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2019 Vol. 16, No. 33
Published: 2019-11-25
 
 
4 Effect of algae eucheuma striatum polysaccharide on mouse vascular smooth muscle cells injured by nano-hydroxyapatite crystals
HAN Jin1 YAO Zhihui2 MA Xiaotao1 GUI Baosong1
Objective To investigate the effect of algae eucheuma striatum polysaccharide (ESP) on mouse vascular smooth muscle cells injured (MOVAS) induced by nano-hydroxyapatite crystals (nano-HAP). Methods Cultured vascular smooth muscle cells were divided into the blank control group, the model group and the experimental group. Fresh medium was added to the control group, the model group was stimulated by nano-HAP for 24 h. The cells in the experimental group were treated with different concentrations (50, 150, 450 μg/mL) of ESP. The activity of cells was determined by MTT assay and LDH release by LDH kit, cell morphology was observed by hematoxylin-eosin staining. Results Compared with the blank control group, cell viability in the model group decreased significantly (P ＜ 0.05), LDH release was significantly increased (P ＜ 0.05). Compared with the model group, the activity of cells in the experimental group increased with the increase of ESP concentration, and the release of LDH decreased with the increase of ESP concentration, with statistically significant differences (all P ＜ 0.05). Conclusion ESP can alleviate the damage of nano-HAP crystal to the membrane of vascular smooth muscle.
2019 Vol. 16 (33): 4-6,35 [Abstract] ( 215 ) HTML (1 KB)  PDF (1018 KB)  ( 95 )
7 Effect of endothelial cell-derived exosomes on immune factors in atherosclerotic rats
LUO Xueting1 ZHOU Yong2 JIANG Manhong2 LUO Baoping1
Objective To investigation the effect of vascular endothelial cells derived exosomes on the immune response and inflammatory damage mechanism in atherosclerotic rats. Methods Vascular endothelial cells derived exosomes were cultivated and identified. Thirty Wistar rats were divided into three groups according to the random digital table method, including the control, model and immune groups, 10 rats in each group. The latter two groups were used to establish atherosclerotic models, and the immune group was injected with exosomes at the fifth week of feeding. Vascular endothelial cells were separated from rat serum at the eighth week to detect the biochemical criterion [blood glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], mRNA expression of cytokine [interleukin-2 (IL-2), interleukin-4 (IL-4), γ-interferon (IFN-γ)] and expression levels of inflammatory factor [tumor necrosis factor (TNF-α), interleukin-1 (IL-1), endothelin-1 (ET-1) and nitric oxide (NO)]. Results Vascular endothelial cells and rat model were established successfully. Compared with the control group, the differences of blood glucose, TG, TC, HDL-C, LDL-C in the model group were highly statistically significant (P < 0.01). The TG, TC and LDL-C of the immune group were lower than those of the model group (P < 0.05 or P < 0.01). Compared with the control group, the levels of cytokines, TNF-α, IL-1 and ET-1 were significantly increased and the level of serum NO was significantly decreased after the modeling (P < 0.01). Compared with the model group, the levels of cytokines, TNF-α, IL-1 and ET-1 in the immune group were significantly decreased, and the serum NO level was significantly increased (P < 0.05 or P < 0.01). The number of peripheral blood endothelial cells in the model group was significantly increased under the microscope. The number of peripheral blood endothelial cells in the immue group had slight increase, but was than that in the model group. Conclusion In the pathological process of atherosclerosis, vascular endothelial cells derived exosomes may protect the damaged endothelial cells, alleviate immune response and inflammatory damage, and reduce the clinical indicators.
2019 Vol. 16 (33): 7-12,39 [Abstract] ( 186 ) HTML (1 KB)  PDF (1385 KB)  ( 129 )
13 Effect of Dahuang Huanglian Xiexin Decoction on the expression of AMPKα, PGC-1α and GLUT4 in skeletal muscle of type 2 diabetic rats
HAO Jianhua1* BAO Yimin2* BAO Yun3 LU Wei3 ZHANG Chaowei1 HAO Yijie1
Objective To observe the effect of Dahuang Huanglian Xiexin Decoction on AMP-acticated protein kinase α (AMPKα), peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) , and glucose tRNAsporter 4 (GLUT4) expression in skeletal muscle of type 2 diabetic rats. Methods According to the random number table method, 40 healthy SPF male Wister rats were divided into the blank control group with 10 rats and the building model group with 30 rats. The building model group was prepared by using high-sugar and high-fat diet combined with a small dose streptozotocin to prepare the rat model of type 2 diabetes mellitus. After successful modeling, the building model group was divided into the model group, the traditional Chinese medicine group and the Metformin group according to the random number table, with 10 rats in each group. The traditional Chinese medicine group was given Dahuang Huanglian Xiexin Decoction with a dose of 1 g/(100 g·d). The Metformin group was given Metformin by gavage with a dose of 18 mg/(100 g·d). The blank control group and model group were given the same amount of saline. After 4 weeks, fasting blood glucose (FPG), cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were detected in the rats, and pathomorphological changes of pancreatic tissue were observed under optical microscope. RT-PCR was used to detect mRNA expressions of AMPKα, PGC-1α, GLUT4 in skeletal muscle of rats. The expressions of AMPKα, phosphorylated AMPKα (P-AMPKα), PGC-1α and GLUT4 were detected by Western blot. After modeling, compared with the blank control group, FPG in the building model group was significantly increased (P ＜ 0.01), which means models were induced successfully. With gavaging Dahuang Huanglian Xiexin Decoction for 4 weeks, compared with the model group, FPG, TC, TG, LDL-C of the traditional Chinese medicine group significantly decreased (P ＜ 0.01 or P ＜ 0.05), and the expressions of AMPKα, PGC-1α, GLUT4 obviously increased in skeletal muscle (P ＜ 0.01 or P ＜ 0.05). Under optical microscope, islet structure was still complete, the degeneration of islet cell β was light and the number of physaliphore reduced. Conclusion The hypoglycemic mechanism of Dahuang Huanglian Xiexin Decoction is related to AMPK signaling pathway. By activating AMPKα, the expressions of PGC-1α and GLUT4 are up-regulated to regulate glucose and lipid metabolism.
2019 Vol. 16 (33): 13-18 [Abstract] ( 238 ) HTML (1 KB)  PDF (863 KB)  ( 126 )
19 Expression and clinical significance of negative regulatory protein 2 of cytokine signal transduction in allergic rhinitis
LIU Haitao1 LUO Qing1 FAN Li1 YANG Tian2▲
Objective To observe the expression of negative regulatory protein 2 (SOCS2) of cytokine signal transduction in the nasal mucosa of allergic rhinitis (AR) and its clinical significance. Methods The expression levels of SOCS2, interferon-γ (IFN-γ), FOXP3, interleukin (IL)-4, IL-5 and IL-13 mRNA in inferior turbinate mucosa of 20 AR patients (AR group) and 15 patients with simple deviation of nasal septum (control group) underwent nasal septum deviation or pterygoid canal neurotomy from February to July 2018 in the First Affiliated Hospital of Nanchang University were detected by real-time quantitative PCR. Immunohistochemical method was used to detect the expression of SOCS2 protein in nasal mucosa of two groups of patients. Visual analogue scale (VAS) was used to evaluate the subjective symptoms of patients. Results The expression of SOCS2 was immunohistochemistry in AR group and control group. The average absorbance value of SOCS2 in AR group was significantly lower than that in control group, the difference was statistically significant (P < 0.05). The relative expression of SOCS2, IFN-γ and FOXP3 in AR group was significantly lower than that in control group, while the relative expression of IL-5, IL-13 and IL-4 in AR group was significantly higher than that in control group, the differences were statistically significant (P < 0.05). In AR patients, the relative expression of SOCS2 was negatively correlated with the total score of IL-4, IL-5, IL-13 and VAS (r = -0.66, -0.50, -0.51, -0.65, P < 0.05), positively correlated with the relative expression of FOXP3 (r = 0.67, P < 0.05), and not correlated with the relative expression of IFN-γ (P > 0.05). Conclusion The decrease of SOCS2 in the nasal mucosa of AR patients is related to many cytokines of AR, suggesting that SOCS2 may play a key role in the pathogenesis of AR.
