2~5岁儿童反复发生上呼吸道感染影响因素分析

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (537 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the influencing factors of 2-5 years old children with recurrent upper respiratory tract infection(RRTI), and to provide a reference for significantly reducing the incidence of RRTI in children. Methods A total of 100 cases of RRTI children in Pediatric Outpatient of Suzhou Municipal Hospital (hereinafter referred to as “our hospital”) from January to December 2018 were selected as the observation group. Another 100 children who had physical examination in Pediatric Department of our hospital during the same period were selected as the control group. The baseline data and blood multielement levels of children in the two groups were compared, and the influencing factors of RRTI in children were analyzed by Logistic regression. Results Univariate analysis showed that RRTI in children was related to mother′s educational level, parents′ allergy history, family members′ smoking, outdoor activities, annual use of antibiotics and nursery care (all P < 0.05). The levels of iron, calcium, zinc and copper in the children of the observation group were lower than those in the control group (all P < 0.05). Multivariate Logistic regression analysis showed that the risk factors for RRTI recurrence of children were: mothers with high school education level and below (OR = 1.495, 95%CI: 1.244-5.933), parents with allergy history (OR = 1.195, 95%CI: 1.088-3.405), family members′ smoking (OR = 1.294, 95%CI: 1.105-3.954), outdoor activity < 2 h/d (OR = 1.944, 95%CI: 1.774-4.582), annual use of antibiotics ≥3 times (OR = 4.823, 95%CI: 3.845-10.835), nursery care (OR = 1.673, 95%CI: 1.553-2.384), iron deficiency (OR = 1.384, 95%CI: 1.104-4.982), calcium deficiency (OR = 1.275, 95%CI: 1.027-3.225), zinc deficiency (OR = 1.055, 95%CI: 1.958-4.958) and copper deficiency (OR = 1.296, 95%CI: 1.022-3.656) (P < 0.05). Conclusion The risk of RRTI in children aged 2-5 years is increased by mothers with high school education and below, parents with allergy history, family members smoking, outdoor activities < 2 h/d, annual use of antibiotics ≥3 times, nursery care and inadequate blood multielement. The risk of RRTI may be reduced by taking corresponding preventive measures against the above factors.

Key words： Recurrent upper respiratory tract infection Children Influencing factors Logistic regression analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Zhenglan1 WU Ping1 LI Shiqin1 MA Jun2 YE Kan3

Cite this article:

LI Zhenglan1 WU Ping1 LI Shiqin1 MA Jun2 YE Kan3. Analysis of influencing factors of 2-5 years old children with recurrent upper respiratory tract infection[J]. 中国医药导报, 2019, 16(33): 88-91.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I33/88

[1] Raijmakers RPH，Jansen AFM，Keijmel SP，et al. A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome [J]. Eur J Immunol，2019，49（7）：1015-1022.
[2] Li Y，Fu X，Ma J，et al. Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children [J]. Nat Commun，2019，10（1）：2288-2289.
[3] 张媛媛，高菲，贾伟娜，等.白三烯B4与25-羟维生素D3在反复呼吸道感染学龄前儿童中表达的临床意义[J].临床与病理杂志，2018，38（11）：2442-2446.
[4] 彭丽琨，张翠香，董宇莹，等.3-6岁儿童反复发生上呼吸道感染的相关因素分析[J].临床肺科杂志，2018，23（6）：1112-1115.
[5] 高丽芳.儿童反复上呼吸道感染的原因与可行性方案分析[J].中国保健营养，2015，25（7）：184．
[6] 李春，叶梅.0~3岁反复上呼吸道感染患儿血清细胞因子IL-6、IL-10和TNF-α的水平及意义[J].河北医药，2017， 39（1）：14-16.
[7] 李昕，刘娟，杨薇，等.反复呼吸道感染的运动障碍患儿免疫功能相关因素的研究[J].中华医院感染学杂志，2019， 29（1）：139-141.
[8] 王欣煜.儿童反复呼吸道感染的危险因素及维生素D的干预作用研究[J].湖南师范大学学报：医学版，2019，16（2）：164-167.
[9] 张慧，沈定，计建军，等.益气健脾防感汤与西药联合治疗小儿反复呼吸道感染73例[J].中国中医药科技，2018， 25（5）：768-769.
[10] Passali D，Passali GC，Vesperini E，et al. The efficacy and tolerability of Streptococcus salivarius 24SMB and Streptococcus oralis 89a administered as nasal spray in the treatment of recurrent upper respiratory tract infections in children [J]. Eur Rev Med Pharmacol Sci，2019，23（1）：67-72.
[11] Hamilos DL. Biofilm Formations in Pediatric Respiratory Tract Infection：Part 1：Biofilm Structure，Role of Innate Immunity in Protection Against and Response to Biofilm，Methods of Biofilm Detection，Pediatric Respiratory Tract Diseases Associated with Mucosal Biofilm Formation [J]. Curr Infect Dis Rep，2019，21（2）：6.
[12] 石正英，管建宏，施益农.儿童反复呼吸道感染72例致病因素分析[J].临床肺科杂志，2017，22（9）：1711-1713.
[13] Mitwalli M，Wahba Y，Shaltout A，et al. Lymphocyte subgroups and recurrent infections in children with Down syndrome-a prospective case control study [J]. Cent Eur J Immunol，2018，43（3）：248-254.
[14] 徐红，魏娟，周琳，等.徐州地区学龄前儿童反复呼吸道感染现状及影响因素分析[J].中国医学前沿杂志：电子版，2018，10（5）：99-102.
[15] 刘平辉，孟微，曲治权，等.牡丹江市学龄前儿童反复呼吸道感染现状及影响因素分析[J].中国公共卫生，2017， 33（6）：1004-1007.
[16] 陈晓君，郭瑞娟，曾丽森，等.影响3~6岁儿童反复发生上呼吸道感染的相关因素分析[J].中国儿童保健杂志，2018，26（11）：1244-1247.
[17] 李红.坝上地区儿童反复呼吸道感染影响因素分析[J].中国临床研究，2015，28（5）：636-638.
[18] 张日安，黄杏雄，陈国权.小儿反复上呼吸道感染的危险因素分析及临床预防对策[J].临床医学工程，2017， 24（10）：1471-1472.
[19] 刘菁.儿童反复上呼吸道感染血清微量元素的缺乏情况及间断补锌、铁的防治效果分析[J].中国妇幼保健，2019，34（9）：2036-2038.
[20] 陶双.200例反复上呼吸道感染患儿血清微量和常量元素的缺乏情况及间断补锌、铁的防治效果分析[J].中国妇幼保健，2017，32（7）：1498-1501.