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2021 Vol. 18, No. 1 Published: 2021-01-05

	4	Effect of electroacupuncture on HPA function in anxiety rats model
		TONG Qiuyu SHEN Weidong WANG Jian
		Objective To explore the effect of acupuncture on the functional changes of the hypothalamic-pituitary-adrenal (HPA) in anxious rat model. Methods Seventy-two SPF female SD rats of four to eight weeks were used to establish a single prolonged stress anxiety model. They were divided into six groups, each with 12 rats. Control group (normal feeding without treatment); model group (anxiety model established by a single prolonged stress method); sham electroacupuncture group (acupuncture superficially near the acupoints, leaving the needle without electricity); electroacupuncture group (acupuncture Baihui, Shen Men, Neiguan, Yintang, 2 Hz, 1 mA, lasting 15 min); AM251 (calculate the dose according to 1 mg/kg body weight, intraperitoneal injection 30 min before acupuncture) + electro-acupuncture group (the same points as electroacupuncture group); AM251+sham electroacupuncture group (same method as sham electroacupuncture group) were included. The behavioral testing was conducted, while glucocorticoid (GC), corticotropin releasing hormone (CRH), corticotropin (ACTH), cortisol (CORT) content were detected by enzyme linimmunosorbent assay. Results Compared with the control group, the model group had longer exercise time in the marginal area and shorter open arm stay time, and the differences were statistically significant (P ＜ 0.05). Compared with the model group, in the electroacupuncture group, the movement time of the marginal area was shortened, while the open arm stay time was significantly longer (P ＜ 0.05). Compared with the electro-acupuncture group, the sham electro-acupuncture group and AM251+ electro-acupuncture group were increased the movement time of the marginal area and shortened the staying time of the open arm, and the differences were statistically significant (P ＜ 0.05). Compared with the control group, the release of serum ACTH, CORT, CRH, and GC proteins in the model group were increased significantly, and the differences were highly statistically significant (P ＜ 0.01). Compared with the model group, the electroacupuncture group could significantly inhibit the expression of the above-mentioned proteins in the serum, and the differences were highly statistically significant (P ＜ 0.01). Compared with the electroacupuncture group, the release of serum ACTH, CORT, CRH, and GC proteins in the sham electroacupuncture group and AM251+ electroacupuncture group were increased significantly, and the differences were highly statistically significant (P ＜ 0.01). Conclusion Electroacupuncture can effectively alleviate the anxiety of rats with single prolonged stress. Electroacupuncture down-regulates the effect of HPA axis on ACTH, CORT and CRH, GC protein by regulating CB1 receptor, thereby reducing anxiety.
		2021 Vol. 18 (1): 4-8 [Abstract] ( 236 ) HTML (1 KB) PDF (999 KB) ( 38 )

	9	Preparation and targeted evaluation of Gαi2 C-terminal peptide targeted-ultrasound contrast agent
		JIANG Hua1 MU Yuming2 WANG Chunmei2 ZHOU Xianhui3 ZHANG Jian3
		Objective To explore the feasibility and targeting of Gαi2 C-terminal peptide (Gαi2ctp) targeted-ultrasound contrast agent. Methods The targeted microbubbles were divided into three groups of 0.5, 1.5, 3 mg/L according to the quality of Gαi2ctp. Gαi2ctp-targeted microbubbles were prepared by electrostatic attraction way, and the optimal combined dose was explored by detecting the size, carrying rate of microbubbles. The best dose was choosed for animal experiments by making a canine atrial fibrillation model. Ultrasound-targeted microbubble destruction was used to destroy the microbubbles and immunofluorescence method was used to detect the targeting of the microbubbles. Results Gαi2ctp and SonoVue microbubbles could be combined effectively by electrostatic attraction way. The Gαi2ctp targeted microbubble carrying rate of 1.5 mg/L group was higher than that of 3 mg/L group at 0.5, 1 and 2 h after standing, and the differences were highly statistically significant (all P < 0.01). There was no significant difference in the Gαi2ctp targeted microbubble carrying rate between 1.5 mg/L group and 0.5 mg/L group after 0.5 mg/L at 0.5, 1 and 2 h (P > 0.05). There was no statistically significant difference in the carrying rate of 1.5 mg/L group before and after washing (P > 0.05). After washing, the Gαi2ctp targeted microbubble carrying rate of 3 mg/L group and 0.5 mg/L group were lower than those before washing, and the differences were highly statistically significant (all P < 0.01). Frozen sections of canine left atrium and pulmnoary vein were showed that bright orange-red fluorescence expression in the left atrium and pulmnoary vein of dogs in experimental group (carrying 1.5 mg/L Gαi2ctp targeting microbubbles group), but no orange-red fluorescence was in control group (SonoVue blank group). Conclusion In this study, Gαi2ctp-targeted ultrasound contrast agent is successfully prepared. It is uniform in size, stable in nature, and specifically binded to target tissues.
		2021 Vol. 18 (1): 9-13,21 [Abstract] ( 111 ) HTML (1 KB) PDF (871 KB) ( 138 )

	13	Optimization of extraction technology for Xiao’er Yifei Jianpi Paste by central composite design-response surface methodology
		WEI Yanping1 TAN Zhi’en1 TUO Haiyan1 ZENG Peiqin1 LIU Yating1 QIN Liuxin1 YI Wei1 CHEN Weiwei1,2,3
		Objective To optimize the extraction technology for Xiao’er Yifei Jianpi Paste by central composite design-response surface methodology. Methods Based on taking water volume and extraction time as investigation factors, overall rating of “normalized value” of dry extract yield and the content of Hesperidin as evaluation index, the two-factor and five-level test was carried out. The experimental data were fitted by multiple linear regression and binomial fitting, and the obtained response surface were used to predict the results. Results The optimal extraction technology was as follows: 21-folds of water, extracted twice, 212 min per time. The overall rating of “normalized value” was 0.836 30, compared with the predicted value, the deviation rate was -16.531% (which was within -20.000%). Conclusion The optimal extraction process is simple, stable and has good and reliable predictability.
		2021 Vol. 18 (1): 13-17,35 [Abstract] ( 125 ) HTML (1 KB) PDF (1066 KB) ( 105 )

	18	Inhibitory effect of tripterine on human breast cancer cell line MDA-MB-231
		SHI Xiaona XU Xia XIE Guie
		Objective To study the antitumor effect of tripterine on MDA-MB-231 breast cancer cells and its mechanism. Methods The effect of tripterine on the growth of MDA-MB-231 was determined by MTT colorimetric method, and its half maximal inhibitory concentration (IC50) was calculated. The experiments on its mechanism were divided into two groups: control group and treatment group. The control group cells were untreated. After the treatment group cells were treated with 2.0 μmol/L tripterine, the ratio of apoptotic cells was determined by Annexin V-FITC fluorescence staining and TUNEL staining. The protein expression levels of p-Akt, Akt, Survivin and Bcl-xL were analyzed by Western blot. Results Tripterine inhibited the growth of MDA-MB-231 with IC50 of 0.93 μmol/L for 48 h. The ratio of Annexin V-FITC staining positive apoptotic cells and the ratio of TUNEL staining positive cells in the treatment group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). Compared with the control group, p-Akt, Survivin and Bcl-xL protein expressions in the treatment group decreased, and the differences were statistically significant (all P ＜ 0.05). Comparison of Akt total protein expression between the two groups showed no statistically significant difference (P ＞ 0.05). Conclusion Tripterine induces the apoptosis of MDA-MB-231 cells by regulating the Akt signaling pathway, and then inhibits the growth of MDA-MB-231 cells.
		2021 Vol. 18 (1): 18-21 [Abstract] ( 386 ) HTML (1 KB) PDF (806 KB) ( 164 )

	22	Study on the pathogenesis and molecular target of pulpitis
		Nuerbiyamu·Maimaitiyiming WU Long ZHAO Jin
		Objective To identify the pathogenesis and molecular target of pulpitis. Methods Differentially expressed genes in pulpitis tissue were identified by GEO data GSE77459 (February 2016) and GSE92681 (December 2017). Enrichment analysis and gene set enrichment analysis were used to evaluate the mechanism of differential genes in pulpitis. The key factors associated with pulpitis were identified by PPI network and molecular experiments. Results There were 1280 differentially expressed genes (DEGs) were identified in pulpitis tissue from GSE77459 data. Eighty-one DEGs were verified by GSE92681 data set. Enrichment analysis and gene set enrichment analysis showed that DEGs was significantly correlated with immune and inflammatory responses. PPI network analysis screened 55 network genes and identified CD44 as the core network factor and regulatory gene. The expression of CD44 in pulpitis tissue was significantly up-regulated by real-time quantitative polymerase chain reaction and Western blot analysis. Conclusion CD44 is a potential biomarker and therapeutic target for pulpitis and is involved in the development of pulpitis through the ERK1/2 signaling pathway.
		2021 Vol. 18 (1): 22-26 [Abstract] ( 173 ) HTML (1 KB) PDF (1544 KB) ( 37 )

