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| Research status of Pseudomonas aeruginosa pilus induce IL-1β |
| PAN Xingguo1* LI Ronghui2* ZHANG Hua2 |
1.Department of Labroatory Medicine, Zunyi Medical University, Guizhou Province, Zunyi 563099, China;
2.Department of Clinical Laboratory, Guizhou Provincial People's Hospital, Guizhou Province, Guiyang 550002, China |
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Abstract Pseudomonas aeruginosa can induces inflammatory response after successful infection on the host. However, the surface of the bacterial Type Ⅳ Pili is one of the inflammatory factors. The main composition of the pilus is PilA. One pilus is made up of thousands PilA subunits. PilA can induce host macrophages to produce IL-1β, IL-1β is a key important inflammatory cytokine in host defence which mediates a diverse range of effects, including T-cell polarization, antibody production, fever and endothelial and phagocyte activation. This paper summarizes the research status of pseudomonas aeruginosa pilus induce IL-1β.
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