血清可溶性细胞间黏附分子1、半胱氨酸天冬氨酸蛋白水解酶3水平对颅内破裂动脉瘤术后脑血管痉挛的预测价值

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Abstract Objective To investigate the predictive value of serum soluble intercellular adhesion molecule 1 (SICAM-1) and cysteine aspartate proteolytic enzyme 3 (caspase-3) levels in cerebral vasospasm (CVS) after intracranial ruptured aneurysm surgery. Methods A total of 203 patients with ruptured intracranial aneurysm subarachnoid hemorrhage (SAH) admitted to Zaozhuang Municipal Hospital, Shandong Province from January 2016 to December 2019 were selected. All of them received craniotomy clipping or interventional embolization treatment, and underwent digital subtraction angiography four days after surgery. According to different degrees of postoperative CVS, they were divided into severe CVS group (19 cases), moderate CVS group (44 cases), mild CVS group (23 cases) and no CVS group (117 cases). Serum levels of caspase-3 and SICAM-1 were detected before and 3, 7 days after surgery. The serum levels of SICAM-1 and caspase-3 in the four groups were compared before and after intracranial ruptured aneurysm. The correlation between serum SICAM-1 and caspase-3 after intracranial ruptured aneurysm was analyzed by Pearson correlation coefficient. Receiver operating characteristic (ROC) curve was drawn to determine the predictive value of serum SICAM-1 and caspase-3 on postoperative CVS of ruptured intracranial aneurysm three days after surgery. Results Serum levels of SICAM-1 and caspase-3 in the four groups 3 and 7 days after surgery were higher than those before surgery, and serum levels of SICAM-1 and caspase-3 seven days after surgery were lower than those three days after surgery (P < 0.05). Pearson correlation andlysisshowed that there was a positive correlation between serum SICAM-1 and caspase-3 levels of ruptured intracranial aneurysm 3 and 7 days after surgery (r = 0.493, 0.585, P < 0.05). The ROC curve showed that the area under the curve, sensitivity and specificity of SICAM-1 + caspase-3 in the diagnosis of postoperative CVS of ruptured intracranial aneurysm 3 days after surgery were higher than those of SICAM-1 and caspase-3 alone. Conclusion Serum levels of SICAM-1 and caspase-3 in patients with intracranial ruptured aneurysm after surgery are significantly increased, and combined detection can effectively predict the occurrence of CVS.

Key words： Intracranial ruptured aneurysm Cerebral vasospasm Soluble intercellular adhesion molecule 1 Cysteine aspartate proteolytic enzyme 3 Predictive value

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	YIN Hang FENG Lijun XIAO Longhai LI Changge QIN Hao

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YIN Hang FENG Lijun XIAO Longhai LI Changge QIN Hao. Predictive value of serum soluble intercellular adhesion molecule 1 and cysteine aspartate proteolytic enzyme 3 levels in cerebral vasospasm after intracranial ruptured aneurysm surgery[J]. 中国医药导报, 2021, 18(14): 67-71.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/67

