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2018 Vol. 15, No. 12
Published: 2018-04-25
 
 
4 The effect of bone marrow mesenchymal stem cell synergistic BMP-2 in the proliferation of hematopoietic stem cell
LI Shutan HUANG Chunlan
Objective To explore the proliferation effect of bone morphogenetic protein (BMP)-2 on hematopoietic stem cell (HSC) cocultured with mesenchymal stem cell (MSC)． Methods MSCs were expanded to the third passage (P3) in the plastic dish; CD34+ cells were sorted by MACS Miltenyi Biotec. MSCs(P3) and HSCs were identified by FCM separately, and then MSC (P3) and HSC were co-cultured in the Transwell interfered with BMP-2 protein, four groups in the study: HSC group, HSC+BMP2 group, HSC+MSC group, HSC+MSC+BMP2 group. Cells were collected after 3 d to test HSC proliferation using the following methods：counting of the number, detecting of the total RNA, the mRNA and protein expression of Ki67 were detected by fluorescence qRT-PCR and immunofluorescence methods. Results The number of HSC, totel RNA, Ki67 expression of the HSC+BMP2 group was higher than HSC group, HSC+MSC group was higher than HSC group, HSC+MSC+BMP2 group was higher than HSC+MSC group (P < 0.05). Conclusion MSCs synergistic with BMP-2 can enhance MSC proliferation effect on HSC.
 
2018 Vol. 15 (12): 4-7,24 [Abstract] ( 208 ) HTML (1 KB)  PDF (1305 KB)  ( 193 )
8 Effect of Dexmedetomidine pretreatment on HMGB1 mRNA expression in LPS-stimulated astrocytes
CHEN Xiaoshi1 XIAO Yingying1 ZHOU Jiao2 ZENG Wenqiang1 YANG Jinguo1
Objective To investigate the effect of Dexmedetomidine pretreatment on the high mobility group box 1 (HMGB1) mRNA expression in lipopolysaccharide (LPS)-stimulated astrocytes (AS), and to explore its relationship with α7 subtype of nicotinic acetylcholine receptor (α7nAChR). Methods The new-born 1-2 day SD rats were selected, and the AS of cerebral cortex was isolated and cultivated. The cells were inoculated on cell culture plates, and they were divided into blank control group, LPS group, DEX-pretreatment group, α-bungatotoxin (α-BGT, which was α7nAChR antagonist) group and α-BGT-pretreatment group. The immunocytochemical technique was used to determine the expression of AS specific marker glial fibrillary acidic protein (GFAP). Methyl thiazolyl tetrazolium (MTT) was to used detect cytoactive. Real-time quantitative PCR was used to detect the mRNA expression levels of HMGB1. Results The purity of the 3rd generation of AS reached above 95%. The expression of AS HMGB1 mRNA was up-regulated, which had statistically significant differences compared with those of blank control group (P ＜ 0.01). Compared with LPS group, the expression of HMGB1 mRNA in DEX-pretreatment group was decreased significantly (P ＜ 0.01). Compared with DEX-pretreatment group, α-BGT-pretreatment had significant effects of reversing DEX-pretreatment (P ＜ 0.01), while single application of α-BGT for AS had no significant effects on the expression of HMGB1 gene (P ＞ 0.05). Conclusion Dexmedetomidine pretreatment can reduce the expression of HMGB1, the DEX-pretreatment effect disappears after cutting off α7nAChR, which indicates that the anti-inflammatory action of DEX-pretreatment may be related to activating α7nAChR.
2018 Vol. 15 (12): 8-12 [Abstract] ( 220 ) HTML (1 KB)  PDF (601 KB)  ( 86 )
13 Effects of Shenyu Buxue Decotion on the Th17 cells and expression of its related IL-6, IL-17 and IL-23 expression in mice with aplastic anemia
ZENG Qing1 LU Haisong1 CHENG Weimin1 HE Ai1 DENG Dejun2 LAI Chunfeng3
Objective To observe the effect of Shenyu Buxue Decotion on Th17 cells and the expression of IL-6, IL-17 and IL-23 in aplastic anemia (AA) model mice, and to explore its curative effect for AA. Methods Eighty clean-class BALB/c mice were divided into control group, model group, Shenyu Buxue Decotion group and Prednisone (positive control) group by random number table. The AA models were established by irradiated with 60CO-γ ray together with intraperitoneal injection of cyclophosphamide (CY) and chloramphenicol (CH). After AA models were successfully established, mice were given to medicines for 4 weeks. The changes of mice peripheral hemogram, Th17 cells and the expression levels of IL-6, IL-17 and IL-23, and the degree of bone marrow hyperplasia under light microscope were observed. Results Compared with the control group, the peripheral hemogram and bone marrow hyperplasia were decreased, while Th17 cells and expression of IL-6, IL-23 and IL-17 were increased in the model group, with statistically significant difference (P < 0.05). Compared with the model group, in the Shenyu Buxue Decotion group, the peripheral hemogram were increased, Th17 cells and the expression of IL-6, IL-23 and IL-17 were decreased, and bone marrow hyperplasia was improved, with statistically significant difference (P < 0.05). Conclusion Shenyu Buxue Decotion can improve the bone marrow hematopoietic function of AA mice, which may due to the inhibition of the T cell immune function related IL-6, IL-17 and IL-23.
2018 Vol. 15 (12): 13-16 [Abstract] ( 250 ) HTML (1 KB)  PDF (706 KB)  ( 58 )
17 Expression of ANO1 and its correlation with the prognosis of head and neck squamous cell carcinoma
ZHOU Hong LI Wenping PEI Fei WU Gang
Objective To investigate the expression of ANO1 in head and neck squamous cell carcinoma (HNSCC) and to determine the prognostic value of ANO1 for HNSCC patients. Methods The differences of ANO1 mRNA expressions in HNSCC and normal mucosa tissues were analyzed based on Oncomine database. The specimens of patients undergoing surgery with laryngeal cancer in Fudan University Pudong Medical Center from February to October 2017 were collected. ANO1 mRNA expressions in laryngeal cancer (26 cases) and normal mucosa tissues (26 cases) were determined using RT-PCR. The relationship between ANO1 mRNA expression and prognosis of HNSCC patients was analyzed using Oncomine and cBioPortal database. Results The mRNA expression of ANO1 was significantly higher in multipe HNSCC tissues than normal mucosa tissues (P < 0.05). Using Rickman statistics, there was no significant difference in 5-year overall survival (OS) between ANO1 mRNA high expression and low expression patients (P ﹥ 0.05). However, there were significant differences in OS and disease/progression-free survival (DFS/PFS) between ANO1 mRNA high expression and low expression patients through searching cBioPortal database (TCGA, Provisional) (P < 0.05). Conclusion The expression of ANO1 is elevated in HNSCC tissues. Patients with high expression of ANO1 had lower survival than those with low expression.
2018 Vol. 15 (12): 17-20 [Abstract] ( 269 ) HTML (1 KB)  PDF (757 KB)  ( 95 )
21 Research Progress of Glutathione in Bacteria
LI Chenglong1 LIU Xianghong1 WU Yeke2
Glutathione is a small molecule peptide that is one of the most abundant thiols present in gram-negative bacteria and most gram-positive bacteria. Some bacteria can synthesis glutathione directly, some may acquire glutathione form external environment. Bacteria encounter various stress conditions from the environment and their own metabolites, such as oxidative stress, osmotic stress and other stresses coming from chlorine compounds, metal ions and so on. Glutathione can protects the bacterial cells from these stress damage directly or indirectly. This article is to review the synthesis, metabolic balance and main roles of Glutathione in bacteria.
2018 Vol. 15 (12): 21-24 [Abstract] ( 312 ) HTML (1 KB)  PDF (499 KB)  ( 603 )
25 Advances of nanotechnology in treatment of gliomas
HU Dandan LIU Xiaoying LI Minghui PENG Haisheng▲
Brain tumor is one of the most challenging diseases in treatment. Although surgery and multimodal adjuvant therapy serve to the treatment of this disease, treating brain cancer still remains as a challenge. Due to the non-specificity and the potentially toxic of drugs and the blood–brain barrier, the efficiency of drug in treating brain cancer is relatively low, and therefore nanoparticles become an alternative treatment forbrain cancer. During the past decades, there have been great developments in the area of brain tumor treatment adopting brain tumor-targeted method. For example, the nanocarriers can simultaneously carry out specific detection, treatment, and follow-up monitoring of the tumor. New treatment strategies with nanotechnology have some important advantages, for example decreased toxicity and improved therapeutic effect. In this paper, the classification of glioma, the limitations of treating glioma, and how to target glioma using nanoparticles are summarized in detail.
