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| A study of the total serum oxidant/antioxidant status in patients with minor recurrent aphthous ulcer |
| ZHANG Zichuan1 WANG Hongyan2 CHEN Guang1 WU Zhongyin1 FANG Huiqing1 |
1.Department of Stomatology, Bethune International Peace Hospital, Hebei Province, Shijiazhuang 050082, China;
2.Hebei Provincial Institute of Medical Information, Hebei Province, Shijiazhuang 050000, China |
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Abstract Objective To investigate the serum content of total oxidant status (TOS) and total antioxidant status (TAS) in patients with minor recurrent aphthous ulcer (MiRAU) and compare them versus healthy individuals, and then to analyze that whether there is a possible relationship between TOS/TAS and the pathogenesis of RAU. Methods Ninety-seven patients having been diagnosed with minor recurrent aphthous ulcer (MiRAU) who presented in the Department of Stomatology of Bethune International Peace Hospital ("our hospital" for short) from March 2015 to December 2016 and 102 healthy persons being taken normal medical examination in our hospital were selected as observation group and control group respectively. The serum content of TOS, TAS, malondialdehyde (MDA) and uric acid (UA) were measured by the colorimetric measurement method, and then the oxidative stress index (OSI) being calculated were compared. Results The serum content of TOS and MDA and the value of OSI in the observation group were all higher than those in the control group, while the serum content of TAS was lower than that of the control group, with statistically significant difference (P < 0.05). No statistically significant differences were found between the two groups in the serum content of the UA (P > 0.05). Conclusion The oxidative stress status seems to have certain correlation with the pathogenesis of recurrent aphthous ulcer.
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[1] Edgar NR，Saleh D，Miller RA. Recurrent aphthous stomatitis：a review [J]. J Clin Aesthet Dermatol，2017，10（3）：26-36.
[2] Cui RZ，Bruce AJ，Rogers RS. Recurrent aphthous stomatitis [J]. Clin Dermatol，2016，34（4）：475-481.
[3] Natah SS，Konttinen YT，Enattah NS，et al. Recurrent aphthous ulcers today： a review of the growing knowledge [J]. Int J Oral Maxillofac Surg，2004，33（3）：221-234.
[4] Akintoye SO，Greenberg MS. Recurrent aphthous stomatitis [J]. Dent Clin North Am，2014，58（2）：281-297.
[5] Li XY，Zhang ZC. Assessment of serum malondialdehyde，uric acid，and vitamins C and E levels in patients with recurrent aphthous stomatitis [J]. J Dent Sci，2016，11（4）：401-404.
[6] Zhang Z，Li S，Fang H. Enzymatic antioxidants status in patients with recurrent aphthous stomatitis [J]. J Oral Pathol Med，2017，46（9）：817-820.
[7] Erel O. A new automated colorimetric method for measuring total oxidant status [J]. Clin Biochem，2005，38（12）：1103-1111.
[8] Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation，more stable ABTS radical cation [J]. Clin Biochem，2004，37（4）：277-285.
[9] Esen C，Alkan BA，Kιrnap M，et al. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index [J]. J Periodontol，2012，83（6）：773-779.
[10] Scully C，Gorsky M，Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis：a consensus approach [J]. J Am Dent Assoc，2003，134（2）：200-207.
[11] Chavan M，Jain H，Diwan N，et al. Recurrent aphthous stomatitis：a review [J]. J Oral Pathol Med，2012，41（8）：577-583.
[12] Preeti L，Magesh K，Rajkumar K，et al. Recurrent aphthous stomatitis [J]. J Oral Maxillofac Pathol，2011，15（3）：252-256.
[13] Bandeira SM，Fonseca LJ，Guedes GS，et al. Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus [J]. Int J Mol Sci，2013，14（2）：3265-3284.
[14] Sereflican M，Sereflican B，Dagistan E，et al. Subclinical atherosclerosis in patients with recurrent aphthous stomatitis [J]. Oral Dis，2016，22（6）：573-577.
[15] Qasim M，Bukhari SA，Ghani MJ，et al. Relationship of oxidative stress with elevated level of DNA damage and homocysteine in cardiovascular disease patients [J]. Pak J Pharm Sci，2016，29（6 Suppl）：2297-2302.
[16] Katakwar P，Metgud R，Naik S，et al. Oxidative stress marker in oral cancer： A review [J]. J Cancer Res Ther，2016， 12（2）：438-446.
[17] Hussain T，Tan B，Yin Y，et al. Oxidative stress and inflammation：what polyphenols can do for us？[J]. Oxid Med Cell Longev，2016，2016：7 432 797.
[18] Kesarwala AH，Krishna MC，Mitchell JB. Oxidative stress in oral diseases [J]. Oral Dis，2016，22（1）：9-18.
[19] Zalewska A，Kna M，Gińdzieńska-Sie■kiewicz E，et al. Salivary antioxidants in patients with systemic sclerosis [J]. J Oral Pathol Med，2014，43（1）：61-68.
[20] Tugrul S，Koçyi■it A，Do■an R，et al. Total antioxidant status and oxidative stress in recurrent aphthous stomatitis [J]. Int J Dermatol，2016，55（3）：e130-e135.
[21] Akoglu G，Metin A，Kilinc F，et al. Total serum oxidant/ antioxidant status and arylesterase activity in recurrent aphthous stomatitis [J]. Ann Dermatol，2013，25（3）：273-277.
[22] Babaee N，Hosseinkazemi H，Pouramir M，et al. Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis [J]. Caspian J Intern Med，2016，7（1）：13-18.
[23] Ca■layan F，Miloglu O，Altun O，et al. Oxidative stress and myeloperoxidase levels in saliva of patients with recurrent aphthous stomatitis [J]. Oral Dis，2008，14（8）：700-704.
[24] Sautin YY，Johnson RJ. Uric acid：the oxidant-antioxidant paradox [J]. Nucleosides Nucleotides Nucleic Acids，2008，27（6）：608-619. |
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