2019 Vol. 16 (33): 19-22 [Abstract] ( 170 ) HTML (1 KB)  PDF (837 KB)  ( 79 )
23 Research progress on the role of Th17 cells and Treg cells in liver diseases
ZHOU Xiaobo1 ZHANG Rongzhen2 CHEN Xiangyu1 LYU Chao1 MO Jinglin1 MAO Dewen2
Liver is the main metabolic organ of the body, which should not only face the invasion of various external environment factors, but also deal with the disorder of the internal environment of the body. T helper cell 17 (Th17) cell population and regulatory T cell (Treg) cell population, which are differentiated by primary CD4+T cells under the action of various cytokines, are functionally antagonistic to each other and maintain a balance in the body′s immune homeostasis. Studies have shown that the distribution level of Th17 cells and Treg cells in the liver and the changes in their balance are closely related to the occurrence and development of liver diseases. This paper summarizes the research progress of the two types of cells in liver diseases such as viral hepatitis, non-alcoholic fatty liver disease, liver fibrosis and cirrhosis, autoimmune liver disease, liver cancer and liver failure, hoping to provide certain basis for the later research of relevant scholars.
2019 Vol. 16 (33): 23-27 [Abstract] ( 189 ) HTML (1 KB)  PDF (592 KB)  ( 98 )
28 Advances in drug research for advanced hepatocellular carcinoma
ZHANG Wenwen1,2 ZHENG Xizi3 ZHENG Xiaohong1,2 LIU Xiaodong1,2
Hepatocellular carcinoma is one of the most common and fatal cancers in the world. It is the fourth most common malignant tumor and the third leading cause of death in China. Due to high rate of intermediate or late diagnosis, the majority of patients have no opportunity to undergo potentially curative surgery. Moreover, the overall efficacy and safety of local treatment, radiotherapy, systemic chemotherapy and “gold standard” Sorafenib targeted therapy are not satisfactory, more safe and effective treatment means and drugs are urgently needed. Systemic chemotherapy regimens containing Oxaliplatin are able to improve the efficacy of Asia Pacific patients with advanced liver cancer, but the survival benefit is limited. The success of the new molecular targeted drugs Levatinib and Regofenib in the first and second line treatment provide new treatment options for patients. Immunotherapy, represented by the checkpoint inhibitors Nivolumab and Pembrolizumab, has shown great advantages in the clinical study of advanced liver cancer, opening a new era of immunotherapy for liver cancer. This article reviews the latest development and trends of advanced liver cancer drugs.
2019 Vol. 16 (33): 28-31 [Abstract] ( 278 ) HTML (1 KB)  PDF (673 KB)  ( 76 )
32 Research progress of traditional Chinese medicine nano-preparation in treating ischemic stroke
WANG Li ZHOU Luyao REN Jungang ZHANG Wenjun LI Xin
Stroke is a relatively common disease, how to treat stroke has become a top priority for people. Most Chinese medicine has a good effect in treating stroke, however, the usage and dosage are not convincing. In recent years, nano drug delivery systems have become a research hotspot due to the advantages of targeted delivery, sustained release administration, altered body distribution, permeability to the blood-brain barrier, and improved bioavailability and so on. This article reviews the research progress of ischemic stroke from different routes of administration, aiming to provide a theoretical basis for drug research.
2019 Vol. 16 (33): 32-35 [Abstract] ( 263 ) HTML (1 KB)  PDF (535 KB)  ( 126 )
36 Research progress on the correlation between PDGF, VEGF and receptor Flk-1 and IgA nephropathy
AN Lili1 GUO Dengzhou2
There are high expression of plate derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and Flk-1 receptor in local kidney of IgA nephropathy patients. Among them, PDGF can not only directly stimulate the proliferation of mesangial cells and induce the increase of extracellular matrix, but also can initiate multiple renal fibrosis information pathways to induce and aggravate renal damage. After binding to Flk-1 receptor, VEGF, on the one hand, can induce new blood vessels; on the other hand, it can also induce oxidative stress response and accumulation of downstream inflammatory factors, resulting in aggravation of local inflammatory reaction in glomerular, further stimulate the proliferation of mesangial cells and increase extracellular matrix. In addition, high expression of PDGF can also up-regulate the expression of VEGF and accelerate the progression of IgA nephropathy.
2019 Vol. 16 (33): 36-39 [Abstract] ( 194 ) HTML (1 KB)  PDF (545 KB)  ( 142 )
40 Discussion on follow-up strategy of breast cancer patients
FENG Ran1 GAO Jinnan2 YANG Haibo2
Breast cancer is a most common malignancy of women. The characteristics of breast cancer, such as high incidence and good prognosis, make follow-up an important part of breast cancer management. Knowing about current progress will help us to carry out better follow-up strategies. The adherence to follow-up may be related to different patients characteristics, living area, age groups and treatment regimen. Individualized follow-up strategy has become a trend for breast cancer patients′ follow-up management. Meanwhile, more psychological interventions should be added to the work. This article reviews the current breast cancer follow-up strategies and will benefit for the long-time management of breast cancer patients.
2019 Vol. 16 (33): 40-42,54 [Abstract] ( 171 ) HTML (1 KB)  PDF (899 KB)  ( 71 )
43 Research progress on ischemia-reperfusion injury of diabetic organs
YI Haoran WANG Lei ZHU Hengcheng
Diabetes is a high incidence of metabolic disorders, the patient′s blood sugar stayed high for a long time, cell damage is mediated by inflammatory response and oxidative stress. Ischemia-reperfusion injury (IRI) is a phenomenon that the injury of ischemic organs is further aggravated after the restoration of blood perfusion. It plays an important role in the pathophysiological mechanism of cerebral infarction, myocardial infarction, renal IRI, intestinal IRI and liver IRI. These are the leading causes of organ damage, including transplant failure, and even death. Recent studies have shown that diabetes can worsen IRI in organs. This paper reviews the research progress of IRI in major diabetic organs.
2019 Vol. 16 (33): 43-46,62 [Abstract] ( 194 ) HTML (1 KB)  PDF (904 KB)  ( 84 )
47 Competency-oriented analysis of learning needs of standardized training residents
JIA Jianjun1 LI Zheng1 MA Jiale1 SHI Xiaohui2▲
Objective To investigate the current situation and learning needs of resident standardization training in Shanghai Changhai Hospital with guide of competency. Methods A total of 128 standardized training residents were selected from Shanghai Changhai Hospital in October 2018 to conducted a questionnaire survey by systematic sampling, including the present situation of the standardized training, learning needs and suggestions on the training work and so on. Results The 128 questionnaires were distributed and the recovery rate was 100%. 88.28% of the standardized training residents worked more than 40 hours a week in clinical practice. 27.34% of the standardized training residents came into contact with teachers more than 40 hours a week. 78.90% of the standardized training residents always or often carried out clinical work under their direct guidance of the teachers. 83.59% of the standardized training residents believed that it was necessary to strengthen the training of the teachers. 62.50% of the standardized training residents was more looking forward for the methods of problem-oriented, student-oriented, discussion and communication and so on. During learning of professional departments, 92.97% of the standardized training residents expected to acquire more profound professional knowledge, and 70.31% of the standardized training residents expected to gain knowledge of the progress of professional diagnosis and treatment. 39.84% of the standardized training residents considered that they could not cope with a single outpatient or emergency clinic. However, only 13.28% of the standardized training residents said that they would carry out relevant emergency treatment. Conclusion The contents, teaching methods and training modes of the standardized resident training need to be further refined and improved.
