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2018 Vol. 15, No. 15
Published: 2018-05-25
 
 
4 Effect of water extraction of green tea on survival and proliferation of PC12 cells
CAI Zhenlu1 FENG Yunran2 LI Xingxing1 LI Mu3▲ LV Haixia1
Objective To investigate the effect of green tea on the survival and proliferation of neural cells during development. Methods PC12 cells were selected as the cell model for toxicological analysis, green tea leaves were boiled in distill water of 100℃ for three times, tea solution was then filtered and freeze dried. The powder was dissolved with sterilized pure water. DMEM medium was applied to make different concentrations of tea extraction (diluer for 100, 200 400, 800, and 1600 times) before use. The morphology of PC12 cells was observed, cell viability and apoptosis were detected by CCK-8 assay and flow cytometry assay after treatment. The proliferation of PC12 was detected by Ki67 immunostaining. Results Compared with low concentration (diluer 800 and 1600 times), after treated with green tea extraction in high concentration, PC12 cell morphology changed dramatically and cell viability was decreased significantly (P < 0.05). Proliferation of PC12 also declined dramatically, as showed by the reduced number of Ki67+ cells (P < 0.05). While the apoptosis of PC12 had no statistically significant difference compared with control group (P > 0.05). Conclusion Green tea in high concentration, so it is recommended to reduce the drinking of strong green teadurn pregancy could reduce the survival and proliferation of PC12 cells
2018 Vol. 15 (15): 4-7 [Abstract] ( 183 ) HTML (1 KB)  PDF (745 KB)  ( 182 )
8 Epidemiological characteristics and risk factors of T2DM in premenopausal and postmenopausal women
LI Qingjun1 WANG Xiaoqing2 HU Wen2 YU Weinan2
Objective To analyze the prevalence of type 2 diabetes mellitus (T2DM) in premenopausal and postmenopausal women and providing effective data for the prevention and intervention of the occurrence and development of T2DM. Methods A total of 3227 women with T2DM met the requirements from June to December in 2014 were selected, they were divided into two groups according to the questionnaire, including 207 cases of premenopausal women and 3020 cases of postmenopausal women. The prevalence of T2DM and the associated risk factors in the two groups were analyzed. Results Prevalence of premenopausal women with T2DM was 12.1% while the prevalence in postmenopausal state was 19.4%, the difference was statistically significant (P < 0.05). The serum total protein (TP) was a major risk factor for premenopausal women with T2DM (OR=1.16, 95%CI: 1.02-1.32, P < 0.05). In postmenopausal women, the prevalence of T2DM was associated with age (OR=1.04, 95%CI: 1.02-1.05, P < 0.05), BMI(OR=1.08, 95%CI: 1.04-1.11, P < 0.05), Triglyceride (TG) (OR=1.11, 95%CI: 1.03-1.20, P < 0.05), blood urea nitrogen (BUN) (OR=1.07, 95%CI: 1.00-1.13, P < 0.05), alanine aminotransferase (ALT) (OR=1.01, 95%CI: 1.00-1.02, P < 0.05), TP (OR=1.03, 95%CI: 1.01-1.06, P < 0.05)and blood pressure (OR=1.52, 95%CI: 1.23-1.88, P < 0.05). Conclusion Postmenopausal women with type 2 diabetes have a higher rate than premenopausal women. TP is a major risk factor for premenopausal women with T2DM. Postmenopausal risk factors in addition to traditional risk factors such as lipidemia, blood pressure, TP, ALT, and BUN. Risk factors should be monitored, and prevention and intervention measures should be taken early to reduce the prevalence of diabetes and improve the quality of life of women before and after menopause.
2018 Vol. 15 (15): 8-12 [Abstract] ( 253 ) HTML (1 KB)  PDF (574 KB)  ( 121 )
13 Effect of putative receptor protein related to the angiotensin receptor AT1 antagonist Apelin13 (F13A) on the invasion induced by M2 type tumor related macrophages in breast cancer cells line MCF-7 cells and probable mechanism
PENG Chuanzhen SONG Zhaolu LI Kaiyan WU Xiao LENG Ning
Objective To investigate effect of putative receptor protein related to the angiotensin receptor AT1 (APJ) antagonist Apelin13 (F13A) on the polarization of tumor-associated macrophages (TAM) and the invasion induced by M2 type macrophages in breast cancer cells line MCF-7 cells. Methods Macrophage RAW264.7 cells were treated with IL-13 (10 ng/mL) for 24 h to induce M2 type polarization (M2RAW) and the cells were treated with Apelin-13(F13A) (10.00 pm/mL) for 24 h. RAW and MCF-7 cells were co-cultured for 48 h in non-contact manner. The proliferation of RAW and MCF-7 was detected by MTT. Levels of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) in culture medium were tested by ELISA. Expression of marker protein of M2 type polarization arginase 1 (Arg-1) were measured by Western blot. Migration and invasiveness of MCF-7 cells were tested by scratch test and Transwell method. Results Compared with RAW group, levels of TGF-β and IL-10 and expression of Arg-1 in M2RAW group were significantly increased, the differences were statistically significant (P < 0.05). Compared with M2RAW group, levels of TGF-β and IL-10 and expression of Arg-1 in M2RAW+Apelin-13 (F13A) group were significantly decreased, the differences were statistically significant (P < 0.05). Compared with RAW+MCF-7 group, scratch area was significantly decreased, the number of cell through the membrane was significantly increased in M2RAW+MCF-7 group, the differences were statistically significant (P < 0.05). Compared with M2RAW+MCF-7 group, scratch area was significantly increased, the number of cell through the membrane was significantly decreased in Apelin-13(F13A)+M2RAW+MCF-7 group, the differences were statistically significant (P < 0.05). Conclusion Apelin13 (F13A) inhibits the polarization of tumor related macrophages and the invasion induced by M2 type macrophages in breast cancer cells line MCF-7 cells.
2018 Vol. 15 (15): 13-17,42 [Abstract] ( 306 ) HTML (1 KB)  PDF (1420 KB)  ( 62 )
18 Study on the differences of the expression of vascular endothelial growth factor and the activity of NK cells in lung cancer mice with different behavior characteristics
ZANG Fucai1 LIU Mingyue2 LIU Min1 TANG Wei1
Objective To investigate the differences of the expression of vascular endothelial growth factor (VEGF) and the activity of NK cells in lung cancer mice with different behavior characteristics. Methods Eighty male Balb/c mice were taken open field test to screen high active group and low active group, with 20 mice in each group. The logarithmic phase LLC cells were inoculated in the right axillary subcutaneous of high active group and low active group to establish lung cancer model. After 14 days under the same feeding condition, the killing activity of spleen NK cells in the two groups was detected by MMT method. The long and short diameters of tumor were detected by vernier caliper, the tumor volume was calculated, and the tumor weight was measured by electronic scales. Immunohistochemistry method was used to detect the expression of VEGF in the two groups. Results The killing activity of NK cells in the high active group was (19.73±3.55)%, which was significantly higher than that of low active group [(16.47±3.29)%], the difference was statistically significant (P ＜ 0.05). The tumor volume of high active group was (0.78±0.14) cm3, which was smaller than that of low active group [(0.94±0.24) cm3], the difference was statistically significant (P ＜ 0.05). The tumor weight of high active group was (0.84±0.19) g, which was lower than that of low active group [(1.00±0.22) g], the difference was statistically significant (P ＜ 0.05). The positive expression rate of VEGF in the high active group was 85.0%, which was lower than that of low active group (95.0%), there was statistically significant difference (P ＜ 0.05). Conclusion Different activity degrees of tumor-bearing mice have different growth rates of lung cancer tissue, which may be connected with the activity of NK cells and the expression of VEGF protein in tumor tissue.
2018 Vol. 15 (15): 18-21 [Abstract] ( 221 ) HTML (1 KB)  PDF (554 KB)  ( 90 )
22 Advances in the treatment of neuroparalytic keratitis
SUN Yaru ZHAO Haixia
Neuroparalytic keratitis is also called as neurotrophic keratitis. When trigeminal nerve suffers from trauma, surgery, inflammation or tumor destruction, the sensitivity of cornea losing eneurosis will be decreased and the dystrophia will be occurred, the defense capability for the external harmful factors will be weakened, thus, the corneal epithelium will turn dry and be susceptible to mechanical damage. What's worse, it will probably result in corneal ulcer, fusion and perforation. The therapeutic aim of neuroparalytic keratitis is to promote corneal healing and prevent the progress of corneal damage. The treating methods include physical therapy, drug therapy, operative treatment, and so on. In recent years, the novel therapeutic strategies, such as local application of nerve growth factor, pay attention to improve the eneurosis of cornea and support corneal growth and healing.
