孕期教育联合营养干预对妊娠期糖尿病患者母婴体重及免疫功能的影响

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Abstract Objective To investigate the effect of prenatal education combine nutrition intervention on maternal and infant weight and immune function in patients with gestational diabetes mellitus. Methods From March 2013 to March 2017, 96 cases of gestational diabetes patients diagnosed in the Fourth Affiliated Hospital of Nantong University were randomly divided into control group (46 cases) and observation group (50 cases). The control group was given routine examination and routine health education. The observation group was given comprehensive prenatal education combine nutrition intervention besides routine examinations and health education. Maternal weight gain, immune function and neonatal weight were compared between the two groups. Results Maternal weight gain in observation group was (13.7±2.4) kg, significantly lower than that in control group [(17.1±2.7) kg], and the difference was statistically significant (P < 0.05). Neonatal weight in observation group was (3.21±0.71) kg, which was obviously lower than that in control group [(3.85±0.83) kg], and the difference was statistically significant (P < 0.05). At the end of pregnancy, levels of CD3+, CD4+ and CD4+/CD8+ in observation group were significantly higher than those in control group, while CD8+ was significantly lower than control group, and the differences were all statistically significant (P < 0.05). Conclusion Prenatal education combined nutritional intervention have significant effect on maternal weight gain and neonatal weight, and it could effectively improve the immune function in patients with gestational diabetes mellitus.

Key words： Prenatal education Nutritional intervention Gestational diabetes mellitus Maternal-fetal outcome

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	ZHU Ya WANG Jianqing XUE Jingling

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ZHU Ya WANG Jianqing XUE Jingling. The effect of prenatal education combined with nutrition intervention on maternal and infant weight and immune function in patients with gestational diabetes mellitus[J]. 中国医药导报, 2018, 15(15): 111-114.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I15/111

[1] IDF. IDF Diabetes Atlas 7th Edition. http：//www.diabetesatlas.org/across-the-globe.html.
[2] Chang Y，Chen X，Cui H，et al. Follow-up of postpartum women with gestational diabetes mellitus （GDM） [J]. Diabetes Res Clin Pract，2014 Nov，106（2）：236-240.
[3] 中华医学会妇产科学分会产科学组，中华医学会围产医学分会妊娠合并糖尿病协作组.妊娠合并糖尿病诊治指南（2014）[J].中华妇产科杂志，2014，49（8）：561-569.
[4] Standards of medical care in diabetes-2015：summary of revisions [J]. Diabetes Care，2015，38 Suppl：S4.
[5] National Collaborating Centre for Women's and Children's Health （UK）. Diabetes in pregnancy： management of diabetes and its complications from preconception to the postna?鄄tal period [J]. London： National Institute for Health and Care Excellence （UK）；2015 Feb. National Institute for Health and Care Excellence：Clinical Guidelines.
[6] Committee on Practice Bulletins—Obstetrics. Practice Bulletin No.180：Gestational Diabetes Mellitus [J]. Obstet Gynecol，2017，130（1）：e17-e37.
[7] Ho YR，Wang P，Lu MC，et al. Associations of mid-pregnancy HbA1c with gestational diabetes and risk of adverse pregnancy outcomes in high-risk Taiwanese women [J]. PLoS One，2017，12（5）：e0177563.
[8] Kjos SL，Peters RK，Xiang A，et al. Predicting future diabetes in Latino women with gestational diabetes. Utility of early postpartum glucose tolerance testing [J]. Diabetes，1995， 44（5）：586-591.
[9] HAPO Study Cooperative Research Group，Metzger BE，Lowe LP，et al. Hyperglycemia and adverse pregnancy outcomes [J]. N Engl J Med，2008，358（19）：1991-2002.
[10] Wahlberg J，Ekman B，Nyström L，et al. Gestational diabetes：Glycaemic predictors for fetal macrosomia and maternal risk of future diabetes [J]. Diabetes Res Clin Pract，2016，114：99-105.
[11] Hod M，Kapur A，Sacks DA，et al. The International Federation of Gynecology and Obstetrics （FIGO） Initiative on gestational diabetes mellitus：A pragmatic guide for diagnosis，management，and care [J]. Int J Gynaecol Obstet，2015，131（Suppl 3）：S173-S211.
[12] Canadian Diabetes Association Clinical Practice Guidelines Expert Committee，Cheng AY. Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada [J]. Can J Diabetes，2013，37，（Suppl 1）：S1-S3.
[13] Landon MB，Spong CY，Thom E，et al. A multicenter，randomized trial of treatment for mild gestational diabetes [J]. N End J Med，2009，361（14）：1339-1348．
[14] Cao X，Wang Z，Yang C，et al. Comprehensive intensive therapy for Chinese gestational diabetes benefits both newborns and mothers [J]. Diabetes Technol Ther，2012， 14（11）：1002-1007.
[15] 王颖，杨莎，冯辉.健康教育联合营养干预综合治疗对妊娠期糖尿病的影响[J].实用预防医学，2017，24（3）：347-348.
[16] Rayanagoudar G，Hashi AA，Zamora J，et al. Quantification of the type 2 diabetes risk in women with gestational diabetes：a systematic review and meta-analysis of 95，750 women [J]. Diabetologia，2016，59（7）：1403-1411.
[17] Miao M，Dai M，Zhang Y，et al. Influence of maternal overweight，obesity and gestational weight gain on the perinatal outcomes in women with gestational diabetes mellitus [J]. Sci Rep，2017，7（1）：305.
[18] 杨晓菊，刘刚，韩淑娟，等.妊娠糖尿病患者红细胞免疫黏附功能与T细胞亚群的变化及其临床意义[J].中国糖尿病杂志，2008，16（3）：139-141.
[19] 张玉兰，倪新红，范小燕.妊娠糖尿病患者细胞免疫功能及hs-CRP水平的研究[J].中国医药指南，2013，11（22）：605-606.
[20] Cade WT，Reeds DN，Mondy KE，et al. Yoga lifestyle intervention reduces blood pressure in HIV-infected adults with cardiovascular disease risk factors [J]. HIV Med，2010，11（6）：379-388.
[21] Keustermans G，van der Heijden LB，Boer B，et al. Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children [J]. PLoS One，2017，12（10）：e0187068.