2019 Vol. 16 (33): 47-50 [Abstract] ( 285 ) HTML (1 KB)  PDF (546 KB)  ( 133 )
51 Investigation on awareness of olfactory function and related diseases among the elderly in a community in Beijing
ZHANG Lin1,2 SHAO Shuang1 YAO Linyin3 DU Juan1 ZHAO Yali1▲
Objective To understand the cognitive status and importance of olfactory function and olfactory dysfunction in community residents, and to provide research basis for the feasibility and promotion of olfactory function in predicting aging-related diseases at the grass-roots level in the future. Methods A total of 550 people over 60 years old residents in Grongti Community of Dongzhimen Street, Dongcheng District in Beijing were selected from October 2018 to April 2019 by random number table method for investigation of the understanding of olfactory dysfunction, including the importance and impact of olfactory functions in daily life, the awareness of olfactory dysfunction and related diseases. Results  A total of 406 valid questionnaires were collected, and the effective collection rate was 73.8%. 315 people (77.6%) believed that olfactory function plays an important role in daily life. 309 people (76.1%) thought that the sense of smell was important for the alarm, 185 people (45.6%) and 259 people (63.8%) thought that olfactory function had no effect or unclear effect on emotional and cognitive abilities, respectively. The number of residents thought that colds and allergic rhinitis affecting olfactory function was the highest, with 351 people (86.5%) and 288 people (70.9%), respectively. 290 people (71.4%) believed that hyposmia was an olfactory dysfunction, 306 people (75.4%) thought that anosmia was an olfactory dysfunction. Only 27 people (6.7%) had paid attention to olfactory knowledge. 184 people (45.3%) indicated that if they had hyposmia, they would not go to the hospital for professional treatment, and 71 people (17.5%) said that they would not go to the hospital for treatment even they had anosmia. Conclusion Residents have low awareness rate of olfactory effects on digestion, cognition, and regulation of emotions. The awareness rate of olfactory function caused by trauma and neurological diseases is significantly lower than that of viral infection and nasal-sinus disease. They have low attention to olfactory-related knowledge and insufficient attention to olfactory dysfunction disease.
2019 Vol. 16 (33): 51-54 [Abstract] ( 185 ) HTML (1 KB)  PDF (552 KB)  ( 65 )
55 Self-efficacy and social support in the coordinating mediating effect between optimistic tendency and psychological resilience in patients with hematopoietic stem cell transplantation
WANG Yingying1 LI Huiping1 YANG Liu2 WU Yun3
Objective To export the mediating effect of self-efficacy and social support in patients with hemopoietic stem cell transplantation on optimistic tendency and psychological resilience. Methods A total of 228 hospitalized patients with hemopoietic stem cell transplantation in a top three hospital in Anhui Province were enrolled from May 2018 to May 2019 by convenient sampling. Questionnaires were surveyed using the general information questionnaire, the mental resilience scale (RS-14), the life orientation test revision (LOT-R), the general self-efficacy scale (GSES), and the multiple comprehension social support scale (PSSS), to investigate the mediating effect between self-efficacy and social support on optimism tendency and psychological resilience. While the bootstrap method were used for verification. Results The average score of psychological resilience for patients with hemopoietic stem cell transplantation was (73.04±13.41) points. Optimism tendency, self-efficacy, social support and psychological resilience were positively correlated with each other (all P ＜ 0.01). Self-efficacy and social support have a significant mediating effect between optimism tendency and psychological resilience. Conclusion The optimistic tendency can directly affect the psychological resilience, while it can also indirectly affect psychological resilience through the mediation effect of self-efficacy and social support, and the coordinating mediating effect of self-efficacy-social support.
2019 Vol. 16 (33): 55-58 [Abstract] ( 170 ) HTML (1 KB)  PDF (653 KB)  ( 70 )
59 Investigation on compliance and related factors of warfarin in elderly patients with non-valvular atrial fibrillation
WANG Yahong XIAO Hongyan
Objective To study the compliance and related factors of Warfarin in elderly patients with non-valvular atrial fibrillation. Methods Ninety-six elderly patients with non-valvular atrial fibrillation admitted to Wuhan Asian Heart Hospital from March 2016 to December 2018 were selected as the research objects. The compliance of Warfarin in elderly patients with non-valvular atrial fibrillation was investigated and the related factor effecting the compliance of Warfarin in elderly patients with non-valvular atrial fibrillation was analyzed. Results A total of 96 questionnaires were sent out and 82 valid questionnaires were recovered. The effective recovery rate was 85.42%. Among them, 43.90% of the patients had good drug compliance. Good drug compliance of patients was related to gender, education level, number of complications, age and WRKS scores (all P ＜ 0.05). However, there were no related to marital status, occupation, drinking history, smoking history and the number of combined drugs (P ＞ 0.05). The influencing factors of drug compliance in elderly patients with non-valvular atrial fibrillation were  male (OR = 1.661, 95%CI: 1.108, 1.924, P = 0.037), primary school education or below (OR = 2.512, 95%CI: 1.494，4.324, P = 0.009), number of complications≥3 types (OR = 1.573, 95%CI: 0.616, 1.234, P = 0.026) and WRKS scores≤8 points(OR = 1.798, 95%CI: 1.103， 3.506, P = 0.017). Conclusion Elderly patients with non-valvular atrial fibrillation have poor compliance with Warfarin. They are susceptible influenced by gender, education level, number of complicationsand WRKS scores. Clinical attention should be paid to the above factors as much as possible to improve the compliance of Warfarin in elderly patients with non-valvular atrial fibrillation.
2019 Vol. 16 (33): 59-62 [Abstract] ( 163 ) HTML (1 KB)  PDF (566 KB)  ( 77 )
63 Effect of Jiaotai Pills combined with hypoglycemic rehabilitation exercise on adiponectin and islet function in type 2 diabetes mellitus patients with dampness and spleen syndrome
CAO Wen FAN Yaofu LIU Chao HU Yongxing CHU Xiaoqiu DI Hongjie
Objective To investigate the effects of Jiaotai Pills combined with hypoglycemic rehabilitation on blood adiponectin and β cell function of the pancreas in patients with type 2 diabetes dampness and spleen syndrome. Methods From March 2017 to August 2018, 300 patients with type 2 diabetes with dampness and spleen syndrome who were admitted to the Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine were selected, Random number table method was used to divide 150 cases into the control group and the combined group, respectively. Control group according to the original drug regimen (Western medicine hypoglycemic, hypohypertensive, lipid-lowering) treatment. The combined group was treated with oral Jiaotai Pills combined with rehabilitation exercise. The course of Treatment was 12 weeks. The changes of TCM syndrome score, fasting blood glucose (FBG), glycosylated hemoglobin(HbA1c), serum adiponectin (APN), islet β function index (HOMA-β), fasting insulin (FINS) before and after treatment in the two groups were observed, and the clinical efficacy was compared between the two groups. Results One case of combined group lossed at lase. After treatment, TCM syndrome scores, FBG, and HbA1c levels were decreased in both groups, and APN, HOMA-β and FINS levels were increased in all the groups (P ＜ 0.05). Moreover, the TCM syndrome score, FBG and HbA1c levels in the combined group were lower than those in the control group, and the APN, HOMA-β and FINS levels were higher than those in the control group (P ＜ 0.05). The total effective rate of the combined treatment group was higher than that of the control group (P ＜ 0.05). Conclusion Jiaotai Pills combined with hypoglycemic rehabilitation surgery can effectively reduce blood sugar levels in patients with type 2 diabetes mellitus, improve the symptoms of TCM and the function of islet β cells. The mechanism may be related to the increase of blood adiponectin levels.
