|
|
Clinical analysis of 110 patients with henoch-schonlein purpura |
ZHANG Xiaoming ZHU Haitao LV Jinchuan |
Department of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu Province, Zhenjiang 212000, China |
|
|
Abstract Objective To analyze the epidemiological data, clinical features and susceptibility factors of Henoch-Schonlein purpura and provide references for the clinical diagnosis and treatment of this disease. Methods Clinical data of 110 inpatients with henoch-schonlein purpura diagnosed in pediatrics of Affiliated Hospital of Jiangsu University from January 2011 to December 2014 was retrospectively analyzed, the clinical data were summarized. Results Epidemiological analysis showed that the disease was more frequent in winter and spring, the males incidence was about 1.62 times higher than that in females. The children aged 3-9 were at peak incidence. The predominant infection was predominant infection, especially respiratory tract infection Induced, the first symptom of skin purpura was more common, the first diagnosis of gastrointestinal symptoms with higher misdiagnosis rate, gender (r > 0, P < 0.05), white blood cell count (r > 0, P < 0.05), D-dimer content (r > 0, P < 0.05). The common triggers were associated with the appearance of the main clinical symptoms (r > 0, P < 0.05). Conclusion Children with henoch-schonlein purpura (3-9 years old) have the highest incidence and may be misdiagnosed as the first cases of gastrointestinal symptoms. The multi-index comprehensive consideration of the results of routine laboratory tests can help assess the correlation of the main clinical symptoms, reduce the damage examination, and help the early diagnosis and treatment of the disease.
|
|
|
|
|
[1] 易著文.小儿过敏性紫癜的诊断与治疗[J].中国实用儿科杂志,2009,24(11):827-830.
[2] 赵丽君,李亚萍.过敏性紫癜337例回顾性分析[J].中南大学学报:医学版,2017,42(1):72-77.
[3] 陈楠,张慧娟,高兴华,等.过敏性紫癜695例临床分析[J].中国皮肤性病学杂志,2014,28(5):482-484.
[4] Ozen S,Ruperto N,Dillon MJ,et al. EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides [J]. Ann Rheum Dis,2006,65(7):936-941.
[5] 任献国,张沛,高远赋,等.儿童紫癜性肾炎肾脏病理分级与临床特征关系探讨[J].中国全科医学杂志,2013,16(7C):2441-2443.
[6] Butbul Aviel Y,Dafna L,Pilar G,et al. Endothelial function in children with a history of henoch schonlein purpura [J]. Pediatr Rheumatol Online J,2017,15(1):3.
[7] Lau KK,Suzuki H,Novak J,et al. Pathogenesis of Henoch-Schnlein purpura nephritis [J]. Pediatr Nephrol,2010,25(1):19-26.
[8] Davies M,Nanda Kumar M,Shetty V,et al. Henoch-Schönlein purpura as a rare cause of an acute abdomen [J]. Ann R Coll Surg Engl,2017,99(2):e88-e90.
[9] Lau KK,Suzuki H,Novak J,et al. Pathogenesis of Henoch-Schnlein purpura nephritis [J]. Pediatr Nephrol,2010,25(1):19-26.
[10] 方湘玲,易著文,党西强,等.儿童过敏性紫癜236例临床分析[J].临床儿科杂志,2006,24(1):46-49.
[11] Rivera F,Anaya S,Pérez-ölvarez J,et al. Henoch-Schönlein nephritis associated with streptococcal infection and persistent hypocomplementemia:a case report[J]. J Med Case Rep,2010,4(1):1-5.
[12] Hoshino C. Adult onset Schönlein-Henoch purpura associated with Helicobacter pyloriinfection [J]. Intern Med,2009,48(10):847-851.
[13] Mizerska-Wasiak M,Maldyk J,Demkow U,et al. Treatment Outcomes in Children with Henoch-Schönlein Nephriti [J]. Adv Exp Med Biol,2016,912:65-72.
[14] Trnka P. Henoch-Schönlein purpura in children [J]. J Paediatr Child Health,2013,49(12):995-1003.
[15] 李沫民,柳旎,张淼,等.过敏性紫癜患儿血清中期因子变化的临床意义[J].中国实验血液学杂志,2017,25(1):181-185.
[16] 温杰,杜三军,王晓美,等.D-二聚体水平检测对过敏性紫癜患者的临床诊疗价值[J].昆明医科大学学报,2017, 38(3):90-93.
[17] 符莹,崔建坡,罗继霞,等.过敏性紫癜患儿不同时期血清D-二聚体与病程的关系[J].中国小儿血液与肿瘤杂志,2015,20(1):45-46.
[18] 皮光环,田小兵,马涛,等.血清淀粉酶及血清IgA检测在儿童腹型过敏性紫癜诊断中的价值[J].中国循证医学杂志,2009,9(9):1031-1032.
[19] 王学红,朱永梅,高来强,等.过敏性紫癜患者CRP、C3、D-二聚体的水平与疾病严重程度的相关性[J].中国麻风皮肤病杂志,2015,31(5):739-742.
[20] 周利红,高纯,蒋天茹,等.血清Cys-C、ASO、hs-CRP和尿mLAB对过敏性紫癜患儿早期肾功能损伤的诊断意义[J].国际检验医学杂志,2012,33(23):2908-2909. |
|
|
|