2018 Vol. 15 (12): 25-27 [Abstract] ( 266 ) HTML (1 KB)  PDF (464 KB)  ( 192 )
28 Research progress of extracorporeal membrane oxygenation in liver transplantation using donation after cardiac death
MIAO Mengqiu1 MA Xueping1 MAO Fei1 ZUO Xiangrong2
There is an ongoing shortfall of liver organ donor in the development of liver transplantation in the worldwide. Donation after cardiac death (DCD) is an important way to increase the number of liver donors at the present stage. The use of DCD livers was associated with a significantly higher risk of primary nonfunction and ischemic biliary complications because of prolonged warm ischemia time (WIT). It is a paramount research dilemma to devise how to avert or lessen the warm ischemia injury of DCD livers. Extracorporeal membrane oxygenation (ECMO) can minimize the WIT and injuries induced by warm ischemia through providing respiratory and circulatory support and increasing the perfusion of the organ. Moreover, ECMO facilitates safe transfer of potential DCD donors between hospitals and assessment of the potential DCD graft function, thus enhance the potential DCD donation success ratio and success rate of transplantation. Although, there are some ongoing controversies such as the ethical and technical issues about the use of ECMO in liver transplantation using DCD. It is believed that the application of ECMO will be an important measure to promote the development of liver transplantation using DCD with the continuous development of society and technology.
2018 Vol. 15 (12): 28-31 [Abstract] ( 172 ) HTML (1 KB)  PDF (475 KB)  ( 115 )
32 Research status of Pseudomonas aeruginosa pilus induce IL-1β
PAN Xingguo1* LI Ronghui2* ZHANG Hua2
Pseudomonas aeruginosa can induces inflammatory response after successful infection on the host. However, the surface of the bacterial Type Ⅳ Pili is one of the inflammatory factors. The main composition of the pilus is PilA. One pilus is made up of thousands PilA subunits. PilA can induce host macrophages to produce IL-1β, IL-1β is a key important inflammatory cytokine in host defence which mediates a diverse range of effects, including T-cell polarization, antibody production, fever and endothelial and phagocyte activation. This paper summarizes the research status of pseudomonas aeruginosa pilus induce IL-1β.
2018 Vol. 15 (12): 32-36 [Abstract] ( 184 ) HTML (1 KB)  PDF (542 KB)  ( 59 )
37 Analysis of influencing factors on the levels of hair arsenic and urine cadmium in workers exposed to arsenic and cadmium
LIAO Juan LI Xunya YI Shan WANG Ye YUAN Xiaoyan ZHANG Zhaohui
Objective To investigate the hair arsenic and urinary cadmium exposures status of workers exposure to arsenic and cadmium in a factory in Hengyang City. Methods From July 2014 to July 2016, occupational health examinations were conducted on workers exposed to cadmium and arsenic in a factory in Hengyang City. Atomic fluorescence spectrometry was used to detect the hair arsenic and flame atomic absorption spectrophotometry was used to determine urinary cadmium. Results The over-standard rate of arsenic in 2462 workers was 36.31% (894/2462). The over-standard rate of urinary cadmium in urine samples of 157 workers was 83.44% (131/157). There was no significant difference in arsenic and urinary cadmium exceeding standard rate among workers of different ages (P > 0.05). The rate of over-standard males was higher than that of females, and the longer the length of service was, the higher the rate of over-standard was, with statistically significant difference (P < 0.05). Besides, the rate of arsenic over-standard among management was lower than that among ordinary smelter workers (P < 0.01). Conclusion Workers in this factory have severe arsenic and urinary cadmium levels, and they should take effective protective measures against occupational hazards as soon as possible.
2018 Vol. 15 (12): 37-40 [Abstract] ( 167 ) HTML (1 KB)  PDF (315 KB)  ( 181 )
41 The significance of glycated albumin and glycosylated hemoglobin in the early diagnosis of type 2 diabetes mellitus combined with vasculopathy
ZHANG Mei WANG Huan XU Yong LI Yan CHEN Li PENG Qisong▲
Objective To investigate the significance of glycosylated hemoglobin (HbA1c) and glycated albumin (GA) in the early diagnosis of type 2 diabetes mellitus (T2DM) combined with vasculopathy. Methods From July 2013 to July 2016, 128 cases of patients with type 2 diabetes mellitus in Department of Endocrinology, the Affiliated Jiangning Hospital of Nanjing Medical University were selected as the research objects, which including 65 cases of patients with type 2 diabetes mellitus complicated with vasculopathy (group A) and 63 cases of patients with type 2 diabetes mellitus without vasculopathy (group B). At the same time 68 cases of healthy people were selected as control group (group C). The levels of HbA1c and GA in the 3 groups were detected and the differences of the indicators in the 3 groups were statistically analysed. Results The values of HbA1c and GA in group A and group B were all higher than those of group C, with highly statistically significant differences (P ＜ 0.001), but there were no statistically significant differences between group A and group B (P ＞ 0.05). The receiver operating characteristic curve (ROC curve) showed that the area under the ROC curve of HbA1c of group A and group C was 0.980, the most suitable cutoff value was 6.55 mmol/L, the sensitivity was 95.38% and the specificity was 91.56%. The area under the ROC curve of HbA1c of group B and group C was 0.981, the most suitable cutoff value was 6.50 mmol/L, the sensitivity was 95.24% and the specificity was 91.80%. The area under the ROC curve of GA of group A and group C was 0.965, the most suitable cutoff value was 15.65 mmol/L, the sensitivity was 95.45% and the specificity was 96.72%. The area under the ROC curve of GA of group B and group C was 0.930, the most suitable cutoff value was 15.70 mmol/L, the sensitivity was 88.89% and the specificity was 96.89%. Conclusion The levels of GA and HbA1c in patients with T2DM combined with vasculopathy are significantly higher than those of healthy people, while there are no significant differences in GA and HbA1c between T2DM and T2DM combined with vasculopathy. Therefore, the detection of GA and HbA1c have no effect on the early diagnosis of T2DM combined with vasculopathy.
2018 Vol. 15 (12): 41-44 [Abstract] ( 235 ) HTML (1 KB)  PDF (499 KB)  ( 82 )
45 Clinical efficacy of minimally invasive transurethral plasmakinetic resection of prostate combined with endocrine therapy for elderly patients with advanced prostate cancer complicated by urinary retention
ZHANG Hong ZHANG Yu YI Faxian
Objective To explore the clinical effect of minimally invasive transurethral plasmakinetic resection of prostate (PKRP) combined with endocrine therapy in the treatment of elderly patients with advanced prostate cancer complicated by urinary retention, and its effects on international prostate symptom score (IPSS) and life quality. Methods The clinical data of 70 elderly patients with advanced prostate cancer complicated by urinary retention admitted to the Department of Urology, Affiliated Hospital of Inner Mongolia Medical University and underwent PKRP combined with endocrine therapy from October 2016 to October 2017 were retrospectively analyzed. The residual urine volume (RUV), maximum flow rate (Qmax), prostate specific antigen (PSA), the scores of IPSS and life quality in the two groups were compared before and after treatment. Results After treatment, the RUV and PSA were significantly lower than those of before treatment, Qmax was significantly higher than that of before treatment, with highly statistically significant differences (P ＜ 0.01), the daily urination frequency, difficulty of holding urine and sense of incomplete urination were all significantly lower than those of before treatment, with highly statistically significant differences (P ＜ 0.01), the scores of life quality such as sleep quality, pain, fatigue and appetite were all significantly higher than those of before treatment, with highly statistically significant differences (P ＜ 0.01). Conclusion PKRP combined with endocrine therapy can effectively improve the urethral function, relieve the symptom and promote the life quality of elderly patients with advanced prostate cancer complicated by urinary retention.