2018 Vol. 15 (15): 22-25 [Abstract] ( 241 ) HTML (1 KB)  PDF (558 KB)  ( 113 )
26 Research progress on pathogenesis of atrial fibrillation
WANG Zengxia1 WANG He2 QIU Chengjie2 SI Chunying2 ZHAO Ya′nan1 GUAN Huaimin3 XIE Jinhong2
Atrial fibrillation (AF) is the most common arrhythmia diagnosed in clinical practice. Now, precise mechanisms that lead to the onset and persistence of AF have not completely been elucidated. This paper mainly from the electrophysiological mechanisms of atrial fibrillation (including focal triggering mechanism, multiple wavelet hypothesis, etc.) and pathological physiological mechanism (electrical remodeling, contraction remodeling,structural remodeling, etc.) explain the possible pathogenesis of atrial fibrillation, in order to provide the basis or direction for the prevention and treatment of atrial fibrillation.
2018 Vol. 15 (15): 26-29 [Abstract] ( 261 ) HTML (1 KB)  PDF (559 KB)  ( 244 )
30 Listeria Monocytogenes infection in pregnancy and its impact on mother and infant
XIAO Ling1 ZOU Liying2▲
Listeriosis is an anthropozoonosis caused by Listeria monocytogenes (L. monocytogenes). It is acquired by humans primarily through consumption of contaminated food. Listeria monocytogenes has strong pathogenicity to human through produced the hemolytictoxin, especially high risk patients such as pregnant women, elderly people, immuno compressed people, unborn babies, andneonates (through vertical transmission from the mother or, more rarely, at birth by ascending colonisation from the vagina). Infection causes a spectrum of illness, including bacteraemia, sepsis, meningoencephalitis and abortion, but symptoms are nonspecific and diagnosis is difficult. Alsolisteriosishas a highmortality. The aim of this review article is to introduced the relationship between it and pregnacy, so as to improve the pregnancy outcome.
2018 Vol. 15 (15): 30-33 [Abstract] ( 247 ) HTML (1 KB)  PDF (570 KB)  ( 79 )
34 Progress of non-immunosuppressant therapy for IgA nephropathy with residual proteinuria 
HU Yanqi LI Liusheng
IgA nephropathy (IgAN) is a common cause of end stage renal disease in the world. Any intervention to reduce proteinuria is helpful to slow the progress of IgAN. At present，sometimes complete remission of IgAN with proteinuria cannot be achieved through the use of renin angiotensin system inhibitor, thus other non-immunosuppressant drugs, including fish oil, active vitamin D, Sulodexide, adrenergic inhibitor, aldosterone receptor blockade, statins and so on are often needed. By analyzing the related literature, this paper reviews the progress of non-immunosuppressant therapy for IgAN with residual proteinuria.
2018 Vol. 15 (15): 34-37 [Abstract] ( 268 ) HTML (1 KB)  PDF (562 KB)  ( 149 )
38 Progress of breast-conserving surgery combine intraoperative radiotherapy indication for breast cancer
WANG Zixiang WU Aiguo▲
Breast cancer is the most common disease in women worldwide, the whole-mammectomy surgery greatly effects on the patients′ psychological and beauty. Breast-conserving surgery (BCS) combined intraoperative radiotherapy (IORT) gained international favor because of its reduction in treatment duration, decreased irradiation of healthy organs, and maintain favorable cancer-specific and better cosmetic outcomes. However, in terms of selecting patients, multiple opinions existed, even some with conflicting recommendations. In this review, the existing patient selection guidelines are summarized and compared, in order to provide reference for clinical doctors′ medical decision-making.
2018 Vol. 15 (15): 38-42 [Abstract] ( 256 ) HTML (1 KB)  PDF (569 KB)  ( 114 )
43 Research progress of Bevacizumab in human glioblastoma anti-angiogenesis
XU Yang YUAN Fan'en YANG Xue YANG Ji'an LIU Baohui▲ CHEN Qianxue▲
Glioblastoma is one of the most common primary malignant tumors in the central nervous system of adults. Angiogenesis is one of the most important hallmarks of glioblastoma, and vascular endothelial growth factor plays a key role in this process. Bevacizumab is a monoclonal antibody that can specifically prevent the combination of vascular endothelial growth factor and its receptor, thereby inhibiting the formation of tumor blood vessels and normalizing the tumor blood vessels to achieve anti-tumor effect. However, the effects of Bevacizumab in newly diagnosed and recurrent glioblastoma are not as satisfied as expected, furthermore, some cases occurred resistance. This paper reviews the research progress of the mechanism of angiogenesis, mechanism of Bevacizumab and its clinical trails and resistance mechanism in recent years, hoping to summarize the research achievements of anti-vascular therapy, and predict the next research direction.
2018 Vol. 15 (15): 43-46,58 [Abstract] ( 262 ) HTML (1 KB)  PDF (901 KB)  ( 125 )
47 A cross-sectional study of anxiety and depression in patients with knee osteoarthritis
WU Hai1 PANG Jian1,2▲ CHEN Bo2 CAO Yuelong1,2 ZHAN Hongsheng1,2
Objective To survey the prevalence of anxiety and depressive disorders in patients with knee osteoarthritis (KOA), and examine the interrelationships between demographic factors, anxiety and depression. Methods This is a cross-sectional pilot study. In this study, 156 patients in the Center of Orthopedics and Traumatology of Shuguang Hospital Affiliated to Shanghai University of TCM from August 2016 to October 2017 were selected. They were diagnosed with KOA. The following information ware acquired: age, gender, body mass index (BMI), duration of disease, education, marriage, occupation, employment status, and score of Hospital Anxiety and Depression Scale (HADS). Results Among the 156 patients with KOA, 74 cases had anxiety and (or) depressive symptoms (47.43%). The patients with KOA had higher rates of depression and anxiety compared to the norms of HADS in Shanghai, with statistically significant differences (P ＜ 0.05). In addition, the anxiety and depression symptoms were negatively correlated with age, gender, BMI, duration of disease, education, marriage, occupation and employment status (P ＞ 0.05). Conclusion There is a certain degree of anxiety and depression symptoms in patients with KOA. It is necessary to adopt a muleidisciplinany approach in treating patients with KOA. Furthermore, there are poor correlations between demographic variables and mental symptoms. It suggests that other undiscovered factors may affect anxiety and depression symptoms in KOA.
2018 Vol. 15 (15): 47-50 [Abstract] ( 184 ) HTML (1 KB)  PDF (507 KB)  ( 256 )
51 Analysis of the risk factors of elderly community with heart failure with preserved ejection fraction in Gaohang Community in Shanghai
WU Hong1 ZHENG Liang2 TIAN Cailin3 ZHU Chengying1 JIANG Xiaolan1 YUE Aixue2 FAN Huimin2▲
Objectives To estimate the prevalence of heart failure with preserved ejection fraction (HFpEF) in elderly community, and to discuss the risk factors. Methods All target individuals were included in Gaohang communities from June to October in 2013. And they were divided into HFpEF group and control group. Step-wise Logistic regression was used to explore risk factors of HFpEF. Results A total of 4000 questionnaires were distributed to the community elderly. There were 3950 valid questionnaires and the effectives rate of 98.75%. There were 1312 patients with HFpEF and 2638 control individuals. There were significant difference between two groups in composition ratio of normal weight, overweight and obesity (P < 0.05). The regression model indicated that elderly age, female gender and lower HDL-C level were risk factors of HFpEF (P < 0.05), when adjusted variables included gender, age, SBP, obese, HDL-C, LDL-C and hs-CRP. Conclusion The prevalence of HFpEF is higher in elderly community population in Shanghai. Elderly age, female gender and lower HDL-C level are risk factors of HFpEF.
2018 Vol. 15 (15): 51-53,64 [Abstract] ( 205 ) HTML (1 KB)  PDF (526 KB)  ( 95 )
54 Investigation of satisfaction of community traditional Chinese medicine staff in the medical association
MENG Yaping SONG Shuang WANG Shan WU Xin
Objective To investigate the satisfaction of the traditional Chinese medicine (TCM) staff of the community in the medical association. Methods From April to June 2016, TCM staffs in the community which joined the medical association in Beijing Chaoyang District were invited to make a questionnaire survey, which included basic information of community TCM, evaluation of TCM service measures for community health institutions and external factors that affect the overall satisfaction of community TCM. Results The overall satisfaction of TCM staffs was high. Their satisfaction had a significant statistical difference in different medical association type (P = 0.016). There was a low level of satisfaction among the loose medical association. TCM staffs were satisfied with TCM features service capability, TCM appropriate technology and Chinese medicine service capacity which community provided. However, they were unsatisfied with the salary and medical association performance appraisal. The recognition of the residents′ TCM service ability has an important influence on the overall satisfaction of the community TCM(P = 0.003). Conclusion The government should improve the relevant policies that allow the hospital to make Chinese herbal preparations to flow within the medical association. The community attaches great importance to TCM service ability. On one hand, the community strengthen the construction of the community TCM talent team, on the other hand, the community should provide a good platform for the development of the community TCM. As a result, residents′ sense of identity will be enhanced. Besides, the community should make reasonable pay for TCM staffs and improve the performance appraisal system in medical association in order to improve the satisfaction of community TCM staffs.