	27	Analysis of mutations of mitochondrial DNA 12S rRNA A1555G and C1494T among the population in Jiangsu region
		LI Menglan LIN Ning SHI Hui WANG Lijuan JIANG Zhixin HUANG Lili WU Yulin
		Objective To investigate the mutations of mitochondrial DNA 12S rRNA A1555G and C1494T among the population in Jiangsu region. Methods A total of 1843 cases were enrolled from the deafness genetic screening in Jiangsu Province, and they were divided into three groups according to their deafness status and family history, including 904 cases with non-syndromic deafness as the deafness group, 299 cases with family members of deafness as the deafness high risk group, 640 cases with normal hearing and without family members of deafness as the normal control group. And deafness patients were divided into three groups according to the region: South Jiangsu, Middle Jiangsu and North Jiangsu, including 254 cases in Zhenjiang were from the South Jiangsu group, 287 cases in Taixing, Rugao and Gaoyou were from the Middle Jiangsu group, and 363 cases in Lianshui and Shuyang were from the north Jiangsu group. Relevant date of all these subjects were collected, and genomic DNA were extracted from the whole blood and mitochondrial DNA 12S rRNA A1555G and C1494T were genotyped. Results Comparison of the detection rate of A1555G and C1494T mutation in deafness group, deafness high risk group and normal control group showed statistically significant difference (P ＜ 0.01). The mutation rate of A1555G and C1494T in deafness group and deafness high risk group was higher than that in normal control group, and the difference was highly statistically significant (P ＜ 0.01), There was no significant difference between the deafness high risk group and the deafness group (P ＞ 0.05). The mutation detection rates of A1555G and C1494T in the three groups of South, Middle and North Jiangsu groups were compared, and the differences were statistically significant (P ＜ 0.05), the mutation rate of A1555G and C1494T in the North Jiangsu group was higher than that in the Middle Jiangsu group and the South Jiangsu group, and the differences were statistically significant (P ＜ 0.05), but there was no statistically significant difference between the Middle Jiangsu group and the South Jiangsu group (P ＞ 0.05). Conclusion The mutation rate of mitochondrial DNA 12S rRNA A1555G and C1494T in deafness and deafness high risk population in Jiangsu region is high, and there are regional differences. Screening for mitochondrial DNA 12S rRNA A1555G and C1494T mutations in Jiangsu population, and providing reasonable medication guidance and genetic counseling for mutant gene carriers and their maternal family members, have important clinical significance in reducing the occurrence of drug-related deafness defects.
		2021 Vol. 18 (1): 27-30 [Abstract] ( 103 ) HTML (1 KB) PDF (683 KB) ( 30 )

	31	GC-MS composition analysis and bacteriostatic test of volatile oil and its inclusion compound from Amomum tsaoko
		LIU Na DING Xiong▲ ZHAO Yi SU Liuyan ZHAO Rongyu
		Objective To compare the components before and after the inclusion of volatile oil from Amomum tsaoko, and the bacteriostatic test was carried out. Methods Gas chromatography-mass spectrometry (GC-MS) method was used: HP-5MS quartz capillary column (30 m×0.25 mm×0.25 mm); column temperature: the initial temperature was 40℃; the temperature was increased to 80℃ at 3℃/min, and then to 280℃ at 5℃/min; the column flow rate was 1.0 mL/min; inlet temperature was 250℃; sample injection volume was 1.0 mL; the split ratio was 10∶1; the carrier gas was high-purity helium gas. The standard filter paper method was used to conduct bacteriostatic tests on Candida albicans standard strains SC5314, Candida albicans clinical isolates of drug resistant strains 23#, Staphylococcus aureus and Escherichia coli. Results Sixty-eight compounds in the volatile oil from Amomum tsaoko and 64 inclusion compounds were isolated by GC-MS component analysis. There were 60 common compounds, accounting for 99.11% and 99.65% of the total volatile oil compounds and inclusion compounds, respectively. The bacteriostatic experiments showed that the volatile oil and its inclusion compound had good bacteriostatic effects on Candida albicans and drug-resistant bacteria, and were significantly better than Fluconazole. It also had good bacteriostatic effect on Staphylococcus aureus and Escherichia coli. Conclusion After ultrasonic inclusion, more than 99% of the volatile oil from Amomum tsaoko into beta-cyclodextrin, forming a stable inclusion compound. There is no significant difference in bacteriostatic effect of volatile oil from Amomum tsaoko on the four strains before and after inclusion.
		2021 Vol. 18 (1): 31-35 [Abstract] ( 105 ) HTML (1 KB) PDF (507 KB) ( 46 )

	36	Progress in treatment of acute spinal cord injury
		SHI Yubo YU Ling GUO Weichun
		Acute spinal cord injury results in sensory and motor dysfunction below the level of injury, which seriously affects patients’ quality of life. In recent years, with the deepening studies on pathological mechanism of spinal cord injury, progress has been made in the treatment of acute spinal cord injury. Surgical treatment can rebuild spinal stability and relieve spinal cord compression，resulting in promoting the recovery of neural function, and the timing of surgery should be individualized to patients. Drug therapy plays aneuroprotective role mainly by alleviating secondary injury and promoting nerve regeneration. Cell therapy is the most promising future treatments for acute spinal cord injury; however, how transplanted cell reconstruct the spinal cord structure and function requires further exploration. This article reviews some of the current advances of the treatment in order to provide reference for clinical treatment of acute spinal cord injury.
		2021 Vol. 18 (1): 36-39 [Abstract] ( 169 ) HTML (1 KB) PDF (552 KB) ( 254 )

	40	Progress of the correlation between vitamin D and preeclampsia
		YUAN Chengkun LU Caixia
		Preeclampsia as a group of hypertensive disorders during pregnancy, is one of the four leading causes of maternal death. Adequate vitamin D levels play an important role in maternal and child health during pregnancy. Vitamin D is closely associated with the onset of preeclampsia. Its mechanism is mainly related to oxidative stress, immunity, blood pressure regulation and epigenetics. Vitamin D supplementation can reduce the incidence of pregnancy complications, reduce the risk of preeclampsia, and improve adverse pregnancy outcomes. Future high-quality clinical studies are needed to confirm the benefits of vitamin D supplementation for preeclampsia. Vitamin D supplementation may be an effective intervention strategy to prevent preeclampsia.
		2021 Vol. 18 (1): 40-43 [Abstract] ( 142 ) HTML (1 KB) PDF (556 KB) ( 57 )

	44	Advances in early pulmonary rehabilitation nursing of patients with acute exacerbation of chronic obstructive pulmonary disease by noninvasive mechanical ventilation
		ZHAO Gang1 SHI Yan2 JIANG Jinxia1
		The effect of early pulmonary rehabilitation in the treatment of chronic obstructive pulmonary disease (COPD) is now accepted by scholars at home and abroad. However, there have been few studies on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for noninvasive mechanical ventilation. The concept of early pulmonary rehabilitation is that patients with AECOPD or AECOPD undergo pulmonary rehabilitation-related intervention after discharge from hospital. Studies have shown that nurses play a leading role in patients’ early programmed activities, in addition, a unified activity table of patients’ tolerance can be developed, so as to provide an activity plan for patients and ensure effective implementation. Patients’ tolerance should be evaluated and studied for many times in the process, so as to complete the early pulmonary rehabilitation of patients. This paper lists the role of early pulmonary rehabilitation in patients with AECOPD noninvasive mechanical ventilation and the importance of early pulmonary rehabilitation, nurses play a leading role in the treatment team of pulmonary rehabilitation. The timing and mode of early pulmonary rehabilitation are discussed by studying the situation of patients with noninvasive mechanical ventilation in early pulmonary rehabilitation, and then the nursing research review is carried out, and the prospects are made based on the existing defects.
		2021 Vol. 18 (1): 44-47 [Abstract] ( 163 ) HTML (1 KB) PDF (550 KB) ( 69 )

	48	Research status and implications of poetry therapy in palliative medicine
		LI Mei
		Poetry therapy has the advantages of both reading therapy and expressive writing, and has the advantages of low cost, easy implementation, and free from spatial and geographical restrictions. Domestic research on poetry therapy is still limited to the introduction of its history and principles and the research object is relatively single. Based on the overall background of the “Healthy China 2030” Plan, which proposes to realize the whole process of health services and protection from the fetus to the end of life, in this paper, poetry therapy research is placed in the perspective of palliative care, focusing on sorting out the foreign literature of poetry therapy research in recent years in palliative care, and the existing literature is divided into four categories according to the research theme, that is poetry therapy improves the quality of life of palliative care patients. Research on the improvement of mental health of family members of medical patients/bereaved families by poetry therapy; poetry therapy promotes and soothes the physical and mental health of medical practitioners; poetry therapy helps foster a “people-centered” soothing medical culture. For each topic, this paper presents its main research content and development status. In addition, this paper also discusses the main problems existing in the current research, the future development direction and the enlightenment to the research in China, in order to promote the localized development of poetry therapy in the field of palliative care in China.
		2021 Vol. 18 (1): 48-51 [Abstract] ( 109 ) HTML (1 KB) PDF (554 KB) ( 71 )

	52	The pathogenesis of depression and the research progress of antidepressants
		GAO Guiyuan1 HUANG Jie1 LIU Dan1 ZHANG Fang1 ZHANG Chaoqun1 ZHANG Guoli1 CHEN Lihua1 SHAO Yingxin2
		Depression, a kind of affective disorder caused by many factors. As the pace of life continues to accelerate, the competitive pressures faced by people in life and work are increasing, and the incidence of depression is increasing year by year. Therefore, the in-depth study of the pathogenesis of depression and the development of new drugs against depression are becoming more and more important. This article will review the pathogenesis of depression and the study of antidepressants for various pathogenesis.
		2021 Vol. 18 (1): 52-55,70 [Abstract] ( 224 ) HTML (1 KB) PDF (1049 KB) ( 200 )

	56	Application of peripheral vascular intervention simulation training system in the training of refresher doctor
		LIU Yiren1 CHEN Chao2 TONG Zhu1 CUI Sijun1 QI Lixing1 GU Yongquan1 GUO Lianrui1▲
		Objective To explore the application effect of peripheral vascular intervention simulation training system in the teaching and training of refresher doctors. Methods A retrospective analysis of the general data of 18 who were trained in peripheral vascular intervention in the Department of Vascular Surgery, Xuanwu Hospital of Capital Medical University from January 2016 to July 2019 was conducted, and refresher doctors were divided into the traditional model group (eight people) and the new model group (10 people) according to the training method. The traditional model group adopted the conventional theory combined with practice training model, and the new model group adopted the training model of peripheral vascular intervention simulation system training. The time and complications of two groups of refresher doctors in performing independent lower extremity angiography after training were compared, the impact of peripheral vascular intervention simulation training system training on the clinical teaching of the refresher doctors were analyzed, and then the training effect was judged. Results The refresher doctors in the new model group took (11.95±0.73) min to perform lower extremity angiography, while the refresher doctors in the traditional model group took (16.49±1.26) min. The new model group was significantly better than the traditional model group, and the difference was statistically significant (P ＜ 0.05). No complications occurred during the angiography of the lower extremities. Conclusion The peripheral vascular intervention simulation training system can help the refresher doctors to familiarize themselves with the operation process to a certain extent, improve the operation skills, and shorten the operation time, which is helpful to the refresher doctors’ clinical teaching.
		2021 Vol. 18 (1): 56-59 [Abstract] ( 168 ) HTML (1 KB) PDF (689 KB) ( 178 )

