糖化白蛋白和糖化血红蛋白在T2DM合并血管病变早期诊断中的作用

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Abstract Objective To investigate the significance of glycosylated hemoglobin (HbA1c) and glycated albumin (GA) in the early diagnosis of type 2 diabetes mellitus (T2DM) combined with vasculopathy. Methods From July 2013 to July 2016, 128 cases of patients with type 2 diabetes mellitus in Department of Endocrinology, the Affiliated Jiangning Hospital of Nanjing Medical University were selected as the research objects, which including 65 cases of patients with type 2 diabetes mellitus complicated with vasculopathy (group A) and 63 cases of patients with type 2 diabetes mellitus without vasculopathy (group B). At the same time 68 cases of healthy people were selected as control group (group C). The levels of HbA1c and GA in the 3 groups were detected and the differences of the indicators in the 3 groups were statistically analysed. Results The values of HbA1c and GA in group A and group B were all higher than those of group C, with highly statistically significant differences (P ＜ 0.001), but there were no statistically significant differences between group A and group B (P ＞ 0.05). The receiver operating characteristic curve (ROC curve) showed that the area under the ROC curve of HbA1c of group A and group C was 0.980, the most suitable cutoff value was 6.55 mmol/L, the sensitivity was 95.38% and the specificity was 91.56%. The area under the ROC curve of HbA1c of group B and group C was 0.981, the most suitable cutoff value was 6.50 mmol/L, the sensitivity was 95.24% and the specificity was 91.80%. The area under the ROC curve of GA of group A and group C was 0.965, the most suitable cutoff value was 15.65 mmol/L, the sensitivity was 95.45% and the specificity was 96.72%. The area under the ROC curve of GA of group B and group C was 0.930, the most suitable cutoff value was 15.70 mmol/L, the sensitivity was 88.89% and the specificity was 96.89%. Conclusion The levels of GA and HbA1c in patients with T2DM combined with vasculopathy are significantly higher than those of healthy people, while there are no significant differences in GA and HbA1c between T2DM and T2DM combined with vasculopathy. Therefore, the detection of GA and HbA1c have no effect on the early diagnosis of T2DM combined with vasculopathy.

Key words： Glycated albumin Glycosylated hemoglobin Type 2 diabetes mellitus Vasculopathy

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	ZHANG Mei WANG Huan XU Yong LI Yan CHEN Li PENG Qisong▲

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ZHANG Mei WANG Huan XU Yong LI Yan CHEN Li PENG Qisong▲. The significance of glycated albumin and glycosylated hemoglobin in the early diagnosis of type 2 diabetes mellitus combined with vasculopathy[J]. 中国医药导报, 2018, 15(12): 41-44.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I12/41

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