2018 Vol. 15 (12): 45-47,52 [Abstract] ( 267 ) HTML (1 KB)  PDF (443 KB)  ( 109 )
48 Clinical analysis of anti-neutrophil cytoplasmic antibodies associated with vasculitis in patients of kidney damage
LI Qianqian LI Shengkai▲
Objective To investigate the clinical characteristics and relevant factors of prognosis in patients with anti-neutrophil cytoplasmic antibodies (ANCA) associated with vasculitis (AAV). Methods The clinical data of 65 patients of kidney damage with AAV in Department of Nephrology, the Affiliated Hospital of Xuzhou Medical University from August 2013 to August 2017 were retrospectively analyzed, including the general characteristics, systems involvement, auxiliary examinations and treatment outcomes. For patients with complete follow-up outcomes (54 cases), they were divided into the poor prognosis group (24 cases) and the good prognosis group (30 cases) according to the different prognosis. The clinical characteristics and the auxiliary examinations were compared between the two groups. Results The average age of the patients was (65±12) years, the medium time of diagnosis was 1 (0.5-4.0) months. Multiple systems were damaged, especially in urinary system (65 cases) and respiratory system (45 cases). CT scans showed that interstitial change was common, with 42 cases (42/65, 64.6%). The blood test showed that anemia was 57 cases (57/65, 87.7%). The C-reactive protein and the blood sedimentation were higher, with 57 cases (87.7%) and 58 cases (89.2%) respectively. ANCA was mainly MPO positive (60 cases, 92.3%). Seven routine renal biopsies were performed, 4 were crescent glomerulonephritis and 3 were immunofluorescence negative. Fifity-five cases were treated with glucocorticoids and 47 cases treated with glucocorticoids combined with cyclophosphamide. There were 54 patients with complete follow-up data and showed that 30 cases were remission, 16 were treated with maintenance hemodialysis and 8 were died. The scores of birmingham vasculitis activity scores (BVAS) and the serum creatinine in the poor prognosis group were all higher than those of good prognosis group, the hemoglobin was lower than that of good prognosis group, the incidences of systems damage and the lung interstitial change were all higher than those of good prognosis group, with statistically significant differences (P ＜ 0.05). Conclusion The AAV occurs predominantly in the elderly. Multi-system are involved with a variety of clinical manifestations, particularly in urinary system and respiratory system. It seems that higher BVAS score, lower hemoglobin level, heavier damage of the major organs and seriously lung interstitial change are associated with higher risk of the poor prognosis.
2018 Vol. 15 (12): 48-52 [Abstract] ( 266 ) HTML (1 KB)  PDF (465 KB)  ( 127 )
53 Evaluation of the efficacy and safety of supine flexion traction in the treatment of cervical spondylotic radicular spondylosis with degenerative spinal cord compression
XU Hongzhi LIN Dingkun▲ CHEN Bolai
Objective To investigate the efficacy and safety of supine flexion traction in the treatment of cervical spondylotic radicular spondylosis with degenerative spinal cord compression. Methods From September 2014 to December 2015, 21 middle-aged and elderly patients with degenerative spinal cord compression type cervical spondylotic radicular in Guangdong Province Hospital of Traditional Chinese Medicine were selected as research objects. Supine flexion traction was used as conservative treatment. The visual analogue scale score (VAS) and neck dysfunction index (NDI) were used to evaluate the efficacy. The changes of spinal nerve function were detected with somatosensory evoked potential (CSEP), and the changes of the sagittal diameter of the spinal canal were investigated with the combination of multi position magnetic resonance (MRI) technique. All patients were followed up for 1 year after treatment. Results All 21 patients completed the multiple body position MRI, CSEP examination and 10 days of treatment, and they were followed up for 1 years after treatment, the effective follow-up rate was 100%. One patient was turned into surgical treatment during the follow-up period due to the aggravation of the upper limb numbness. The VAS score of after 2, 4, 6, 8 d and 10 d of treatment and 1 year follow up of the remaining 20 patients were lower than those of before treatment (P < 0.01). The NDI score of after10 days of treatment and 1 year follow up were also significantly lower than those of before treatment (P < 0.01). The evoked potential latency of CSEP and amplitude between in the flexion traction and normal position were compared, the difference were not statistically significant (P > 0.05). The valid sagittal diameter of the spinal canal of flexion position was significantly greater than that of neutral position (t=3.56, P=0.00), while neutral position was significantly greater than that of the posterior extension (t=4.22, P=0.00). Conclusion Supine flexion traction is effective and safe for cervical spondylotic radicular spondylosis with degenerative spinal cord compression. But due to small sample size and short follow-up time, a larger sample size and longer follow-up observation are still needed. The study of indications and contraindications is also needed to improve the curative effect and prognosis. In addition, should further study the relationship between the spinal cord compression and the changes of spinal cord function and the prognosis of the disease so as to provide the basis for the intervention of such diseases.
2018 Vol. 15 (12): 53-57 [Abstract] ( 188 ) HTML (1 KB)  PDF (715 KB)  ( 113 )
58 Effects of Dexmedetomidine on cognitive function in elderly patients after cervical spine surgery
WE Yuqin WANG Hong CHEN Qunsheng WANG Gongming
Objective To investigate the effects of Dexmedetomidine on cognitive function in elderly patients after cervical spine surgery. Methods From December 2016 to May 2017, 50 cases of elderly patients with receive cervical spine surgery in Shandong Provincial Hospital were selected, and divided into Dexmedetomidine group (DEX group) and control group (C group) by random number table, each group with 25 cases. The DEX group was treated with intravenous drip Dexmedetomidine at the beginning of the operation, and the C group was treated the same dose of saline. The mini-mental state examination (MMSE) was scored performed in both groups before and after surgery 3, 5, 10, 20 d and 40 d, and the cognitive function of the patient was evaluated. The postoperative cognitive dysfunction (POCD) incidence rate of the two groups was compared, and the mean arterial blood pressure (MAP), heart rate, operation time, blood loss and the use of narcotic drugs between groups were compared during surgery. Results There was no significant difference between the two groups in the aspect of the MAP, heart rate, operation time, blood loss during surgery (P > 0.05). The dosage of Remifentanil, Fentanyl and Propofol in the DEX group were all lower than those of C group during surgery, the differences were statistically significant (P < 0.05), while there was no significant difference the two groups of the dosage of Vecuronium (P > 0.05). The MMSE score of after surgery 3 d and 5 d in C group was lower than that before surgery, the difference was statistically significant (P < 0.05), however, the MMSE scores after surgery 3, 5, 10, 20 d and 40 d in the DEX group were compared with those before surgery, the difference was not statistically significant (P > 0.05). The MMSE score of after surgery 3 d and 5 d in the DEX group was higher than C group, the difference was statistically significant (P < 0.05). The incidence of POCD after operation in DEX group was 8%, and the C group was 24%, the two groups were compared, the difference was statistically significant (P < 0.05). Conclusion Dexmedetomidine can be effectively prevent the occurrence of cognitive dysfunction in elderly patients after cervical spine surgery, and it reduces the clinical dosages of Remifentanil, Fentanyl and Propofol to a certain extent.
 
2018 Vol. 15 (12): 58-60,77 [Abstract] ( 773 ) HTML (1 KB)  PDF (1000 KB)  ( 87 )
61 The effect of Fresh Shuangbai Ointment in the treatment of early soft tissue injury of tibiofibulas fracture
REN Xiangshun1 HU Dezhi2 LAN Guojian2 SHEN Zuhong2 LI Bifeng2
Objective To observe the effect of Fresh Shuangbai Ointment in the treatment of early soft tissue injury of tibiofibulas fracture. Methods Ninety patients with tibiofibulas fracture from January 2016 to march 2017 in Qingyuan Hospital of Traditional Chinese Medicine were selected and randomly divided into classic Shuangbai Ointment group, fresh Shuangbai Ointment group and control group, with 30 cases in each group. Patients from classic Shuangbai Ointment group and fresh Shuangbai Ointment group were treated with classic Shuangbai Ointment and fresh Shuangbai Ointment respectively, while patients from control group did not receive any external Ointment treatment. The pain, tenderness, stasis score and swelling degree in the three groups were observed and the effect were evaluated. Results The relieving extent of pain, tenderness, ecchymosis, swelling and clinical efficacy in the classic Shuangbai Ointment group and the fresh Shuangbai Ointment group were superior than that of the control group, and the fresh Shuangbai Ointment group was better than the classic Shuangbai Ointment group, the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in clinical efficacy between the two groups (P ＞ 0.05). Conclusion The curative effect of fresh Shuangbai Ointment in the treatment of early soft tissue injury of tibiofibulas fracture have exact effect, it is worthy of clinical application.
2018 Vol. 15 (12): 61-64 [Abstract] ( 217 ) HTML (1 KB)  PDF (574 KB)  ( 95 )
65 Effect of cocktail drug injection on blood loss and safety evaluation after primary total knee arthroplasty
BI Chunqiang1 WEN Jianmin2 ZHANG Hui1 YANG Dawei1 SONG Xue1 LI Duoduo3
Objective To investigate the effectiveness and safety of cocktail drug injection on blood loss and safety evaluation of local injection after primary total knee arthroplasty (TKA). Methods Ninety patients who received primary TKA from June 2015 to October 2016 in Guang′anmen Hospital South district of China Academy of Chinese Medicine Sciences was retrospectively analysed and divided into treatment group and control group, with 45 cases in each group. Treatment group was treated with cocktail drug injection around knee joint capsule and 50 mL intra-articular injection, the control group were treated with saline intra-articular infusion. The bone wax was used to stop the bleeding in the two groups, and the drainage tube was clamped for 3 hours and removed 24 hours after the operation. Postoperative drainage, occult blood loss, prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ration (INR), D-dimer value and deep venous thrombosis cases were recorded in both group. Results The dominant blood loss and hidden hemorrhage in the treatment group were less than the control group, the number of blood transfusion was less than the control group, the differences were highly statistically significant (P ＜ 0.01). Both groups had no statistically significant in PT, APTT, INR, D-dimer value (P ＞ 0.05). The incidence of thrombosis was no statistically significant between the two groups (P ＞ 0.05). Conclusion The cocktail drug injection thearapy is an effective and safe method to control the amount of blood loss during the operation of primary TKA.