2018 Vol. 15 (15): 54-58 [Abstract] ( 282 ) HTML (1 KB)  PDF (543 KB)  ( 78 )
59 Investigation and rationality evaluation of Butyphthalide use in 78 hospitals of 7 cities
WANG Huiyuan ZHAO Zhigang▲
Objective To investigate the current situation and trend of Butyphthalide use in 7 cities of China (Beijing, Hangzhou, Guangzhou, Shanghai, Tianjin, Chengdu and Zhengzhou) and preliminarily evaluate the rationality of its use. Methods Statistical analysis was carried out on the sales amount, defined daily doses and Defined daily dose consumption of Butyphthalide in 78 hospitals of 7 cities from 2013 to 2017. Results In the 5 years, the proportion of male and female patients using Butyphthalide was about 2∶1 in the 7 cities, and their age was mainly between 71-90 years old (41%). The top three primary diagnoses were cerebral infarction (15.5%), cerebrovascular disease (2.4%) and cerebral infarction (1.7%). Drug utilization index (DUI): Beijing > Tianjin > Chengdu > Hangzhou > Shanghai > Guangzhou > Zhengzhou. Defined daily doses (DDDs): Beijing > Hangzhou > Guangzhou > Shanghai > Chengdu > Zhengzhou. Defined daily dose consumption (DDDc): Zhengzhou > Shanghai > Guangzhou > Beijing > Tianjin > Hangzhou. Conclusion Beijing, Hangzhou, Guangzhou and Shanghai are the biggest cities in consuming Butyphthalide. In Zhengzhou, Shanghai and Guangzhou, the price level is the highest and the economic burden is the heaviest. The doctors in Zhengzhou area were too cautious, or the dose was too small, and did not reach the therapeutic effect. The drugs are in accordance with the recommended Chinese guidelines and the most reasonable prescriptions of dosage are in order: Beijing > Tianjin > Chengdu > Hangzhou, and these 4 cities are in good condition.
2018 Vol. 15 (15): 59-64 [Abstract] ( 310 ) HTML (1 KB)  PDF (524 KB)  ( 208 )
65 Performance verification of Mx3000pTM real-time fluorescent quantitative PCR HBV-DNA detection system
WANG Jiao1,2 QIAN Jun1,2 SHI Ying1,2 CAI Wangxi1,2 LIU Guangzhong1,2▲
Objective To verify the performance of Mx3000pTM real-time fluorescent quantitative PCR HBV-DNA detection system, in order to confirm its stability, accuracy and reliability. Methods According to the EP series of document issued by the National Committee for Clinical Laboratory Standards (NCCLS) and requirements for the assessment of laboratory testing systems issued by China National Accreditation Service for Conformity Assessment (CNAS), the precision, accuracy, linear, measurement and/or reportable range and anti-interference ability of Mx3000pTM real-time fluorescent quantitative PCR were performed and evaluated. Results The within-batch precision CV of low value and high value of Mx3000pTM real-time fluorescent quantitative PCR HBV-DNA testing system was 5.21% and 3.40%,respectively, and the between-batch precision CV of middle value and high value was 3.45% and 1.39% respectively. The correctness was valuated by participating in verification of room to judge the qualitative evaluation of the project and PT result was 100%. The linear regression equation was Y = 1.010X +0.004, R2 = 0.991. The linearity range was 5.00×102 - 2.84×108 U/mL, the clinical reportable range was 103 - 108 U/mL; five samples was tested to assess the anti-interference capability, four sample measurement results according to the concentration of expected bias was < ±7.5%. Conclusion The performance of Mx3000pTM real-time fluorescent quantitative PCR HBV-DNA testing system conforms to the requirements in precision, accuracy, linear range, clinical reportable range, anti-interference ability and can be applied to the clinical detection.
2018 Vol. 15 (15): 65-68 [Abstract] ( 331 ) HTML (1 KB)  PDF (379 KB)  ( 56 )
69 Serum hypersensitivity cTnI level and its correlation with kidney related indicators in patients of chronic kidney disease from 3 to 5 stage
WANG Shanzhi1 ZHU Yongjun1 YE Feng2▲ LI Guoquan1 WEI Chuanwa1 HAN Feng2 LIANG Haiqin1 ZHONG Liangbao1
Objective To analyze the level of serum hypersensitive cardiac troponin I (cTnI) in patients of chronic kidney disease (CKD) from 3 to 5 stage without renal replacement therapy. Methods A total of 180 patients of CKD from 3 to 5 stage without renal replacement therapy, severe arrhythmia, acute myocardial infarction and sepsis were selected in the First Affiliated Hospital of Hainan Medical University from January 2016 to November 2017. Then their serum hypersensitivity cTnI were collected, and the correlation between the level of serum hypersensitivity cTnI and glomerular filtration rate (GFR), age, serum creatinine (Scr), blood urea nitrogen (BUN), blood Cystatin-C (CYS-C) and blood albumin (ALB) were analyzed. Results The rank sum test of multiple independent samples showed that the level of serum hypersensitivity cTnI in patients of CKD from 3 to 5 stage without renal replacement therapy was different, and the difference was statistically significant (P ＜ 0.05). Pearson bivariate correlation displayed hypersensitivity cTnI was linearly correlated with CKD staging, GFR and CYS-C (P ＜ 0.05), and was not linearly correlated with Scr, BUN, ALB and age (P ＞ 0.05). The stepwise multiple linear regression analysis showed that the hypersensitive cTnI regression equation was Y = -0.043+0.023X (Y：cTnI，X：CKD3～5). Conclusion The reference value of cTnI in the patients of CKD from 3 to 5 stage can be corrected according to the hypersensitive cTnI regression equation, and then it can be used as a reference for clinical decision of CKD.
2018 Vol. 15 (15): 69-71 [Abstract] ( 232 ) HTML (1 KB)  PDF (401 KB)  ( 84 )
72 The effect comparison of the components of stones analysis and urine physicochemical properties detection-based nursing measurements on patients with urinary stones
LIU Ying XU Hui WANG Zhiyong LIU Xiaowei YANG Dehui
Objective To explore the effect of the components of stones analysis and urine physicochemical properties detection-based nursing measures on patients with urinary stones. Methods A total of 300 patients with urinary stones diagnosed and treated in the Department of Urology, the Affiliated Hospital of Chengde Medical College from December 2013 to December 2015 were selected as the research objects and were divided into the control group, the stones analysis group and the stones analysis with 24 h urine physicochemical analysis group according to the random number table, with 100 patients in each group. The control group was given routine nursing, the stones analysis group was applied the corresponding individualized nursing intervention on the results of the composition analysis of infrared spectrum stones on the based of routine nursing, and the stones analysis with 24 h urine physicochemical analysis group was applied the analysis of the stone components and 24 h urine physicochemical properties detection. The recurrence rate, the recurrence time of urinary tract stones, nursing satisfaction and quality of life were compared among the three groups. Results The recurrence rate in the control group were much higher than those of the stones analysis group and the stones analysis with 24 h urine physicochemical analysis group, the recurrence time in the control group were shorter than those of the other two groups, with statistically significant differences (P ＜ 0.05), but with no statistically significant differences between the stones analysis group and the stones analysis with 24 h urine physicochemical analysis group (P ＞ 0.05). The nursing satisfactory and the life of quality in the two groups were all higher than those of control group, and those in the stones analysis with 24 h urine physicochemical analysis group were all higher than those of stones analysis group, with statistically significant differences (P ＜ 0.05). Conclusion According to the analysis results of infrared spectrophotometry and 24 h urine physicochemical properties detection, the implementation of individualized nursing intervention in patients with urinary tract stones can not only reduce the recurrence rate, extending the recurrence time, but also can improve patients′ nursing satisfaction and promote their life quality. It is worthy of clinical application and popularization.
