帕金森病伴发焦虑、抑郁及认知功能障碍的危险因素分析

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Abstract Objective To observe and analyze the related influencing factors of anxiety, depression and cognitive impairment in Parkinson’s disease (PD) patients. Methods A total of 92 PD patients diagnosed in the Department of Movement Disorders, Neurology Center, Beijing Tiantan Hospital, Capital Medical University from January to October 2016 were selected. The unified Parkinson’s disease rating scale (UPDRS), modified Hoehn-Yahr staging scale, Hamilton anxiety scale, Hamilton depression scale, and the Montreal cognitive assessment scale (MoCA) were evaluated. The incidence of anxiety, depression and cognitive dysfunction in PD patients was understood, and the risk factors associated with anxiety, depression and cognitive dysfunction in PD patients were analyzed and discussed. Results In this group, 92 PD patients with anxiety accounted for 77.17%. The patients with depression accounted for 69.57%. Logistic regression results showed that male was a protective factor for PD patients with anxiety (OR = 0.24, P = 0.048), the long course of disease was a risk factor for PD patients with anxiety (OR = 1.36, P = 0.019), male (OR = 0.22, P = 0.013) and advanced age (OR = 0.95, P = 0.041) were protective factors for PD patients with depression (OR = 0.22, P = 0.013), high UPDRS score was a risk factor for PD patients with depression (OR = 1.08, P = 0.007). MoCA score showed that 78.26% of the patients had cognitive dysfunction. Logistic regression results showed that long years of education was a protective factor for cognitive dysfunction in PD patients (OR = 0.70, P < 0.003). Conclusion Anxiety, depression and cognitive impairment are all common non-exercise symptoms of PD patients with a high incidence and are easily affected by age, gender, course of disease, years of education and other factors, while non-exercise symptoms have a significant impact on the overall treatment effect and quality of life of patients.

Key words： Parkinson’s disease Anxiety Depression Cognitive impairment

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	CHAI Bin MA Huizi▲ FENG Tao

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CHAI Bin MA Huizi▲ FENG Tao. Risk factors analysis of anxiety, depression and cognitive impairment associated with Parkinson’s disease[J]. 中国医药导报, 2021, 18(14): 63-66,71.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I14/63

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