血栓通注射液对不稳定性心绞痛患者血清IL-6及MMP-2的影响

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Abstract Objective To observe the effect of Xueshuantong Injection on soluble interlekin-6 (IL-6) and matrix metalloproteinase-2 (MMP-9) in patients with unstable angina pectoris and its potential mechanism. Methods From January 2017 to October 2017, 120 patients treated in the Department of Cardiology, Handan Central Hospital were divided into control group (n=60) and treatment group (n=60) by random number table. Patients in the control group were treated with routine treatment, and the patients in the treatment group were treated with Xueshuantong Injection based on the control group, they were treated for 14 days. The effects of unstable angina pectoris and electrocardiogram curative were observed． The levels of serum IL-6 and MMP-2 were measured before and after treatment. Results After treatment, the effects of unstable angina pectoris and electrocardiogram curative in the treatment group were significantly higher than those in the control group (P ＜ 0.05). The levels of serum IL-6 and MMP-2 in the two groups were significantly lower than before treatment (P ＜ 0.05). The levels of serum IL-6 and MMP-2 in the treatment group were lower than those in the control group after treatment (P ＜ 0.05). Conclusion Xueshuantong Injection has effect in patients with unstable angina pectoris, which can reduce the levels of serum IL-6 and MMP-2, and inhibit inflammatory reaction.

Key words： Unstable angina pectoris Xueshuantong Injection Interlekin-6 Matrix metalloproteinase-2

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	WANG Tairan1 MA Wei2

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WANG Tairan1 MA Wei2. Influence of Xueshuantong Injection on serum IL-6 and MMP-2 in patients with unstable angina pectoris[J]. 中国医药导报, 2018, 15(15): 127-130.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I15/127

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