2018 Vol. 15 (15): 72-75,88 [Abstract] ( 200 ) HTML (1 KB)  PDF (773 KB)  ( 103 )
76 Influence of different types of knee prostheses on limb function recovery after initial unilateral knee replacement
PU Chao1 ZHANG Shanshan2 BAI Yiguang1 LI Wei1▲ WU Qingxia1 WU Hui1
Objective To compare the influence of different types of knee prostheses on limb function recovery after initial unilateral knee replacement. Methods Form January 2014 to June 2016, in Second Clinical College of North Sichuan Medical College, according to different knee prostheses, 350 patients underwent initial unilateral knee replacement in the were divided into group A (rotating platform, 180 cases) and group B (posterior stabilized platform, 170 cases). The American Knee Association (HSS) scores, the world Knee Society Association (KSS) scores, knee flexion (ROM) and static stability indexes were compared in the two groups before operation and after the operation 6 months. The incidence of complications in the two groups was recorded. Results After operation 6 months, HSS scores, KSS scores and ROM significantly increased, the horizontal offset of GCP to GCP and GCP trajectory significantly decreased, the differences were statistically significant (P < 0.05). 6 months after operation, GCP trajectory in group A was significantly shorter than group B, the differences were statistically significant (P < 0.05), but there was no significant difference in other indicators between two groups (P > 0.05). There was no significant difference in the incidence of complications between the two group (P > 0.05). Conclusion Both of rotating platform and posterior stabilized platform prostheses can significantly promote limb function recovery in patients undergoing initial unilateral knee replacement. The complications are similar but the static stability of the former is relatively better.
2018 Vol. 15 (15): 76-79 [Abstract] ( 206 ) HTML (1 KB)  PDF (486 KB)  ( 139 )
80 Arthroscopic radiofrequency lysis for treatment of gluteal muscle contracture
SUN Shengxuan GE Zhou DONG Qirong ZHOU Haibin
Objective To investigate the clinical effect of arthroscopic radiofrequency lysis in the treatment of gluteal muscle contracture. Methods From August 2011 to June 2015, in the Second Affiliated Hospital of Soochow University, the clinical data of 184 patients of gluteal muscle contracture associated with intramuscular injection were retrospectively analyzed, they were divided into the observation group (95 cases) and the control group (89 cases) according to the different operation methods. The observation group was treated with arthroscopic radiofrequency lysis and the control group was treated with conventional open surgery. The average operating time for one side, incision length, the time out of bed and post-operation length of stay were compared between two groups, and the difference of the evaluation of gluteal muscle contracture at the last follow-up was analyzed. Results Ninety-one patients in the observation group were obtained follow-up data with an average of (19.6±3.4) months, while 87 patients in the control group were obtained follow-up data with an average of (17.4±4.1) months. The average operating time for one side, incision length, the time out of bed and post-op length of stay in observation group was shorter than the control group, the differences were statistically significant (P < 0.05). The good to excellent rate of gluteal muscle contracture in the last follow-up in the observation group (92.3%) and the control group (94.3%) were compared, the difference was not statistically significant (P > 0.05). Conclusion Arthroscopic radiofrequency releasing the bands is the first choice for the treatment of gluteal muscle contracture associated with intramuscular injection, which can reduce tissue trauma, the length of incision, result in early time to rehabilitation for good joint function and shorten length of stay in the hospital.
2018 Vol. 15 (15): 80-83 [Abstract] ( 325 ) HTML (1 KB)  PDF (516 KB)  ( 137 )
84 Recent effect of posterior pedicle screw internal fixation combined with injured vertebral bone graft in the treatment of thoracolumbar fracture
QI Tengmin Suonan′angxiu
Objective To investigate the effect of posterior pedicle screw fixation combined with internal bone graft in the treatment of thoracolumbar fracture. Methods From May 2015 to May 2017, 60 patients with thoracolumbar fracture in Department of Orthopedics, Qinghai Province People′s Hospital were selected, they were divided into posterior pedicle screw fixation combined with vertebral bone graft surgical group (study group, n = 30) and posterior vertebral pedicle screw fixation combined with posterolateral bone fusion group (control group, n = 30), according to surgical treatment methods, the vertebral anterior and posterior margin heights, cranial vertebral angle on the edge of the vertical and caudal vertebral edge vertical (Cobb angle), position of the sagittal diameter of the vertebral canal (Worter index), visual analogue scale (VAS) scores, intraoperation and postoperative indexes and clinical efficacy of the two groups were statistically analyzed. Results Compared with the control group, the height of the anterior and posterior margin of the injured vertebra in the study group were significantly higher, and the Cobb angle was significantly lower, the differences were statistically significant (P < 0.05). Compared with the control group, the Worter index and VAS score in the study group were significantly lower, the differences were statistically significant (P < 0.05). The length of incision, analgesic needle application time and hospitalization time, the intraoperative blood loss and postoperative drainage volume were significantly less than the control group, the differences were statistically significant (P < 0.05). The total treatment effective rate of the study group was significantly higher than the control group, the differences were statistically significant (P < 0.05). Conclusion The effect of posterior pedicle screw fixation combined with internal bone graft in the treatment of thoracolumbar fracture is better than posterolateral bone fusion, it can more effectively improve patients′ vertebral anterior and posterior height ratio, decrease patients′ Cobb angle, Worter index, VAS score, length of incision, shorten patients′ pain medication application time, hospitalization time, reduce patients′ intraoperative bleeding, postoperative drainage, improve patients′ total treatment efficiency.
2018 Vol. 15 (15): 84-88 [Abstract] ( 227 ) HTML (1 KB)  PDF (634 KB)  ( 52 )
89 Analysis of HPV infection status of rural females from parts of Jiangsu area
ZHOU Qing JIANG Zhixin WANG Lijuan SHI Hui LIN Ning WU Yulin XU Haoqin
Objective To understand the infection status of human papilloma virus (HPV) of partial rural females in Jiangsu Province in order to prevent and reduce HPV infection and improve female health level. Methods A total of 401 rural women from Tongshan, Sheyang, Taixing, Gaoyou, Xinghua and Suyu from January to May 2015 were selected, and divided into 4 groups, normal/inflammation group, CIN1 group, CIN2 group and CIN3 group respectively. HPV DNA genotypes were detected and analyzed by genetic chip method. Results One hundred and twenty-five samples were found positive of HPV in 387 samples (eligible) among 401 samples. and the positive rate of HPV was 32.30%. The HPV-positive rates in normal/inflammatory, CIN1, CIN2 and CIN3 groups were 32.04%, 25.74%, 35.16% and 36.96% respectively. The total positive rate of high-risk HPV was 23.51%, and those rates in normal/inflammatory, CIN1, CIN2 and CIN3 groups were 18.45%, 19.80%, 28.57% and 28.26% respectively. There was no statistical difference among the 4 groups (P > 0.05). The top three subtypes were HPV16, HPV58 and HPV18. Conclusion The high-risk HPV infection rate of rural females is high. It is important to enhance HPV screening and HPV vaccination to prevent and reduce cervical cancer.
2018 Vol. 15 (15): 89-91 [Abstract] ( 285 ) HTML (1 KB)  PDF (580 KB)  ( 55 )
92 The expression and diagnostic value of CXCL16 in patients with endometriosis
CHEN Huixian1 ZHANG Zhenzhen2 WAN Guiping2▲
Objective To investigate the diagnostic value of human CXC chemokine ligand 16 (CXCL16) in the diagnosis of endometriosis. Methods Forty-seven patients who underwent laparoscopic surgery from January 2016 to December 2017 in Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine were selected, and were divided into observation group with endometriosis (27 cases) and control group without endometriosis (20 cases). All the levels of serum CXCL16 were tested and the receiver operating characteristic curve (ROC curve) was drawn in order to evaluate the diagnostic value. Results The serum CXCL16 levels in observation group were significantly higher than those in control group, the difference was statistically significant (P < 0.05). Patients with different menstrual stages (follicular phase, ovulation phase, luteal phase) was found had no statistically significant difference (P > 0.05). The CXCL16 leves of patients in stage Ⅲ and Ⅳ endometriosis were significantly lower than that in stage Ⅰ (P < 0.05), and had no statistical difference with stage stage Ⅱ patients (P > 0.05). The ROC curve analysis showed that the area under the ROC curve was 0.768, CI:0.63-0.905, and the cutoff value of the highest total of specificity and sensitivity was 0.9750, specificity was 50% and sensitivity was 96.3%. Conclusion The serum CXCL16 is a valuable biomarker and it may provide a simple, non-invasive tool for the diagnosis of endometriosis.
