集束化干预措施下颅脑肿瘤术后肺血栓栓塞症严重程度危险因素分析

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Abstract Objective To analyze the risk factors of pulmonary thromboembolism with different severity after craniocerebral tumor operation under cluster intervention measures, and to provide reference for early clinical intervention of pulmonary thromboembolism. Methods The clinical information of 56 patients with pulmonary thromboembolism diagnosed by CT pulmonary angiography after craniocerebral tumor operation in the Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University from June 2016 to June 2019 was retrospectively analyzed. The patients were divided into low risk group (36 cases) and high risk group (20 cases) according to the diagnosis and treatment guidelines of pulmonary thromboembolism. Clinical phenotypes, coagulation function and perioperative related factors were compared between the two groups, and multivariate logistic regression was used to analyze the risk factors of pulmonary thromboembolism with different severity. Results Among the 56 patients, 35 were male and 21 were female. The mean age was (46.23±18.12) years old. Postoperative pathology showed malignant tumor in 20 cases, accounting for 35.71%; benign tumors in 36 cases, accounting for 64.29%. Tumor site classification showed sellar region tumors in 26 cases, accounting for 46.43%; supratentorial tumor in 21 cases, accounting for 37.50%; skull base tumor in 7 cases, accounting for 12.5%; infratentorial tumor in 2 cases, accounting for 3.57%. There were no significant differences in clinical phenotype and coagulation function between the two groups (P ＞ 0.05). There was no significant difference in perioperative related factors between the two groups except the time of water fasting before operation (P ＞ 0.05). Multivariate logistic regression analysis showed that the presence of postoperative limb mobility disorder was a risk factor for pulmonary thromboembolism after craniocerebral tumor operation (OR = 9.574, P = 0.02). Conclusion Pulmonary thromboembolism after craniocerebral tumor operation has complex underlying causes and no specific clinical manifestations. The identification of the risk factors of pulmonary thromboembolism combined with the results of laboratory examination is helpful for the early diagnosis and treatment of pulmonary thromboembolism.

Key words： Craniocerebral tumor Pulmonary thromboembolism Clinical characteristics Risk factors

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	YANG Yakun1 HAN Song1 LIU Ning1 ZHANG Xufei2 ZHANG Linpeng1 HAN Mingyang1 ZHANG Yunxin3 YAN Changxiang1▲

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YANG Yakun1 HAN Song1 LIU Ning1 ZHANG Xufei2 ZHANG Linpeng1 HAN Mingyang1 ZHANG Yunxin3 YAN Changxiang1▲. Analysis of risk factors for severity of pulmonary thromboembolism after craniocerebral tumor operation under cluster intervention measure[J]. 中国医药导报, 2021, 18(14): 76-80.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/76

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