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2023 Vol. 20, No. 21
Published: 2023-07-25
 
 
4 Research hotspot of domestic elderly medical and health service utilization based on CiteSpace
HE Yingmei1 LIU Bing1 LIU Xiang2 WU Dongmei3
DOI: 10.20047/j.issn1673-7210.2023.21.01
Objective To construct the visualization knowledge map of the research field of elderly medical and health service utilization in China. Methods The relevant literatures published in CNKI and Web of Science core collection database from January 2000 to June 2022 were respectively searched, and CiteSpace software was used to visualize the annual number of publications, authors, institutions, and keywords. Results A total of 964 articles were included. Since 2000, the annual number of published papers in this field has shown an overall increasing trend, and important research centers such as Peking University and Shandong University have been formed, but there was a lack of extensive cooperation among the centers and core authors. The research focused on the elderly medical and health service demand, utilization and influencing factors, the elderly community health service utilization, and medical security system. Conclusion This study visually shows the trend of publications, core authors, and institutional networks in the field of geriatric medical and health services utilization in China since 2000, the research hotspots and trends in this field are summarized, which can provide reference for the follow-up research and policy formulation in this field.
2023 Vol. 20 (21): 4-8 [Abstract] ( 25 ) HTML (1 KB)  PDF (1749 KB)  ( 178 )
9 Functional study of BMH2 in regulating the pathogenic infection ability of Cryptococcus neoformans
LI Jie1 HE Zhichun2 ZHENG Fanglin1 XU Xinping1
DOI: 10.20047/j.issn1673-7210.2023.21.02
Objective To study the functional role of BMH2 gene in Cryptococcus neoformans. Methods Using CRISPR-Cas9 combined electroporation, the original promoter of BMH2 gene was replaced with the inducible promoter CTR4 construction conditional knockout mutant strain. The original promoter of BMH2 gene was supplemented to construct a complement strain. The strains were cultured in basic YPD/copper-rich YPD solid medium to observe the growth of the strains; the growth curve was plotted in copper-rich YPD liquid medium; the cell morphology was observed in basic YPD/copper-rich YPD liquid medium; the hypha growth was observed in basic V8/copper-rich V8 solid medium; Basic YPD/copper-rich YPD solid medium was cultured at 25℃, 30℃, and 37℃, and the growth was observed at different temperatures; the growth was observed in copper-rich YPD and copper-rich YPD+stress solid medium. Results There was no difference in the growth of all strains in basic YPD solid medium； in copper-rich YPD solid medium, the growth of mutant train was weakened, but there was no difference between wild type and complement strain. Compared with the wild type, the survival curve of mutant train decreased, and the trend of complement strain was consistent with that of wild type. There was no difference in cell morphology of all strains in basic YPD liquid medium; in copium-rich YPD liquid medium, there was no difference in cell morphology between wild-type and complement strain, but the cells of mutant strain became larger and irregular. In copper-rich YPD liquid medium, the cell diameter of mutant strain was larger than that of wild type and complement strain (P＜0.05), but there was no significant difference in cell diameter between wild type and complement strain (P＞0.05). In base V8 solid medium, the mutant strain produced a small amount of hypha compared with the wild type. In copper-rich V8 solid medium, the mutant strains did not produce hypha at all compared with the wild type. In basic YPD solid medium, all strains showed no difference in growth at different temperatures; in copper-rich YPD solid medium, there was no difference in the growth of complement strain and wild type, but the growth of mutant strain showed high temperature sensitivity. Under different stress conditions, there was no difference in the growth of complement strain and the wild type. Compared with wild-type and normal growing strains without stress, mutant strain showed growth inhibition under the stress of 0.005% SDS, 0.250% CR, 1 mol/L KCL, 1 mol/L NaCl, and 1 mol/L Sorbitol; compared with the wild type, the mutant strain showed growth inhibition under the stress of 10, 15 mmol/L, and 20 mmol/L DTT; compared with the normal growing without stress, the growth of the mutant strain under the stress of 10, 15 mmol/L, and 20 mmol/L DTT was enhanced.  Conclusion BMH2 gene plays an important role in normal growth, hyphae growth, high-temperature growth, and stress response of Cryptococcus neoformans.
