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Optimization of extraction technology for Xiao’er Yifei Jianpi Paste by central composite design-response surface methodology |
WEI Yanping1 TAN Zhi’en1 TUO Haiyan1 ZENG Peiqin1 LIU Yating1 QIN Liuxin1 YI Wei1 CHEN Weiwei1,2,3 |
1.College of Pharmacy,Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530001, China;
2.Guangxi Key Laboratory of Common Technology of Traditional Chinese Medicine Preparation in Laboratory, Guangxi Zhuang Autonomous Region, Nanning 530001, China;
3.Guangxi Zhuang Yao Key Laboratory of Medicine, Guangxi Zhuang Autonomous Region, Nanning 530001, China |
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Abstract Objective To optimize the extraction technology for Xiao’er Yifei Jianpi Paste by central composite design-response surface methodology. Methods Based on taking water volume and extraction time as investigation factors, overall rating of “normalized value” of dry extract yield and the content of Hesperidin as evaluation index, the two-factor and five-level test was carried out. The experimental data were fitted by multiple linear regression and binomial fitting, and the obtained response surface were used to predict the results. Results The optimal extraction technology was as follows: 21-folds of water, extracted twice, 212 min per time. The overall rating of “normalized value” was 0.836 30, compared with the predicted value, the deviation rate was -16.531% (which was within -20.000%). Conclusion The optimal extraction process is simple, stable and has good and reliable predictability.
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