinese medicine practitioners. It is suggested to perfect the management organization and establishment of traditional Chinese medicine practitioners, as well as to perfect the policies with specific expertise, so as to promote the unity of legal construction and policy implementation, to promote the improvement of the management system of traditional Chinese medicine practitioners’ qualification.
2021 Vol. 18 (14): 189-192,196 [Abstract] ( 52 ) HTML (1 KB)  PDF (475 KB)  ( 129 )
193 Study on the quality improvement of medical students’ grassroots volunteer service under the background of targeted poverty alleviation
JIANG Jifeng1 LI Baoguo2
The main form of social practice for medical students is “three to the countryside” social practice activities, through the development of medical voluntary services in the national health poverty alleviation strategy to play an important role. Taking the special social practice activity of “health poverty alleviation” organized by the central committee of the communist youth league and the communist youth league work union of pharmaceutical colleges as the research object, the outstanding characteristics and positive effects of the current medical colleges and universities organizing medical students to carry out social poverty alleviation volunteer service practice are summarized. Analyze the medical students in the process of medical volunteer service in the accuracy is not high, the integrity is not enough and the continuity is not strong and other related problems, and put forward the corresponding countermeasures in the aspects of thought guidance, activity platform construction and activity mode improvement.
2021 Vol. 18 (14): 193-196 [Abstract] ( 65 ) HTML (1 KB)  PDF (499 KB)  ( 41 )
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