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| The correlation of OXLDL, TGF-β2, APN, leptin and ApoC Ⅲ and gestational diabetes mellitus |
| CHENG Lilan1 CHENG Yeli2 MA Aijiang1 WEI Zhaoxuan1 |
1.Department of Outpatient Internal Medicine, Hebei Province Directly under the Authority, Hebei Province, Shijiazhuang 050051, China;
2.Department of Obstetrics and Gynecology, Beijing Pinggu District Hospital, Beijing 101200, China |
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Abstract Objective To explore the relationship of OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ and gestational diabetes mellitus (GDM). Methods From September 2016 to June 2017, 200 pregnant women in Department of Outpatient Internal Medicine, Hebei Province Directly under the Authority were selected as the research object, serum was collected during the 16-18 weeks of pregnancy, the serum levels of OXLDL, TGF-β2, ApoC Ⅲ, leptin and APN were detected by ELISA method. Routine OGTT screening was taken during the 24-28 weeks of pregnancy, the normal women as the control group and diagnosed with GDM as the observation group, with 100 cases in each group. Levels of OXLDL, TGF-β2, ApoC Ⅲ, leptin and APN in the two groups were compared, the pregnancy and neonatal outcome in the two groups were compared. Refer to the control of blood glucose, the observation group was divided into poor glucose control group (55 cases) and standard glucose control group (44 cases). Levels of OXLDL, TGF-β2, APN, leptin, ApoC Ⅲwere compared bettwen the two groups. Correlation analysis of fasting glucose and OXLD, TGF-β2, APN, leptin, ApoC Ⅲ were conducted in observation group. Results Levels of the OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ were significantly higher in observation group than those of the control group, level of APN was significantly lower in the observation group than the control group, the differences were statistically significant (P < 0.01). The outcome of mother and fetus were better in control group than the observation group, and the Apgar scores was significantly lower in the observation group than the control group, the difference was statistically significant (P < 0.01). Levels of the OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ were significantly higher in poor glucose control group than standard glucose control group, level of APN was significantly lower in poor glucose control group than the standard glucose control group, the difference was statistically significant (P < 0.01). In the observation group, levels of OXLD, TGF-β2, leptin, ApoC Ⅲ were positive related to the fasting blood glucose (r=0.6315, 0.7412, 0.6155, 0.5411, all P < 0.05), and APN was negatively related to the fasting blood glucose (r=-0.6613, P < 0.05). Conclusion The changes of OXLDL, TGF-β2, APN, leptin, ApoC Ⅲ level in patients with gestational diabetes mellitus are closely related to the occurrence and development of disease.
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