全身免疫炎症指数在乳腺癌患者预后中预测价值的meta分析

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Abstract Objective To investigated the predictive value of systemic immune inflammatory index (SII) in the prognosis of patients with breast cancer. Methods PubMed, Cochrane Library, Embase, and Web of Science databases were searched by computer, all the studies on SII and prognosis of patients with breast cancer were collected from January 2015 to July 2020. Stata 12.0 and Review Manager 5.3 software were used for data analysis. Results A total of eight studies were included in this study, including 2642 cases patients with breast cancer. Meta-analysis results showed that the proportion of tumor diameter > 2.0 cm in high SII patients with breast cancer was higher than that in low SII patients with breast cancer (OR = 1.49, 95%CI: 1.19-1.85, P = 0.0004). The proportion of lymph node metastases in high SII patients with breast cancer was higher than that in low SII patients with breast cancer (OR = 1.38, 95%CI: 1.12-1.69, P = 0.002). Overal survival in high SII patients with breast cancer was shorter than those with low SII breast cancer (HR = 2.06, 95%CI: 1.55-2.74, P < 0.000 01). Distase free survival in high SII patients with breast cancer was shorter than that in low SII patients with breast cancer (HR = 1.93, 95%CI: 1.63-2.30, P < 0.000 01). Conclusion SII can be used as a reliable indicator to predict the prognosis of patients of breast cancer.

Key words： Systemic immune inflammation index Breast cancer Meta-analysis Prognosis

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	GU Jingjing1 ZHANG Weidong2 CHEN Dandan1 ZHANG Jianguo1 HUANG Guanhong3

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GU Jingjing1 ZHANG Weidong2 CHEN Dandan1 ZHANG Jianguo1 HUANG Guanhong3. Meta-analysis of the predictive value of systemic immune inflammatory index in the prognosis of patients with breast cancer[J]. 中国医药导报, 2021, 18(14): 93-97.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/93

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