2018 Vol. 15 (15): 92-95 [Abstract] ( 256 ) HTML (1 KB)  PDF (636 KB)  ( 124 )
96 Effects of autologous blood transfusion on maternal coagulation function, hemodynamics and liver and kidney function in Department of Obstetrics
ZHAO Qingzhen1 SUN Jing2 XIONG Xuguang2 HU Chaofeng2 LI Ping3.▲
Objective To investigate the effect of blood transfusion on maternal coagulation function, hemodynamics and liver and kidney function in Department of Obstetrics. Methods A total of 150 patients with major obstetric hemorrhage from April 2015 to May 2016 in the Affiliated Hospital of Ningbo University and the Second Hospital of Yinzhou District of Ningbo City were selected and divided into control group (75 cases) and experimental group (75 cases) by a random number table method. Allogeneic blood transfusions and autologous blood transfusions were applied respectively. The differences of coagulation function (APTT, PT), electrolytes (K, Na, Cl and pH), hemodynamics [mean arterial pressure (MAP), heart rate (HR)] and liver and kidney function [aspartate aminotransferase (AST), alanine aminotransferase (ALT), urine creatinine (Cr), blood urea nitrogen (BUN)] were analyzed between the two groups before and after transfusion. Results Compared with pretransfusion, the levels of PT, APTT, serum potassium, sodium, chloride, pH, MAP, and HR were significantly changed in the two groups after transfusion, and the differences were statistically significant (P < 0.05). There was no significant change in the levels of AST, ALT, Cr and BUN before and after the study (P > 0.05). Compared with the experimental group, the levels of PT, APTT, serum chloride, pH, MAP and HR in the control group were changed more obviously, and the differences were statistically significant (P < 0.05). Conclusion Autologous blood transfusion is more safer and effective in patients with obstetric hemorrhage, and it is worthy of being widely used in clinical practice.
2018 Vol. 15 (15): 96-99 [Abstract] ( 237 ) HTML (1 KB)  PDF (589 KB)  ( 190 )
100 Screening results of human papillomavirus in asymptomatic women of childbearing age and analysis of risk factors for infection
ZHU Li LIU Qin
Objective To investigate the screening results of human papillomavirus (HPV) in asymptomatic women of childbearing age and the risk factors of infection. Methods A total of 924 asymptomatic women of childbearing age from June to December 2017 in Huizhou Maternal and Child Health and Family Planning Service Center were selected. All subjects were investigated for general condition and HPV infection. Results among 924 subjects, 112 cases were positive for HPV infection and 172 HPV subtypes were infected. The positive rate was 12.12%. Univariate analysis showed that age, smoking history, drinking history, times of pregnancy were not influencing factors of HPV infection (P > 0.05). The education, time of first sexual life, history of abortion, parity, contraceptive method, number of sexual partners, frequency of sexual life, prepuce length of sexual partners were the influencing factors of HPV infection in women of childbearing age (P < 0.05). The results of multivariate Logistic analysis showed that the number of sexual partners was more than 2 (OR=3.902, 95%CI: 1.744-12.690, P < 0.01）, long prepuce of sexual partners (OR=2.770, 95%CI: 1.410-6.472, P < 0.01) were an independent risk factor for HPV infection in women of childbearing age. Condom contraception was the protective factor of HPV infection in women of childbearing age (OR=0.627, 95%CI: 0.389-0.856, P < 0.01). Conclusion There is no symptomatic childbearing age in this area. The infection rate of HPV52, HPV16, HPV58 is a common high risk subtype of HPV58, and the number of sexual partners is more than 2. Sexual partners with long foreskin were independent risk factors for HPV infection in women of childbearing age, condom contraception was the protective factor of HPV infection in women of childbearing age, and clinical monitoring should be strengthened for women with risk factors.
2018 Vol. 15 (15): 100-103 [Abstract] ( 231 ) HTML (1 KB)  PDF (615 KB)  ( 105 )
104 The optimum value of weigh gain during pregnancy for the maternal with different pre-pregnant body mass index and the prediction value of the macrosomia
LIU Xiaofang1 YANG Bo1 YANG Biying1 LUO Miaoqing1 WANG Xu2 CHEN Fenghua3
Objective To research the suitable pregnancy weight gain value of the maternal with different pre-pregnancy body mass index (BMI), predict the appearence probability of the macrosomia using the suitable pregnancy weight gain value. Methods From January 2016 to December 2016, 500 cases of maternal who gave birth in Huadu District People's Hospital of Guangzhou were recruited into this study. According to the pre-pregnancy body mass index, these maternal were divided into low BMI group (group A, 149 cases, BMI<18.5 kg/m2), normal BMI group (group B, 225 cases, 18.5 kg/m2≤BMI<25.0 kg/m2) and high BMI group (group C, 126 cases, BMI≥25.0 kg/m2). The incidence of macrosomia in three groups was counted. The relationship between macrosomia incidence and weight gain during pregnancy was investigated. The consistency of the suitable pregnancy weight gain value and the IOM recommendation value about the three groups was observed. The occurrence of macrosomia was predicted by using the suitable pregnancy weight gain value. Results The suitable pregnancy weight gain value of group A and C had the same value with the value recommended by IOM, was 12.5-18.0 kg and 7.0-11.5 kg respectively. The suitable pregnancy weight gain value of group B was different with the IOM recommended value. The suitable pregnancy weight gain value for the group B was 10.5-15.0 kg. The area under the ROC curve was 0.693, 0.719 and 0.690 respectively. The positive predictive value was 70.73%, 58.62% and 59.02%. The negative predictive value was 73.42%, 74.19% and 76.27% respectively. Conclusion The IOM recommended pregnancy weight gain value is not suitable for the maternal in our region. Based on the characteristics of maternal physical modernised in the added value of pregnancy weight can better predict the occurrence of macrosomia and reduce the incidence of adverse birth outcomes.
2018 Vol. 15 (15): 104-107 [Abstract] ( 167 ) HTML (1 KB)  PDF (632 KB)  ( 88 )
108 Effects comparison between the uterine arterial occlusion and preoperative application of small dosage of Triptorelin in laparoscopic resection of adenomyosis
GUO Hong1 WU Jun2 XU Mengjiao1 ZHANG Lina1 WANG Jianjun1 TONG Xiaowen1▲
Objective To analyze the difference of the clinical effects of laparoscopic adenomyosis resection combined with small-dose Triptorelin injected subcutaneously before operation and intraoperative uterine artery occlusion. Methods From January 2014 to October 2016, patients with adenomyosis who underwent laparoscopic resection in Tongji Hospital, Tongji University were divided into two groups according to intraoperative uterine artery ligation (group A, n = 40) and preoperative use of small-dose Triptorelin group B, n=30), and then the differences of surgery time, blood loss in surgery, intestinal function, postoperative complications, length of stay, hemoglobin change of preoperative and postoperative, potassium concentration of postoperative and hospitalization costs were compared between the two groups. Results There were no significant differences in length of stay, potassium concentration of postoperation and hemoglobin concentration of preoperation and postoperation between the two groups (P > 0.05). Compared with group A, the surgery time was shorter, intraoperative blood loss was less, and recovery time of intestinal function was shorter in group B, but the hospitalization costs was higher, the differences were all statistically significant (P < 0.05). Conclusion Compared with laparoscopic uterine resection combined with intraoperative uterine artery occlusion, preoperative use of small-dose Triptorelin has shorter surgery time, faster recovery of intestinal function, relatively smaller amount of bleeding, and is safer and more effective, so it is worthy of clinical application.
2018 Vol. 15 (15): 108-110,138 [Abstract] ( 199 ) HTML (1 KB)  PDF (1003 KB)  ( 191 )
111 The effect of prenatal education combined with nutrition intervention on maternal and infant weight and immune function in patients with gestational diabetes mellitus
ZHU Ya WANG Jianqing XUE Jingling
Objective To investigate the effect of prenatal education combine nutrition intervention on maternal and infant weight and immune function in patients with gestational diabetes mellitus. Methods From March 2013 to March 2017, 96 cases of gestational diabetes patients diagnosed in the Fourth Affiliated Hospital of Nantong University were randomly divided into control group (46 cases) and observation group (50 cases). The control group was given routine examination and routine health education. The observation group was given comprehensive prenatal education combine nutrition intervention besides routine examinations and health education. Maternal weight gain, immune function and neonatal weight were compared between the two groups. Results Maternal weight gain in observation group was (13.7±2.4) kg, significantly lower than that in control group [(17.1±2.7) kg], and the difference was statistically significant (P < 0.05). Neonatal weight in observation group was (3.21±0.71) kg, which was obviously lower than that in control group [(3.85±0.83) kg], and the difference was statistically significant (P < 0.05). At the end of pregnancy, levels of CD3+, CD4+ and CD4+/CD8+ in observation group were significantly higher than those in control group, while CD8+ was significantly lower than control group, and the differences were all statistically significant (P < 0.05). Conclusion Prenatal education combined nutritional intervention have significant effect on maternal weight gain and neonatal weight, and it could effectively improve the immune function in patients with gestational diabetes mellitus.