2018 Vol. 15 (12): 65-68 [Abstract] ( 200 ) HTML (1 KB)  PDF (552 KB)  ( 145 )
69 The application of rhBMP-2 combined with PLIF in the treatment of degenerative spondylolisthesis
HU Qingzhu DAI Guo YU Ling GUO Weichun
Objective To investigate the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with posterior pedicle screw system fixation and intervertebral bone graft fusion (PLIF) in degenerative lumbar spondylolisthesis. Methods The clinical data of 50 patients with degenerative lumbar spondylolisthesis and treated in Renmin Hospital of Wuhan University from May 2015 to May 2016 were analyzed retrospectively, and divided into test group with 30 cases, they were treated with rhBMP-2 combined with PLIF surgery, and 20 cases in control group were treated with simple PLIF surgery. The Prolo score, slippage rate, Terry disability index (ODI), visual analogue scale (VAS) and lumbar fusion rate in preoperative and postoperative follow-up were statistically analyzed. Results The ODI score and VAS score in the two groups at 3 months and 6 months after postoperatively were all lower than those preoperative (P < 0.05), and the test group was lower than those of control group, the difference was statistically significant (P < 0.05). The lumbar fusion rate in the test group at 3 months and 6 months after postoperatively was all higher than control group, the difference was statistically significant (P < 0.05). The slippage rate in the two groups after postoperatively was lower than preoperative (P < 0.05), and the Prolo score was higher than preoperative (P < 0.05), the slippage rate in test group after postoperatively was lower than control group (P < 0.05), and the Prolo score was higher than control group, the difference was statistically significant (P < 0.05). Conclusion PLIF is a method for the treatment of degenerative lumbar spondylolisthesis bone is effective and reasonable and simple, the combined use of rhBMP-2 can improve the curative effect, and it shows that improve the postoperative Prolo score, reduce the ODI spine score and VAS score and reduce postoperative slippage rate and improve lumbar fusion rate. The prognosis is good, and it is worth promoting clinically.
2018 Vol. 15 (12): 69-72 [Abstract] ( 185 ) HTML (1 KB)  PDF (550 KB)  ( 53 )
73 The correlation of OXLDL, TGF-β2, APN, leptin and ApoC Ⅲ and gestational diabetes mellitus
CHENG Lilan1 CHENG Yeli2 MA Aijiang1 WEI Zhaoxuan1
Objective To explore the relationship of OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ and gestational diabetes mellitus (GDM). Methods From September 2016 to June 2017, 200 pregnant women in Department of Outpatient Internal Medicine, Hebei Province Directly under the Authority were selected as the research object, serum was collected during the 16-18 weeks of pregnancy, the serum levels of OXLDL, TGF-β2, ApoC Ⅲ, leptin and APN were detected by ELISA method. Routine OGTT screening was taken during the 24-28 weeks of pregnancy, the normal women as the control group and diagnosed with GDM as the observation group, with 100 cases in each group. Levels of OXLDL, TGF-β2, ApoC Ⅲ, leptin and APN in the two groups were compared, the pregnancy and neonatal outcome in the two groups were compared. Refer to the control of blood glucose, the observation group was divided into poor glucose control group (55 cases) and standard glucose control group (44 cases). Levels of OXLDL, TGF-β2, APN, leptin, ApoC Ⅲwere compared bettwen the two groups. Correlation analysis of fasting glucose and OXLD, TGF-β2, APN, leptin, ApoC Ⅲ were conducted in observation group. Results Levels of the OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ were significantly higher in observation group than those of the control group, level of APN was significantly lower in the observation group than the control group, the differences were statistically significant (P < 0.01). The outcome of mother and fetus were better in control group than the observation group, and the Apgar scores was significantly lower in the observation group than the control group, the difference was statistically significant (P < 0.01). Levels of the OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ were significantly higher in poor glucose control group than standard glucose control group, level of APN was significantly lower in poor glucose control group than the standard glucose control group, the difference was statistically significant (P < 0.01). In the observation group, levels of OXLD, TGF-β2, leptin, ApoC Ⅲ were positive related to the fasting blood glucose (r=0.6315, 0.7412, 0.6155, 0.5411, all P < 0.05), and APN was negatively related to the fasting blood glucose (r=-0.6613, P < 0.05). Conclusion The changes of OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ level in patients with gestational diabetes mellitus are closely related to the occurrence and development of disease.
2018 Vol. 15 (12): 73-77 [Abstract] ( 224 ) HTML (1 KB)  PDF (650 KB)  ( 178 )
78 Analysis the prethrombotic state of recurrent spontaneous abortion in the plateau and zero altitude areas
JIANG Weihong1 Maixiati·maimaituohuti2 MO Li3 Ayinaziri ·apotukelimu4
Objective To analyze and compare the prethrombotic state (PTS) of RSA in the plateau areas and the zero altitude areas, to provide a theoretical basis of Western anticoagulant therapy and traditional Chinese medicine for blood circulation treatment for the RSA, particulary in the plateau areas. Methods From January 2012 to December 2016, 60 women with RSA (≤10 weeks) and 108 women with normal early pregnancy (≤10 weeks) who were hospitalized for termination of pregnancy at Shenzhen University Hospital of Guangzhou University of Traditional Chinese Medicine were selected as the Zero altitude areas RSA group and the Zero altitude areas normal group, 40 women with RSA (≤10 weeks) and 52 women with normal early pregnancy (≤10 weeks) who were hospitalized for termination of pregnancy at the same peroid in the People′s Hospital of Taxkorgan County in Xinjiang Uygur Autonomous Region were selected as the plateau areas RSA group and the plateau areas normal group. The prothrombin time (PT), partial thromboplastin time (APTT), thrombin time (TT), fibrinogen content (Fbg) and platelet (PLT), hematocrit (HCT) were determined for each group of case and compared. Results The RSA group compared with the normal group in the zero altitude areas, PT decreased significantly, Fbg and HCT increased significantly (P < 0.01), APTT and TT decreased (P < 0.05), and PLT decreased slightly (P > 0.05). The normal group in the plateau areas compared with the normal group in the zero altitude areas, PT, TT and APTT were significantly lower (P < 0.01). while the levels of Fbg and HCT were significantly increased (P < 0.05), and PLT decreased slightly (P > 0.05). The RSA group Compared with the normal groupin the plateau areas, PT was significantly lower (P < 0.01), Fbg was significantly higher (P < 0.01), PLT slightly decreased, (P > 0.05) , APTT and TT decreased (P < 0.05) , HCT increased (P < 0.05). The RSA group in the plateau areas, compared with the RSA group in the zero altitude areas, PT, TT and APTT were significantly lower(P < 0.01), Fbg and HCT were significantly increased (P < 0.01), PLT slightly decreased (P > 0.05). Conclusion Both the zero altitude areas and the plateau areas RSA groups (≤ 10 weeks) women′s blood are in a state of hypercoagulability, but the RSA group in the plateau areas are especially obvious. The RSA group women in the plateau areas should strengthen anticoagulant therapy for the next pregnancy in order to improve the fertility status.
2018 Vol. 15 (12): 78-81 [Abstract] ( 200 ) HTML (1 KB)  PDF (677 KB)  ( 124 )
82 Comparison of therapeutic effects of different surgical methods on hydrocephalus in infants
JI Wenyu CAI Ning TU Kebai WANG Yongxin FAN Yandong Geng·Dangmurenjiafu
Objective To explore the clinical effect of different treatment methods for children with hydrocephalus. Methods From February 2014 to March 2017, 70 cases of hydrocephalus in the First Affiliated Hospital of Xinjiang Medical University were admitted, and they were divided into ETV group (20 cases), VPS group (27 cases) and the control group (23 cases) according to the treatment methods. After 6 months of follow-up, the improvement of clinical symptoms in children was counted, the preoperative and postoperative developmental quotients (DQ) were evaluated in children with different age among the groups and between the two surgical groups. The index values of the ventricle width in the two operation groups before and after the operation were measured by CT/MRI. Results The clinical symptoms of 18 cases in ETV group and 27 cases in VPS group were improved respectively, the DQ value of 6 months after operation in ETV group and 2, 6 months after operation in VPS group were significantly higher than those before operation (P < 0.05). The DQ values of 2, 6 months after operation in ETV group were significantly different from those of the corresponding VPS group (P < 0.05). Compared with the preoperative, the lateral ventricle and three ventricle of the ETV group, the three ventricle of the VPS group were reduced (P < 0.05). The DQ values of children under 1 year old in ETV group 6 months after operation and VPS group 2 months after operation were higher than that of children older than 1 year at the same term (P < 0.05). Conclusion The clinical effect of two kinds surgical treatment for hydrocephalus is significant, and the improvement of cognitive function is more obvious by ventriculoperitoneal shunt.