2023 Vol. 20 (21): 9-13,18 [Abstract] ( 14 ) HTML (1 KB)  PDF (1487 KB)  ( 199 )
14 Role of macrophage migration inhibitor in early brain injury after subarachnoid hemorrhage in rats
SHENTU Huasong CHEN Yihua CHENG Zhenyu
DOI: 10.20047/j.issn1673-7210.2023.21.03
Objective To investigate the role of macrophage migration inhibitory factor (MIF) in early brain injury (EBI) after subarachnoid hemorrhage (SAH) in rats. Methods A total of 120 12-month-old healthy male Sprague Dawley rats (clean grade) were divided into Sham group, SAH group and inhibitor group according to random number table method, with 40 rats in each group. 0.5 h before operation, rats in the inhibitor group were intraperitoneally injected with MIF inhibitor (10 mg/kg), and rats in the SAH group and Sham group were intraperitoneally injected with 0.9% sodium chloride injection, and then SAH group and inhibitor group were constructed by secondary blood injection in the occipital cisterna. In the Sham group, 0.9% sodium chloride injection was injected with the same amount of liquid twice. Cortical MIF protein, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-6, nerve cell apoptosis, brain water content, blood-brain barrier permeability and neurobehavioral function were determined after surgery. Results Compared with Sham group, MIF protein, IL-1β, TNF-α, IL-6, proportion of apoptotic nerve cells, brain water content index and content of Evan’s blue of rats in SAH group were significantly increased, and neurobehavioral scores were significantly decreased (P＜0.05). Compared with SAH group, IL-1β, TNF-α, IL-6, proportion of apoptotic nerve cells, brain water content index and content of Evan’s blue in inhibitor group were significantly decreased, and neurobehavioral scores were significantly increased (P＜0.05), but there was no statistical significance in MIF protein level between SAH group and inhibitor group (P＞0.05). Conclusion MIF may induce EBI after SAH, and inhibition of MIF may protect EBI.
2023 Vol. 20 (21): 14-18 [Abstract] ( 23 ) HTML (1 KB)  PDF (1119 KB)  ( 84 )
19 Study on the quality evaluation of Smilax glabra Roxb. based on UPLC fingerprint, grey correlation analysis， and chemical pattern recognition
TIAN Qingqing1 ZHONG Zhikui1 ZHANG Xuelan1 LIN Weixiong1 WANG Mei1 SUN Jianyan1 LIU Liaoyuan1 LIU Xiaotong2
DOI: 10.20047/j.issn1673-7210.2023.21.04
Objective To establish a quality evaluation method for Smilax glabra Roxb. Methods Similarities for various batches were evaluated based on ultra performance liquid chromatography (UPLC) fingerprint chromatography. The detection method for astilbin was set up, with contents of moisture, ethanol-based extractives, and water-based extractives of Smilax glabra Roxb. being detected as well. Results A total of eight common peaks were demarcated in UPLC fingerprint of Smilax glabra Roxb., five of which were identified. The astilbin content exhibited good linearity was 2.024-202.355 μg/ml, the average recovery was 99.35%, and the RSD value was 0.573%. Grey correlation analysis showed that the quality of (light) red brown poria was better. By clustering analysis, the (light) red-brown Tuckahoe was classified as the first group, and the other white Tuckahoe was classified as the second group; according to the importance projection value, the markers were selected as astilbin, alcohol extract and water by orthogonal partial least square discriminant analysis. Conclusion This method can effectively differentiate between qualities of different colors and provide quality evaluation basis for Smilax glabra Roxb.