	60	Discussion on the connotation, framework and elements of the core literacy of medical postgraduates
		ZHANG Xiaobo1 LIU Lanru2 HAN Yue2 SONG Anqi3 ZHU Hong2
		The cultivation of the core literacy of medical postgraduate students has important practical significance for the construction of national high-level medical talents, the training of high-level talents in medical schools and the individual development of medical graduate students. Through literature review and expert interviews, based on the overall framework of the core literacy of Chinese students, combined with the characteristics of medical graduate training and medical career orientation, the core literacy of medical postgraduate students is decomposed into basic literacy composed of cultural foundation, independent development, social participation, and practical innovation, and the growth literacy composed of medical academic literacy, medical professional literacy, medical humanistic literacy, and development support literacy, and with all-round development as the core, build a three-ring concentric structure of the core literacy of medical postgraduate students. It is expected to provide a basis for further exploring the core literacy training strategy and reform practice of medical graduate students.
		2021 Vol. 18 (1): 60-63 [Abstract] ( 160 ) HTML (1 KB) PDF (918 KB) ( 35 )

	64	Discussion on the training model of clinical practice skills for postgraduates in orthopedics of traditional Chinese medicine
		LI Yuanfeng REN Shujun LIU Di JIANG Yichang XU Weiming SONG Hanbing
		Traditional Chinese medicine postgraduate students are the viable and reserve force for the development of Chinese medicine, and the cornerstone of the development of traditional Chinese medicine. It is even more important to strengthen the training of clinical skills for postgraduates in the department of orthopedics and traumatology. At present, the clinical ability training of clinical postgraduates in the department of orthopedics and traumatology of traditional Chinese medicine is mainly to follow the instructor to copy prescriptions and ward clinical practice. The training method is similar to the training mode of general clinicians, not the training of high-level talents in the true sense. In view of the current status and problems, combined with the importance of training the clinical practice skills of postgraduates in the department of orthopedics and traumatology, combine the clinical thoughts and experience inheritance of famous elderly traditional Chinese medicine doctors with the training of clinical practice skills of postgraduates in the department of orthopedics and traumatology, and at the same time strengthen the outpatient cases collection, and operation standardization, improve the disposal capacity of wards, and improve the management awareness of graduate students’ wards in the mean while. Discuss the necessity of innovation and reform of the training model for traditional Chinese medicine orthopedics and traumatology postgraduates, systematically explore the advantages of the classification of clinical practice skills training management models for traditional Chinese medicine orthopedics and traumatology postgraduates, and focus on the connotation and management model of traditional Chinese medicine orthopedics and traumatology clinical medicine advanced medical personnel training management model, to improve the high-level traditional Chinese medicine orthopedics talents has important practical significance.
		2021 Vol. 18 (1): 64-66,78 [Abstract] ( 137 ) HTML (1 KB) PDF (635 KB) ( 126 )

	67	The two-tier construction of the English for Academic Purposes curriculum system in traditional Chinese medicine universities
		LI Chenghua SUN Huiming KONG Ranran
		English for Academic Purposes (EAP) is designed to meet the specific needs of learners and is a language teaching based on professional content. Based on the difference between the needs of medical undergraduates and graduate students in the traditional Chinese medicine universities, this article puts forward the idea of a two-tier construction of an EAP curriculum system that is demand-oriented, application-oriented, and output-driven. This system develops traditional Chinese medicine English teaching based on the professional English needs of undergraduates, and teaches English medical paper writing based on the academic ability requirements of graduate students. It also designs and implements a mixed teaching method combining project teaching methods and online and offline teaching methods. This kind of EAP curriculum system based on demand differences solves the long-standing problem of disconnection between English learning and majors, can cultivate the professional English ability of medical undergraduates, and improve the EAP writing level of graduate students.
		2021 Vol. 18 (1): 67-70 [Abstract] ( 99 ) HTML (1 KB) PDF (623 KB) ( 79 )

	71	Thoughts on systemically construction of professional postgraduate degree of pharmacy based on good clinical practice
		GUO Wei1 JIA Yi2 DENG Youcai2
		In the context of the country’s deepening reform of the medical and health system and the vigorous implementation of the “Healthy China 2030” policy, the importance of drug clinical research related industries has become increasingly prominent. There is an increasing gap in high-end talents who master the good clinical practice (GCP). Pharmacy professional degree postgraduate students are the most important way to supplement high-level applied talents in the field of pharmaceutical applications. However, at the present stage, there are still many problem in the training of this type of postgraduate students still has insufficient understanding of curriculum teaching, weak professional training and practice models, and imperfect evaluation system of GCP background training. Combining the status of this type of postgraduate training and the needs of industry development, the author proposes to start with improving the top-level design of GCP background postgraduate courses, improving the training model, enriching teaching methods, and reforming the evaluation system. It is expected to provide new ideas for the teaching reform of this type of pharmacy professional degree postgraduate students.
		2021 Vol. 18 (1): 71-74 [Abstract] ( 196 ) HTML (1 KB) PDF (654 KB) ( 133 )

	75	Exploration of standardized training for residents of ultrasound professionals aiming at post competence
		YANG Jinru SONG Yan BAI Xiaofang RUAN Litao
		One of the challenges facing the standardized training of residents is how to develop suitable training plans and evaluation systems for residents of different levels. The purpose of this study is to explore the establishment of hierarchical training courses for resident physicians in order to achieve clinical competence, carry out theoretical teaching for different stages of training students, establish a one-to-one tutor responsibility system, regulate training doctors’ difficult case reporting system, and “MOOC+reversal class” and strict and standardized assessments, so as to promote the stepped development of standardized training of residents, gradually improve and improve their post competence, so that the trained residents have a clear understanding of clinical post competence, in order to meet the needs of social development.
		2021 Vol. 18 (1): 75-78 [Abstract] ( 188 ) HTML (1 KB) PDF (621 KB) ( 68 )

	79	Application of Mini-CEX teaching mode in first aid skills training for junior nurses
		YING Ying ZHAN Wangzhen▲
		Objective To explore the application effect of mini-clinical evaluation exercise (Mini-CEX) teaching mode in first aid skills training for junior nurses. Methods From July 2017 to June 2018, 81 junior nurses from 10 wards of Shanghai Tenth People’s Hospital were selected as the research subjects, and they were divided into 42 cases of control group and 39 cases of experimental group by single-blind random sampling. The control group adopted traditional training modes such as case analysis, explanation, demonstration, situational exercises and guidance feedback, while the experimental group adopted the Mini-CEX teaching mode. The clinical nursing skills, first aid nursing abilities and critical thinking abilities of the two groups of junior nurses were compared. Results The nursing consultation, nursing examination, nursing diagnosis, nursing measures, health consultation, human relations, organizational effectiveness and overall evaluation scores of junior nurses in the experimental group were higher than those in the control group (all P ＜ 0.05). The theoretical scores of cardiopulmonary resuscitation, electrocardiogram monitoring, sputum suction, syringe pump use, infusion pump use, gastric lavage and emergency care of junior nurses in the experimental group were higher than those of the control group (all P ＜ 0.05). The total score of open thinking, analytical ability, systematic ability, self-confidence, curiosity and critical thinking ability of junior nurses in the experimental group were higher than those of the control group (all P ＜ 0.05). Conclusion The Mini-CEX teaching model can improve the clinical nursing skills and first aid nursing abilities of junior nurses, and promote the development of critical thinking abilities.
		2021 Vol. 18 (1): 79-82 [Abstract] ( 204 ) HTML (1 KB) PDF (627 KB) ( 75 )

	83	Effect of probiotics enhance enteral nutrition support on intestinal mucosal barrier function and inflammatory factors in patients with severe craniocerebral injury
		ZHENG Aidong1 YAN Xixiang1 CUI Yonghua2 ZHANG Zhen’en1 PAN Guocui1
		Objective To explore the effect of probiotics enhance enteral nutrition support on intestinal mucosal barrier function and inflammatory factors in patients with severe craniocerebral injury. Methods According to the random number table method, 105 cases of patients with severe craniocerebral injury admitted to Jianhu Hospital Affiliated to Nantong University from April 2017 to April 2019 were selected and divided into control group (52 cases) and observation group (53 cases). The control group was treated with enteral nutrition support, while the observation group was treated with probiotics enhance enteral nutrition support. The two groups were treated for one month. The Glasgow (GCS) scores and serum levels of immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), D-lactic acid, procalcitonin (PCT), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were compared between the two groups before and after treatment. The Incidence of infection and complications after one month of treatment were compared between the two groups. Results After treatment, GCS score, the serum levels of IgA, IgG, IgM of the two groups were all higher than those before treatment, while those in the observation group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). After treatment, the serum levels of D-lactic acid, PCT, TNF-α and IL-6 in the two groups were all lower than those before treatment, while those in the observation group were lower than those in the control group, with statistically significant differences (all P < 0.05). After treatment, the incidence of infection and complications in the observation group was lower than that in the control group, with statistically significant differences (all P < 0.05). Conclusion Probiotics enhance enteral nutrition support in treatment of patients with severe craniocerebral injury can reduce the degree of disturbance of consciousness, improve the immune function and intestinal mucosal barrier function, inhibit the inflammatory reaction, reduce the incidence of infection and complications.
		2021 Vol. 18 (1): 83-86,91 [Abstract] ( 163 ) HTML (1 KB) PDF (634 KB) ( 108 )