2018 Vol. 15 (12): 82-85 [Abstract] ( 769 ) HTML (1 KB)  PDF (636 KB)  ( 113 )
86 Clinical significance to patients with recurrent spontaneous abortion by ultrasonic hemodynamic test
ZOU Shuwei1 HAN Yanfeng2 WU Xiuying1▲
Objective To discuss the clinical significance to patients with recurrent spontaneous abortion by ultrasonic hemodynamic. Methods From January 2016 to June 2017, 25 patients with recurrent spontaneous abortion were selected as observation group, 40 normal healthy age of childbearing women were selected as control group. The differences in ultrasound-related indices such as endometrial and ovarian hemodynamics were compared between two groups. Results There was statistical significance in the comparison of average endometrial thickness (t = 5.095, P < 0.05), there was statistical significance in the comparison of the structural excellent rate (χ2 = 31.454, P < 0.01), and there were statistical significance in the uterine artery, endometrial artery, ovarian artery PSV and EDV (t = 2.239, 2.894, 4.520, 4.841, 5.021, 4.852, all P < 0.05). There were statistical significance in the indexes of RI, PI, RI and RI, the differences were statistically significant (t = 2.625, 2.746, 4.732, 4.991, 5.841, all P < 0.05). However, there was no significant difference in PI index between two groups (t = 0.095, P > 0.05). Conclusion There is significant differences in endometrial and ovarian hemodynamic parameters between recurrent spontaneous abortion and healthy women, it can initially determine the endometrial receptivity  by ultrasound hemodynamic monitor, it provides a new idea for the diagnosis and prognosis evaluation of recurrent spontaneous abortion. There is important clinical significance in recurrent spontaneous abortion treatment guidance and efficacy evaluation.
2018 Vol. 15 (12): 86-89 [Abstract] ( 178 ) HTML (1 KB)  PDF (634 KB)  ( 117 )
90 The effect of bronchoscopic alveolar lavage combined with local injection of Acetylcysteine or Ambroxol Hydrochloride in the treatment of neonatal severe pneumonia
YAO Xiaoyan1 DING Wujun2 YANG Longwei2 ZHU Lingxian1
Objective To explore the effect of bronchoscopic alveolar lavage combined with local injection of Acetylcysteine or Ambroxol Hydrochloride in the treatment of neonatal severe pneumonia. Methods The children of neonatal severe pneumonia were selected in the Jiaxing Maternal and Children Care Service Hospital from January 2016 to December 2017, and they were divided into control group and treatment group according to randon number table, with each group of 38 cases. Treatment group received bronchoalveolar lavage surgery combined therapy with local injection of Acetylcysteine, and control group received bronchoalveolar lavage surgery combined therapy with local injection of Ambroxol Hydrochloride. The above-mentioned children of two groups were compared with body temperature, moist rales, imageology, length of hospital stay and adverse reactions to evaluate the therapeutic effect of bronchoscope alveolar lavage operation combined Acetylcysteine or Ambroxol Hydrochloride in neonatal severe pneumonia. Results Between the two groups, there were significant differences in the recovery time of temperaturet, moist rales, imageology and length of stay, which were all shorter in the treatment group (P < 0. 05). Otherwise, no significant difference was found in the curative effect and incidence of adverse reactions between the treatment and control group  (P > 0.05). Conclusion Bronchoscopic alveolar lavage combined with local injection of Acetylcysteine or Ambroxol Hydrochloride is effective and safe in the treatment of neonatal severe pneumonia. Local injection of Acetylcysteine can shorten the course of disease compared with Ambroxol Hydrochloride, making children recover as soon as possible. In a word, this method is worthy of clinical promotion.
2018 Vol. 15 (12): 90-93 [Abstract] ( 309 ) HTML (1 KB)  PDF (633 KB)  ( 105 )
94 The relationship between human-induced protein 16 and preeclampsia
YE Yaoqun1 ZHEN Songbai2 LONG Jianling2 DONG Fucang2
Objective To explore the relationship between human interferon-inducible protein 16 (IFI16) and the onset of preeclampsia (PE). Methods From June 2015 to March 2017, 125 patients with PE in Panyu District He Xian Memorial Hospital of Guangzhou ("our hospital" for short) were selected as the research group. In addition, 53 cases of healthy pregnant women in our hospital during the same period were treated as control group. The levels of IFI16 in serum and IFI16 protein expression in the placenta of pregnant women were detected by enzyme-linkedimmunosorbent assay and Western blotting respectively. The correlation between the level of IFI16 in serum and the expression of IFI16 in the placenta of pregnant women with PE was analyzed by Pearson. Results The levels of IFI16 in serum and the expression of IFI16 in the placenta of research group were significantly higher than those in the control group (t=17.580, 16.135, all P < 0.01). Compared with patients of mild PE, the level of IFI16 in serum and the expression of IFI16 in the placenta of patients with severe PE significantly increased (t=18.883, 14.845, all P < 0.01). There were no statistically significant differences of the level of IFI16 in serum and the expression of IFI16 in the placenta between early onset and late onset (t=0.360, 0.840, all P > 0.05). The expression levels of IFI16 in the serum of PE patients were positively correlated with the expression level of IFI16 in the placenta (r=0.725, P < 0.05). Conclusion The level of IFI16 in serum and the expression of IFI16 in the placenta of patients with PE are abnormally elevated, they are closely related to the disease development, which can be used as a clinical diagnosis of indicator and provide a new target for the treatment of PE.
2018 Vol. 15 (12): 94-97 [Abstract] ( 210 ) HTML (1 KB)  PDF (682 KB)  ( 39 )
98 Influencing factors of emotional disorders during assisted reproductive treatment in elderly women with non tubal infertility
XIANG Yuhua
Objective To explore the influencing factors of emotion disorders during assisted reproductive treatment in elderly women with non tubal infertility. Methods The clinical data of 150 cases of elderly non-tubal infertile women and given the assisted reproductive treatment in the Central Hospital of Enshi Autonomous Prefecture from October 2015 to May 2017 were retrospectively analyzed. The negative emotions were evaluated according to self-rating depression scale (SDS) and self-rating anxiety scale (SAS). According to the results, the patients were divided into the normal group and the emotional disorders group. The clinical data of the two groups were analyzed, and the influencing factors for their emotional disorders were explored. Results Among the 150 patients, there were 94 cases with mood disorders and 56 cases with normal mood. Univariate analysis showed that the proportions of gynecological inflammation, venereal diseases and unemployed status were 82.9%, 14.8% and 58.3% respectively in the emotional disorders group, which were significantly higher than those in the normal group with 67.9%, 3.5% and 75.0%, the differences were statistically significant (P < 0.05). And there were significant differences in the proportions of economic source from male, female and the combined male and female between the emotional disorders group and the normal group [(56.4%, 39.4%, 4.2%) vs (48.2%, 25%, 26.8%)] (P < 0.05). The incidence rates of irregular menstruation, menstrual disorders and dysmenorrhea were 79.8%, 71.3% and 90.4% in the emotional disorders group, which were significantly higher than those in the normal group with 62.5%, 60.7% and 75.0%, the differences were statistically significant (P < 0.05). The biochemical pregnancy rate and clinical pregnancy rates were 5.3% and 4.3% respectively, which were significantly lower than those in the normal group with 16.1% and 14.3%, the differences were statistically significant (P < 0.05). Multivariate analysis showed that gynecological inflammation, economic sources, occupational status, biochemical pregnancy and clinical pregnancy were risk factors for emotional disorders in elderly women with non tubal infertility (P < 0.05). Conclusion Emotional disorders are prone to occur during assisted reproductive treatment in elderly women with non tubal infertility, and the physiological conditions, gynecological inflammation and economic incomes are the inducing factors for negative emotion, and precautions should be taken in providing assisted reproductive services.