2023 Vol. 20 (21): 19-24 [Abstract] ( 28 ) HTML (1 KB)  PDF (1668 KB)  ( 138 )
25 Effect of pyroptosis pathway nuclear factor κB/cysteine aspartic acid specific protease-1 on myocardial vulnerability after renal ischemia reperfusion in diabetic rats with Dexmedetomidine
GENG Qiang1　ZHANG Jingjing2　Yiheshan·Ainiwaer2 ZHANG Bing2
DOI: 10.20047/j.issn1673-7210.2023.21.05
Objective To investigate the role of nuclear factor κB (NF-κB)/ cysteine aspartic acid specific protease-1 (caspase-1) in Dexmedetomidine (Dex) in alleviating myocardial vulnerability after renal ischemia reperfusion in diabetic rats. Methods Thirty SPF male Wistar rats aged 8-12 weeks, weighing 200-300 g, were fed with high fat for four weeks and intraperitoneal injection of 1% Streptozotocin (30 mg/kg) was used to establish a diabetes model. The animals were divided into control group, model group, and Dex group with eight animals in each group. Renal ischemia reperfusion model was established in the model group and the Dex group, while the control group was laparotomy only. Dex was injected into the tail vein at a rate of 2 μg/(kg·h) from 30 min before ischemia to 4 h after reperfusion in the left kidney in the Dex group, and the same amount of normal saline was injected into the model group and the control group simultaneously. At the end of the experiment, the myocardial and serum samples of the three groups were collected, and serum cardiac troponin I (cTnI), interleukin (IL)-1β, IL-18, IL-17a, IL-10, and tumor necrosis factor-α (TNF-α) levels were determined by enzyme- linked immunosorbent assay, and the apoptosis rate of cardiomyocytes was determined by TUNEL staining. The expressions of NF-κB p65, p-NF-κB p65, caspase-1, and GSDMD-N in myocardial tissues of the three groups were determined by Western blot. Results The levels of IL-1β, IL-18, cTnI, TNF-α, IL-17a, p-NF-κB, caspase-1, GSDMD-N, and apoptosis rate of cardiomyocytes in model group were higher than those in control group, and the levels of IL-10 were lower than those in control group (P＜0.05). The levels of IL-1β, IL-18, cTnI, TNF-α, IL-17a, p-NF-κB, caspase-1, GSDMD-N, and apoptosis rate of cardiomyocytes in Dex group were lower than those in model group, and the levels of IL-10 were higher than those in model group (P＜0.05). Conclusion Dex can reduce myocardial injury after renal ischemia-reperfusion in diabetic rats, improve cardiac function, and reduce the release of inflammatory factors, the mechanism of which may be related to inhibiting the expression of myocardial pyrogenic protein.
2023 Vol. 20 (21): 25-28,34 [Abstract] ( 23 ) HTML (1 KB)  PDF (994 KB)  ( 123 )
29 Study on medication rules of Professor Chen Bainan in treating chronic venous insufficiency of lower limbs based on data mining
ZHANG Xiaoqian1 FAN Qichen2 WANG Genyi2 WANG Yannan3
DOI: 10.20047/j.issn1673-7210.2023.21.06
Objective To summarize the medication rules of Professor Chen Bainan in treating chronic venous insufficiency (CVI) of lower limbs. Methods The clinical prescriptions of Professor Chen Bainan for the treatment of CVI in the Outpatient Department of Peripheral Vascular Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2017 to March 2022 were collected. The methods of frequency analysis, association rule analysis, topological data analysis, and cluster analysis were used to analyze drug frequency, nature and flavour, channel tropism, new prescription construction, and drug combination, and to explore the rule of drug use. Results A total of 520 prescriptions were collected in this study, including 152 traditional Chinese medicine, among which 35 were high-frequency traditional Chinese medicine. High-frequency drugs were clearing heat drugs, promoting blood circulation for removing blood stasis drugs, tonifying drugs. The drug natures were mostly cold or warm, the drug flavours were bitter, pungent or sweet, the drugs main into the liver channel. A total of 24 strong association rules were obtained, one new formula was constructed, and and three cluster combinations were obtained. Conclusion Professor Chen Baonan’s medication rules for CVI treatment is to promote blood and detoxification, taking into account strengthening vital qi, advocating the regulation of qi movement, regulating qi and activating blood, paying attention to dampness pathogen, and being good at removing dampness flexibly.
2023 Vol. 20 (21): 29-34 [Abstract] ( 23 ) HTML (1 KB)  PDF (1372 KB)  ( 31 )
35 Reasearch progress of signaling pathways and related therapies in neurogenesis after ischemic stroke
CHEN Yanxi1 XU Zhidong2 SUN Fangling1 WANG Wen1
DOI: 10.20047/j.issn1673-7210.2023.21.07
Ischemic stroke is a cerebrovascular disease that seriously reduces people’s quality of life. The effective therapeutic drug of this disease, Alteplase, has a narrow thrombolytic time window, which limits the application of patients. Wnt/β-catenin, Notch, PI3K/Akt, MAPK, and Eph-ephrin pathways play important roles in the development of central nervous system and are involved in cell growth, migration, and adhesion. Since adult nerve cells growth have been stopped, reactivation of these pathways may bring hope for endogenous regeneration and repair of brain injury. Finding mechanisms and drugs targeting these pathways involved in neurogenesis will be beneficial to stroke rehabilitation. This article reviews the key processes and drug development of these pathways involved in neurogenesis.
