术前T淋巴细胞水平对脊柱手术后感染及血清促炎性细胞因子的影响

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Abstract Objective To study the effect of preoperative T lymphocyte level on postoperative spinal infection and serum proinflammatory cytokines after spinal surgery. Methods From January 2017 to June 2018, 119 patients who underwent spinal surgery in Wuhan Fourth Hospital of Hubei Province were selected for the study, patients with CD3+＜50% were set as the observation group (60 cases), and patients with CD3+≥50% were set as the control group (59 cases). The operation conditions, the changes of tumor necrosis factor α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10), and interleukin-1β (IL-1β) levels before and after surgery, gastrointestinal function and postoperative infection were compared between the two groups. Results There was no significant difference in operation time between the two groups (P ＞ 0.05). The amount of bleeding in the observation group was more than that in the control group, and the length of hospitalization was longer than the control group (P ＜ 0.05). Before operation, the levels of TNF-α, IL-8, IL-10 and IL-1β in the observation group were significantly higher than those in the control group (P ＜ 0.05). After operation, the levels of serum inflammatory factors in the two groups were significantly increased, and the observation group was significantly higher than that in the control group (P ＜ 0.05). After operation, the disappearance of bowel sounds, anal exhaust, defecation, diet recovery and abdominal distension relief time in the observation group were significantly higher than those in the control group (P ＜ 0.05). After operation, the total incidence of infection in the observation group was significantly higher than that in the control group (P ＜ 0.05). Conclusion Postoperative infection in patients with spinal surgery is directly related to the preoperative T lymphocyte level, and patients with low preoperative T lymphocyte level have a high postoperative infection rate. The T lymphocyte level of patients should be monitored and improved clinically.

Key words： Preoperative T lymphocytes Spinal surgery Postoperative infection Inflammatory cells

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	ZHANG Shujun1
	2 ZHAO Zhigang1 HU Jun1 CUI Wei1 XIE Wei1 WANG Xin1 SONG Sheng2 SUN Zhenzhong2

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ZHANG Shujun1,2 ZHAO Zhigang1 HU Jun1 CUI Wei1 XIE Wei1 WANG Xin1 SONG Sheng2 SUN Zhenzhong2. Effect of preoperative T lymphocyte level on postoperative spinal infection and serum pro-inflammatory cytokines[J]. 中国医药导报, 2019, 16(33): 78-81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I33/78

[1] 王宇强，冯世庆，王小华，等.脊柱手术术后感染的病原菌和药敏分析及血清炎症因子的辅助诊断价值[J].中华医院感染学杂志，2017，27（1）：147-150.
[2] 王殊秀，孙焱芫，王异，等.右美托咪定经鼻滴注对脊柱手术患者围术期血流动力学变化及镇静作用的临床研究[J].现代生物医学进展，2017，17（23）：4462-4465.
[3] 王建聪，卢晓燕.脊柱手术后患者外科手术部位感染及相关危险因素[J].中国感染控制杂志，2017，16（1）：16-22.
[4] 钟惠，江英强，尹亚岚，等.麻醉方式对胃癌患者术后呼吸道感染及T淋巴细胞和应激水平的影响[J].中华医院感染学杂志，2017，27（3）：609-612.
[5] 宋俊刚，毕中先，唐俊霞，等.不同麻醉方式对上腹部手术老年患者肺功能指标与炎症因子及T淋巴细胞亚群的影响[J].中华医院感染学杂志，2017，27（17）：3929-3932.
[6] 邹美银，汪美华，顾丽华，等.CD4+及CD8+T淋巴细胞预测人类免疫缺陷病毒感染患者抗反转录病毒治疗效果的价值[J].中华实用诊断与治疗杂志，2017，31（7）：690-693.
[7] 王淅克，黄岩石，郑铁牛，等.脊柱手术后切口感染患者血清炎症因子变化及临床意义[J].中华医院感染学杂志，2017，27（24）：5638-5641.
[8] 何志刚，姜娟.超容量血液稀释联合血液回收对脊柱手术全麻患者应用的效果观察[J].贵州医药，2017，41（12）：1257-1259.
[9] 孙英飞，蒋欣，移平.检测感染相关指标对脊柱手术后深部切口感染的早期预判价值研究[J].中华医院感染学杂志，2018，28（14）：69-71，82.
[10] 吴翠萍，赵利.外周血T淋巴细胞亚群变化特点及血清因子表达水平的研究[J].检验医学与临床，2018，15（4）：523-525.
[11] Helenius IJ，Bauer JM，Verhofste B，et al. Os Odontoideum in Children： Treatment Outcomes and Neurological Risk Factors [J]. J Bone Joint Surg Am，2019，101（19）：1750-1760.
[12] 史娜，陈鹏，刘燕，等.动态监测胃癌术后感染患者T淋巴细胞亚群水平的临床价值[J].中华医院感染学杂志，2019，29（6）：884-887.
[13] Ishida W，Perdomo-Pantoja A，Elder BD，et al. Effects of Intraoperative Intrawound Antibiotic Administration on Spinal Fusion：A Comparison of Vancomycin and Tobramycin in a Rat Model [J]. J Bone Joint Surg Am，2019， 101（19）：1741-1749.
[14] 曹喜华，王帅，李海中，等.胸腰椎后路内固定术后早期手术部位感染患者的促炎因子和抗炎因子水平变化研究[J].中华医院感染学杂志，2017，27（1）：151-153.
[15] 李秋月，许海玉，杨洪军，等.促炎因子TNF-α，IL-1β，IL-6在神经病理性疼痛中的研究进展[J].中国中药杂志，2017，42（19）：3709-3712.
[16] 李超，郭旗.细胞因子IL-1β、IL-2、IL-6、IL-8和TNF-α水平在癫痫患者外周血中的变化及其意义[J].解放军预防医学杂志，2018，36（3）：375-377.
[17] 李腊梅，杨雪梅，伍洋平，等.肝细胞LO2中细胞因子诱导的含CISH基因的表达及其炎性因子调控的研究[J].成都医学院学报，2017，12（1）：44-48.
[18] 陈烁，陈怡.美沙拉嗪联合双歧三联活菌治疗溃疡性结肠炎的疗效及对炎性因子的影响[J].中国现代医生，2019，57（8）：40-43.
[19] Urquhart JC，Collings D，Nutt L，et al. The Effect of Prolonged Postoperative Antibiotic Administration on the Rate of Infection in Patients Undergoing Posterior Spinal Surgery Requiring a Closed-Suction Drain： A Randomized Controlled Trial [J]. J Bone Joint Surg Am，2019， 101（19）：1732-1740.
[20] 陈海龙，杜彪，张军玲，等.不同术前免疫状态脊椎手术患者术后术前细胞免疫状态对脊柱手术后感染及血清炎性因子水平的影响[J].中华医院感染学杂志，2016， 26（22）：5172-5174.
[21] 石磊，李海峰，阮狄克，等.脊柱术后手术部位感染的危险因素分析[J].中国脊柱脊髓杂志，2017，27（10）：908-912.
[22] 王玉，王清秀，张清，等.压力控制容量通气对行脊柱手术的临床效果及血流动力学的影响[J].中国医学装备，2018，15（11）：105-108.
[23] 王淅克，黄岩石，郑铁牛，等.脊柱手术后切口感染患者血清炎症因子变化及临床意义[J].中华医院感染学杂志，2017，27（24）：5638-5649.