哈萨克族食管鳞癌中hMSH2及FHIT表达的临床病理学意义

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Abstract Objective To investigate the expression of hMSH2 and FHIT genes in Kazakh esophageal squamous cell carcinoma, and analyze the correlation between gene expression and its clinicopathological significance. Methods Esophageal cancer and its adjacent normal tissue specimens were selected from 43 patients who underwent radical resection of esophageal cancer in the First Affiliated Hospital of Xinjiang Medical University from May 2013 to May 2017. qRT-PCR method was used on 30 cases, while immunohistochemistry was conducted on 43 cases to study their clinicopathological characteristics. Results The mRNA expression levels of both hMSH2 and FHIT genes in esophageal squamous cell carcinoma tissues were significantly lower than those in adjacent normal tissues, and the differences were statistically significant (P ＜ 0.05). Results of immunohistochemistry showed that the positive expression rate of hMSH2 and FHIT protein in esophageal squamous cell carcinoma tissues was significantly lower than that in adjacent normal tissues, and the difference was statistically significant (P ＜ 0.05). The expression level of HMSH2 protein was related to the degree of tumor differentiation, lymph node metastasis and postoperative pathological stage (P ＜ 0.05), while it had nothing to do with the age, sex and tumor location of the patients with esophageal cancer (P ＞ 0.05). The expression level of FHIT was only related to the depth of infiltration (P ＜ 0.05). Kaplan-Meier survival analysis found that the expression level of HMSH2 in esophageal cancer was correlated with survival rate (P ＜ 0.05). The results of COX multivariate survival analysis showed that the loss of hMSH2 gene expression and the degree of tumor differentiation were independent risk factors for poor prognosis in Kazakh patients with esophageal squamous cell carcinoma (P ＜ 0.05). Conclusion hMSH2 and FHIT may be involved in the occurrence and development of Kazakh esophageal cancer, so the detection of co-expression could be used as an important indicator for prognosis.

Key words： Kazakh Esophageal squamous cell carcinoma hMSH2 Fragile histldine triad

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	Dannier·Duolikun1
	2 Kawuli·Jumai3 ZHANG Haiping3 Madiniyet·Niyaz1 Edris·Awut2
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Dannier·Duolikun1,2 Kawuli·Jumai3 ZHANG Haiping3 Madiniyet·Niyaz1 Edris·Awut2,3. Clinicopathological significance of hMSH2 and FHIT expression in Kazakh esophageal squamous cell carcinoma[J]. 中国医药导报, 2021, 18(14): 13-17.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/13

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