	87	Effect of preventive hemostatic clip on preventing delayed bleeding after gastric polypectomy
		LIU Tao HUA Chuanzeng HU Wenhai WANG Guizhou
		Objective To investigate the clinical effect of preventive hemostatic clip on preventing delayed bleeding after gastric polypectomy. Methods A total of 100 patients who underwent gastric polypectomy in Fuyang Women and Children’s Hospital, Anhui Province from September 2018 to January 2020 were selected and divided into control group and observation group, with 50 patients in each group, according to whether preventive hemostatic clip treatment was performed. The control group received conventional drug treatment, and the observation group received conventional drug and hemostatic clip treatment. Intraoperative hemostasis, postoperative delayed bleeding rate, fecal occult blood transfusion and discharge time, postoperative vital signs and hemoglobin concentration, and complications were compared between the two groups. Results There was no significant difference in the immediate hemostasis rate between the observation group and the control group (P ＞ 0.05). The effective hemostasis rate in the observation group was higher than that in the control group, and the duration of intraoperative hemostasis was shorter than that in the control group, with statistically significant differences (all P < 0.05). The delayed bleeding rate in the observation group was lower than that in the control group, and the time of fecal occult blood transfusion and the time of hospitalization were shorter than those in the control group, with statistically significant differences (all P < 0.05). The overall analysis showed that the intergroup comparison, time point comparison and interaction difference were highly significant (all P < 0.01). Intra-group comparison: systolic blood pressure increased and heart rate decreased 24 and 48 h after surgery compared with 12 h after surgery; while systolic blood pressure increased and heart rate decreased 48 h after surgery compared with 24 h after surgery, with statistically significant differences (all P < 0.05). The diastolic blood pressure in the observation group increased 24 and 48 h after surgery compared with 12 h after surgery, and increased 48 h after surgery compared with 24 h after surgery, while the diastolic blood pressure in the control group increased 48 h after surgery compared with 12 and 24 h after surgery, with statistically significant differences (all P < 0.05). The hemoglobin level was increased at three and five days after surgery compared with that at one day after surgery, and increased at five days after surgery compared with that at three days after surgery, with statistically significant differences (all P < 0.05). Comparison between groups: The systolic blood pressure and diastolic blood pressure of the observation group were higher than those of the control group at 12, 24 and 48 h after surgery, the heart rate was lower than that of the control group, and the hemoglobin level was higher than that of the control group at one, three and five days after surgery, with statistically significant differences (all P < 0.05). There were no serious complications in both groups after surgery. Conclusion The use of preventive hemostatic clips in gastric polypectomy can effectively stop bleeding and prevent delayed bleeding.
		2021 Vol. 18 (1): 87-91 [Abstract] ( 108 ) HTML (1 KB) PDF (622 KB) ( 88 )

	92	Analysis on expression level of PD-1 on the surface of CD4+T lymphocytes in peripheral blood of patients with primary immune thrombocytopenia
		CHEN Zhe1 ZHANG Ling1 LIU Jie1 Zhang Bin2 GAO Binghua1
		Objective To detect the expression level of programmed death factor-1 (PD-1) on the surface of CD4+T lymphocytes in peripheral blood of patients with primary immune thrombocytopenia (ITP), and to investigate the role of PD-1 in the pathogenesis of ITP. Methods A total of 100 ITP patients admitted to the Department of Hematology, the First Affiliated Hospital of Hebei North University (hereinafter referred to as “our Hospital”) from December 2015 to December 2017 were selected as the study group. Dexamethasone intravenous infusion of 0.15 mg/ (kg·d) was administered once per day or methylprednisolone intravenous infusion of 0.8 mg/(kg·d) was administered once per day, and prednisolone administration 1 mg/ (kg·d) were given after improvement, and the treatment lasted for four weeks. A total of 50 healthy subjects who underwent physical examination in our outpatient department during the same period were selected as the control group. The expression of PD-1 on the surface of CD4+T lymphocytes in peripheral blood was detected by flow cytometry. The changes of platelet count and PD-1 positive expression rate on the surface of CD4+T lymphocytes before and after treatment in the study group were observed. According to the treatment effect, the study group was divided into the complete response group, the effective group and the invalid group, and the differences of PD-1 positive expression rate on the surface of CD4+T lymphocytes in different treatment groups were compared. Results After treatment, the platelet count in the study group was higher than that before treatment, but still lower than that in the control group, and the differences were statistically significant (all P ＜ 0.05). After treatment, the positive expression rate of PD-1 on the surface of CD4+T lymphocytes in the study group was lower than that before treatment, but still higher than that in the control group, with statistically significant differences (all P ＜ 0.05). After treatment, the positive expression rates of PD-1 on the surface of CD4+T lymphocytes in both the complete response group and the effective group were lower than that before treatment, and the differences were statistically significant (all P ＜ 0.05). The positive expression rate of PD-1 on the surface of CD4+T lymphocytes before and after treatment in the invalid group showed no statistical significance (P ＞ 0.05). The positive expression rate of PD-1 on the surface of CD4+T lymphocytes in the complete response group was lower than that in the effective group and the invalid group, and that in the effective group was lower than that in the invalid group, with statistically significant differences (all P ＜ 0.05). Conclusion The up-regulated expression rate of PD-1 on the surface of CD4+T lymphocytes in peripheral blood may be related to the degree of disease development and prognosis of ITP patients.
		2021 Vol. 18 (1): 92-95 [Abstract] ( 181 ) HTML (1 KB) PDF (617 KB) ( 297 )

	96	Effect of target-oriented liquid therapy on prognosis of emergency craniotomy patients with craniocerebral injury
		CHEN Kun1 YU Minsheng2 XI Tao3 WANG Bin4
		Objective To study the effect of target-oriented liquid therapy on the prognosis of patients with emergency head injury craniotomy. Methods A total of 61 patients with emergency craniocerebral injury who underwent craniotomy in Chuiyangliu Hospital Affiliated to Tsinghua University from August 2017 to February 2019 were selected and divided into two groups according to the treatment method. The control group (30 cases) was treated with conventional infusion, the observation group (31 cases) was treated with goal-oriented liquid infusion. Through the observation and statistics of the patient’s hospitalization time, urine output, infusion volume, Glasgow coma score (GCS) at 48 h postoperatively, intracranial pressure and complications under the two treatment methods, the effects of the two treatment methods on the patient’s prognosis were compared. Results The observation group’s hospital stay was shorter than that of the control group, the urine output was more than that of the control group, and the infusion volume was less than that of the control group, and the differences were statistically significant (P < 0.05). The GCS score of the two groups were higher than those before treatment at 48 h after operation, and the intracranial pressure were lower than those before treatment, and the differences were statistically significant (P < 0.05). The GCS score of the observation group was higher than that of the control group at 48 h after operation, while the intracranial pressure was lower than that of the control group, and the differences were statistically significant (P < 0.05). The complication rate of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Target-oriented liquid therapy can improve the prognosis of patients with emergency craniocerebral injury and reduce the incidence of complications. It is an excellent fluid therapy method.
		2021 Vol. 18 (1): 96-98,106 [Abstract] ( 206 ) HTML (1 KB) PDF (663 KB) ( 75 )

	99	Application effect of clinical pathway management under endoscopic treatment of colonic polyps
		GE Jun1 HUA Min1 YAN Xuefang2 ZHAO Bing1▲
		Objective To explore the application effect of clinical pathway management under endoscopic treatment of colon polyps. Methods A total of 636 patients with colon polyps admitted to Jiangsu Shengze Hospital from July 2018 to April 2019 were selected as the research objects. All patients were treated under endoscopy, and were divided into clinical pathway group (334 cases) and non-clinical path waygroup (302 cases) according to different management methods. The hospitalization expenses, hospital stay time, postoperative gastrointestinal function recovery, satisfaction degree and incidence of complications were compared between the two groups. Results Compared with the non-clinical pathway group, the total hospitalization costs, surgical costs and drug costs of clinical pathway group were lower, and the differences were statistically significant (P ＜ 0.05). The clinical pathway group had shorter hospital stay time than that of the non-clinical pathway group, while the cost of hospitalization was lower than that of the non-clinical pathway group, and the differences were statistically significant (P ＜ 0.05). The first normal defecation time, the first liquid feeding time, and the general eating time of clinical pathway group were shorter than those of the non-clinical pathway group, and the differences were statistically significant (P ＜ 0.05). The comparison of patient satisfaction scores between the two groups showed that the patient satisfaction score of the clinical pathway group was higher than that of the non-clinical pathway group, and the differences were statistically significant (P ＜ 0.05). After management, the physiological function, social function, physical function and material life scores of the two groups were higher than before management, while the clinical pathway group were higher than those of the non-clinical pathway group, and the differences were statistically significant (P ＜ 0.05). Conclusion Patients are highly satisfied with the clinical pathway management of colon polyp endoscopic treatment. Treatment under the clinical pathway management is beneficial to reduce the total hospitalization cost of the patient, speed up the recovery time of the patient after surgery, shorten the hospital stay, and improve the living standard of the patient after treatment.
		2021 Vol. 18 (1): 99-102 [Abstract] ( 88 ) HTML (1 KB) PDF (645 KB) ( 93 )

	103	Analysis of the occurrence and influencing factors of hyperamylaseemia after ERCP
		ZHOU Zuoling GUO Ying YANG Na
		Objective To observe the occurrence of hyperamylaseemia after endoscopic retrograde cholangiopancreatography (ERCP), and to analyze the factors affecting the occurrence of hyperamylaseemia, aiming to provide the prevention and treatment of hyperamylaseemia after ERCP in the future guide. Methods The clinical data of 112 patients who underwent ERCP treatment at the Hospital of Shunyi District Beijing from October 2015 to June 2019 were retrospectively analyzed, and they were divided into groups based on whether postoperative hyperamylaseemia occurred or not, logistic multiple regression model was used to analyze the influencing factors of hyperamylaseemia after ERCP. Results All 112 patients developed hyperamylaseemia after ERCP in 24 cases, and 88 cases did not develop hyperamylaseemia after ERCP. The incidence rate was 21.43%. The proportions of common bile duct stenosis and duodenal papillary diverticulum in the occurrence group were higher than those in the non-occurring group, and the levels of PT, GGT and TG were higher than those in the non-occurring group, and the differences were statistically significant (P ＜ 0.05). Univariate and multivariate logistic regression showed that common bile duct stenosis, duodenal papillary diverticulum, high PT level, high GGT level, and high TG level were the influencing factors of hyperamylaseemia after ERCP (OR ＞ 1, P ＜ 0.05). Conclusion Common bile duct stenosis, duodenal papillary diverticulum, high PT level, high GGT level, and high TG level may increase the risk of hyperamylaseemia after ERCP. The clinic should pay attention to the implementation of reasonable interventions for patients with the above risk factors. It may be of positive significance to reduce the incidence and improve the prognosis.
		2021 Vol. 18 (1): 103-106 [Abstract] ( 117 ) HTML (1 KB) PDF (658 KB) ( 125 )

