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| Effect of probiotics enhance enteral nutrition support on intestinal mucosal barrier function and inflammatory factors in patients with severe craniocerebral injury |
| ZHENG Aidong1 YAN Xixiang1 CUI Yonghua2 ZHANG Zhen’en1 PAN Guocui1 |
1.Department of Critical Care Medicine, Jianhu Hospital Affiliated to Nantong University, Jiangsu Province, Jianhu 224700, China;
2.Department of Neurosurgery, Jianhu Hospital Affiliated to Nantong University, Jiangsu Province, Jianhu 224700, China |
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Abstract Objective To explore the effect of probiotics enhance enteral nutrition support on intestinal mucosal barrier function and inflammatory factors in patients with severe craniocerebral injury. Methods According to the random number table method, 105 cases of patients with severe craniocerebral injury admitted to Jianhu Hospital Affiliated to Nantong University from April 2017 to April 2019 were selected and divided into control group (52 cases) and observation group (53 cases). The control group was treated with enteral nutrition support, while the observation group was treated with probiotics enhance enteral nutrition support. The two groups were treated for one month. The Glasgow (GCS) scores and serum levels of immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), D-lactic acid, procalcitonin (PCT), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were compared between the two groups before and after treatment. The Incidence of infection and complications after one month of treatment were compared between the two groups. Results After treatment, GCS score, the serum levels of IgA, IgG, IgM of the two groups were all higher than those before treatment, while those in the observation group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). After treatment, the serum levels of D-lactic acid, PCT, TNF-α and IL-6 in the two groups were all lower than those before treatment, while those in the observation group were lower than those in the control group, with statistically significant differences (all P < 0.05). After treatment, the incidence of infection and complications in the observation group was lower than that in the control group, with statistically significant differences (all P < 0.05). Conclusion Probiotics enhance enteral nutrition support in treatment of patients with severe craniocerebral injury can reduce the degree of disturbance of consciousness, improve the immune function and intestinal mucosal barrier function, inhibit the inflammatory reaction, reduce the incidence of infection and complications.
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