2019 Vol. 16 (33): 63-66 [Abstract] ( 168 ) HTML (1 KB)  PDF (386 KB)  ( 80 )
67 Clinical observation and functional mechanism study of Huichun Yuzi Granules in treatment of oligospermia and/or asthenospermia
XUE Gangqiang1 LI Sanni2 GAO Shuli1 YUAN Jingchuan3 SUN Zhiyong1 ZHANG Yang1
Objective To explore the clinical observation and functional mechanism study of Huichun Yuzi Granules in treatment of Oligospermia and/or asthenospermia and to demonstrate the scientific rationality of Huichun Yuzi Granules so as to provide the basis data for the further study. Methods From July 2005 to June 2017, 200 cases with kidney essence deficiency (oligospermia and/or asthenospermia) in the Fourth Hospital of Shijiazhuang were selected. The average semen volume, sperm concentration, sperm activity rate (PR) of forward movement, total sperm activity of Huichun Yuzi Granules before treatment, and aftere 4, 8 weeks and 12 weeks of treatment were compared, and the TCM syndrome score before treatment and after 12 weeks of treatment were evaluated and the therapeutic effect was evaluated. Results Compared with before treatment, the average semen volume and sperm concentration, PR and total sperm activity were increased significantly than those of after 4 weeks treatment, the differences were statistically significant (P < 0.05). Compared with 4 weeks treatment, the average semen volume, sperm concentration, PR and total sperm activity increased significantly than those of after 8 weeks of treatment, the differences were highly statistically significant (P < 0.01). Compared with 8 weeks treatment, the average semen volume, sperm concentration, PR and total sperm activity increased significantly than those of after 12 weeks of treatment, the differences were highly statistically significant (P < 0.01). TCM syndromes were also significantly improved after 12 weeks of treatment (P < 0.01). The cure rate was 24.5%, the effective rate was 67.5% and the total effective rate was 92.0%. Conclusion Huichun Yuzi Granules is effective in treating hypoasthenospermia, and its prescription is scientific and reasonable.
2019 Vol. 16 (33): 67-70 [Abstract] ( 220 ) HTML (1 KB)  PDF (398 KB)  ( 104 )
71 A case report of individualized design for navigation template of pedicle screw installation
LIN Ze1 CHEN Siying1 LIN Guo1 ZOU Tingting1 YE Bowen1 XIANG Ziyuan1 LUO Haowei1 PENG Jianqiao2
Objective To design a case of individualized template for navigating pedicle screw installation, and to simply assess the effect for training or clinical practice. Methods A set of CT data was randomly select from Department of Radiographic of the First Affiliated Hospital of Guangzhou Medical University in June 2018. The navigation template and pedicle screw were designed by softwares such as Mimics and Pro-E, and the solid model was printed out by 3D print technique. The screw was integrated and installed in reality so as to observe the immobilization between the template and spine, the accuracy of screw path, and whether the length of nail met the previous design. Then the possibility of the design process for teching training was evaluated. Results The template was fitted into the spine firmly. After screws installed, the navigation model was fitable to the screw path accurately and correspondently, the depth of nail matched the preoperative design, the effect of training during processing had a good effect. Conclusion The design of individualized spinal navigation template is of significance in both teching training and clinical practice.
2019 Vol. 16 (33): 71-73,95 [Abstract] ( 294 ) HTML (1 KB)  PDF (1029 KB)  ( 82 )
74 Application effect of intra-articular injection combined with ultrashort wave in patients with osteoarthritis
LIU Rui CHEN Juan ZHANG Yanning HUA Rongli GUO Jianbin ZHANG Yumin
Objective To explore the effect of intra-articular injection combined with ultrashort wave in patients with osteoarthritis. Methods Eighty-six patients with osteoarthritis were enrolled in the Department of Joint Surgery in the Honghui Hospital Affiliated to Xi′an Jiaotong University Medical College from August 2017 to September 2019. They were divided into two groups according to the random number table method. The singular group was the LI group (intraluminal injection of sodium hyaluronate for the treatment), and the double number was the LU group (ultrashort wave combined with intra-articular injection for the treatment), with 43 cases in each group. The clinical efficacy and adverse reactions of the two groups were compared. The Western Ontario-Mcmasst University Osteoarthritis Scale (WOMAC), visual analogue scale (VAS), scores of life quality and serum inflammatory factors were analyzed before and after treatment. Results The total effectiveness of LU group was higher than that of LI group (P ＞ 0.05). After treatment, WOMA and VAS scores in the LU group were lower than those in the LI group (P ＜ 0.05), scores of life quality were higher than those in the LI group (P < 0.05), the relative expression of inflammatory factors was lower than that in the LI group (P ＜ 0.05), and the incidence of adverse reactions in the LU group was lower than that in the LI group (P ＜ 0.05). Conclusion Clinically, intra-articular injection combined with ultrashort wave in the treatment of osteoarthritis has a significant effect, which can significantly reduce pain, strong repair ability and the therapeutic effect is good.
2019 Vol. 16 (33): 74-77 [Abstract] ( 181 ) HTML (1 KB)  PDF (488 KB)  ( 67 )
78 Effect of preoperative T lymphocyte level on postoperative spinal infection and serum pro-inflammatory cytokines
ZHANG Shujun1,2 ZHAO Zhigang1 HU Jun1 CUI Wei1 XIE Wei1 WANG Xin1 SONG Sheng2 SUN Zhenzhong2
Objective To study the effect of preoperative T lymphocyte level on postoperative spinal infection and serum proinflammatory cytokines after spinal surgery. Methods From January 2017 to June 2018, 119 patients who underwent spinal surgery in Wuhan Fourth Hospital of Hubei Province were selected for the study, patients with CD3+＜50% were set as the observation group (60 cases), and patients with CD3+≥50% were set as the control group (59 cases). The operation conditions, the changes of tumor necrosis factor α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10), and interleukin-1β (IL-1β) levels before and after surgery, gastrointestinal function and postoperative infection were compared between the two groups. Results There was no significant difference in operation time between the two groups (P ＞ 0.05). The amount of bleeding in the observation group was more than that in the control group, and the length of hospitalization was longer than the control group  (P ＜ 0.05). Before operation, the levels of TNF-α, IL-8, IL-10 and IL-1β in the observation group were significantly higher than those in the control group (P ＜ 0.05). After operation, the levels of serum inflammatory factors in the two groups were significantly increased, and the observation group was significantly higher than that in the control group (P ＜ 0.05). After operation, the disappearance of bowel sounds, anal exhaust, defecation, diet recovery and abdominal distension relief time in the observation group were significantly higher than those in the control group (P ＜ 0.05). After operation, the total incidence of infection in the observation group was significantly higher than that in the control group (P ＜ 0.05). Conclusion Postoperative infection in patients with spinal surgery is directly related to the preoperative T lymphocyte level, and patients with low preoperative T lymphocyte level have a high postoperative infection rate. The T lymphocyte level of patients should be monitored and improved clinically.
2019 Vol. 16 (33): 78-81 [Abstract] ( 190 ) HTML (1 KB)  PDF (490 KB)  ( 39 )
82 25（OH）D status and risk of gestational diabetes in Chinese population: a Meta-analysis
WU Yubi ZHANG Lijuan▲ CHEN Jun FU Jinjian LIN Zhong
Objective To analyze the relationship between 25(OH)D insufficiency and gestational diabetes mellitus (GDM) risk and the geographical variation in Chinese pregnant women. Methods A systematic literature search was conducted via PubMed, MEDLINE, CNKI, Wanfang and Weipu to obtain observational studies evaluating gestational diabetes risk in relation to 25(OH)D status from January 1990 to March 2018. Odds ratios (ORs) with 95% confidence intervals (CI) were pooled using the random effect models. Results The prevalence of maternal 25(OH)D insufficiency of patients with GDM was 0.71 (95%CI = 0.62-0.80). A noteworthy decrease of 1.81 ng/mL (95%CI=1.48-2.14 ng/mL) in serum 25(OH)D was demonstrated in the patents with GDM compared with normal pregnant women. Regional differences analysis showed that, the serum 25(OH)D level of GDM patients was reduced by 1.23 ng/mL (95%CI=0.81-1.65 ng/mL) in the north than that of the south, and the serum 25(OH)D level of GDM patients in the south was reduced by 2.31 ng/mL (95%CI=1.81-2.80 ng/mL) than that in the north (P < 0.001). Conclusion Low level of 25(OH)D will increase the risk of gestational diabetes.
