血清PTEN水平与子痫前期患者氧化应激及妊娠结局的关系

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Abstract Objective To investigate the relationship between serum levels of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and oxidative stress and pregnancy outcome in patients with preeclampsia (PE). Methods 136 patients with PE who were admitted to General Hospital of Southern War Zone (hereinafter referred to as “our hospital”) from January 2017 to February 2019 were selected, and they were divided into mild group (n = 67) and severe group (n = 69) according to the severity of the disease. Another 60 healthy pregnant women who came to our hospital for physical examination during the same period were selected as control group. The levels of PTEN, oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA), 8-isoprostaglandin F2α (8-iso-PGF2α)] of each group were compared. Pearson correlation analysis was used to analyze the relationship between PTEN and oxidative stress indicators. Logistic multiple regression analysis was used to analyze the influencing factors of adverse pregnancy outcomes. Results The PTEN and SOD levels in mild group and severe group were lower than those in control group (P < 0.05), while the MDA and 8-iso-PGF2α were higher than those in control group (P < 0.05). With the increase of the severity of the disease, the levels of PTEN and SOD decreased (P < 0.05), while MDA, 8-iso-PGF2α showed an upward trend (P < 0.05). The levels of PTEN and SOD in adverse pregnancy were lower than those in normal pregnancy (P < 0.05), while the MDA and 8-iso-PGF2α were higher than those in normal pregnancy (P < 0.05). Pearson correlation analysis showed the level of PTEN was positively correlated with SOD in patients with PE (r = 0. 596, P < 0.05). The level of PTEN in patients with PE was negatively correlated with MDA and 8-iso-PGF2α (r = -0.468, -0.429, P < 0.05). Logistic multiple regression analysis showed that low expression of serum PTEN, the decreased of SOD, the increase of MDA and 8-iso-PGF2α were independent risk factors affecting adverse pregnancy outcomes in PE patients (P < 0.05). Conclusion The expression of PTEN is low in patients with PE, and it is involved in the disease progression of PE patients through the regulation of oxidative stress indicators, which can be assisted to evaluate the condition of PE patients by rational monitoring in clinical practice.

Key words： Preeclampsia Oxidative stress PTEN Pregnancy outcomes

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	WAN Shumei PENG Ping GAO Yan

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WAN Shumei PENG Ping GAO Yan. Relationship between serum PTEN level and oxidative stress and pregnancy outcome in patients with preeclampsia[J]. 中国医药导报, 2019, 16(33): 96-99.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I33/96

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