广泛性焦虑障碍与甲状腺激素水平的相关性研究

Abstract
Figure/Table
References (27)
Related Citation (0)

Download: PDF (551 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship and correlation between generalized anxiety disorder (GAD) and thyroid hormone level. Methods With the cross-sectional study method, a total of 62 patients with generalized anxiety disorder who visited the Department of Encephalopathy of the Third Affiliated Hospital of Beijing University of Chinese Medicine (“our hospital” for short) from June 2019 to January 2020 were selected as study group, a total of 60 healthy adults who take a physical examination in the physical examination center of our hospital during the same period were selected as the control group. Serum thyroid hormone levels were measured in all subjects, including thyroid stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4) and free thyroxine (FT4). Hamilton anxiety scale (HAMA) was used to evaluate the anxiety level of all members of the study group, there were 20 cases in the mild anxiety group, 32 cases in the moderate anxiety group and 10 cases in the severe anxiety group. The differences of thyroid hormone levels between the study group and the control group and among the groups with different degrees of generalized anxiety disorder were compared. The relationship between generalized anxiety disorder and thyroid hormone levels was analyzed, the correlation between the groups with different degrees of generalized anxiety disorder and thyroid hormone levels was explored. Results The levels of T3 and T4 in the study group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in FT3, TSH and FT4 levels between the two groups (P ＞ 0.05). There were significant differences in T4 level among groups with different anxiety levels (P ＜ 0.05), and T4 level in severe anxiety group was higher than that in mild anxiety group and moderate anxiety group, respectively, with statistical significance (P ＞ 0.05). There were no significant differences in TSH, T3, FT3 and FT4 levels among the three groups (P ＞ 0.05). The anxiety level of GAD patients was positively correlated with T4 level (r = 0.332, P ＜ 0.01), and had no significant correlation with FT3, TSH, T3 and FT4. Conclusion Patients with GAD have abnormal thyroid hormone level, that is abnormal thyroid hormone level is correlated with the occurrence of GAD to a certain extent. Reasonable regulation of thyroid hormone level can reduce the risk of GAD to a certain extent.

Key words： Generalized anxiety disorder Thyroid hormone level Thyroxine lever Degree of anxiety

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Zhihui1 PEI Qinghua2 LU Meimei1 WANG Chenxi1

Cite this article:

YANG Zhihui1 PEI Qinghua2 LU Meimei1 WANG Chenxi1. Study on correlation between generalized anxiety disorder and thyroid hormone level[J]. 中国医药导报, 2021, 18(14): 119-122.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/119

[1] 郑晓敏，叶芳，刘翠平.甲状腺疾病与贫血的相关关系研究进展[J].中国医药导报，2018，15（30）：40-43.
[2] 焦杨，蓝长安，胡华.甲状腺功能异常对患者焦虑、抑郁情绪的影响[J].重庆医科大学学报，2008（4）：453-456.
[3] Alonso J，Liu Z，Evans-Lacko S，et al. Treatment gap for anxiety disorders is global： Results of the World Mental Health Surveys in 21 countries [J]. Depress Anxiety，2018， 35（3）：195-208.
[4] American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders： Fifth Edition，DSM-5 [M]. Washington DC：American Psychiatric Association，2013：155-188.
[5] 张明圆.精神评定量表手册[M].长沙：湖南科学技术出版社，1998：121-126，133-136，163-166.
[6] 王维治.神经病学[M].2版.北京：人民卫生出版社，2013：2102.
[7] 唐启盛，曲淼，孙文军.焦虑障碍中医证候诊断标准及治疗方案[J].北京中医药，2018，37（2）：103-104.
[8] 季日格，伊琦忠，高文玉.多药联合治疗广泛性焦虑障碍的效果及其对患者生活质量的影响[J].中国医药导报，2016，13（9）：157-159，164.
[9] Nex?覬 MA，Watt T，Cleal B，et al. Exploring the experiences of people with hypo-and hyperthyroidism [J]. Qualitative Health Research，2015，25（7）：945-953.
[10] Du Xin，Pang Terence Y. Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases? [J]. Frontiers in Psychiatry，2015，6：32.
[11] Fischer S，Ehlert U. Hypothalamic-pituitary-thyroid（HPT）axis functioning in anxiety disorders. A systematic review [J]. Depression and Anxiety，2018，35（1）：98-110.
[12] Aarab C，Hammani Z，Aalouane R，et al. Acute psychosis secondary todysthyroidism：about 2 cases [J]. Pan Afr Med J，2016，25（12）：216.
[13] Yu D，Zhou H，Yang Y，et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J]. Hormones and Behavior，2015，69：106-115.
[14] Bense?觡or IM，Nunes MA，Sander Diniz MF，et al. Subclinical thyroid dysfunction and psychiatric disorders： cross-sectional results from the Brazilian Study of Adult Health （ELSA-Brasil） [J]. Clinical Endocrinology，2016， 84（2）：250-256.
[15] 夏春梅，翟慧，佟玉英，等.甲状腺功能亢进患者心理健康与冲动性人格关系[J].中国公共卫生，2012，28（11）：1491-1493.
[16] 栗玉辉.甲状腺功能亢进与焦虑、抑郁情绪及生活质量的关系[D].石家庄：河北医科大学，2017.
[17] Ling L，Zhi M，Hou Z，et al. Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism： a resting-state functional MRI study [J]. Oncotarget，2017，8（4）：6283-6294.
[18] 金睿，徐理，杨玥，等.焦虑与抑郁障碍共病患者症状与血清甲状腺激素水平的相关分析[J].四川精神卫生，2016， 29（4）：323-326.
[19] 刘振静，王珣，宋欣欣，等.女性焦虑障碍患者家庭环境、生活事件及甲状腺激素水平的分析[J].临床精神医学杂志，2018，28（5）：335-337.
[20] 肖迎光，杜惠兰，谈金莲，等.焦虑症患者的COR、甲状腺激素及自主神经的功能特点及神经内分泌、自主神经功能影响因素分析[J].国际精神病学杂志，2015，42（4）：36-39.
[21] 程敏锋，温盛霖，甘照宇.广泛性焦虑症患者甲状腺激素的变化及其与人格特征的关联性[J].中华临床医师杂志：电子版，2010，4（8）：1406-1408.
[22] 刘彩兴，张少丽，宋欣欣，等.142例女性广泛性焦虑障碍患者甲状腺激素水平及相关因素分析[J].国际精神病学杂志，2018，45（5）：875-877，887.
[23] 赵子然.甲状腺功能异常对焦虑、抑郁情感及生活质量的影响[D].济南：山东大学，2014.
[24] 王敏，逄力男，柳林，等.甲状腺功能亢进症伴发焦虑障碍的相关因素探讨[J].中国医药科学，2013，3（10）：213-214.
[25] 冯畅，施克新，杨梅，等.甲状腺激素水平与更年期综合征女性情绪障碍程度、性激素水平及免疫功能的相关性分析[J].临床和实验医学杂志，2020，19（24）：2654-2657.
[26] 祝颖，陈一丹，韩怡雯，等.产后抑郁症与甲状腺功能关系的研究进展[J].中国现代医生，2019，57（35）：165-168.
[27] 谈颂桃，曹健伟，郑小泳，等.双相障碍、抑郁障碍患者甲状腺激素水平与治疗转归的相关性研究[J].中国基层医药，2020（9）：1046-1050.