2023 Vol. 20 (21): 35-39 [Abstract] ( 18 ) HTML (1 KB)  PDF (560 KB)  ( 129 )
40 Research progress on atherosclerosis induced by clonal hematopoiesis of indeterminate potential and the therapeutic effect of NLRP3 inflammasome
CHEN Yafang1 LI Si1 SHI Yang2 WEI Liping3
DOI: 10.20047/j.issn1673-7210.2023.21.08
In recent years, some studies have shown that the increase of inflammatory markers, which results from the clonal hematopoiesis of indeterminate potential (CHIP) caused by somatic cell driven gene mutation, is one of the factors for the occurrence and development of atherosclerotic cardiovascular disease. The NLRP3 inflammasome in the Pyrin domain of the nucleotide-binding oligomeric domain-like receptor family, is an important regulator of pyroptosis and plays a key role in the inflammatory process. As a specific small-molecule inhibitor, MCC950 has a selective inhibitory effect on NLRP3 inflammasome mediated pyroptosis. Therefore, MCC950 is expected to become an effective drug for the clinical treatment of atherosclerotic cardiovascular diseases caused by inflammation mediated by CHIP. Starting from the related mutation of CHIP induced gene, this paper summarizes the pathogenesis of atherosclerosis mediated by the regulation of pyroptosis by NLRP3 inflammasome, and the role and mechanism of selective inhibitor MCC950 of NLRP3 inflammasome on the induction of atherosclerosis by CHIP, so as to provide a basis for clinical treatment of atherosclerosis.
2023 Vol. 20 (21): 40-44 [Abstract] ( 18 ) HTML (1 KB)  PDF (563 KB)  ( 56 )
45 Research progress on stigma in patients with bladder cancer undergoing urostomy
XIE Yuqing JIANG He JI Xuebi WANG Haifeng WANG Jun
DOI: 10.20047/j.issn1673-7210.2023.21.10
Based on the review and analysis of the literatures on urostomy for bladder cancer at home and abroad, this paper reviews from five aspects: the source of stigma in urostomy patients, its impact on disease and health, related factors, intervention strategies and measures, and research limitations, including patients themselves, intervention methods, and society. The impact on disease and health includes quality of life, social psychology, physical and healthy behavior, and seeking health assistance. Related factors include demographic sociology, disease-related factors, family social support systems, mastery of disease knowledge, and self-care ability during colostomy. Intervention strategies and measures include both public and individual aspects. Point out the limitations of urostomy research in China, and propose suggestions and prospects. In order to provide assistance in solving the practical problems caused by the shame of urostomy, and to provide a basis for formulating and implementing effective clinical intervention measures.
2023 Vol. 20 (21): 45-48,61 [Abstract] ( 21 ) HTML (1 KB)  PDF (745 KB)  ( 80 )
49 Emergence, spread and influence of antibiotic resistance in ecological environment
KE Shuwen1 WANG Yuying2 LI Hao3 DUAN Yueqing1 LIU Yuehuan4
DOI: 10.20047/j.issn1673-7210.2023.21.09
Due to the excessive use of antibiotics in medical treatment, breeding, agriculture, and other fields, antibiotic resistance is spreading rapidly around the world, bringing a huge crisis to ecological environment security and human health. Aiming at the generation and spread of antibiotic resistance in ecological environment, this paper discusses the generation mechanism of antibiotic resistance, summarizes the transmission and storage hotspots of antibiotic resistance in ecological environment such as antibiotic pharmaceutical factory, farm and farmland, and summarizes the biological and environmental transmission of antibiotic resistance in ecological environment. The related factors affecting the spread of antibiotic resistance in ecological environment are discussed. Finally, the research direction of the spread of antibiotic resistance in the ecological environment in the future is prospected, in order to provide reference for the related research of antibiotic resistance in the ecological environment.