2018 Vol. 15 (12): 98-101 [Abstract] ( 215 ) HTML (1 KB)  PDF (676 KB)  ( 73 )
102 Clinical analysis of 110 patients with henoch-schonlein purpura
ZHANG Xiaoming ZHU Haitao LV Jinchuan
Objective To analyze the epidemiological data, clinical features and susceptibility factors of Henoch-Schonlein purpura and provide references for the clinical diagnosis and treatment of this disease. Methods Clinical data of 110 inpatients with henoch-schonlein purpura diagnosed in pediatrics of Affiliated Hospital of Jiangsu University from January 2011 to December 2014 was retrospectively analyzed, the clinical data were summarized. Results Epidemiological analysis showed that the disease was more frequent in winter and spring, the males incidence was about 1.62 times higher than that in females. The children aged 3-9 were at peak incidence. The predominant infection was predominant infection, especially respiratory tract infection Induced, the first symptom of skin purpura was more common, the first diagnosis of gastrointestinal symptoms with higher misdiagnosis rate, gender (r > 0, P < 0.05), white blood cell count (r > 0, P < 0.05), D-dimer content (r > 0, P < 0.05). The common triggers were associated with the appearance of the main clinical symptoms (r > 0, P < 0.05). Conclusion Children with henoch-schonlein purpura (3-9 years old) have the highest incidence and may be misdiagnosed as the first cases of gastrointestinal symptoms. The multi-index comprehensive consideration of the results of routine laboratory tests can help assess the correlation of the main clinical symptoms, reduce the damage examination, and help the early diagnosis and treatment of the disease.
2018 Vol. 15 (12): 102-105,113 [Abstract] ( 215 ) HTML (1 KB)  PDF (1213 KB)  ( 138 )
106 Efficacy of CGF fibrin fluid combined with Bio-Oss bone meal on implantation of anterior teeth missing with labial bone defect
WANG Yi1 WAN Zhe1 LIU Yang2 HU Yang3
Objective To investigate the efficacy of concentrated growth factors (CGF) fibrin liquid combined with Bio-Oss bone meal in the treatment of implantation of anterior teeth missing with labial bone defect. Methods From December 2014 to February 2016, 85 patients with anterior teeth missing with labial bone defect admitted to Chinese Medicine Hospital Affiliated to Xinjiang Medical University were selected as the research subjects, and they were divided into observation group (43 cases) and control group (42 cases) by random number table. The observation group was treated with CGF fibrin liquid combined with Bio-Oss bone meal planting, and the control group was treated with Bio-Oss bone meal planting. The success situations of dental implant were compared between the two groups. The change of the thickness of the implant lip lateral bone, the thickness and density of the newborn between the two groups were measured and compared at 1, 3 and 6 months after implantation. Results Postoperative 10 days, the wound healing was good and the implantation was successful. The thickness of the implant lip lateral bone at 6 months after planting was lower than 1 month (P < 0.05), but there was no significant difference between the two groups (P > 0.05). At 1, 3, and 6 months after planting, the average thickness and density of the new bone in the observation group was significantly higher than that in the control group (P < 0.05), and the data at 6 months was higher than 1 months (P < 0.05). Conclusion CGF fibrin liquid combined with Bio-Oss bone powder has better curative effect on patients with upper anterior teeth defect and labial defect, which can effectively promote the growth of new bone tissue and improve bone quality.
2018 Vol. 15 (12): 106-109 [Abstract] ( 182 ) HTML (1 KB)  PDF (552 KB)  ( 266 )
110 A study of the total serum oxidant/antioxidant status in patients with minor recurrent aphthous ulcer
ZHANG Zichuan1 WANG Hongyan2 CHEN Guang1 WU Zhongyin1 FANG Huiqing1
Objective To investigate the serum content of total oxidant status (TOS) and total antioxidant status (TAS) in patients with minor recurrent aphthous ulcer (MiRAU) and compare them versus healthy individuals, and then to analyze that whether there is a possible relationship between TOS/TAS and the pathogenesis of RAU. Methods Ninety-seven patients having been diagnosed with minor recurrent aphthous ulcer (MiRAU) who presented in the Department of Stomatology of Bethune International Peace Hospital ("our hospital" for short) from March 2015 to December 2016 and 102 healthy persons being taken normal medical examination in our hospital were selected as observation group and control group respectively. The serum content of TOS, TAS, malondialdehyde (MDA) and uric acid (UA) were measured by the colorimetric measurement method, and then the oxidative stress index (OSI) being calculated were compared. Results The serum content of TOS and MDA and the value of OSI in the observation group were all higher than those in the control group, while the serum content of TAS was lower than that of the control group, with statistically significant difference (P < 0.05). No statistically significant differences were found between the two groups in the serum content of the UA (P > 0.05). Conclusion The oxidative stress status seems to have certain correlation with the pathogenesis of recurrent aphthous ulcer.
2018 Vol. 15 (12): 110-113 [Abstract] ( 230 ) HTML (1 KB)  PDF (481 KB)  ( 81 )
114 Prognosis evaluation of patients with idiopathic sensorineural hearing loss by hyperglycemia
CHEN Xianglei ZHANG Nianwu ZHAO Dan LIU Shuai
Objective To evaluate the prognostic value of hyperglycemia in patients with idiopathic sensorineural hearing loss (ISSHL). Methods From June 2015 to August 2017, 94 patients with ISSHL treated at Department of Otolaryngology, Rizhao Hospital of TCM were selected and divided into normal glucose tolerance group (45 cases), prediabetes group (28 cases) and diabetes mellitus group (21 cases) according to the results of glucose tolerance test and glycosylated hemoglobin level test. Before and after treatment, they were tested by pure tone audiometry examination to compare the hearing recovery of the three groups. Results The rate of hearing recovery in normal glucose tolerance group was higher than that the in prediabetes group and diabetes mellitus group (P < 0.05). There was no statistically significant difference in the rate of hearing recovery between the in prediabetes group and diabetes mellitus group (P > 0.05). Conclusion Hyperglycemia can affect the prognosis of patients with ISSHL, which can be used as an index for evaluating the rehabilitation of patients with ISSHL.
2018 Vol. 15 (12): 114-116 [Abstract] ( 209 ) HTML (1 KB)  PDF (460 KB)  ( 60 )
117 Clinical observation of abdominal acupuncture combined with repetitive transcranial magnetic stimulation in the treatment of hemiplegic shoulder pain
SU Caixia1 YAO Rui1 GONG Zunke1,2 WANG Shiyan2 WANG Mi2
Objective To investigate the clinical effects of abdominal acupuncture combined with high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for hemiplegic shoulder pain. Methods Sixty patients with hemiplegic shoulder pain met with research criteria treated in Xuzhou Central Hospital from January 2016 to May 2017 were selected and randomly divided into abdominal acupuncture group, rTMS group and combination group according to random number table method, with 20 cases in each group. All patients were forbidden to take painkillers and given conventional symptomatic drugs and rehabilitation training. The abdominal acupuncture group was treated with abdominal acupuncture, the rRMS group was treated with HF-rTMS, the combination group was given abdominal acupuncture combined with 10 Hz rTMS. The stimulation site was ipsilateral hemisphere M1 area. Before treatment and after treatment for 4 weeks, the upper extremity portion of simple Fugl-Meyer assessment (FMA) and visual analogue scale (VAS) were used to evaluate the efficacy. Results After treatment, the scores of VAS in the three groups were all lower than those before treatment, and the scores of FMA were all higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the VAS score of combination group was lower than those of abdominal acupuncture group and rTMS group, the VAS score of abdominal acupuncture group was lower than that of rTMS group, the differences were statistically significant (P ＜ 0.05). After treatment, the FMA score of the combination group was higher than those of abdominal acupuncture group and rTMS group, and the FMA score of rTMS group was higher than that of abdominal acupuncture group, the differences were statistically significant (P ＜ 0.05). Conclusion Abdominal acupuncture combined with HF-rTMS can significantly improve the miplegic shoulder pain and upper extremity motor function.
2018 Vol. 15 (12): 117-120,128 [Abstract] ( 257 ) HTML (1 KB)  PDF (923 KB)  ( 109 )
121 The preliminary study on the history of disaster medicine in China
LIU Tongting
Disaster refers to the phenomenon of sudden change of environment, resulting in casualties, property losses and ecological damage. It can be divided into natural disasters and man-made disasters. The former mainly includes meteorological disasters, while the latter mainly includes war disasters. Disaster medicine is the science of providing medical assistance and disaster prevention for the affected population. China is a country with frequent disasters. In recent 5000 years, the natural climate change in China has been divided into 4 years' warm period and 4 year cold period. Meanwhile, the replacement of the dynasty and the outbreak of war are closely related to climate change, and also have obvious regularity characteristics. This study finds that in the process of struggling with disasters, China's disaster medicine has undergone embryonic, initial, foundation, improvement, development, improvement and expansion. It can provide some references for the development and construction of modern disaster medicine.
