细胞因子信号转导负调控蛋白2在变应性鼻炎中的表达及临床意义

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Abstract Objective To observe the expression of negative regulatory protein 2 (SOCS2) of cytokine signal transduction in the nasal mucosa of allergic rhinitis (AR) and its clinical significance. Methods The expression levels of SOCS2, interferon-γ (IFN-γ), FOXP3, interleukin (IL)-4, IL-5 and IL-13 mRNA in inferior turbinate mucosa of 20 AR patients (AR group) and 15 patients with simple deviation of nasal septum (control group) underwent nasal septum deviation or pterygoid canal neurotomy from February to July 2018 in the First Affiliated Hospital of Nanchang University were detected by real-time quantitative PCR. Immunohistochemical method was used to detect the expression of SOCS2 protein in nasal mucosa of two groups of patients. Visual analogue scale (VAS) was used to evaluate the subjective symptoms of patients. Results The expression of SOCS2 was immunohistochemistry in AR group and control group. The average absorbance value of SOCS2 in AR group was significantly lower than that in control group, the difference was statistically significant (P < 0.05). The relative expression of SOCS2, IFN-γ and FOXP3 in AR group was significantly lower than that in control group, while the relative expression of IL-5, IL-13 and IL-4 in AR group was significantly higher than that in control group, the differences were statistically significant (P < 0.05). In AR patients, the relative expression of SOCS2 was negatively correlated with the total score of IL-4, IL-5, IL-13 and VAS (r = -0.66, -0.50, -0.51, -0.65, P < 0.05), positively correlated with the relative expression of FOXP3 (r = 0.67, P < 0.05), and not correlated with the relative expression of IFN-γ (P > 0.05). Conclusion The decrease of SOCS2 in the nasal mucosa of AR patients is related to many cytokines of AR, suggesting that SOCS2 may play a key role in the pathogenesis of AR.

Key words： Allergic rhinitis Cytokine signal transduction negative regulatory protein 2 Cytokine Inflammation

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	LIU Haitao1 LUO Qing1 FAN Li1 YANG Tian2▲

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LIU Haitao1 LUO Qing1 FAN Li1 YANG Tian2▲. Expression and clinical significance of negative regulatory protein 2 of cytokine signal transduction in allergic rhinitis[J]. 中国医药导报, 2019, 16(33): 19-22.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I33/19

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