	107	Correlation between self-management ability and pulmonary rehabilitation of patients with chronic obstructive pulmonary disease treated with home non-invasive ventilator
		HE Xiaorong WANG Jie LI Linwei LI Chunyu
		Objective To analyze the correlation between self-management ability and pulmonary rehabilitation of patients with chronic obstructive pulmonary disease treated with non-invasive ventilator. Methods A retrospective analysis of the clinical data of 80 patients with chronic obstructive pulmonary disease who were treated with home non-invasive ventilator after diagnosis and treatment by the First People’s Hospital of Guangyuan, Sichuan Province from August 2017 to February 2019. The lung function (forced vital capacity [FEV1], the ratio of forced expiratory volume in the first second to all expiratory volume [FEV1/FVC]) levels and self-management ability were compared before and after three months of treatment. According to the evaluation results of patients’ self-management ability, they were divided into groups: high-level group (12 cases), middle-level group (54 cases), and low-level group (14 cases). The pulmonary rehabilitation of each group were compared and the correlation between self-management ability and pulmonary rehabilitation were analyzed. Results After three months of non-invasive ventilator treatment, the scores of the main dimensions of the patient’s self-management ability scale and total scores were higher than those before treatment, and the differences were statistically significant (P ＜ 0.05). After thre months of non-invasive ventilator treatment, the patients’ FEV1, FEV1/FVC were higher than those before treatment, and the differences were statistically significant (P ＜ 0.05). The FEV1 and FEV1/FVC of high-level self-management patients were higher than those of middle and low-level patients, and the FEV1 and FEV1/FVC of middle-level patients were higher than those of low-level patients, and the differences were statistically significant (P ＜ 0.05). All dimensions and overall scores of self-management ability of COPD patients treated with home non-invasive ventilator were positively correlated with FEV1 and FEV1/FVC (r ＞ 0, P ＜ 0.05). Conclusion Patients with chronic obstructive pulmonary disease can obtain better pulmonary rehabilitation effects through home non-invasive ventilator treatment, but the size of pulmonary rehabilitation benefits is related to the patient’s self-management ability. It is recommended that certain interventions be taken early to improve patients’ self-management ability. It is of great significance to improve the pulmonary rehabilitation effect of home non-invasive ventilator.
		2021 Vol. 18 (1): 107-110 [Abstract] ( 115 ) HTML (1 KB) PDF (649 KB) ( 85 )

	111	Effect of Dexmedetomidine on serum inflammatory factors and neurocytokines levels and prognosis in patients with severe craniocerebral injury after surgery
		GAO Jian1 ZHANG Hua1 LIU Guocheng1 WANG Decong1 ZHAO Zeyu2▲
		Objective To investigate the effect of Dexmedetomidine (DEX) on serum inflammatory factors and neurocytokines levels and prognosis in patients with severe craniocerebral injury after surgery. Methods From January 2017 to December 2019, 50 patients with severe craniocerebral injury admitted to intensive care unit (ICU) of Pidu District People’s Hospital of Chengdu City were selected and divided into group D and group C according to random number table method, 25 cases in each group. Group D received DEX 0.5-0.8 μg/(kg·h), group C received Midazolam 0.05-0.1 mg/(kg·h) for seven days. NIHSS scores were used to evaluate the degree of neurological deficit and intracranial pressure (ICP) at the time of admission to ICU (T0) and seven days after treatment (T1) in two groups. The incidence of complications of two groups was recorded at T1. Peripheral venous blood samples were collected at T0 and T1 to determine the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), central nerve specific protein (S100β), neuron specific enolase (NSE). The length of ICU stay and the total length of stay of two groups were recorded, and the prognosis was evaluated of two groups after three months. Results NIHSS score and ICP at T1 were lower than those at T0 in two groups (P < 0.01). NIHSS score and ICP at T1 in group D were lower than those in group C (P < 0.05 or P < 0.01). Total complication rate at T1 in group D was lower than that in group C (P < 0.01). The levels of IL-6 and TNF-α at T1 were significantly lower than those at T0 in two groups (P < 0.01). The levels of IL-6 and TNF-α at T1 in group D were lower than those in group C (P < 0.05 or P < 0.01). The levels of S100β and NSE at T1 were higher than those at T0 in two groups (P < 0.01). At T1, S100β and NSE levels in group D were lower than those in group C (P < 0.01). The length of ICU stay and total length of stay in group D were shorter than those in group C (P < 0.05 or P < 0.01). The prognosis of group D was better than that of group C after three months (P < 0.05). Conclusion DEX can reduce the degree of neurological deficit, reduce the incidence of ICP and complications, shorten the length of ICU stay and total hospital stay and improve the prognosis of patients.
		2021 Vol. 18 (1): 111-114,139 [Abstract] ( 153 ) HTML (1 KB) PDF (1024 KB) ( 80 )

	115	Effect of Oxycodone combined with Flurbiprofen Axetil on the analgesic effect and immune status of postoperative breast cancer patients
		ZHANG Zhengzheng GAO Hong AN Minghao
		Objective To investigate the effect of Oxycodone combined with Flurbiprofen Axetil on the analgesic effect and immune status of patients with postoperative breast cancer. Methods Eighty patients underwent radical mastectomy in Wuxi People’s Hospital Affiliated to Nanjing Medical University from January to December 2018 were selected and divided into control group and study group according to the random number table method, 40 cases in each group. Control group was given Sufentanil combined with Flurbiprofen Axetil for analgesia, while study group was given Oxycodone combined with Flurbiprofen Axetil for analgesia. The analgesic effect, immune status, the use of PCIA pump within 48 hours after operation and the adverse reactions during treatment between two groups were recorded. Results The overall analysis showed that there were significant differences on immune function in the time, inter group and interaction between two groups (P < 0.01). There was no significant difference in CD3+, CD4+, CD8+ and CD4+/CD8+ between two groups at T0 (P > 0.05). At T3, T4 and T5, CD3+, CD4+ and CD4+/CD8+ in two groups decreased first and then increased, and CD8+ increased first and then decreased (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ in study group were higher than those in control group at T3, T4 and T5, while CD8+ was lower than that in control group (P < 0.05). The overall analysis showed that there were significant differences on visual analogue scale (VAS) in time, inter group and interaction between two groups (P < 0.01). There was no significant difference in VAS at T1 between two groups (P > 0.05). VAS of two groups showed a downward trend at T2-T5, and study group was lower than that control group (P < 0.05). The times of PCIA pump press and total consumption of PCIA pump in study group were less than those in control group (P < 0.05). There was no significant difference in the total incidence rate of adverse reactions between two groups (P > 0.05). Conclusion The analgesic effect of Oxycodone combined with Flurbiprofen Axetil in patients with breast cancer after operation is definite. It can also reduce the immunosuppression of the body, the times of pressing PICA pump, the total consumption of PICA pump.
		2021 Vol. 18 (1): 115-118,144 [Abstract] ( 181 ) HTML (1 KB) PDF (1047 KB) ( 23 )

	119	Effect of ultrasound-guided iliohypogastric / ilioinguinal nerve block on postoperative analgesia after cesarean section
		WANG Weiming
		Objective To study the effect of ultrasound-guided iliohypogastric/ilioinguinal nerve block on postoperative analgesia after cesarean section. Methods From April 2019 to March 2020, 80 pregnant women who had cesarean section in Huangshan Shoukang Hospital of Anhui Province were selected for the study. They were divided into control group and experimental group according to random number table, 40 cases in each group. Control group was given patient-controlled intravenous analgesia, and experimental group was given ultrasound-guided iliohypogastric/ilioinguinal nerve block analgesia on the basis of control group. Visual analogue scale (VAS) six hours before operation and 12 hours after operation, times of pressing analgesia pump, time of first exhaust and recovery rate of analgesia, serum prolactin level at different time points and colostrum time in two groups were analyzed. The incidence of adverse reactions was compared between two groups. Results At 12 hours after operation, VAS of two groups was lower than that of six hours before operation, and VAS of experimental group was lower than that of control group, the difference was statistically significant (P < 0.05). The times of pressing analgesia pump in experimental group were less than those in control group within 24 hours after operation, the first exhaust time of experimental group was shorter than that of control group, and the analgesic recovery rate of experimental group was lower than that of control group, the difference was statistically significant (P < 0.05). Twenty four hours after operation, the serum prolactin levels of two groups were higher than that of one day before operation, and the serum prolactin level of experimental group was higher than that of control group, the difference was statistically significant (P < 0.05). The colostrum time of experimental group was shorter than that of control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups within 24 hours (P > 0.05). Conclusion Ultrasound-guided iliohypogastric/ilioinguinal nerve block can effectively relieve postoperative pain and promote gastrointestinal function recovery and early lactation, it is worth popularizing and applying.
		2021 Vol. 18 (1): 119-122 [Abstract] ( 226 ) HTML (1 KB) PDF (529 KB) ( 36 )