2018 Vol. 15 (12): 121-124 [Abstract] ( 177 ) HTML (1 KB)  PDF (748 KB)  ( 69 )
125 Analysis of the new theory of andrology in traditional Chinese medicine
WANG Xuyun1 ZHANG Hong2 SHANG Jianwei3
In recent years, there have been some new understandings and theories about the pathogeny of anatomy physiology and disease in TCM male department. For example, the physiological understanding of “sperm chamber is man's unique organ” “internal and external kidney theory”. There are new understandings of etiology and treatment like “physical fitness”“the treatment of impotence by replenishing kidney and activating blood”, differentiating and treating male infertility from “microscopic aspect” “kidney deficiency, wet heat, stasis” and so on. This paper analyzes the new theory of anatomy physiology of male department, new theory of etiological differentiation and treatment of andrology, as well as the new discoveries of related basic researches, which should promote the development of andrology in traditional Chinese medicine.
2018 Vol. 15 (12): 125-128 [Abstract] ( 787 ) HTML (1 KB)  PDF (706 KB)  ( 427 )
129 Discussion on warm disease theory applied in treating childhood psoriasis based on syndrome differentiation
LI Kunshi DU Zhanglin YANG Xinxin LI Youle ZHAO Yansong
This paper discusses the pathogenesis and treatment of childhood psoriasis, based on syndrome differentiation of weifen, qifen, yingfen and xuefen of warm disease, syndrome differentiation of macula, and hidden pathogen theory. Connected with aetiological agent, pathogenesis and paediatric physiology, the pathogenic factors, classification, clinical features and attack of childhood psoriasis are studied and analyzed. A case report about childhood psoriasis is listed, to investigate its characteristics of warm disease theory.
2018 Vol. 15 (12): 129-131 [Abstract] ( 303 ) HTML (1 KB)  PDF (791 KB)  ( 111 )
132 Research on names related to apoplexy in ancient literatures
CAO Xia PEI Li
“Apoplexy” was first found in Plain Questions·Wind, which is different from the present meaning. Zhang Zhongjing created the name of “apoplexy” in the Han Dynasty. In Sui and Tang Dynasty, Chao Yuanfang proposed “wind stroke”. In the Southern Song Dynasty, Chen Yan proposed the term “head apoplexy” firstly. Wang Andao proposed “Zhenzhong” and “Leizhong” in Yuan Dynasty. In Ming Dynasty, Lou Ying named apoplexy as “Zuzhong”. In the late Qing Dynasty, Zhang Xichun proposed that encephalemia and brain anemia, which is coincided with the understanding of the pathogenesis of modern “hemorrhagic apoplexy” and “ischemic apoplexy”. This paper reveals the historical evolution of apoplexy by combing ancient literatures on the names of apoplexy and related diseases, so as to provide philology foundation for the modern people to understand and master apoplexy.
2018 Vol. 15 (12): 132-134 [Abstract] ( 171 ) HTML (1 KB)  PDF (697 KB)  ( 111 )
135 Effect of pricking blood therapy on acute gouty arthritis and its effect on serum metabolites
QIU Fanghui1 ZHANG Hongzhu2
Objective To investigate the curative effect of pricking blood therapy in the treatment of patients with acute gouty arthritis and its influence on serum metabolites. Methods Forty patients with acute gouty arthritis in Outpatient and Inpatient Department of Hangzhou Geriatric Hospital from March 2016 to November 2017 were selected. They were divided into pricking blood group and western medicine group by random number table method, with 20 cases in each group. The pricking blood group was treated with pricking blood therapy, and the western medicine group was given Colchicine Tablets orally, for 1 week respectively. The scores of joint pain index, joint functioning score, blood uric acid and erythrocyte sedimentation rate were evaluated before and after treatment. 10 patients were randomly selected from the pricking blood group. The serum before treatment was taken as group A, and the serum after treatment was taken as group B. Besides 10 healthy people's serum was taken as group D, which were from the volunteers that selected from the healthy employee in the hospital. The serum metabolites of group A, B and D were detected by liquid chromatography - mass spectrometry (LC-MS), and the difference was studied. Results After treatment, serum uric acid, erythrocyte sedimentation rate, joint pain score and joint functioning score of the two groups were significantly lower than those before treatment (P ＜ 0.05), and the joint pain score and joint function score of the pricking blood group were lower than those of the western medicine group (P ＜ 0.05). Tested by metabonomics, the differences in serum metabolites with group A were D- gluconic acid, L-glutamic acid, hypoxanthine, leukotriene B4. And the differences in metabolites between group B and group A were L- arginine, glycerin phospholipid, and insulin like growth factor. Conclusion Pricking blood therapy is better than oral Colchicine in comprehensive efficacy. According to the results of metabonomics detection and KEGG database, we hypothesizes that acute gouty arthritis occurs due to the disturbance of glucose metabolism, amino acid metabolism, hypoxanthine metabolism, and increasing of blood uric acid. And the curative effect of pricking blood therapy is to maintain the patency of the blood vessels and improve the metabolic disorder by affecting the synthesis of nitric oxide and the metabolism of lipids.
2018 Vol. 15 (12): 135-139 [Abstract] ( 257 ) HTML (1 KB)  PDF (765 KB)  ( 68 )
140 Research on soft science of traditional Chinese medicine and its development status
WANG Song1 ZHU Jiaqing2▲
This article mainly analyzes soft science of traditional Chinese medicine research by its origin, status quo, existing problems and suggestions. As a new discipline, soft science of traditional Chinese medicine has been developing continuously in exploration. Although the progress has been made, there are still some problems such as lack of knowledge of the category and system, insufficient research attention, lack of innovation and talent. In view of these problems, we must firmly grasp the opportunities of the development of traditional Chinese medicine, study and find a solution to the problem. At the same time, we also see that these issues will also be a breakthrough in the future sustainable development of traditional research on soft science of.
2018 Vol. 15 (12): 140-143,180 [Abstract] ( 206 ) HTML (1 KB)  PDF (1107 KB)  ( 189 )
144 Effect of Longdan Xiegan Decoction in the treatment of herpes zoster and on the expression of p38 MAPK gene
WU Weilian HUANG Changjin CAO Guixian
Objective To analyze the clinical efficacy of Longdan Xiegan Decoction in the treatment of herpes zoster and its influence on the expression of p38 MAPK gene in the affected skin. Methods Clinical data of 153 cases treated in the Dermatology Department of Guangzhou Red Cross Hospital from June 2017 to January 2016 was randomized into observation group (80 cases) and control group (73 cases). The control group received basic treatment combined with red-blue light treatment, the observation group was treated with Longdan Xiegan Decoction combined with red-blue light therapy. Both groups were treated for 4 weeks. Blister subsided time, scabby time, pain relief time were recorded before and after treatment, the clinical curative effect was evaluated. At the same time, the expression level of p38 MAPK gene was detected in each group. Results After treatment, blister subsided time, scabby time, pain relief time in the observation group were significantly shorter than those of the control group (P ＜ 0.05), the total effective rate of the observation group after treatment was significantly higher than that of the control group (P ＜ 0.05). In the two groups, the expression levels of p38 MAPK after treatment were significantly lower than those before treatment (P ＜ 0.05), while the observation group was significantly lower than that of control group (P ＜ 0.05). Conclusion Longdan Xiegan Decoction combined with red-blue light in the treatment of herpes zoster can effectively improve the clinical efficacy and the level of p38 MAPK gene in the attacked area.
2018 Vol. 15 (12): 144-147 [Abstract] ( 220 ) HTML (1 KB)  PDF (746 KB)  ( 58 )
148 Differentiation and treatment from lung and spleen on one proved case of rare classic Kapos′s Sarcoma in Han nationality
XU Weiru ZHANG Qing
One rare classic Kaposi′s Sarcoma in Han nationality diagnosed with pathology was presented with red and purplish red nodules subcutaneously or slightly elevated types on four extremities, chest and abdomen without system damage. The nodules were mainly on four extremities without pain, pruritus and desquamation. The patient denied East Europe bloodline or minority bloodline, and the history of organ transplantation, treatment with immunosuppressive agents and sexually transmitted disease. Anti-human immunodeficiency virus (HIV) antibody detection was negative. The patient was treated with traditional Chinese medicine at local hospital, but no remission was observed. Then the patient was treated with decoction orally to supplement lung and spleen, promote blood circulation and remove toxicity in oncology department of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Partial nodules regressed after treatment. Now the disease is stable.