2023 Vol. 20 (21): 49-53 [Abstract] ( 22 ) HTML (1 KB)  PDF (580 KB)  ( 135 )
54 Clinical research progress of efficacy and safety of Remazolam in painless gastroenteroscopy
SHEN Yue1 LU Hongxiu2
DOI: 10.20047/j.issn1673-7210.2023.21.11
At present, Remimazolam is being widely used as a new benzodiazepine sedative in painless gastroenteroscopy. Compared with commonly used sedative drugs such as Propofol and Midazolam, it is still unknown to a certain extent whether its sedative effect is superior and its safety is higher, and further clinical verification is needed. This review of PubMed and CNKI studies on Remimazolam applied to painless gastroenteroscopy find that Remimazolam has significant sedative effect, guaranteed comfort, less adverse reactions to circulation system, respiratory system, and cognitive function, and is used in combination with analgesics, especially alfentanil, during painless procedures to reduce the risk of respiratory depression.
2023 Vol. 20 (21): 54-57 [Abstract] ( 25 ) HTML (1 KB)  PDF (586 KB)  ( 39 )
58 Research progress on the application of novel oral anticoagulants after percutaneous left atrial appendage closure
WANG Wei WANG Yong
DOI: 10.20047/j.issn1673-7210.2023.21.12
Atrial fibrillation includes valvular atrial fibrillation and non-valvular atrial fibrillation. It has the characteristics of high morbidity and poor prognosis, which seriously threatens human life and health. Percutaneous left atrial appendage closure (PLAAC) has been widely used in the treatment of patients with non-valvular atrial fibrillation who have a high risk of bleeding or contraindications to oral anticoagulants. Although PLAAC has some risks for patients who have difficulty tolerating the risks of anticoagulant therapy, it remains an important step in the treatment of patients with atrial fibrillation. Device-related thrombus and ischemic stroke are common complications after PLAAC. Anticoagulant drugs such as Warfarin and vitamin K antagonists are often used in clinical treatment, but the actual effect of these drugs is often sub-optimal. At present, various guidelines recommend the regimentation of anticoagulation therapy after PLAAC surgery, the safety and effectiveness of anticoagulation therapy, especially the novel oral anticoagulant (NOACs) after PLAAC surgery still needs further research. This article summarizes and discusses the application research of NOACs after PLAAC surgery.
2023 Vol. 20 (21): 58-61 [Abstract] ( 24 ) HTML (1 KB)  PDF (517 KB)  ( 139 )
62 Investigation and analysis of self-acceptance, stigma， and negative emotion in patients with permanent colostomy of colorectal cancer
GE Yifan YANG Hongsheng MEI Guanghong WANG Feng CHEN Qiuxiang
DOI: 10.20047/j.issn1673-7210.2023.21.13
Objective To investigate the status quo of self-acceptance, stigma, and negative emotion in patients with permanent colostomy (PC) for colorectal cancer and analyze the influencing factors. Methods From March 2019 to March 2022, 198 cases of PC patients with colorectal cancer admitted to Haian People’s Hospital in Jiangsu Province were selected as the investigation objects. General information questionnaire, self-acceptance questionnaire (SAQ), social impact scale (SIS), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were used to investigate the subjects. Multivariate regression was used to analyze the influencing factors of PC patients’ self-acceptance, stigma, and negative emotion. Results A total of 210 questionnaires were distributed, and 198 valid questionnaires were collected, with an effective recovery rate of 94.3%. The scores of SAQ, SIS, SAS, and SDS of 198 patients were (29.03±3.95), (68.74±12.91), (49.06±7.11) points and (47.45±7.68) points, respectively. Multivariate linear regression analysis results showed that the SAQ score of PC patients was affected by fecal leakage, odor leakage, and exhaust sound in the past one month (P＜0.05). Gender, odor leakage, exhaust sound, and conscious image change in the past one month were the factors influencing SIS score of PC patients (P＜0.05). The type of medical insurance, whether there was odor leakage and exhaust sound in the past one month were the influencing factors of SAS score of PC patients (P＜0.05). Gender, spouse status, exhaust sound in the past one  month, and conscious image change were the influencing factors for SDS scores of PC patients (P＜0.05). Conclusion PC patients with colorectal cancer self-acceptance is not high, while stigma and negative emotions are high, patients self-acceptance, stigma, negative emotions are related to gender, medical costs, spouse status, stool leakage, exhaust sound, leakage of smell, conscious image change, etc., should be paid attention to.
