晚期原发性肝癌药物研究进展

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Abstract Hepatocellular carcinoma is one of the most common and fatal cancers in the world. It is the fourth most common malignant tumor and the third leading cause of death in China. Due to high rate of intermediate or late diagnosis, the majority of patients have no opportunity to undergo potentially curative surgery. Moreover, the overall efficacy and safety of local treatment, radiotherapy, systemic chemotherapy and “gold standard” Sorafenib targeted therapy are not satisfactory, more safe and effective treatment means and drugs are urgently needed. Systemic chemotherapy regimens containing Oxaliplatin are able to improve the efficacy of Asia Pacific patients with advanced liver cancer, but the survival benefit is limited. The success of the new molecular targeted drugs Levatinib and Regofenib in the first and second line treatment provide new treatment options for patients. Immunotherapy, represented by the checkpoint inhibitors Nivolumab and Pembrolizumab, has shown great advantages in the clinical study of advanced liver cancer, opening a new era of immunotherapy for liver cancer. This article reviews the latest development and trends of advanced liver cancer drugs.

Key words： Hepatocellular carcinoma Molecular targeted therapy Immunotherapy Immune checkpoint inhibitors

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	Articles by authors
	ZHANG Wenwen1
	2 ZHENG Xizi3 ZHENG Xiaohong1
	2 LIU Xiaodong1
	2

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ZHANG Wenwen1,2 ZHENG Xizi3 ZHENG Xiaohong1,2 LIU Xiaodong1, et al. Advances in drug research for advanced hepatocellular carcinoma[J]. 中国医药导报, 2019, 16(33): 28-31.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I33/28

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