1] 王雄.动脉瘤性蛛网膜下腔出血的流行病学特征及破裂的血流动力学变化研究[J].河北医药，2019，41（3）：352-355，360.
[2] 谭占国，黄圣明.蛛网膜下腔出血后迟发脑血管痉挛诊治新进展[J].中国临床神经外科杂志，2019，24（8）：505-506.
[3] 元少鹏，廖伟强，邓妙峰，等.动脉瘤性蛛网膜下腔出血后影响脑血管痉挛的原因分析及防治体会[J].中国医药科学，2018，8（10）：202-204.
[4] 刘旻谛，罗良生.炎症在蛛网膜下腔出血后脑血管痉挛的作用的研究进展[J].临床神经外科杂志，2015，12（2）：157-160.
[5] 周丹丹，白晓光.可溶性细胞间黏附分子-1与糖尿病视网膜病变的关系[J].内蒙古医科大学学报，2015，37（4）：358-362.
[6] 李顺延，高飞，郭虎林.盐酸洛拉曲克通过调控caspase-3促进人肝癌细胞HepG-2凋亡[J].现代消化及介入诊疗，2020，25（1）：11-15.
[7] 陈孝平，汪建平.外科学[M].8版.北京：人民卫生出版社，2013：220-222.
[8] 中华医学会神经外科学分会.脑血管痉挛防治神经外科专家共识[J].中华医学杂志，2008，3（5）：356-362.
[9] 金珂，吕涛，金义超，等.蛛网膜下腔出血后迟发性脑缺血机制的研究进展[J].上海交通大学学报：医学版，2017， 37（1）：114-117.
[10] 苏优勒，张占普，窦长武，等.血管内介入栓塞与开颅手术夹闭治疗破裂颅内动脉瘤的疗效及安全性比较[J].疑难病杂志，2019，18（5）：455-458，463.
[11] 姜波涛，谭红，彭旭，等.不同脑脊液引流速度对蛛网膜下腔出血患者脑脊液中IL-6及CRP的影响[J].中国医师杂志，2019，21（2）：291-293.
[12] 彭浩，陈健龙，刘朝晖，等.血清和肽素、MMP-9水平对动脉瘤性蛛网膜下腔出血患者手术治疗预后的预测价值[J].疑难病杂志，2020，19（9）：874-879.
[13] Pellettieri L，Carlson CA，Lindholm L. Is the vasospasm following subarachnoidal hemorrhage an immunoreactive disease? [J]. Experientia，1981，37（11）：1170-1171.
[14] 周洁，吉玲，王新华，等.细胞间黏附分子-1在支气管哮喘儿童支气管黏膜中的表达及其对支气管上皮细胞凋亡的影响[J].新乡医学院学报，2019，36（2）：31-35.
[15] Habas K，Shang L. Alterations in intercellular adhesion molecule 1（ICAM-1）and vascular cell adhesion molecule 1 （VCAM-1） in human endothelial cells [J]. Tissue Cell，2018，54：139-143.
[16] Dalvi P，Sun B，Tang N，et al. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway [J]. Sci Rep，2017，7（1）：9954.
[17] 孙新刚，侯亚芝，马乾，等.血管内穿刺法建立大鼠蛛网膜下腔出血后早期脑损伤模型[J].临床医药实践，2017， 26（3）：211-213.
[18] 刘秀娟，韩雨薇，李晓明.齐墩果酸通过抑制NF-κB/ICAM-1信号通路减轻大鼠蛛网膜下腔出血后早期脑损伤的研究[J].中国现代应用药学，2017，34（9）：1225-1228.
[19] Sanchez AR，Gregory MA，Leticia MA. Soluble intercellular adhesion molecule（SICAM-1）as a biomarker of vascular cognitive impairment in older adults [J]. Innovat Aging，2019，3（1）：256-257.
[20] 孙勇，佟玉文，徐海燕，等.血清ICAM-1、sICAM-1、hs-CRP在浆细胞性乳腺炎中的表达及临床意义[J].国际检验医学杂志，2018，39（6）：658-660.
[21] Mohr A，Deedigan L，Jencz S，et al. Caspase-10：a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment [J]. Cell Death Differ，2018，25（2）：340-352.
[22] 倪欣，黄坤，马俊杰. Procaspase-3小分子激活剂的研究进展[J].中国现代应用药学，2019，36（3）：112-115.
[23] Pu X，Storr SJ，Zhang Y，et al. Caspase-3 and caspase-8 expression in breast cancer：caspase-3 is associated with survival [J]. Apoptosis，2017，22（3）：357-368.
[24] 黄昌恒，赵文可，何一川，等.黄芪甲苷的抗凋亡作用对大鼠蛛网膜下腔出血后迟发性脑血管痉挛的影响[J].中华实验外科杂志，2019，36（1）：94-96.
[25] Yilmaz C，Cansever T，Kircelli A，et al. The Effects of Proanthocyanidin on Vasospasm After Experimental Subarachnoidal Hemorrhage in Rats [J]. Turk Neurosurg，2018，28（4）：667-674.
[26] 陈博文，苏飞，冉继朋，等.利多卡因对大鼠SAH后神经细胞凋亡和迟发性脑血管痉挛的保护作用[J].神经解剖学杂志，2019，35（6）：641-645.
[27] Sun J，Zhang Y，Lu J，et al. Salvinorin A ameliorates cerebral vasospasm through activation of endothelial nitric oxide synthase in a rat model of subarachnoid hemorrhage [J]. Microcirculation，2018，25（3）：e12442.