2019 Vol. 16 (33): 82-87 [Abstract] ( 159 ) HTML (1 KB)  PDF (1181 KB)  ( 46 )
88 Analysis of influencing factors of 2-5 years old children with recurrent upper respiratory tract infection
LI Zhenglan1 WU Ping1 LI Shiqin1 MA Jun2 YE Kan3
Objective To study the influencing factors of 2-5 years old children with recurrent upper respiratory tract infection(RRTI), and to provide a reference for significantly reducing the incidence of RRTI in children. Methods A total of 100 cases of RRTI children in Pediatric Outpatient of Suzhou Municipal Hospital (hereinafter referred to as “our hospital”) from January to December 2018 were selected as the observation group. Another 100 children who had physical examination in Pediatric Department of our hospital during the same period were selected as the control group. The baseline data and blood multielement levels of children in the two groups were compared, and the influencing factors of RRTI in children were analyzed by Logistic regression. Results Univariate analysis showed that RRTI in children was related to mother′s educational level, parents′ allergy history, family members′ smoking, outdoor activities, annual use of antibiotics and nursery care (all P < 0.05). The levels of iron, calcium, zinc and copper in the children of the observation group were lower than those in the control group (all P < 0.05). Multivariate Logistic regression analysis showed that the risk factors for RRTI recurrence of children were: mothers with high school education level and below (OR = 1.495, 95%CI: 1.244-5.933), parents with allergy history (OR = 1.195, 95%CI: 1.088-3.405), family members′ smoking (OR = 1.294, 95%CI: 1.105-3.954), outdoor activity < 2 h/d (OR = 1.944, 95%CI: 1.774-4.582), annual use of antibiotics ≥3 times (OR = 4.823, 95%CI: 3.845-10.835), nursery care (OR = 1.673, 95%CI: 1.553-2.384), iron deficiency (OR = 1.384, 95%CI: 1.104-4.982), calcium deficiency (OR = 1.275, 95%CI: 1.027-3.225), zinc deficiency (OR = 1.055, 95%CI: 1.958-4.958) and copper deficiency (OR = 1.296, 95%CI: 1.022-3.656) (P < 0.05). Conclusion The risk of RRTI in children aged 2-5 years is increased by mothers with high school education and below, parents with allergy history, family members smoking, outdoor activities < 2 h/d, annual use of antibiotics ≥3 times, nursery care and inadequate blood multielement. The risk of RRTI may be reduced by taking corresponding preventive measures against the above factors.
2019 Vol. 16 (33): 88-91 [Abstract] ( 148 ) HTML (1 KB)  PDF (537 KB)  ( 67 )
92 Relationship between serum LRRFIP1 level and platelet function in patients with hypertensive disorder complicating pregnancy
LI Shanshan ZHANG Chen YAN Jingling
Objective To investigate the correlation between serum leucine repeat sequence interacting protein 1 (LRRFIP1) and platelet function in patients with hypertensive disorder complicating pregnancy. Methods From January 2016 to December 2018, 150 patients with hypertensive disorder complicating pregnancy in Zaozhuang Maternal and Child Health Hospital of Shandong Province (hereinafter referred to as “our hospital”) were selected as the observation group, and patients in the observation group were divided into pregnancy hypertension group (n = 59), mild preeclampsia group (n = 48) and severe preeclampsia group (n = 43) according to the severity of patients′ condition. Another 50 healthy pregnant women who underwent prenatal examination in our hospital during the same period were selected as the control group. Serum levels of LRRFIP1, platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) were measured and compared between the two groups. The correlation between LRRFIP1 level and PLT, MPV and PDW was analyzed by Pearson test. Results The levels of LRRFIP1, MPV and PDW of the observation group were higher than those of the control group, while the PLT was lower than that of the control group, and the differences between the two groups were statistically significant (P < 0.05). In the observation group, the levels of LRRFIP1, MPV and PDW gradually increased, while the levels of PLT gradually decreased with the aggravation of pregnancy induced hypertension, and the differences among the three groups were statistically significant (P < 0.05). Pearson correlation test showed that LRRFIP1 was negatively correlated with PLT (r = -0.471, P = 0.009) and positively correlated with MPV and PDW (r = 0.396, 0.364; P = 0.012, 0.016). Conclusion LRRFIP1 changes with the changes in the occurrence and development of the patients with hypertensive disorder complicating pregnancy, indicating that LRRFIP1 may be involved in the pathogenesis of hypertensive disorder complicating pregnancy and may affect the function of platelet.
2019 Vol. 16 (33): 92-95 [Abstract] ( 153 ) HTML (1 KB)  PDF (524 KB)  ( 70 )
96 Relationship between serum PTEN level and oxidative stress and pregnancy outcome in patients with preeclampsia
WAN Shumei PENG Ping GAO Yan
Objective To investigate the relationship between serum levels of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and oxidative stress and pregnancy outcome in patients with preeclampsia (PE). Methods 136 patients with PE who were admitted to General Hospital of Southern War Zone (hereinafter referred to as “our hospital”) from January 2017 to February 2019 were selected, and they were divided into mild group (n = 67) and severe group (n = 69) according to the severity of the disease. Another 60 healthy pregnant women who came to our hospital for physical examination during the same period were selected as control group. The levels of PTEN, oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA), 8-isoprostaglandin F2α (8-iso-PGF2α)] of each group were compared. Pearson correlation analysis was used to analyze the relationship between PTEN and oxidative stress indicators. Logistic multiple regression analysis was used to analyze the influencing factors of adverse pregnancy outcomes. Results The PTEN and SOD levels in mild group and severe group were lower than those in control group (P < 0.05), while the MDA and 8-iso-PGF2α were higher than those in control group (P < 0.05). With the increase of the severity of the disease, the levels of PTEN and SOD decreased (P < 0.05), while MDA, 8-iso-PGF2α showed an upward trend (P < 0.05).  The levels of PTEN and SOD in adverse pregnancy were lower than those in normal pregnancy (P < 0.05), while the MDA and 8-iso-PGF2α were higher than those in normal pregnancy (P < 0.05).  Pearson correlation analysis showed the level of PTEN was positively correlated with SOD in patients with PE (r = 0. 596, P < 0.05). The level of PTEN in patients with PE was negatively correlated with MDA and 8-iso-PGF2α (r = -0.468, -0.429, P < 0.05). Logistic multiple regression analysis showed that low expression of serum PTEN, the decreased of SOD, the increase of MDA and 8-iso-PGF2α were independent risk factors affecting adverse pregnancy outcomes in PE patients (P < 0.05). Conclusion The expression of PTEN is low in patients with PE, and it is involved in the disease progression of PE patients through the regulation of oxidative stress indicators, which can be assisted to evaluate the condition of PE patients by rational monitoring in clinical practice.
2019 Vol. 16 (33): 96-99 [Abstract] ( 158 ) HTML (1 KB)  PDF (538 KB)  ( 68 )
100 Effect of mixing method on edge microleakage of glass ionomer cement filling body
QIUTao1 MAO Bochun1 ZHANG Jiayu1 MA Pingchuan1 CHEN Shengkai1 XU Qinghong2
Objective To study the effect of mixing method on edge microleakage of glass ionomer cement (GIC), to provide guidance for the correct use of GIC in filling treatment of tooth defects. Methods Twenty premolars for orthodontic treatment were extracted from the Department of Maxillofacial Surgery, West China School/Hospital of Stomatology Sichuan University from January to March 2019. According to the random number table method they were divided into four groups, four mixing methods commonly used in clinic were adopted, namely one way clockwise mixing method (group Ⅰ), one-way counterclockwise mixing method (group Ⅱ), positiue and negative two-way rotation mixing method (group Ⅲ), up-down pull folding mixing method (group Ⅳ), transfer 5 copies of GIC respectively. Packed into the already good Ⅰ kinds of hole type in vitro teeth, the micro leakage of each pack edge was measured using the dye penetration method. Results The penetration depth of GIC filling body edge of the group Ⅳ was significantly higher than group Ⅲ (P ＜ 0.05), there was no significant difference between the other groups (P ＞ 0.05). Conclusion When using GIC filling materials in clinical practice, it is recommended to use the positive and negative two-way alternating rotation method, rather than the up-down pull folding method, need to further strict mixing requirements, improve the material mixing qualified rate.
