帕金森病异动症治疗进展

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Abstract Levodopa-induced dyskinesia is a complication caused by long-term treatment of Levodopa in patients with Parkinson’s disease. The treatment of Levodopa-induced dyskinesia is mainly divided into two parts, drug therapy and non-drug therapy. In non-drug therapy, deep brain stimulation and unilateral pallidotomy is considered to be effective. Drug therapy focuses on providing continuous dopaminergic stimulation, such as the development of new Dopamine preparations, catechol-O-methyltransferase inhibitors, Subcutaneous Apomorphine and Levodopa-carbidopa enteral gel continuous jejunal infusion, the second is the use of non-dopaminergic drugs such as Amantadine, Clozapine and Levetiracetam. Although the preclinical results of most non-dopaminergic drugs are encouraging, however, due to the uncertainty of its effect and its side effects, at present, the transformation to clinical practice is still challenging. This article describes in detail the latest treatment of Levodopa-induced dyskinesia at home and abroad, so as to provide reference for daily clinical work.

Key words： Parkinson’s disease Levodopa-induced dyskinesia Pathophysiological mechanisms Treatment progress

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	ZHONG Zhe XU Min CHEN Weijie GAO Huan YE Min

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ZHONG Zhe XU Min CHEN Weijie GAO Huan YE Min. Progress in the treatment of dyskinesia in Parkinson’s disease[J]. 中国医药导报, 2021, 18(14): 39-42.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/39

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