高原与零海拔区域复发性流产的血栓前状态分析

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Abstract Objective To analyze and compare the prethrombotic state (PTS) of RSA in the plateau areas and the zero altitude areas, to provide a theoretical basis of Western anticoagulant therapy and traditional Chinese medicine for blood circulation treatment for the RSA, particulary in the plateau areas. Methods From January 2012 to December 2016, 60 women with RSA (≤10 weeks) and 108 women with normal early pregnancy (≤10 weeks) who were hospitalized for termination of pregnancy at Shenzhen University Hospital of Guangzhou University of Traditional Chinese Medicine were selected as the Zero altitude areas RSA group and the Zero altitude areas normal group, 40 women with RSA (≤10 weeks) and 52 women with normal early pregnancy (≤10 weeks) who were hospitalized for termination of pregnancy at the same peroid in the People′s Hospital of Taxkorgan County in Xinjiang Uygur Autonomous Region were selected as the plateau areas RSA group and the plateau areas normal group. The prothrombin time (PT), partial thromboplastin time (APTT), thrombin time (TT), fibrinogen content (Fbg) and platelet (PLT), hematocrit (HCT) were determined for each group of case and compared. Results The RSA group compared with the normal group in the zero altitude areas, PT decreased significantly, Fbg and HCT increased significantly (P < 0.01), APTT and TT decreased (P < 0.05), and PLT decreased slightly (P > 0.05). The normal group in the plateau areas compared with the normal group in the zero altitude areas, PT, TT and APTT were significantly lower (P < 0.01). while the levels of Fbg and HCT were significantly increased (P < 0.05), and PLT decreased slightly (P > 0.05). The RSA group Compared with the normal groupin the plateau areas, PT was significantly lower (P < 0.01), Fbg was significantly higher (P < 0.01), PLT slightly decreased, (P > 0.05) , APTT and TT decreased (P < 0.05) , HCT increased (P < 0.05). The RSA group in the plateau areas, compared with the RSA group in the zero altitude areas, PT, TT and APTT were significantly lower(P < 0.01), Fbg and HCT were significantly increased (P < 0.01), PLT slightly decreased (P > 0.05). Conclusion Both the zero altitude areas and the plateau areas RSA groups (≤ 10 weeks) women′s blood are in a state of hypercoagulability, but the RSA group in the plateau areas are especially obvious. The RSA group women in the plateau areas should strengthen anticoagulant therapy for the next pregnancy in order to improve the fertility status.

Key words： Recurrent spontaneous abortion Elevation Prethrombotic state Prothrombin time Activated partial thrombin time Thrombin time Fibrinogen Platelets Hematocrit

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	JIANG Weihong1 Maixiati·maimaituohuti2 MO Li3 Ayinaziri ·apotukelimu4

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JIANG Weihong1 Maixiati·maimaituohuti2 MO Li3 Ayinaziri ·apotukelimu4. Analysis the prethrombotic state of recurrent spontaneous abortion in the plateau and zero altitude areas[J]. 中国医药导报, 2018, 15(12): 78-81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I12/78

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