2018 Vol. 15 (12): 148-150 [Abstract] ( 223 ) HTML (1 KB)  PDF (412 KB)  ( 126 )
151 Ability training of medical graduate students in writing research articles
ZHANG Yulin QIAO Luxin HUA Wei JIN Ronghua▲
Most findings of scientific research need to be shown through publishing research papers, so it is very important for train medical graduate students writing research articles. This article discusses the several issues about writing a research paper, including that research data are the basis of research articles, references reading is a precondition and innovation is a core of the articles. The skill and the procedure of writing a research article are also discussed, which involves that a central axis is necessary for an research article, results need to be planned and figures or tables need to be precisely prepared, a directivity is necessary for introduction, discussion should focus on results, methods reveal the research design, abstract need to be condensed, key words should be appropriate and title must be accurate. It should be shown in a research article that the research design and ideas, as well as the author's specific knowledge and writing skills.
2018 Vol. 15 (12): 151-153 [Abstract] ( 162 ) HTML (1 KB)  PDF (627 KB)  ( 76 )
154 Reform study of multi-professioned license of department of Dermatology specialist
SHI Ke1 SUN Zhonghe2
The number of patients from dermatology outpatient increases year by year and newly-recruited doctors rises slowly, the total number of dermatology outpatient doctors is obviously smaller. The PEST analysis model is used in this article to demonstrate the feasibility of multi-professioned lisence of department of dermatology specialists, analyze and break the law barrier and problem of promotion during the multi-professioned lisence in the department of dermatology specialist. The skin specialist hospital is taken as the pilot project to improve the management model of specialists’ scope of practice, change the laws of and broaden the practicing scope,which can change the single into multi-profession and make doctors equipped with many kinds of special skills to adjust themselves to the social development, promote their clinical practice ability and strengthen the efficiency of using medical resource. It also provides theoretical basis for the promotion of professional practice in dermatology hospitals and other specialized hospitals.
2018 Vol. 15 (12): 154-158 [Abstract] ( 212 ) HTML (1 KB)  PDF (645 KB)  ( 306 )
159 Analysis of patent situation of a medical university affiliated hospital for 2007-2016 years and correlative countermeasures
LI Fangjian1,2 WANG Ying2 CHEN Zhengjun2 SU Wei1
Objective To investigate the way to improve the quality and translational potential of patents by analyzing the patent applications of the Affiliated Hospital of Southwest Medical University in last ten years, in order to provide a reference for the establishment of relevant policies. Methods The date of applied and authorized patents in Affiliated Hospital of Southwest Medical University from January 2007 to December 2016 were made statistics, the number of applications, authorizations, patent types, translation and the basic information of the first inventors were analyzed by χ2 test and descriptive analysis with SPSS 19.0. Results From January 2015 to December 2016, the number of patent applications was 158 cases (54.67%), and authorizations was 118 cases (65.92%), these were significantly higher than the first eight years. Specifically, there was a significant difference in the percentage of invention patent(5.03%), utility model patent(94.41%) and design patent(0.56%) among all the authorized patents (P < 0.01). People with primary or intermediate titles were the majority of patent inventors, made up 72.07% of the total number. However, the patent enforcement rate was low. Conclusion There is a good trend of hospital patent work, however, the patents quality needs to be further improved. To promote the transformations and implementations, more efforts should be focussed on the intellectual property rights protection, incentive policy, as well as the construction of scientific and technological achievements conversion platform.
2018 Vol. 15 (12): 159-162 [Abstract] ( 168 ) HTML (1 KB)  PDF (766 KB)  ( 50 )
163 Effect of clinical pharmacist intervention on rational drug use and health management in patients with type 2 diabetes
MEN Chao1 ZHOU Yugang2 MA Guoku3
Objective To analyze the clinical pharmacist intervention in rational use of medicine and health management on patients with type 2 diabetes. Methods From January 2014 to June 2015, in Langfang TCM Hospital, 90 T2DM patients were selected, specialized personnel registered and established the patients' personal files, all patients were given health education and proper medication guidance. Followed-up for 1 year, unreasonable medication, fasting blood glucose, blood pressure, body weight and self-management changes before and after intervene of patients were observed. Results The dosage of unreasonable drugs, unreasonable choice of drugs, drug administration of repeated administration and hyper-indications after intervention were lower than those before intervention, the differences were statistically significant (P < 0.05); fasting blood glucose, 2-hour postprandial blood glucose, hemoglobin and systolic blood pressure after intervention were lower than before intervention, the differences were statistically significant (P < 0.05). The Proportion of medication compliance, blood glucose monitoring, diet and exercise to improve the number after intervention were higher than before intervention, the differences were statistically significant (P < 0.05). Conclusion The participation of clinical pharmacists is conducive to rationally use drugs in patients with T2DM, and improve the clinical efficacy of patient health management.
2018 Vol. 15 (12): 163-166 [Abstract] ( 186 ) HTML (1 KB)  PDF (689 KB)  ( 71 )
167 Preliminary study of the obstructive sleep apnea hypopnea syndrome screening model for female snorers
BU Mengying1 HUANG Rong2 XIAO Yi2 LUO Jinmei2 YU Lijun1
Objective To investigate the obstructive sleep apnea hypopnea syndrome (OSAHS) screening model for female snorers. Methods The clinical data of 223 female snorers, that had conducted sleep monitor in Peking Union Medical College Hospital from January 2017 to February 2018, was analyzed to investigate the risk factors of OSAHS and snoring conditions. According to the Logistic regression coefficient, the indices were assigned, a screening model was established, the score of the screening model was calculated and the ROC curve was plotted to evaluate the screening effect. Results There were 110 females diagnosed with OSAHS and the other 113 females were not. There were statistically significant significance in the body mass index (BMI), menstrual status, modified Mallampati index (MMP), number of year of snoring and degree of snoring categorized into Logistic regression equation model (P ＜ 0.05). The indices were assigned as BMI ≥ 24.55 kg/m2 (3 points), menopause (3 points), MMP ≥ Ⅲ class (2 points), year of snoring ≥ 10.25 years (4 points), degree of snoring was severe (2 points). The screening model score ranged from 0 to 14 points, the area under the ROC curve A was 0.795, the 95% confidence interval was (0.737, 0.853), which had significant difference (P ＜ 0.001). When the score got 7 points, Youden index was 0.452 the maximum, so 7 points were taken as the best division point. When screening model in this study set apnea hypopnea index (AHI) ≥ 5 times/h as standard of diagnosis, the sensitivity, specificity, positive predictive value, and negative predictive value were 70.9%, 74.3%, 72.6% and 71.8%. Conclusion Through this research of risk factors of OSAHS and snoring conditions of female snorers, the OSAHS screening model of female snorers is constructed, which has a certain clinical application value.
2018 Vol. 15 (12): 167-171 [Abstract] ( 219 ) HTML (1 KB)  PDF (739 KB)  ( 52 )
172 Design and study on priority review procedure of drug registration in China
FENG Yuanyuan1,2 YANG Yue1▲
The quality and effectiveness of drug review is associated with the total procedure of drugs. Based on the practice of drug review in China and lessons from the successful experience of priority review in the United States, this paper takes the priority review procedure of drug registration as the main line. The defects and shortcomings are found out by comparing the procedure design of China with the one of the United States. Furthermore, this paper puts forward related suggestions to improve the priority review procedure of drug registration in China, and provides references for the construction of priority review system of drug registration.
2018 Vol. 15 (12): 172-176 [Abstract] ( 183 ) HTML (1 KB)  PDF (643 KB)  ( 175 )
177 Application of formative assessment in electrocardiogram teaching
GUO Mei1 WANG Guochang1 GUO Rui2 GUO Peng3▲
Objective To explore the application effect of the formative assessment in electrocardiogram teaching. Methods From June of 2012 to June of 2015, 240 clinical medical undergraduate students of Grade 2009 and Grade 2010 practiced in Shanxian Central Hospital were selected as the study subjects, they all came from Jining Medical Collage. Students of Grade 2010 were selected as test group, they given trial reporting before class, performance in class, stage of testing and the teaching practice combined with self-evaluation, got formative assessment achievement; students of Grade 2010 were selected as control group, they were given traditional teaching method. The average score,pass rate and excellent rate were as evaluation indicators, the effect of two teaching methods were compared. Results The average score,the excellent rate and the pass rate of students in test group were higher than control group, the differences were statistically significant (P < 0.05); the satisfaction degree of students in the test group was better than control group, the difference was statistically significant (P < 0.05). Conclusions The effect of the formative assessment teaching methods is better than the traditional teaching methods, it can be used in clinical teaching practice of electrocardiogram. 
2018 Vol. 15 (12): 177-180 [Abstract] ( 237 ) HTML (1 KB)  PDF (690 KB)  ( 110 )
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