子宫内膜异位患者CXCL16的表达情况及诊断价值

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Abstract Objective To investigate the diagnostic value of human CXC chemokine ligand 16 (CXCL16) in the diagnosis of endometriosis. Methods Forty-seven patients who underwent laparoscopic surgery from January 2016 to December 2017 in Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine were selected, and were divided into observation group with endometriosis (27 cases) and control group without endometriosis (20 cases). All the levels of serum CXCL16 were tested and the receiver operating characteristic curve (ROC curve) was drawn in order to evaluate the diagnostic value. Results The serum CXCL16 levels in observation group were significantly higher than those in control group, the difference was statistically significant (P < 0.05). Patients with different menstrual stages (follicular phase, ovulation phase, luteal phase) was found had no statistically significant difference (P > 0.05). The CXCL16 leves of patients in stage Ⅲ and Ⅳ endometriosis were significantly lower than that in stage Ⅰ (P < 0.05), and had no statistical difference with stage stage Ⅱ patients (P > 0.05). The ROC curve analysis showed that the area under the ROC curve was 0.768, CI:0.63-0.905, and the cutoff value of the highest total of specificity and sensitivity was 0.9750, specificity was 50% and sensitivity was 96.3%. Conclusion The serum CXCL16 is a valuable biomarker and it may provide a simple, non-invasive tool for the diagnosis of endometriosis.

Key words： Endometriosis Human CXC chemokine ligand 16 IL-8 CAM

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	CHEN Huixian1 ZHANG Zhenzhen2 WAN Guiping2▲

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CHEN Huixian1 ZHANG Zhenzhen2 WAN Guiping2▲. The expression and diagnostic value of CXCL16 in patients with endometriosis[J]. 中国医药导报, 2018, 15(15): 92-95.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I15/92

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