2019 Vol. 16 (33): 100-102,115 [Abstract] ( 204 ) HTML (1 KB)  PDF (980 KB)  ( 55 )
107 Retrospective clinical analysis of Voriconazole trough serum concentration monitoring in severe elderly patients
WANG Jia XU Bingfa QIN Kan
Objective To explore the importance of monitoring Voriconazole trough serum concentration (Cmin) in severe elderly patients. Methods From January 2014 to December 2018, a retrospective analysis was used to analyze 43 cases who admitted to the Third Affiliated Hospital of Anhui Medical University with severe elderly patients. All patients were treated with Voriconazole, monitored and observed for Cmin. The effects of different factors on the blood drug Cmin of Voriconazole and the clinical effects and adverse reactions of plasma albumin (ALB) on voriconazole were compared. Results The Cmin was tested 78 times and 54 times (69.2%) of Cmin was 1.0~5.5 mg/L. ALB and AST were independent risk factors for Cmin, and ALB was negatively correlated with Cmin (r = -0.903, P = 0.0003). AST was positively correlated with serum concentration (r = 0.872, P = 0.0005). The effective rate of ALB<35 g/L was lower than that of ALB≥35 g/L, and the incidence of adverse reactions was higher than that of ALB≥35 g/L, the differences were statistically significant (P < 0.05). Conclusion There are many factors that affect the concentration of voriconazole in the severe elderly patients. It is particularly necessary to monitor the concentration of Voriconazole in the blood.
2019 Vol. 16 (33): 107-110 [Abstract] ( 194 ) HTML (1 KB)  PDF (591 KB)  ( 60 )
111 Study on the general character of acupuncture points for post-stroke depression based on complex network analysis
WANG Xue YANG Dongting LIU Wenna ZHANG Jingsha▲ GENG Lianqi
Objective To analyze the general character of acupuncture points for post-stroke depression by using data mining technology. Methods Chinese keywords were (“acupuncture and moxibustion” or “acupuncture” or “filiform acupuncture” or “electroacupuncture”) and (“stroke” or “apoplexia”) and (“depression” or “depression disease” or “depression syndrome” or “melancholy”). English subject words were MESH words (“acupunture” or “electronic acupunture”) and “post-stroke expression”, which were used to retrieve the literatures published by CNKI, VIP, Wanfang, China biomedical literature database, PubMed as of July 2018 on acupuncture treatment of post-stroke depression. The database was established, SPSS Modeler 18.0 was used for modeling, association rules were analyzed, and Gephi 0.9.1 was used for complex network analysis. Results 647 prescriptions of acupuncture and moxibustion were extracted from 2145 literatures. The main methods of acupoint matching were the method of distance and proximity (484 prescriptions), the method of secondary acupoint matching and the method of lower acupoint matching (522 prescriptions). The top 10 single acupoints were Baihui, Neiguan, Taichong, Sanyinjiao, Sishencong, Yintang, Shenmen, Shenting, Hegu and Zusanli, among which, the head acupoints were the most frequently used and selected, when the support degree was ≥ 30% and the confidence degree was ≥ 75%, Baihui + Yintang was the first acupoint combination. Conclusion With the core of governor meridians, it follows the principles of local acupoint selection, up and down acupoint selection and syndrome differentiation of viscera, with the core idea of adjust mind, we select Baihui, Sishengcong, Yintang, Neiguan, Taichong, Sanyinjiao, Shenting as the core acupoint prescriptions of acupuncture therapy for post-stroke depression.
2019 Vol. 16 (33): 111-115 [Abstract] ( 233 ) HTML (1 KB)  PDF (1070 KB)  ( 66 )
116 Discussion on clinical practice of traditional Chinese gynecology under the requirement of inheriting famous and old traditional Chinese medicine based on SECI model
YAO Meiyu1 WEN Xin2 HAN Fengjuan1 LI Yuanfeng3
In view of the current situation and problems of clinical practice of traditional Chinese gynecology, this paper expounds the classification of knowledge and the concept of SECI model. Based on SECI theory of knowledge transformation, combined with the characteristics of the subject, the characteristics of postgraduates and the needs of teaching and training, a teaching model of clinical practice training in traditional Chinese gynecology is constructed, which enables the clinical practice mode of postgraduates to realize the transformation of "observation, semi participation and full participation". It pays attention to the transformation of tacit knowledge and explicit knowledge, as well as the inheritance of prestigious traditional Chinese medical doctors′ academic thoughts and clinical experience, and puts forward the requirements for the processes of socialization, externalization, combination and internalization.
2019 Vol. 16 (33): 116-119,124 [Abstract] ( 210 ) HTML (1 KB)  PDF (898 KB)  ( 173 )
120 Study on medication regularity of Zhao Shuhua in the treatment of epigastralgia
LIU Minghui ZHAO Shuhua
Objective To analyze the medication features and compatibility regularity of professor Zhao Shuhua′s prescription in the treatment of epigastralgia, in order to provide a reference for clinical treatment. Methods Patients with epigastralgia diagnosed and treated by professor Zhao Shuhua in Traditional Chinese Medicine Clinic of China-Japan Union Hospital of Jilin University from December 2017 to May 2019 were selected. The frequency, compatibility and core drug combination of the drugs were analyzed by using traditional Chinese medicine inheritance support system(V2.5) exploited by Institute of Chinese Materia Medica China Academy of  Chinese Medical Sciences. Results Three hundred and eight prescriptions were included, involving 207 drugs. There were 15 drugs with frequency ≥ 60 times; the drug properties were mainly warm, cold and flat, and the drug tastes were mainly bitter, pungent and sweet; the four meridians of spleen, stomach, lung and liver were the main meridians of drugs; there were 16 pairs of high-frequency drugs; 13 association rules were found and 16 new prescriptions were extracted. Conclusion Professor Zhao Shuhua is good at using methods, such as tonifying the middle jiao, moistening the stomach, regulating the qi, etc. in the treatment of epigastralgia. It has distinct characteristics, close to classic, and in line with epidemiological characteristics, and is worth learning and studying.
2019 Vol. 16 (33): 120-124 [Abstract] ( 211 ) HTML (1 KB)  PDF (1031 KB)  ( 130 )
125 Clinical experience of Wang Juyi′s meridian examination in the treatment of tendons disease
MENG Xiaonan1 YU Haikuo2 SUN Jie3 LI Chunying1
The syndrome of meridians and tendons is a common and frequently occurring clinical disease of acupuncture and moxibustion. In clinical practice, pain is often regarded as shu, while meridians and collaterals are ignored for diagnosis, differentiation and selection of meridians. Therefore, the clinical effect is affected. Deeply rooted in the traditional theory of traditional Chinese medicine and through more than 50 years of clinical practice, professor Wang Juyi has established and improved the applied channel theory and accumulated rich experience in the treatment of tendons disease. It is believed that the treatment should be based on the meridian diagnosis to determine the meridians of the affected meridians, and guide the final selection of meridian treatment through syndrome differentiation. In clinical practice, he should make good use of “source point and He-sea point” and pay attention to the hierarchy theory of “skin, vessel, muscle, tendon and bone” in treatment. In addition, it can combine acupuncture with traditional classical techniques such as “die method” and “jieji method” in the treatment process. Therefore, systematic treatment under the guidance of meridian medicine can often achieve better clinical results. Learn from professor Wang for many years, combing and summarizing his clinical treatment ideas and clinical cases.
