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| Effect of Jiaotai Pills combined with hypoglycemic rehabilitation exercise on adiponectin and islet function in type 2 diabetes mellitus patients with dampness and spleen syndrome |
| CAO Wen FAN Yaofu LIU Chao HU Yongxing CHU Xiaoqiu DI Hongjie |
| Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210028, China |
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Abstract Objective To investigate the effects of Jiaotai Pills combined with hypoglycemic rehabilitation on blood adiponectin and β cell function of the pancreas in patients with type 2 diabetes dampness and spleen syndrome. Methods From March 2017 to August 2018, 300 patients with type 2 diabetes with dampness and spleen syndrome who were admitted to the Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine were selected, Random number table method was used to divide 150 cases into the control group and the combined group, respectively. Control group according to the original drug regimen (Western medicine hypoglycemic, hypohypertensive, lipid-lowering) treatment. The combined group was treated with oral Jiaotai Pills combined with rehabilitation exercise. The course of Treatment was 12 weeks. The changes of TCM syndrome score, fasting blood glucose (FBG), glycosylated hemoglobin(HbA1c), serum adiponectin (APN), islet β function index (HOMA-β), fasting insulin (FINS) before and after treatment in the two groups were observed, and the clinical efficacy was compared between the two groups. Results One case of combined group lossed at lase. After treatment, TCM syndrome scores, FBG, and HbA1c levels were decreased in both groups, and APN, HOMA-β and FINS levels were increased in all the groups (P ＜ 0.05). Moreover, the TCM syndrome score, FBG and HbA1c levels in the combined group were lower than those in the control group, and the APN, HOMA-β and FINS levels were higher than those in the control group (P ＜ 0.05). The total effective rate of the combined treatment group was higher than that of the control group (P ＜ 0.05). Conclusion Jiaotai Pills combined with hypoglycemic rehabilitation surgery can effectively reduce blood sugar levels in patients with type 2 diabetes mellitus, improve the symptoms of TCM and the function of islet β cells. The mechanism may be related to the increase of blood adiponectin levels.
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