2018 Vol. 15 (15): 111-114 [Abstract] ( 261 ) HTML (1 KB)  PDF (622 KB)  ( 94 )
115 A study on changes in corneal refractive and corneal surface regularity before and after pterygium excision surgery
TAO Lihui1,2 YANG Weihua1▲
Objective To assess the corneal refractive and corneal surface regularity changes before and after pterygium excision surgery. Methods A total of 126 clinical data of patients with pterygium who received surgery in the First Affiliated Hospital of Huzhou University from March 2016 to June 2017 were analyzed retrospectively and were divided into three groups according to the position of the advancing pterygium edge with respect to corneal diameter: less than one third of corneal diameter (group Ⅰ, 50 cases, 50 eyes), between one third of corneal diameter and the pupil (group Ⅱ, 46 cases, 46 eyes) and within the pupillary area (group Ⅲ, 30 cases, 30 eyes). Average corneal power (ACP), corneal astigmatism (CA), surface regularity index (SRI) and surface asymmetry index (SAI) were analyzed by topographic modeling system using one-way analysis of variance (ANOVA). Statistical analysis of ACP, CA, SRI and SAI were done by corneal topography before, 3 months and 6 months after pterygium excision surgery using one-way analysis of variance (ANOVA). Results With the increase in the grades of pterygium, CA, SRI and SAI were increased, ACP was decreased. ANOVA showed that there were highly statistically significant differences in CA, SRI, SAI and ACP among the three groups (all P ＜ 0.01). CA, SRI and SAI in group Ⅱ and group Ⅲ were all higher than those of group Ⅰ, group Ⅲ was higher than that of group Ⅱ, with statistically significant differences (all P ＜ 0.05). ACP in group Ⅲ were lower than those of group Ⅰ and group Ⅱ, with statistically significant differences (P ＜ 0.05), but there was no statistically significant difference between group Ⅰ and group Ⅱ(P ＞ 0.05). ANOVA showed that there were highly statistically significant differences in CA, SRI, SAI and ACP before operation, 3 month and 6 month after operation (all P ＜ 0.01). After operation of 3 month and 6 month, CA, SRI and SAI were significantly lower than those before operation, ACP was higher than that of before operation, with statistically significant differences (all P ＜ 0.01); there were no statistically significant differences in CA, SRI, SAI and ACP between 3 month and 6 month after operation ( all P ＞ 0.05). Conclusion The topographic indices of ACP, CA, SRI and SAI are associated with pterygium size. With increasing size of pterygium, CA, SRI and SAI were increased, ACP was decreased. The regularity of corneal surface can be improved and CA can be reduced after pterygium excision surgery.
2018 Vol. 15 (15): 115-118 [Abstract] ( 219 ) HTML (1 KB)  PDF (401 KB)  ( 75 )
119 Changes and significance of serum sVCAM-1 level in patients with sudden deafness
YANG Ming FU Feida ZHU Xiaoyan
Objective To explore the expression of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and its clinical significance. Methods A total of 97 patients with sudden deafness admitted to Nanjing Integrated Traditional Chinese and Western Medicine Hospital from January 2016 to June 2017 were selected as the case group, 60 healthy subjects were randomly selected as the control group at the same period. The serum sVCAM-1 level in the two groups was measured by the enzyme-linked immunosorbent assay, in addition, the relationship between sVCAM-1 with patients' demographic data and the diagnostic value of sVCAM-1 for sudden deafness were analyzed. Results The serum sVCAM-1 level in the case group was higher than that of control group, with statistically significant difference (P ＜ 0.05). The sVCAM-1 level of patients at the age≥45 was higher than the age＜45, and sVCAM-1 level in patients with severe hearing loss was more higher, and sVCAM-1 level in patients with total deafness type was more higher than those in other types, sVCAM-1 level of patients with upper respiratory tract infection and cardiovascular complications were more higher, with statistically significant differences (P ＜ 0.05). The ROC area of sVCAM-1 in the diagnosis of sudden deafness was 0.904 (95%CI：0.841-0.967), the sensitivity was 76.5% and the specificity was 91.8%, the best truncation value of sVCAM-1 at this time was 579.23 ng/mL. Conclusion The serum sVCAM-1 in patients with sudden deafness is significantly elevated, which is closely related to age, hearing loss, hearing curve, upper respiratory tract infection and cerebrovascular complications. Early detection can effectively predict the occurrence of sudden deafness.
2018 Vol. 15 (15): 119-122 [Abstract] ( 213 ) HTML (1 KB)  PDF (426 KB)  ( 97 )
123 Clinical efficacy of Butylphthalide combined with Sodium Ozagrel in treating acute severe cerebral infarction  
WANG Yanru ZHOU Guoliang▲ ZHANG Yuechan BAI Fengying SONG Guijü
Objective To investigate the clinical efficacy of Butylphthalide combined with Sodium Ozagrel in the treatment of acute severe cerebral infarction. Methods In this study, 204 patients with acute severe cerebral infarction treated in the Jizhou District Hospital from January 2014 to January 2016 were analyzed retrospectively. They were divided into observation group (120 cases) and control group (84 cases) according to clinical treatment methods. Patients in the control group were treated with basic treatment combined with Sodium Ozagrel, while patients in the observation group were treated with Butylphthalide based on the control group. They were treated for 1 week. The serum cholinesterase (CHE), interleukin-6 (IL-6) and the rate of ECG change before and after treatment were observed. The national institutes of health (NIHSS) score and Glasgow coma (GCS) were wsed to compare the clinical efficacy of the two groups. Results After treatment, the GCS scores and CHE levels were increased (P < 0.05), NIHSS scores and the IL-6 levels were decreased (P < 0.05), while the improvement of the observation group was more remarkable than control group (P < 0.05). Besides, the rate of abnormal ECG change was lower than that of the control group (P < 0.05). Conclusion The combination of Butyphthalide and Sodium Ozagrel in treating acute severe cerebral infarction can effectively increase the serum cholinesterase level, down-regulate the level of IL-6, reduce the incidence of ECG abnormalities and improve the curative effect of neurological deficits.
2018 Vol. 15 (15): 123-126 [Abstract] ( 200 ) HTML (1 KB)  PDF (408 KB)  ( 94 )
127 Influence of Xueshuantong Injection on serum IL-6 and MMP-2 in patients with unstable angina pectoris
WANG Tairan1 MA Wei2
Objective To observe the effect of Xueshuantong Injection on soluble interlekin-6 (IL-6) and matrix metalloproteinase-2 (MMP-9) in patients with unstable angina pectoris and its potential mechanism. Methods From January 2017 to October 2017, 120 patients treated in the Department of Cardiology, Handan Central Hospital were divided into control group (n=60) and treatment group (n=60) by random number table. Patients in the control group were treated with routine treatment, and the patients in the treatment group were treated with Xueshuantong Injection based on the control group, they were treated for 14 days. The effects of unstable angina pectoris and electrocardiogram curative were observed． The levels of serum IL-6 and MMP-2 were measured before and after treatment. Results After treatment, the effects of unstable angina pectoris and electrocardiogram curative in the treatment group were significantly higher than those in the control group (P ＜ 0.05). The levels of serum IL-6 and MMP-2 in the two groups were significantly lower than before treatment (P ＜ 0.05). The levels of serum IL-6 and MMP-2 in the treatment group were lower than those in the control group after treatment (P ＜ 0.05). Conclusion Xueshuantong Injection has effect in patients with unstable angina pectoris, which can reduce the levels of serum IL-6 and MMP-2, and inhibit inflammatory reaction.
2018 Vol. 15 (15): 127-130 [Abstract] ( 235 ) HTML (1 KB)  PDF (440 KB)  ( 56 )
131 Study on the implementation path of “individualized” teaching reform of “five-in-one” in the traditional health-care P.E. course of universities of Chinese medicine
LIU Jiali WANG Bin
Shanghai University of Traditional Chinese Medicine is a pilot unit of “individualized” teaching reform of public sports in the first batch of universities in Shanghai. The basic aim of the physical education in Shanghai University of Traditional Chinese Medicine is to improve the students' physical and mental health. Combined with the advantages of universities of Chinese medicine, characterized by carrying forward Chinese traditional culture, Shanghai University of Traditional Chinese Medicine develops the path of “individualized” teaching reform of university public sports, and build “individualized” physical education curriculum system in the universities of Chinese medicine. This paper systematically summarizes the implementation path of “individualized” teaching reform of public sports courses, which are carrying out specialist classroom teaching, increasing students' extracurricular activities, cultivating interest in sport activities, showing students' style in competitions, inheriting the national spirit of sports culture, the “five-in-one” concrete practice path provides a feasible reference for other universities to carry out physical education reform.