	123	Analysis of hemodynamics and clinical effect of general anesthesia combined with epidural anesthesia on patients with laparoscopic rectal cancer resection
		BAO Yu
		Objective To explore the influence of hemodynamics and clinical effect of general anesthesia combined with epidural anesthesia on patients with laparoscopic rectal cancer resection. Methods From April 2016 to May 2019, 145 patients undergoing laparoscopic rectal cancer resection in Fuxin General Hospital of Liaoning Health Industry Group were selected and divided into combined group (75 cases, general anesthesia combined with epidural anesthesia) and single group (70 cases, general anesthesia). The extubation time, complete recovery time, hemodynamic indexes, visual analogue scale (VAS), alertness/sedation score (OAA/S) and complications were compared between two groups. Results The overall analysis showed that there were significant differences in ECG monitoring related indicators between two groups, time point comparison and interaction (P < 0.05). Further pairwise comparison, intra group comparison: one hours after pneumoperitoneum establishment, heart rate (HR) was faster than that before anesthesia, and mean arterial pressure (MAP), end expiratory CO2 partial pressure (PETCO2) and airway pressure (Paw) were higher than those before anesthesia in two groups (P < 0.05). One hour after operation, HR was faster than that before anesthesia, MAP and Paw were higher than those before anesthesia in two groups (P < 0.05). Comparison between two groups: one hours after pneumoperitoneum establishment, HR of combined group was slower than that of single group, MAP, PETCO2 and Paw of combined group were lower than those of single group (P < 0.05). One hour after operation, HR of combined group was slower than that of single group, MAP and Paw of combined group were lower than those of single group (P < 0.05). The extubation time and complete recovery time of combined group were shorter than those of single group, VAS of combined group was lower than that of single group, OAA/S of combined group was higher than that of single group, the differences were statistically significant (P < 0.05). The incidence of postoperative complications in combined group was lower than that in single group (P < 0.05). Conclusion General anesthesia combined with epidural anesthesia can stabilize the hemodynamic indexes during and after operation, shorten the time of extubation, relieve the pain after recovery, have good sedative effect and do not increase the postoperative complications. It is an effective anesthesia method for laparoscopic rectal cancer operation.
		2021 Vol. 18 (1): 123-126 [Abstract] ( 209 ) HTML (1 KB) PDF (555 KB) ( 49 )

	127	Analysis on prescription rules of acupuncture and moxibustion in the treatment of rectal prolapse
		ZHOU Jiaojiao LI Huashan▲
		Objective To analyze and summarize the prescription rules for acupuncture and moxibustion in the treatment of rectal prolapse in modern research. Methods Subject retrieval about CNKI, Wanfang Data, VIP, PubMed and Web of Science core integrated acupuncture and moxibustion in the treatment of rectal prolapse from the database establishment to December 2019 was carried out. After manual screening and data normalization, the prescription rules were analyzed by using data mining software CiteSpace. Results A total of 94 literatures were enrolled, involving 112 prescriptions and 67 acupoints. The mediating centrality of moxa-wool moxibustion and acupuncture on píshù was the largest, and the most frequent prescriptions were acupuncture of chángqiáng and acupuncture of bǎihuì. The application of frequency of specific points was more than that of non-specific points, among which, chángqiáng and bǎihuì were the most frequently selected acupoints. In the prescription cluster analysis, a total of seven clusters were obtained, which were acupuncture of dàchángshù, acupuncture of bāliáo, acupuncture of bǎihuì, electro-acupuncture of huánmén, moxa-wool moxibustion of chángqiáng, moxa-wool moxibustion of zúsānlǐ and acupuncture of tiānshū. Conclusion The treatment of rectal prolapse by acupuncture and moxibustion is mainly acupuncture, and the acupoints are mainly governor channel, bladder meridian, conception channel and stomach meridian. The acupoints are mainly chángqiáng and bǎihuì, and the acupoint compatibility and specific points application are emphasized.
		2021 Vol. 18 (1): 127-131 [Abstract] ( 161 ) HTML (1 KB) PDF (915 KB) ( 109 )

	132	Clinical study of individualized acupuncture acupoint selection and standardized acupuncture acupoint selection in the treatment of polycystic ovary syndrome
		LI Qian1 WU Xiaoke2
		Objective To explore the clinical effect of individual acupuncture point selection and standardized acupuncture point selection in the treatment of polycystic ovary syndrome (PCOS), and to provide reference for clinical treatment. Methods A total of 80 PCOS patients from May to December 2017 in the Reproductive Immunity Clinic of Xuzhou Maternal and Child Health Hospital were selected and divided into individualized acupoint selection group and standardized acupoint selection group according to the central random method, with 40 cases in each group. The patients in individualized acupoint selection group were treated according to the corresponding acupoints of syndrome of yang deficiency of spleen and kidney or syndrome of yin deficiency of liver and kidney, while standardized acupoint selection group received fixed acupoint therapy. Both groups were treated with acupuncture on the fifth day after spontaneous menstrual or progesterone withdrawal bleeding, twice a week, with an interval of no less than two days. The treatment lasted for four months, with a total of 32 acupuncture sessions. Body mass index (BMI), waist hip ratio (WHR), fasting blood glucose (FPG), luteinizing hormone/follicle stimulating hormone (LH/FSH), total testosterone (T), homeostasis model assessment of insulin resistance index (HOMA-IR) and recovery of ovulatory menstruation were compared between two groups before and after treatment. Results The levels of BMI, WHR and FPG in two groups after treatment were lower than those before treatment, the differences were statistically (P < 0.05). After treatment, LH/FSH, T and HOMA-IR of two groups were lower than those before treatment, and individualized acupoint selection group was lower than standardized acupoint selection group, the differences were statistically significant (P < 0.05). After treatment, the number of patients in individualized acupoint selection group was higher than that in standardized acupoint selection group (P < 0.05). Conclusion Individualized acupoint selection is superior to standardized acupoint selection in improving menstruation, endocrine disorders and insulin resistance in PCOS.
		2021 Vol. 18 (1): 132-135,152 [Abstract] ( 213 ) HTML (1 KB) PDF (771 KB) ( 37 )

	136	Overview of toxin and pathogen theory
		WANG Xueke1 CUI Yinglin2
		Toxin and pathogen belongs to the etiological concept of traditional Chinese medicine, and it is the general name of a kind of pathogenic substance. Doctors of all ages have combined wisdom and humanity to further develop and perfect the theory of toxin and pathogen. From ancient times till now, there are more than 40 categories of toxin and pathogen, including internal toxin, external toxin, environmental toxin, and toxin of six climatic exopathogens, which are characterized by obstinacy, internal damage, violence, dependency, etc. Clinically induced diseases involve cardiovascular and cerebrovascular systems, liver, spleen, kidney, etc. Doctors have accumulated rich experience in diagnosis and treatment of diseases caused by toxin and pathogen, which is worthy of in-depth discussion and continuous learning. This paper summarizes the theoretical origin, ancient and modern classification, pathogenic characteristics, pathogenic syndrome and problem prospects of toxin and pathogen, which provides better theoretical basis for clinical research and application.
		2021 Vol. 18 (1): 136-139 [Abstract] ( 110 ) HTML (1 KB) PDF (704 KB) ( 87 )

	140	Effect of selective acupoint application on dyspnea and cough in patients with acute stage of chronic obstructive pulmonary disease
		HE Wenfang XIONG Shuyun LI Guanlan ZHOU Xun CHENG Danwei
		Objective To investigate the clinical effect of selective acupoint application on dyspnea and cough in patients with acute stage of chronic obstructive pulmonary disease (COPD). Methods By using prospective observational research method, 90 COPD patients admitted to Guangdong Provincial Hospital of Traditional Chinese Medicine from March 2019 to June 2020 were selected and divided into three groups according to random number table method, with 30 cases in each group. Control group was treated with routine therapy for one week. Non selective acupoint application group was treated with acupoint application for one week on the basis of routine therapy, selective acupoint application group was treated with selective acupoint application for one week on the basis of routine therapy, and acupoint application was treated with the combination of the weakest lung meridian and the most vigorous kidney meridian. Clinical efficacy, modified Medical Research Council dyspnea index (mMRC) grading after treatment and pulmonary function indicators’ level and clinical symptom score before and after treatment among three groups were compared. Results After treatment, total effective rate of selective acupoint application group was significantly higher than that of non selective acupoint application group and control group, and total effective rate of non selective acupoint application group was significantly higher than that of control group (P < 0.05). After treatment, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) of three groups were higher than those before treatment, FEV1 and FVC of selective acupoint application group were higher than those of non selective acupoint application group and control group, and FEV1 and FVC of non selective acupoint application group were higher than those of control group (P < 0.05). After treatment, the scores of shortness of breath, expectoration, cough and gasping in three groups were lower than those before treatment, the scores of shortness of breath, expectoration, cough and gasping in selective acupoint application group were lower than those in non selective acupoint application group and control group, while those in non selective acupoint application group were lower than those in control group (P < 0.05). The difference of mMRC grading among three groups after treatment was statistically significant (P < 0.05); the mMRC grading of selective acupoint application group after treatment was better than that of control group (P < 0.05). Conclusion Selective acupoint application is effective in treating dyspnea and cough in patients with acute stage of COPD, it can improve the symptoms of shortness of breath, expectoration, cough, gasping, and the pulmonary function, it is worthy of clinical application.
		2021 Vol. 18 (1): 140-144 [Abstract] ( 169 ) HTML (1 KB) PDF (756 KB) ( 184 )

	145	Network pharmacology research on active ingredients and mechanism of Jianwei Shoutai Pills in the treatment of spontaneous abortion
		HE Shan1 NING Yan2 JIANG Shaoyan1 LIU Dayan3 DENG Shaojie1 LIU Xuefang1 ZENG Dan1
		Objective To screen the main active ingredients of Jianwei Shoutai Pills (JWSTP) based on the network pharmacology technology, predict the targets of the active ingredients and discuss mechanisms of JWSTP in the treatment of spontaneous abortion (SA). Methods The active ingredients and targets in JWSTP were screened on traditional Chinese medicine system pharmacology database and analysis platform. Disease targets of SA were screened and potential targets of JWSTP in the treatment of SA were predicted with GeneCards and OMIM database. The protein-protein interaction of potential targets were constructed on STRING online platform. The gene ontology analysis in biological processes and Kyoto Encyclopedia of Genes and Genomes pathways were enriched by DAVID 6.8 online platform to obtain key pathways, and to construct a network of active ingredients and potential targets and key pathways. Results A total of 18 active ingredients were obtained from JWSTP, and 108 possible targets for the treatment of SA were obtained. The key targets included transcription factor AP-1, tumor necrosis factor, protein kinase AKT1, IL-6, vascular endothelial growth factor A, mitogen-activated protein kinase 1, and so on. The key targets were mainly enriched in biological processes such as positive regulation of transcription from RNA polymerase Ⅱ promoter, apoptosis and inflammatory response, and they are mainly concentrated in PI3K-Akt, mitogen-activated protein kinase, and tumor necrosis factor and other signaling pathways. Conclusion The multi-components, multi-targets and multi-pathways action characteristics of JWSTP were confirmed by network pharmacology technology, and the possible mechanisms of JWSTP in the treatment of SA provided theoretical basis to its mechanisms and active ingredients in further study.
		2021 Vol. 18 (1): 145-152 [Abstract] ( 130 ) HTML (1 KB) PDF (1977 KB) ( 124 )