2019 Vol. 16 (33): 125-128 [Abstract] ( 168 ) HTML (1 KB)  PDF (772 KB)  ( 174 )
129 Clinical research of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after acute myocardial infarction
XU Mujuan WANG Ling HAN Yue
Objective To investigate clinical efficacy of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after acute myocardial infarction (AMI). Methods Eighty patients with heart failure after AMI admitted to Shenzhen Traditional Chinese Medicine Hospital from June 2015 to February 2019 were divided into control group (40 cases) and study group (40 cases) according to random number table method. The patients in control group were treated with conventional treatment. The patients in study group were treated with self-made Yiqi Huoxue Decoction on the basis of control group. The patients in two groups were treated for 2 weeks continuously. The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), central venous pressure (CVP), heart rate (HR), serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), endothelin (ET), nitric oxide (NO) were measured and compared between two groups before and after treatment. The adverse reactions of two groups during the treatment were observed. Results After treatment, LVEF was higher than that before treatment, LVEDD was less than that before treatment, CVP was lower than that before treatment, HR was slower than that before treatment in two groups; after treatment, LVEF, LVEDD, CVP and HR in study group were significantly improved compared with those in control group, the differences were highly statistically significant (P < 0.01). After treatment, the levels of serum hs-CRP and TNF-α were lower than those before treatment, the level of IL-10 was higher than that before treatment in two groups; after treatment, the levels of serum hs-CRP, TNF-α and IL-10 in study group were significantly improved compared with those in control group, the differences were highly statistically significant (P < 0.01). After treatment, the level of serum ET was lower than that before treatment, the level of serum NO was higher than that before treatment in two groups; after treatment, the levels of ET and NO in study group were significantly improved compared with those in control group, the differences were highly statistically significant (P < 0.01). During treatment, there was no significant difference in incidence of adverse reactions between two groups (P > 0.05). Conclusion Clinical effect of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after AMI is significant, which can significantly improve the cardiac function and inflammatory response, adjust the endothelial function and has good safety.
2019 Vol. 16 (33): 129-132 [Abstract] ( 180 ) HTML (1 KB)  PDF (775 KB)  ( 56 )
133 Application of invigorating the spleen and regulating qi in the treatment of non-small cell lung cancer
LIU Dianlong1 CHEN Yu2 CUI Shusheng3 HOU Wei1
“Spleen deficiency and qi mechanism disorder” is an important pathogenesis of non-small cell lung cancer (NSCLC). From the perspective of traditional Chinese medicine theory, in the process of tumor occurrence and development, spleen deficiency and qi mechanism disorder affect the human body dynamically, resulting in dampness accumulation, phlegm generation, stasis and finally leading to the formation of NSCLC. By analyzing the evolution of pathogenesis and the typical symptoms in each stage of its development, the method of invigorating the spleen and regulating qi can achieve good curative effect. This paper summarizes the pathogenesis, pathology, symptoms, prescriptions and special features of NSCLC in various stages of treatment in traditional Chinese medicine, so as to provide new ideas for the treatment of NSCLC in the same way.
2019 Vol. 16 (33): 133-136 [Abstract] ( 167 ) HTML (1 KB)  PDF (771 KB)  ( 125 )
137 Practice and thinking on the medical treatment alliance in osteology and traumatology of traditional Chinese medicine
CHEN Wenpeng
Based on the practice and exploration of the mode of operation of the medical treatment alliance in osteology and traumatology of traditional Chinese medicine, this paper analyzes and discusses the natural looseness of the medical treatment alliance, the lack of a unified mechanism of rights and responsibilities sharing, the absence of medical insurance policies and the lagging construction of information sharing platform, puts forward to promote the medical treatment alliance in osteology and traumatology of traditional Chinese medicine from loose to close shift, achieves integrated development of upper and lower level hospitals, integrates the interests of all participants, build a community of responsibility with positive interaction, promotes reform of the medical insurance payment system, explores a mechanism for pooling medical insurance funds and accelerates the construction of orthopedic information sharing platform and other measures, in order to promote the healthy development of Chinese medicine bone injury medical couplet, implement the hierarchical diagnosis and treatment system.
2019 Vol. 16 (33): 137-139,143 [Abstract] ( 215 ) HTML (1 KB)  PDF (783 KB)  ( 101 )
140 Discussion on the tentative diagnosis method of Tibetan medicine
GONGBAO Dongzhu MI Ma
The diagnosis of diseases in Tibetan medicine is generally divided into three methods: look, smell and touch. Tentative diagnosis method is a comprehensive diagnostic method, which can be diagnosed by observing the patient's response, urine, tongue image and changes of the disease after internal and external use of drugs, or by directly detecting the patient′s urine and saliva to diagnose the disease. This paper collects 100 tentative diagnostic methods from 15 representative ancient books of Tibetan medicine in different periods. According to the analysis in order of historical sequence, the application proportion of tentative diagnostic method in the classification of diseases of Tibetan medicine in the "the fifteen divisions" is calculated, and it is found that tentative diagnostic method is first recorded in the 8th century ancient books of Tibetan medicine, such as smgn dbyd zla rgayl and bi ji bo ti ka ser. Along with the development of Tibetan medicine, tentative diagnostic method has always been its development trend. It is mainly used in clinical diagnosis of poisoning, trauma, pathogenic disease, fever and other difficult to identify diseases, scientific nature is very strong, and it has significant diagnostic benefits for difficult diseases.
2019 Vol. 16 (33): 140-143 [Abstract] ( 183 ) HTML (1 KB)  PDF (770 KB)  ( 47 )
144 Discussion on hydraulic expansion combined with acupotomy in the treatment of frozen shoulder
ZHANG Chang1 HU Xianglin2 LIU Naigang3 XU Yao1 WANG Quangui4
This paper expounds the clinical manifestations, clinical stages, special physical examination, imaging examination, diagnosis and treatment of frozen shoulder. The pathological characteristics of this disease are contracture of shoulder joint capsule and significant decrease of joint volume. The clinical characteristics of this disease are limited active and passive movement of shoulder joint. According to the pathological mechanism and functional anatomic characteristics of shoulder joint, the author emphasizes to treat frozen shoulder by stages. In the pain stage, spasmolysis and pain relief should be given, and intra-articular injection is the first choice. In the freezing period, the first choice is the hydraulic expansion of joint cavity combined with acupotomy to relieve the contracture of joint capsule. The targets of acupotomy include the capsule of shoulder joint, coracobrachial ligament, the antagonistic muscle of shoulder joint movement and the method of stimulating cervical and shoulder nerves. The combination of hydraulic expansion and needle scalpel can achieve satisfactory clinical effect on most frozen shoulder patients, which is worthy of in-depth clinical research and further standardized clinical operation.
2019 Vol. 16 (33): 144-146,166 [Abstract] ( 193 ) HTML (1 KB)  PDF (832 KB)  ( 121 )
147 Visualization analysis of research progress of spirituality measurement abroad
CUI Shuang1,2,3 HAN Buxin1▲
Objective To understand the status of spiritual measurement research, reveal the hot spots of related research, and explore the evolution and development of its knowledge, so as to provide reference for the development of spiritual measurement research in China. Methods In February 2018, 1789 literatures related to spiritual measurement were selected from the database of the core collection of Web of Science, and CiteSpace V software was applied for visual analysis. Results The literature on spiritual measurement has increased year by year since 2013; Scientific research institutions are dominated by universities, and the cooperation between universities has certain breadth and depth; At present, the research objects are mainly tumor patients, end-stage patients and religious personages. The research focuses are the influence of spirituality on quality of life, empirical research on spiritual measurement results, the relationship between spirituality and health, and the relationship between spirituality and religious belief and so on; From 2013 to 2017, the functional assessment of chronic illness therapy—spiritual well-being scale was widely used. Conclusion Spiritual measurement research is in its infancy. In the future, in-depth research on different subjects should be conducted for different groups of people to further deepen the application of spiritual measurement results and strengthen interdisciplinary cooperation.
2019 Vol. 16 (33): 147-153 [Abstract] ( 192 ) HTML (1 KB)  PDF (1900 KB)  ( 141 )
154 Study on the dilemma and development path of medical social work in China
LI Songshan YU Huiling
Medical social work has been carried out in China for nearly 30 years, but there is no prosperous situation so far. The reasons are as follows, the current situation of medical social work restricts the development prospect, the lack of talents restricts the quality of development, inadequate support systems are hampering the pace of development, the weak consciousness of theoretical research problems restricts the aftereffect of development. The development of medical social work must be based on the analysis of the root causes of “problems”, and form the synergy of system guarantee, social support, talent training and theoretical research around “problems”, so as to provide favorable conditions for the development of medical social work in the new era.
