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| Research progress on ischemia-reperfusion injury of diabetic organs |
| YI Haoran WANG Lei ZHU Hengcheng |
| Department of Urology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Diabetes is a high incidence of metabolic disorders, the patient′s blood sugar stayed high for a long time, cell damage is mediated by inflammatory response and oxidative stress. Ischemia-reperfusion injury (IRI) is a phenomenon that the injury of ischemic organs is further aggravated after the restoration of blood perfusion. It plays an important role in the pathophysiological mechanism of cerebral infarction, myocardial infarction, renal IRI, intestinal IRI and liver IRI. These are the leading causes of organ damage, including transplant failure, and even death. Recent studies have shown that diabetes can worsen IRI in organs. This paper reviews the research progress of IRI in major diabetic organs.
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