呼出气一氧化氮对支气管哮喘的诊断价值与Astograph法支气管激发试验相关性研究

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Abstract Objective To investigate the diagnostic value of fractional exhaled nitric oxide (FeNO) test for bronchial asthma and the correlation between the bronchial provocation test. Methods From June 2016 to April 2017, 162 patients with suspected asthma underwent bronchial provocation test in the First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine were selected, and the receiver operating characteristic (ROC) curves of FeNO for the diagnosis of bronchial asthma were drawn according to the medical history, physical signs, clinical symptoms, laboratory tests and the results of bronchial provocation test. The correlation between FeNO and the forced oscillation continuous tracing respiratory resistance method (Astograph) bronchial excitation test indexes was compared. Results A total of 162 patients with suspected bronchial asthma were divided into asthma group (78 patients) and non-asthma group (84 patients), and the FeNO value of asthma group was significantly higher than that of non-asthma group (P ＜ 0.001). The optimal threshold for diagnosis was 19.5 ppb, the sensitivity was 82.05%, the specificity was 65.48%, the positive predictive value was 68.1%, and the negative predictive value was 79.7%. FeNO was negatively correlated with response threshold of bronchial provocation test by astograph and minimum concentration at the beginning of resistance rise (r = -0.263, -0.253, all P ＜ 0.05). Conclusion The increase of FeNO level has a certain guiding effect on the diagnosis of asthma.

Key words： Fractional exhaled nitric oxide Bronchial asthma Bronchial provocation test Astograph method

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	CHEN Bin CHEN Fang▲

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CHEN Bin CHEN Fang▲. Correlation research of diagnostic value of fractional exhaled nitric oxide in bronchial asthma and its correlation with bronchial provocation test by Astograph[J]. 中国医药导报, 2021, 18(14): 123-127.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/123

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