2018 Vol. 15 (15): 131-134 [Abstract] ( 181 ) HTML (1 KB)  PDF (591 KB)  ( 109 )
135 Clinical study of “Tongyuan needling technique” for essential hypertension
ZHENG Jie1 LAI Xinsheng2 LIN Shaozhen1 WU Peilong2
Objective To observe the efficacy and safety of Tongyuan needling technique in the treatment of essential hypertension. Methods Sixty cases of patients with essential hypertension treated in Department of Acupuncture and Moxibustion, Guangzhou Hospital of Traditional Chinese Medicine and the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from August 2015 to December 2017 were selected, and they were divided into observation group (30 cases) and control group (30 cases) by random number table method. The observation group was treated with Tongyuan needling technique, twice a week, for 8 weeks; the control group was treated with oral Nifedipine Controlled Released Tablets 30 mg, once a day, for 8 weeks. The clinical blood pressure and adverse reactions of the two groups were recorded. Results The systolic and diastolic blood pressures of the two groups were all significantly lower than those before treatment (P ＜ 0.05), but the systolic and diastolic blood pressures after treatment between the two groups had no statistically significant difference (P ＞ 0.05). The total effective rate of observation group and control group was 96.67% and 86.67% respectively, with no statistically significant difference between the two groups (P ＞ 0.05). The incidence of adverse reactions in the observation group and the control group was 3.3% and 23.33% respectively, there was a significant difference (P ＜ 0.05). Conclusion Tongyuan needling technique in the treatment of essential hypertension is effective, with few adverse reactions and high security.
2018 Vol. 15 (15): 135-138 [Abstract] ( 238 ) HTML (1 KB)  PDF (624 KB)  ( 111 )
139 Analysis on the hot topics and developing trend of Chimonanthus nitens based on mapping of science
ZHANG Xiaoqin LAN Yan HUANG Xiaoyan CHEN Liping
Objective To explore and uncover the hot topics and developing trend of Chimonanthus nitens. Methods The related articles about Chimonanthus nitens published in CNKI from January 1, 1996 to September 30, 2017 were retrieved. Excel and SPSS were used for descriptive analysis, and the CiteSpace was used to draw the knowledge maping and take co-occurrence and clustering analysis of key words. Results The time from 2005 to 2016 was the fast development period of researches about Chimonanthus nitens. The author, Liu Zhongda, had posted the most papers about Chimonanthus nitens and the organization that published the most articles was Lishui Hospital of Traditional Chinese Medicine. The hot topic was chemical compositions of Chimonanthus nitens. Research trends were the researches of chemical compositions, traditional She Medicine, conservation of resources and genetic diversity. Conclusion Analysis on the hot topics and tendency of Chimonanthus nitens will provide a certain reference for its further development and utilization.
2018 Vol. 15 (15): 139-142 [Abstract] ( 271 ) HTML (1 KB)  PDF (913 KB)  ( 115 )
143 Application of twenty-four solar terms therapy in chronic disease management of chronic obstructive pulmonary disease
WANG Jialing1 LIU Wenwen1 ZHENG Yanchan1 XU Yinji2▲
Chronic obstructive pulmonary disease has relationship with five zang viscera, and acute exacerbation is clearly relevant to climates. According to the theory of six climatic factors, the twenty-four solar terms can be divided into six stages. During the first stage, the time of wind wood of jueyin, the patients can be easily affected by the over uprising of liver qi, so it is necessary to strengthen the regulation of qi movement of liver and lung. While in the second stage, the time of sovereign fire of shaoyin, the heart qi is getting hotter, the patients who have developed into pulmonary heart disease should strengthen the therapy of nourishing heart. In the third stage, the time of shaoyang assistant fire, summerheat dampness is striking, and the patients with chronic obstructive pulmonary disease are easily attacked by summerheat dampness, thus it is necessary to strengthen the therapy of clearing heat and eliminating dampness. In the fourth stage, the time of wet earth of taiyin, the spleen was disturbed by dampness pathogen, the patients with deficiency of both lung and spleen should nourish spleen based on syndrome differentiation. In the fifth stage, the time of dry gold of yangming, the main manifestation is lung dryness, so it is necessary to strengthen the therapy of clearing lung-heat and moistening dryness. In the sixth stage, the time of cold water of taiyang, the kidney begins to accumulate the needed essence, the patients with deficiency of both lung and kidney can invigorate lung and kidney based on syndrome differentiation. The chronic management of combining medicine and daily aftercare can achieve the purpose of improving the quality of life and prognosis of patients with chronic obstructive pulmonary disease.
2018 Vol. 15 (15): 143-146 [Abstract] ( 159 ) HTML (1 KB)  PDF (591 KB)  ( 177 )
147 Analysis of the causes of treatment failure and corresponding strategies of needle knife in treating stenosing tenosynovitis
HU Xianglin1 ZHANG Chang2 GUO Wenxin1
Stenosing tenosynovitis is a clinical common and frequently-occurring disease. Needle knife is extensively used in treating stenosing tenosynovitis and the clinical effect is approved, while there are still some reports about failure treatment of needle knife. Aiming at common treatment failure phenomenons, such as snapping sound of joint after treatment, hematoma, numbness, scleroma, weakness of muscle-tendon or inhibited bending and stretching, this paper puts forward some coping strategies, such as familiar with anatomy, accurate positioning, dynamic positioning, ultrasound guidance, grasp of dissection degree, timely functional training after operation, rational use of hormone drugs, and so on.
2018 Vol. 15 (15): 147-149 [Abstract] ( 205 ) HTML (1 KB)  PDF (449 KB)  ( 41 )
150 Research progress of acupotomy in treating cervicogenic headache based on anatomical structure
SHEN Yifeng ZHOU Qiaoyin LI Shiliang▲
Acupotomy treatment in cervicogenic headache is mainly using needle knife to prick and cut the muscles, fascia, and facet joints of the cervical occipital region, so as to release the nerves entrapment. This article summarizes the anatomical basis and application status of acupotomy treatment in cervicogenic headache, analyzes the problems from anatomical structure and pathogenesis, and summarizes common operation and target of treatmentarticle, aims to provide a reference for the surgical procedure and improve safety of acupotomy treatment in cervicogenic headache.
2018 Vol. 15 (15): 150-153 [Abstract] ( 200 ) HTML (1 KB)  PDF (421 KB)  ( 114 )
154 A case of severe chronic renal tubular-interstitial injury induced by Cyclosporin A
WU Huiyi1 PAN Yuhua2 LAO Haiyan2
One patient with membranous nephropathy used Cyclosporin A and low dose of glucocorticoid for treatment, after continuous medication, the patient′s serum creatinine and blood pressure progressively increased. The pathological changes after repeated kidney biopsy suggested the phase Ⅲ membranous nephropathy associated with severe chronic renal tubular-interstitial injury. In combination with medical history, clinical manifestations, laboratory and pathological examination, excluding other factors, Cyclosporin A is considered to be the main contributor to irreversible chronic renal tubule-interstitial injury. By analyzing and summarizing of the case, chronic renal toxicity is the obvious side effect of Cyclosporin A. Although the renal toxicity depends on the dose or concentration of Cyclosporin A, it can still happen when the plasma concentration in the normal range of treatment. Therefore, clinicians should attach great importance to the use of Cyclosporin A, fully grasp its relevant knowledge, prevent early and interfere timely to Cyclosporin A related nephrotoxicity, reducing the risk and harm.
2018 Vol. 15 (15): 154-157 [Abstract] ( 233 ) HTML (1 KB)  PDF (597 KB)  ( 87 )
158 Exploration of development strategy of hospital preparations in hospital based on SWOT analysis
WANG Chenguang LIU Xiaoliang ZHAO Huaping CAO Guoying▲
Beijing Hospital (“our hospital” for short) preparations has a long history. Our staff and resources are well-configured and the management system is scientific and efficient. We have always strictly implemented the GPP for production, testing, storage and distribution. The preparation varieties are consistent with the medical characteristics of our hospital and it is well known in Beijing. The downside is that the hardware conditions limit the expansion of production, so it can not suit the clinical needs. And we are week in the new formulation development technology. For a long time the pricing is too low, so we suffered heavy losses. Using SWOT method to analyze the development trend of the preparation in our hospital, combined with current situation of hospital preparations and the new healthcare reform to explore the development strategy of hospital preparations, increase R&D investment, expand production, strengthen the introduction of qualified personnel, develop new varieties to better adapt to academic development and clinical needs.