	153	Treatment of fatigue after stroke from the spleen and kidney theory
		LEI Simin1 HAN Zucheng2▲ ZHANG Ziyi1
		Fatigue is a common symptom after stroke, which seriously affects functional exercise and quality of life of patients, thus resulting in poor overall recovery effect. Traditional Chinese medicine has sufficient theoretical support and experiential summary in the treatment of fatigue after stroke. Based on the congenital and acquired theory, it is believed that the disorder of spleen and kidney is closely associated with this disease. The core pathogenesis is the deficiency of spleen, which leads to deficiency of source. And the deficiency of kidney leads to yin-yang disharmony. Deficiency of spleen and kidney leads to deficiency of qi, blood, yin-yang, and on this basis, it is easily affected by such excessive pathogens as dampness, phlegm, blood stasis and stagnation. This paper points out that focusing on the spleen and kidney is the key to the treatment of fatigue after stroke, based on invigorating spleen and kidney. At the same time, eliminating dampness, dissipating phlegm, promoting blood circulation and regulating qi-flowing, both manifestation and root cause are taken into account, and the curative effect is significant.
		2021 Vol. 18 (1): 153-155,159 [Abstract] ( 154 ) HTML (1 KB) PDF (720 KB) ( 76 )

	156	Guiding significance of “five zang viscera and six fu viscera all make people cough” in the treatment of dyspnea syndrome
		ZHANG Qun ZHAO Xutao▲
		Dyspnea syndrome is a common disease in the lung system. No matter what kind of cough and dyspnea, it is always closely related to lungs. However, in clinical treatment, excessive attention is paid to the changes in the pathogenesis of the lungs, and the connection between the five zang viscera and six fu viscera is ignored, thus affecting the therapeutic effect of dyspnea syndrome. Therefore, it is necessary to follow the ancient maxims, Suwen points out that “five zang viscera and six fu viscera all make people cough, not only the lung”. Taking this as the guiding ideology, this paper discusses the internal relationship between the five zang viscera and six fu viscera in the pathogenetic process of dyspnea syndrome. It is clear that the five zang viscera and six fu viscera are connected by meridians, and the zang-fu viscera both are interior and exterior. They rely on each other and also restrict each other. They also influenced each other through the pathological products such as phlegm and fluid retention and static blood. The imbalance can affect the lungs and cause dyspnea syndrome. Therefore, this paper takes this as a clue in the treatment of dyspnea syndrome, emphasizes the lung as the center, and starts from the connection between the five zang viscera and six fu viscera, physiological functions, pathogenesis, pathological products, balance between qi and blood, yin and yang, etc., to elaborate the connotation and extension of the treatment of dyspnea syndrome, reflecting the holism and treatment based on syndrome differentiation.
		2021 Vol. 18 (1): 156-159 [Abstract] ( 101 ) HTML (1 KB) PDF (706 KB) ( 108 )

	160	Clinical significance of CT angiography in detecting hemodynamic parameters after autologous arteriovenous fistulaplasty in hemodialysis patients
		JIA Xiufen1 LIU Jinjin1 ZHENG Chenfei2
		Objective To observe the hemodynamic parameters in the numerical model established under the CT angiography (CTA) detection data after autologous arteriovenous fistulaplasty (AVF) in hemodialysis patients. Methods From April 2019 to April 2020, 80 hemodialysis patients in the First Affiliated Hospital of Wenzhou Medical University were retrospectively analyzed. According to the patient’s hemodialysis results, they were divided into the dysfunction group (21 cases) and the control group (59 cases), and the hemodynamic parameters of two groups were compared and the predictive value of hemodynamic parameters for AVF dysfunction were analyzed. Results The blood flow velocity at the venous end of the anastomosis after AVF in the dysfunction group was lower than that of the control group, and the radial artery shear force was higher than that of the control group, and the differences were statistically significant (P < 0.05). Logistic regression analysis showed that slow blood flow velocity at the venous end of the anastomosis, high radial artery shear force were the influencing factors of AVF dysfunction (OR > 1, P < 0.05). Area under curve of blood flow velocity at the venous end of the anastomosis and radial artery shear force for AVF dysfunction prediction were 0.847 and 0.843 respectively, and the combined detection was 0.943. Conclusion The high incidence of AVF dysfunction after autologous AVF in hemodialysis patients may be related to slow blood flow velocity at the venous end of the anastomosis and high radial artery shear force. The blood flow velocity and radial artery shear force embodied in the numerical model established under the early CTA detection data can predict the risk of dysfunction after AVF and may have positive significance on guiding AVF effect evaluation and early intervention in hemodialysis patients.
		2021 Vol. 18 (1): 160-163 [Abstract] ( 183 ) HTML (1 KB) PDF (449 KB) ( 99 )

	164	Empirical study on the evaluation index system of scientific research performance of departments in a level A tertiary hospital in Xinjiang
		MA Tingyu1,2 HE Xiangyan1 GAN Xiaocheng2 WENG Zhenqun1
		Objective To take the clinical department of a level A tertiary hospital in Xinjiang as the assessment object, to empirically analyze the feasibility of the scientific research performance evaluation index system. Methods The relevant literature from 2015 to 2019 was found, the literature data method, Delphi method, analytic hierarchy process, and boundary value method to summarize, filter, and assign weights were used to the department’s scientific research performance evaluation indicators, and the hospital’s 2018 surgical system for 21 departments empirical analysis of the scientific research status of the country. Results The finally established performance evaluation index system included 3 first-level indicators, 14 second-level indicators, and 49 third-level indicators as the main body of the scientific research evaluation index system of general hospital departments. Compared with the old evaluation indicators, the importance of talents, management system, and scientific research of equipment investment were reflected. Conclusion The establishment of a scientific research performance evaluation index system and empirical research have found that it is more scientific to add scientific research management indicators to the system.
		2021 Vol. 18 (1): 164-167 [Abstract] ( 104 ) HTML (1 KB) PDF (387 KB) ( 51 )

	168	Effect of preoperative process communication mode in patients with liver cancer
		MIAO Suqin LIU Wei ZHANG Qiong WANG Gang
		Objective To explored the effect of preoperative process communication mode in patients with liver cancer. Methods From May 2017 to May 2019, 120 patients with liver cancer admitted to Eastern Theater General Hospital were selected as objects. They were divided into the control group and the observation group by random number table method, with 60 cases in each group. The control group was given routine intervention mode, while the observation group was given the preoperative process communication mode. The negative emotions and psychological stress response at 12 h before operation (before intervention), 6 h after operation (after intervention) were compared. And quality of life before intervention and 3 d after operation of the two groups were compared. Results Before intervention, there were no statistically significant differences in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) between the two groups (all P > 0.05). After intervention, the scores of SAS and SDS in the two groups after intervention were lower than those before the intervention, and the observation group was lower than the control group (all P < 0.05). There were no significant differences in the levels of norepinephrine (NE) and epinephrine (E) between the two groups before intervention (P > 0.05). After intervention, the levels of NE in the two groups were higher than those before intervention; the levels of E in the two groups were lower than those before intervention; and the levels of NE and E of the observation group were lower than those of the control group, and the differences were statistically significant (all P < 0.05). There was no significant difference in quality of life between the two groups before intervention (P > 0.05). Three days after intervention, the scores of physiological function, role physical, emotional function, social function, pain, mental state, vitality and total scores in the two groups after intervention were higher than those before intervention, and the observation group was higher than the control group (all P < 0.05). Conclusion The preoperative process communication mod in patients with liver cancer can effectively alleviate adverse emotions, reduce psychological stress reaction, and promote the quality of life.
		2021 Vol. 18 (1): 168-171,179 [Abstract] ( 176 ) HTML (1 KB) PDF (676 KB) ( 15 )

	172	Effect of teach-back health education on self-management ability and quality of life of patients with coronary heart disease after percutaneous coronary artery stent implantaition
		WANG Zhen YAO Minghua▲ ZHU Liqun
		Objective To explore the effect of teach-back health education on self-management ability and quality of life of patients with coronary heart disease after percutaneous coronary artery stent implantaition (PCI). Methods From October 2016 to September 2018, 92 patients with coronary heart disease after PCI who admitted to Liyang People’s Hospital of Jiangsu Province were selected as study objects. According to the random number table method, they were divided into the treatment group (48 cases) and the control group (44 cases). The control group was given regular health education, and the treatment group was given teach-back health education. Both groups were followed up for 1 year, the self-management ability, quality of life, fatality rate and readmission rate were compared between the two groups. Results There were no significant differences in self-management ability scores between the two groups before education (P > 0.05). After education, the scores of self-management ability of patients between the two groups were higher than those of the same group before education and the scores of adverse habits management, symptom management, disease knowledge management, daily life management, treatment compliance management and total scores of the treatment group were higher than those of the control group (P < 0.01). There were no significant differences in quality of life scores between the two groups before education (P > 0.05). After education, the scores of the quality of life of patients between the two groups were higher than those of the same group before education and the scores of symptom control, physical function, psychosocial function, cognitive function, treatment satisfaction, and total scores of the treatment group were higher than those of the control group (P < 0.05 or P < 0.01). There were no deaths in either group. The readmission rate of the treatment group was lower than that of the control group (P < 0.05). Conclusion Teach-back based health education helps to promote the self-management ability of patients with coronary heart disease after PCI, reducing postoperative rehospitalization and improving the quality of life of patients.
		2021 Vol. 18 (1): 172-175 [Abstract] ( 170 ) HTML (1 KB) PDF (653 KB) ( 117 )