2019 Vol. 16 (33): 154-157 [Abstract] ( 192 ) HTML (1 KB)  PDF (689 KB)  ( 139 )
158 Study on Delphi method for constructing the course of clinical nutrition for the elderly for continuing education of community nurses
DU Juan CAI Shaolian LIANG Huilian CHEN Xingqiang YIN Xing HUANG Jieying
Objective Delphi method was used to construct the course of clinical nutrition for the elderly suitable for the continuing education and training of community nurses. Methods From October 2017 to January 2018, 28 experts with rich experience in aging, nutrition, community and education in tertiary hospitals, community hospitals and nursing colleges in Guangdong Province were selected. Three rounds of nursing experts questionnaire consultation were carried out, and the data was analyzed. Results The curriculum of clinical nutrition for the elderly for community nurses was constructed. The questionnaire recovery rates in the three rounds of correspondence consultation were 100.0%, 92.9% and 89.3% respectively. The rates of putting forward opinions were 42.6%, 23.1% and 4.0%, respectively. The authoritative coefficients of experts are respectively 0.88, 0.89 and 0.88, the authoritative coefficients of Delphi methool ≥0.7. Conclusion Applying Delphi method to establish the course of clinical nutrition for the elderly applicable to the training of community nurses has higher reliability, which can provide reference for the continuing education of community nurses.
2019 Vol. 16 (33): 158-161 [Abstract] ( 174 ) HTML (1 KB)  PDF (701 KB)  ( 49 )
162 Application of artificial intelligence in drug discovery
SUN Yajing LI Chunyang ZENG Xiaoxi
Artificial intelligence plays an important role in drug discovery field. This paper summarizes artificial intelligence technology applications in the medical field, such as to efficiently screen therapeutic targets and design drugs, saving the costs of drug discovery and shortening the time required for drug discovery; to deal with the problems of molecular characteristics, water-solubility, toxicity and oral absorption potential in preclinical development stage; to analyze issues about drug redirection, patient recruitment, clinical trial design optimization in the drug clinical research stage; as well as to analyze the research information and to make a drug safety evaluation after drug approval and marketing. This paper studies the achievements and problems of artificial intelligence research in the key stages of drug discovery, preclinical development, clinical research and approval for marketing, and looks forward to the trend of new drug research and development driven by artificial intelligence technology. The purpose is to provide reference for relevant scientific research and technical personnel engaged in the landing of artificial intelligence in the field of medicine.
2019 Vol. 16 (33): 162-166 [Abstract] ( 324 ) HTML (1 KB)  PDF (848 KB)  ( 576 )
167 Research on cooperation mode of Shaanxi biopharmaceutical industry
SHI Wenjing1,2 MENG Xianghai2 YANG Jian′gang3 XIAO Zhiqiang2▲
There are 213 pharmaceutical manufacturers in Shaanxi Province, with 6600 drug approval numbers. There are abundant biomedical resources and complete categories of pharmaceutical industry. However, in recent years, the growth of pharmaceutical output value is slow, and the number of new products is less. In order to speed up the development of Shaanxi′s pharmaceutical industry, based on the triple helix theory, the following countermeasures are put forward for the development of biomedicine in Shaanxi Province: enhancing the support policy of biomedicine; accelerating the basic research and transformation of biomedicine; strengthening the collaborative innovation and establishing the ecological chain of pharmaceutical industry.
2019 Vol. 16 (33): 167-169,173 [Abstract] ( 167 ) HTML (1 KB)  PDF (707 KB)  ( 69 )
170 Pregnancy outcome analysis in 9 cases of intrauterine pregnancy with intrauterine device without intervention
YANG Yuehua XU Haoqin▲ ZHOU Jian▲ ZHANG Min
Objective To analyze the pregnancy outcome of intrauterine pregnancy with intrauterine device (IUD) and explore the related influencing factors. Methods From January 2009 to December 2018, 9 cases of intrauterine pregnancy with IUD and requiring continued pregnancy which were collected by national network for contraceptives adverse reaction surveillanc were analysed. The population characteristics and pregnancy outcomes were comprehended. Results IUDs used in 9 cases of intrauterine pregnancy were different types and were in different positions in the uterine cavity. IUDs of 9 cases were all not removed or expelled until the termination of pregnancy and the difficulty of IUD removal was not increased by pregnancy. No symptoms such as vaginal bleeding and lower abdominal pain were found during pregnancy. Finally, 2 cases were taken induced labor due to birth defects, 5 cases were taken caesarean section for scarred uterus, 1 case was taken caesarean section for intrauterine fetal anoxia and 1 case was by vaginal delivery. The maternal age of 2 birth defect cases and 1 severe neonatal asphyxia case were all over 35 years old. Conclusion Maternal age may be a risk factor for adverse pregnancy outcomes in intrauterine pregnancy with IUD, but it is not yet possible to determine whether some features of coexisting IUD such as structure, copper surface, locations, number of use, duration between IUD placement and fertilization affect adverse pregnancy outcomes.
2019 Vol. 16 (33): 170-173 [Abstract] ( 162 ) HTML (1 KB)  PDF (696 KB)  ( 35 )
174 Discussion on standardization of scientific research ethics management in research-oriented hospital
LIN Aicui1 WANG Lei2
Scientific research ethics management in research-oriented hospital can protect the rights and interests of the subjects, and prevent the researchers from making principled mistakes. However, there are still some problems in ethical management of scientific research, the ethics committees lack of systematic external supervision and assessment, the function of scientific research ethics committee has not been distinguished in detail, the ethics committees lack of organization, the members of ethics committees are not professional enough, the ethics committees didn′t make continuous follow-up supervision to the projects and didn′t give enough ethical propaganda. To gunrantee the supervision of scientific research projects by scientific research ethics committee, in addition to the need to promote the establishment of the ethics committee′s regulatory department, the hospital should distinguish the functions of scientific research ethics committee in detail, construct ethics committee as required; strengthen the training of ethics committee members; provide enough staffs for the ethics committee; strengthen the ethical propaganda of scientific research ethics consciousness.
2019 Vol. 16 (33): 174-177 [Abstract] ( 173 ) HTML (1 KB)  PDF (690 KB)  ( 104 )
178 Nomogram model of predicting postoperative deep sternal wound infection based on the front page information of medical records of Peking Union Medical College Hospital
ZHANG Chaoji1 LIU Jianzhou1 MA Guotao1 LIU Xingrong1 LIU Aimin2 LI Xiaofeng1 LIANG Mei1 MIAO Qi1
Objective To analyze the information on the front page of the medical records of Peking Union Medical College Hospital (“our hospital” for short), while to construct and internally verify a concatenated model that predicts the risk of deep sternal wound infection (DSWI) after cardiac surgery. Methods A total of 2610 patients with cardiac surgery in our hospital from January 2007 to October 2017 were enrolled. The information on the front page of the medical records was collected, and the best risk factor subset was obtained by using LASSO regression to apply 10-fold cross-validation. The risk predictors were analyzed by multivariate Logistic regression model. A nomogram for predicting cardiac DSWI risk was built by R software. The internal validation was using by bootstrap method, while the predictive performance of the model was evaluated by area under the curve (AUC) of receiver operating characteristic, calibration curve and decision curve. Results Major vascular surgery (OR = 2.625), redo operation (OR = 4.554), diabetes mellitus (OR = 2.463) and allogeneic bone transplantation (OR = 3.498) were independent prognostic factors for DSWI risk (P ＜ 0.05). AUC for the nomogram model was 0.725, showed a moderate degree of discrimination; the predicted probability was highly consistent with the actual probability (P = 0.754); the internal validation consistency index was 0.720. The analysis of the decision curve indicated that the clinical applicability was high. Conclusion The nomogram model established in this study for predicting the risk of DSWI has good discrimination, accuracy and clinical practicability. While it has certain guiding significance for predicting high-risk population of DSWI and making clinical decision.
2019 Vol. 16 (33): 178-封三 [Abstract] ( 221 ) HTML (1 KB)  PDF (1032 KB)  ( 186 )
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