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| Clinical observation and functional mechanism study of Huichun Yuzi Granules in treatment of oligospermia and/or asthenospermia |
| XUE Gangqiang1 LI Sanni2 GAO Shuli1 YUAN Jingchuan3 SUN Zhiyong1 ZHANG Yang1 |
1.Department of Pharmaceutic Preparation, the Fourth Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050011, China;
2.Department of Pharmacy, Children′s Hospital of Hebei Province, Hebei Province, Shijiazhuang 050030, China;
3.Department of Reproductive Medicine Center, the Fourth Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050011, China |
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Abstract Objective To explore the clinical observation and functional mechanism study of Huichun Yuzi Granules in treatment of Oligospermia and/or asthenospermia and to demonstrate the scientific rationality of Huichun Yuzi Granules so as to provide the basis data for the further study. Methods From July 2005 to June 2017, 200 cases with kidney essence deficiency (oligospermia and/or asthenospermia) in the Fourth Hospital of Shijiazhuang were selected. The average semen volume, sperm concentration, sperm activity rate (PR) of forward movement, total sperm activity of Huichun Yuzi Granules before treatment, and aftere 4, 8 weeks and 12 weeks of treatment were compared, and the TCM syndrome score before treatment and after 12 weeks of treatment were evaluated and the therapeutic effect was evaluated. Results Compared with before treatment, the average semen volume and sperm concentration, PR and total sperm activity were increased significantly than those of after 4 weeks treatment, the differences were statistically significant (P < 0.05). Compared with 4 weeks treatment, the average semen volume, sperm concentration, PR and total sperm activity increased significantly than those of after 8 weeks of treatment, the differences were highly statistically significant (P < 0.01). Compared with 8 weeks treatment, the average semen volume, sperm concentration, PR and total sperm activity increased significantly than those of after 12 weeks of treatment, the differences were highly statistically significant (P < 0.01). TCM syndromes were also significantly improved after 12 weeks of treatment (P < 0.01). The cure rate was 24.5%, the effective rate was 67.5% and the total effective rate was 92.0%. Conclusion Huichun Yuzi Granules is effective in treating hypoasthenospermia, and its prescription is scientific and reasonable.
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