	176	Clinical application value of T-shaped shoes for acupoint massage with removable and inflatable pads after THA
		CHE Xiaoqiao1 PENG Zhihua2 TANG Gangjian1 ZENG Weiqing1 YUAN Zhenzhong1 DENG Zhangrong1 WEN Fang1
		Objective To analyze the clinical application value of T-shaped shoes for acupoint massage with removable and inflatable pads after total hip arthroplasty （THA）. Methods From January 2017 to December 2018, 150 patients with THA in Department of Orthopaedics, Guilin Traditional Chinese Medicine Hospital were selected. They were divided into traditional group and intervention group according to the random number table method, with 75 cases in each group. Traditional group voluntarily received care with traditional T-shaped, and intervention group voluntarily received care with T-shaped shoes for acupoint massage with removable and inflatable pads. The clinical effect, anti-rotation effect, pain, comfort degree and complications between two groups were compared. Results The total effective rate of intervention group was higher than that of traditional group, and the difference was statistically significant (P < 0.05). The dislocation rate of prosthesis in intervention group was lower than that in traditional group, and the difference was statistically significant (P < 0.05). The visual analogue scale score of intervention group was lower than that of traditional group; and Kolcaba score was higher than that of traditional group, and the differences were highly statistically significant (P < 0.01). The total complications rate of intervention group was lower than that of traditional group, and the difference was highly statistically significant (P < 0.01). Conclusion T-shaped shoes for acupoint massage with removable and inflatable pads can significantly improve the comfort after THA, reduce pain and fracture healing time, and improve the clinical effect and anti-rotation effect. Clinical use is recommended.
		2021 Vol. 18 (1): 176-179 [Abstract] ( 153 ) HTML (1 KB) PDF (653 KB) ( 63 )

	180	The value of health education under the hospital-community-family medical alliance management mode in the intervention of patients with acute stroke
		GE Jia’nan1 HUANG Hua2▲
		Objective To investigate the value of health education intervention under the hospital-community-family medical alliance management mode for acute stroke, and to provide reference for the development of long-term rehabilitation treatment plan for patients with acute stroke. Methods From July 2018 to March 2019, 100 patients with acute stroke who were treated in the Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were selected as the research subjects. All the patients were assigned into the control group and the observation group according by the random number table method, with 50 cases in each group. The control group was given routine community health service nursing mode, and the observation group was given hospital-community-family medical alliance management mode. The two groups received one-year nursing management, and the quality of life, neurological deficit and limb movement disorder were evaluated by Chinese version of the world health organization quality of life scale (WHOQOL-100), national institutes of health stroke scale (NIHSS) and Fugl-Meyer Assessment and compared before intervention and after intervention for one year. The compliance of patients was evaluated and compared after one year of intervention. Results The scores of quality of life in the two groups of patients after intervention for one year were higher than those before intervention, and the scores of patients in the observation group were higher than those in the control group, with statistically significant differences (P ＜ 0.05). The NIHSS scores of the two groups of patients after intervention for one year were lower than those before intervention, and the Fugl-Meyer scores were higher than those before intervention, the NIHSS scores in the observation group were lower than those in the control group, and the Fugl-Meyer scores in the observation group were higher than those in the control group, with statistically significant difference (P ＜ 0.05). The compliance in the observation group was higher than that in the control group, with statistically significant difference (P ＜ 0.05). Conclusion Health education mode under the hospital-community-family medical alliance management mode can promote recovery of nerve function in patients with acute stroke, improve limb dysfunction, enhance quality of life and compliance, and accelerate rehabilitation process.
		2021 Vol. 18 (1): 180-183,188 [Abstract] ( 172 ) HTML (1 KB) PDF (675 KB) ( 178 )

	184	Influence of lung rehabilitation nursing based on cloud platform of internet of things on lung function of elderly patients with chronic obstructive pulmonary disease in stable plase
		ZHU Yutong1,2 LIU Zuoyan1,2▲
		Objective To investigate the effect of lung rehabilitation nursing on elderly patients with chronic obstructive pulmonary disease (COPD for short) in stable phase based on internet of things cloud platform. Methods Retrospectively analyzsis was carried out in this study, clinical data of 69 elderly patients with COPD who had received routine pulmonary rehabilitation care and completed follow-up in West China Hospital of Sichuan University from March 2018 to December 2018 was collected and as routine group; the clinical data of 72 elderly patients with COPD who received lung rehabilitation nursing based on the internet of things cloud platform and completed follow-up in West China Hospital of Sichuan University from February 2019 to November 2019 was collected and as the research group. Before and after six months of intervention, examined the lung function of the two groups; the british medical research council modified dyspnea scale (mMRC) was used to assess the changes in dyspnea in the two groups. The COPD quality of life scale (CAT score) was used to assess the impact of patients’ daily life, a self-made questionnaire was used to investigate the two groups’ mastery of lung rehabilitation training. Results After six months of intervention, the forced expiratory volume in one second, forced vital capacity, and forced expiratory volume in the first second accounted for the proportion of all expiratory volumes and the maximum expiratory flow rate of the two groups were higher than those before the intervention. while those in the study group were higher than those in the conventional group (P ＜ 0.05); mMRC score and CAT score in both groups were lower than those before the intervention, and those in the study group were lower than those in the conventional group (P ＜ 0.05); the relevant knowledge mastery score of the study group was higher than that of the conventional group (P ＜ 0.05). Conclusion Elderly patients with chronic obstructive pulmonary disease in stable stage have a definite effect of lung rehabilitation nursing based on the internet of things cloud platform. It is helpful to improve the patient’s grasp of lung rehabilitation related knowledge, improve the patient’s lung function, reduce the symptoms of dyspnea, and reduce the impact of the disease on the patient’s daily life, which is worthy of clinical promotion and application.
		2021 Vol. 18 (1): 184-188 [Abstract] ( 103 ) HTML (1 KB) PDF (663 KB) ( 88 )

	189	Application of JCI standard guide standardized nursing mode in patients with interventional treatment of acute myocardial infarction
		FU Yongning FU Zhen
		Objective To explore the application effect of JCI standard guide standardized nursing mode in patients with interventional treatment of acute myocardial infarction. Methods A total of 82 patients with acute myocardial infarction who underwent interventional therapy in Traditional Chinese Medicine Hospital of Qionghai City, Hainan Province from January 2016 to December 2019 were selected. According to different nursing modes, they were divided into control group and observation group. Forey cases in the control group were used the conventional nursing mode, and 42 cases in the observation group were used the JCI standard to guide the standardized nursing mode, and they were all nursing for three months. The hospitalization expenses and hospitalization time of the two groups were recorded and compared; the incidence of complications after interventional treatment (during hospitalization) was compared between the two groups; self-made scale was used to evaluate nursing compliance; a self-made questionnaire was used to evaluate patient’s nursing satisfaction. Results The hospitalization cost of the observation group was less than that of the control group, and the hospitalization time was shorter than that of the control group(P ＜ 0.05); there was no significant difference in the incidence of thrombosis between the two groups (P ＞ 0.05); the incidence of hypotension and incisional bleeding in the observation group was lower than that in the control group (P ＜ 0.05); the nursing compliance and nursing satisfaction of the observation group were higher than those of the control group (P ＜ 0.05). Conclusion JCI standard guide standardized nursing mode can shorten the hospital stay of patients with acute myocardial infarction interventional treatment, reduce hospitalization costs, improve nursing compliance and nursing satisfaction. It is more conducive to reducing the incidence of complications after intervention treatment and has high clinical application value.
		2021 Vol. 18 (1): 189-192 [Abstract] ( 261 ) HTML (1 KB) PDF (654 KB) ( 180 )

	193	Effect of multidisciplinary rehabilitation nursing combined with Huoxue Huayu Decoction fumigation on the postoperative rehabilitation of patients with femoral neck fracture
		TIAN Xingcui CHEN Min WANG Li LI Linyun XU Qilan▲
		Objective To observe the value of multidisciplinary rehabilitation nursing combined with Huoxue Huayu Decoction fumigation in patients with femoral neck fractures. Methods A total of 103 patients with femoral neck fractures who were treated in Traditional Chinese Hospital of Lu’an of Anhui Province (hereinafter referred to as “our hospital”) from January 2018 to December 2019 were selected as the research object. They were divided into control group （n = 51） and observation group （n = 52） by random number table method. The control group received routine rehabilitation nursing combined with Huoxue Huayu Decoction fumigation, while the observation group received multidisciplinary rehabilitation nursing combined with Huoxue Huayu Decoction fumigation after operation; the pain levels of the two groups were compared one, three and seven days after surgery （using visual analog score [VAS] scale）; after three months of intervention, the recovery of hip function in both groups (using the hip score scale [Harris]) and daily life self-care ability (activities of daily living [ADL] assessment scale) were evaluated; the self-made nursing satisfaction questionnaire of our hospital was used to evaluate the nursing satisfaction of the two groups. Results Three and seven days after surgery, the VAS scores of both groups were lower than that one day after surgery, and the VAS scores seven day after surgery in both groups were lower than that three day after surgery (P ＜ 0.05). However, the VAS score at each time point between the two groups was compared, the difference was not statistically significant (P ＞ 0.05). After three months of intervention, the good rate of hip joint function recovery in the observation group was higher than that in the control group (P ＜ 0.05). After three months of intervention, the ADL scores of the two groups were higher than those before the intervention, and the observation group was higher than the control group (P ＜ 0.05). The total satisfaction rate of nursing in the observation group was higher than that in the control group (P ＜ 0.05). Conclusion Multidisciplinary rehabilitation nursing combined with Huoxue Huayu Decoction fumigation as intervention for patients with femoral neck fracture is more conducive to improving postoperative hip function, patients’ daily living ability and the nursing satisfaction is high.
		2021 Vol. 18 (1): 193-196 [Abstract] ( 209 ) HTML (1 KB) PDF (619 KB) ( 80 )

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