2018 Vol. 15 (15): 158-161 [Abstract] ( 186 ) HTML (1 KB)  PDF (613 KB)  ( 56 )
162 Analysis about use of glucocorticoid drug in inpatients of our hospital in 2017
LI Jia1 JIANG Li2 LI Rubing2
Objective To investigate the application of glucocorticoid drugs with the existing problems in Guangzhou General Hospital of Guangzhou Military Command ("our hospital" for short), in order to provide a reference for the clinical use of glucocorticoid drugs. Methods 1200 inpatient glucocorticoid prescriptions were randomly selected from January to December in 2017, the using type and the medication of the glucocorticoid drugs were counted, and the unreasonable prescriptions were analyzed. Results 6 kinds of glucocorticoid drugs were used in the 1200 inpatient glucocorticoid prescriptions, including 1 injection, 3 kinds of troche, 1 powder-injection and 1 inhalation, the most commonly used drug were Dexamethasone Sodium Phosphate (71.42%) and Prednnisone Acetate (19.50%). According to the comment of prescriptions, 213 irrational prescriptions amounted to 17.79% among 1200 prescriptions, the inappropriate indications amounted to 45.07% and the inappropriate usage amounted to 23.32%. Conclusion The monitoring and management about the rational use of glucocorticoid drugs should be strengthened in order to reduce the incidence of adverse reactions, and promote the rational use of clinic.
2018 Vol. 15 (15): 162-164,173 [Abstract] ( 229 ) HTML (1 KB)  PDF (660 KB)  ( 165 )
165 Study on relationship between subjective well-being and social support of family members of Alzheimer's disease patients
LIU Jianrong1 ZHANG Shanshan2 YANG Zhenyun2 LI li'na2▲
Objective To explore the relationship between subjective well-being and social support of family members of patients with Alzheimer's disease (AD), and provide the oretical basis for relevant studies of family members of AD patients. Methods From Februry to June 2016, the families of 200 AD patients from Changping District Hospitals of Traditional Chinese And Western Medicine, Department of Geriatrics of Tangshan Gongren Hospital, Fuming Pension Service Center, Qiaotun Pension Service Center were  given questionnaire survey, and the data were given correlation analysis. Results ① The satisfied and interested in life, health concerns, energy, depression or pleasant mood, control of emotion or behavior, subjective support, objective support, utilization factor of suppor, total score of happiness, total score of social support of families of AD patients with different relationship with patients were compared, the differences were statistically significant (P < 0.05). ②The satisfied-and interested in life, health concerns, energy, epressionor pleasant mood, control of emotion or behavior, relaxation and tension, subjective support, objective support, utilization factor of support, total score of happiness, total score of social support in families of AD patients with different family compeer average income per month were compared, the differences were statistically significant (P < 0.05). ③The satisfied and interested in life, depression or pleasant mood, control of emotion or behavior, relaxation and tension, subjective support, objective support, the utilization factor of support, total score, social support total score families of AD patients with different understanding of the disease, the differences were statistically significant (P < 0.01). ④Social support scores and total scores of objective social support scores and well-being, satisfaction of life and interests, concerns about health, energy, depression or happy state of mind, control of the emotional or behavioral, relaxation and stress has significant positive correlation (r > 0, P < 0.05); the subjective social support was positively correlated with the score of all factors other than the control factor of emotion or behavior (r > 0, P < 0.05); there was a significant positive correlation between the use of support and the total score of happiness and all factors other than health concerns (r > 0, P < 0.05). ⑤Social support has a significant predictive effect on the subjective well-being of family members of AD patients (P < 0.05). Conclusion The subjective well-being and social support level of the family members of AD patients are affected by the relationship with the patients, the monthly income of the family and the degree of understanding of the disease. The strength of social support is stronger, the subjective well-being of families of AD patients is higher.
2018 Vol. 15 (15): 165-168 [Abstract] ( 204 ) HTML (1 KB)  PDF (660 KB)  ( 73 )
169 Application effect of flipped classroom teaching method combined with PACS system on the master degree candidates′ neurosurgical internship training
MIN Xiaoli1,2 HE Guoxiang3 LV Hongling2 LI Xiaoyan2 CAO Yi1
Objective To discuss the application effect of flipped classroom teaching method combined with PACS system on the master degree candidates′ neurosurgical internship training. Methods A total of 119 clinical master degree candidates in the First Affiliated Hospital of Yunnan University of traditional Chinese Medicine who were trained in neurosurgery from September 2015 to September 2017 were selected. They were divided into observation group (58 cases) and control group (61 cases) by random numbers table method. The observation group adopted the flipped classroom teaching method combined with PACS system (image storage and transmission system), while the control group adopted the traditional teaching method mainly based on interpretation of teachers. At the end of internship the teaching effect was evaluated by examination scores and questionnaires. Results The examination scores of observation group were significantly higher than that of control group (P < 0.05). Learning interest, internship participation degree, and the abilities including autonomous learning, information acquisition, clinical thinking and clinical practicing in observation group were also significantly improved, compared with control group (P < 0.05). However, there was no significant difference between the two groups  in the learning efficiency improved (P > 0.05). Conclusion The teaching model of flipping classroom based on PACS system can fully motivate master degree candidates to study independently and improve the clinical practice teaching effect on neurosurgery.
2018 Vol. 15 (15): 169-173 [Abstract] ( 151 ) HTML (1 KB)  PDF (659 KB)  ( 104 )
174 Innovative strategies of enhancing teaching effect on medical rescue of nuclear emergency and its implementation
WANG Aiping LI Rong SHI Chunmeng WANG Junping RAN Xinze XU Hui SU Yongping CHENG Tianming
Objective To explore the effect of novel strategies composed of perfect teaching content, excellent teachers and better teaching methods on improving the teaching quality of medical rescue of nuclear emergency. Methods From March 1st to July 30th, 2016, 150 clinical-medicine students at Grade 2012 from Third Military Medical University were divided into control group (n = 72) and experiment group (n = 78) by random number table method. The traditional-teaching methods and the innovative strategies were respectively applied to control group and experiment group to learn emergency medical rescue of nuclear radiation. Score statistics of closed-paper examination and practice-training evaluation were used to analyze teaching effect. Results Compared with those of control group, the theoretical written-test scores in personal protection, on-site rescue process & technical specification and total scores of experiment group were significantly high, the differences were statistically significant (P < 0.05). Also, the experiment group students′ scores on field radiation prection, first aid on the spot, decontamination & washing and total practice essessment were obviously higher than those of control group students, the differences were statistically significant (P < 0.05). Conclusion The innovative strategies, with characteristics of perfect teaching-learning content habouring theory and pactice, excellent teachers and comprehensive application of teaching-learning methods, can effectively upgrade students′ learning ability to master nuclear emergency rescue theory, enhance their operational competence in medical rescue, and improve the teaching-learning quality of medical rescue of nuclear emergency.
2018 Vol. 15 (15): 174-177,181 [Abstract] ( 184 ) HTML (1 KB)  PDF (817 KB)  ( 327 )
178 Analysis on the risk factors and anti-infective treatment of stroke-associated pneumonia in NICU in our hospital
CHOU Xiaohua1 GAO Xing1 LIU Tianya1 WANG Fengzhen1 HAN Qiang1 ZHANG Xiancheng2
Objective To analyze the risk factors and pathogens characteristics of stroke-associated pneumonia in neurological intensive care unit (NICU) of Affiliated Hospital of Xuzhou Medical University ("our hospital" for short), so as to provide evidence for antimicrobial drug choice. Methods Clinical data of 154 patients with stroke from January 2016 to June 2017 in our hospital. The multivariate Logistic regression analysis was used to analyze the risk factors of stroke-associated pneumonia, and the main pathogenic bacteria and drug resistance statistically. It was studied that how to carry out effective anti-infective therapy on the main pathogens. Results Multivariate regression analysis showed significant differences (P ＜ 0.05) in several factors such as age≥65 years, diabetes, dysphagia, hyperglycemia，hypoproteinemia，and high leukocyte count. The main pathogens were G- bacteria 59.09% in proportion, the top three major pathogens were Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. The main pathogens showed severe multidrug resistance. G- bacteria were more sensitive to Tigecycline, Amikacin and so on. Staphylococcus aureus was more sensitive to Vancomycin, Linezolid, Tigecycline, Amikacin and Cotrimoxazole. Conclusion Risk factors of stroke-associated pneumonia in NICU of our hospital include advanced age, diabetes, dysphagia, hyperglycemia, hypoproteinemia, and high leukocyte count, etc. G- bacteria were the main pathogens. The main pathogens show severe multidrug resistance. Amikacin, Tigecycline can be used as the preferred antibacterial drugs, MRSA infection can also choose Vancomycin, Linezolid and other antibacterial drugs.
2018 Vol. 15 (15): 178-181 [Abstract] ( 221 ) HTML (1 KB)  PDF (782 KB)  ( 61 )
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