Clinical study of Xuanjin Jiangni Decoction combined with Zuojin Pills in the treatment of reflux esophagitis
WANG Kun1 WANG Juan2 SUI Xin3 LIU Xiaojin1 MA Aiwen4
1.Department of Pharmacy, Dezhou People’s Hospital, Shandong Province, Dezhou 253000, China;
2.Department of Internal Medicine, Qiancao Town Health Center of Pingyuan County of Dezhou City, Shandong Province, Pingyuan 253113, China; 3.Department of Gastroenterology, Dezhou People’s Hospital, Shandong Province, Dezhou 253000, China;
4.Department of Proctology, Dezhou Anorectal Hospital, Shandong Province, Dezhou 253000, China
Abstract Objective To explore clinical effect of Xuanjin Jiangni Decoction combined with Zuojin Pills in the treatment of reflux esophagitis (RE). Methods Eighty patients with newly diagnosed RE in Dezhou People’s Hospital of Shandong Province from December 2018 to December 2019 were selected and divided into control group and study group according to random number table method, with 100 cases in each group. Control group was treated with conventional Western medicine, and study group was treated with Xuanjin Jiangni Decoction combined with Zuojin Pills. Clinical efficacy, Chinese medicine syndrome score, serological indicators and adverse reactions were compared between two groups. Results Total effective rate of study group was higher than that of control group (P < 0.05). After treatment, the scores of acid regurgitation, poststernal burning, irritability, upset, dry mouth and bitter mouth and constipation in two groups were lower than those before treatment, and the scores in study group were lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, the levels of motilin (MOT) and gastrin (GAS) in two groups were higher than those before treatment, the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in two groups were lower than those before treatment, and the levels of MOT and GAS in study group were higher than those in control group, and the levels of TNF-α and IL-6 in study group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence rate of adverse reactions between two groups (P > 0.05). Conclusion Xuanjin Jiangni Decoction combined with Zuojin Pills is safe and effective in the treatment of RE, which can effectively improve the clinical symptoms. Its mechanism may be related to the improvement of serum GAS, TNF-α, MOT and IL-6 levels.
WANG Kun1 WANG Juan2 SUI Xin3 LIU Xiaojin1 MA Aiwen4. Clinical study of Xuanjin Jiangni Decoction combined with Zuojin Pills in the treatment of reflux esophagitis[J]. 中国医药导报, 2021, 18(14): 136-139.