2023 Vol. 20 (21): 62-66 [Abstract] ( 21 ) HTML (1 KB)  PDF (641 KB)  ( 125 )
67 Research on the application of iTClamp, a new type of hemostatic equipment for foreign military tactical battle wounds
GUAN Taihong1 WANG Xuelian2 ZHAO Lei3▲ WANG Ke3 YAN Ruizhe4 LI Yi1▲
DOI: 10.20047/j.issn1673-7210.2023.21.14
This paper introduces the research, and development background, design features, indications, and contraindication, technical operation, and precautions of iTClamp, a new type of tactical combat casualty care (TCCC) hemostatic device for the foreign army. The safety, effectiveness, and practicability of iTClamp in clinical application are analyzed, and the clinical characteristics, application principle and research status of iTCLamp in foreign countries are discussed. This paper points out its shortcomings and further research direction, and provides reference for developing special equipment for craniomaxillofacial and neck trauma bleeding control based on the principle of hydrostatic pressure in China.
2023 Vol. 20 (21): 67-71 [Abstract] ( 24 ) HTML (1 KB)  PDF (1473 KB)  ( 121 )
72 Correlation of Wanger grade with hematocrit, albumin, difference of hematocrit and albumin in patients with type 2 diabetes mellitus complicated with diabetic foot
SHANG Junliang WANG Guangyu SHI Chunhong XU Xuying
DOI: 10.20047/j.issn1673-7210.2023.21.15
Objective To investigate the correlation of Wanger grade with hematocrit (HCT), albumin (ALB), difference of HCT and ALB (|HCT-ALB|) in patients with type 2 diabetes mellitus complicated with diabetic foot. Methods A retrospective analysis was performed on 90 patients with type 2 diabetes mellitus complicated with diabetic foot admitted to Beijing Hospital of Traditional Chinese Medicine, Capital Medical University from January 2019 to January 2020, and they were divided into Wagner 1 group (30 cases), Wagner 2-3 group (25 cases), and Wagner 4-5 group (35 cases) according to Wanger grade. Clinical data of the three groups were compared. The correlation between serum levels of HCT, ALB, |HCT-ALB|, and Wanger grade were analyzed. Results The age and duration of type 2 diabetes mellitus in Wagner 2-3 and Wagner 4-5 groups were higher than those in Wagner 1 group, and the differences were statistically significant (P＜0.05). The levels of sodium, hemoglobin, HCT, and ALB in Wagner 4-5 group were lower than those in Wagner1 and Wagner 2-3 groups, and the levels of white blood cell count and C-reactive protein were higher than those in Wagner1 and Wagner 2-3 groups, and the differences were statistically significant (P＜0.05). The level of C-reactive protein in Wagner 2-3 group was higher than that in Wagner 1 group, and HCT and ALB were lower than those in Wagner 1 group, the differences were statistically significant (P＜0.05). Wagner grade of type 2 diabetes mellitus complicated with diabetic foot was negatively correlated with serum HCT and ALB levels (rs＜0, P＜0.05), but not with |HCT-ALB| (P＞0.05). Conclusion Serum HCT and ALB levels are closely related to Wagner grade of patients with type 2 diabetes mellitus complicated with diabetic foot, which can provide a reference for evaluating the severity of the disease to a certain extent.
2023 Vol. 20 (21): 72-75 [Abstract] ( 24 ) HTML (1 KB)  PDF (590 KB)  ( 66 )
76 Influence of diabetes mellitus on lower urinary tract symptoms in middle-aged and elderly men
ZHANG Songwei1 WANG Fucheng1 ZHANG Huiqing1 WEN Jianguo2
DOI: 10.20047/j.issn1673-7210.2023.21.16
Objective To investigate the influence of diabetes mellitus on lower urinary tract symptoms in middle-aged and elderly men. Methods A total of 252 middle-aged and elderly male patients admitted to the First Affiliated Hospital of Xinxiang Medical University for lower urinary tract symptoms from December 2021 to March 2022 were selected as the study objects, and were divided into diabetes mellitus group (83 cases) and non-diabetes mellitus group (169 cases) according to whether they had diabetes mellitus. The international prostate symptom score (IPSS), health-related quality of life (HRQL) questionnaire, free urine flow rate examination, and residual urine volume (RUV) measurement were performed between the two groups. The differences of each scale score between the two groups were compared, and the differences of each scale score between the different disease course (≥ five years, 55 cases; ＜ five years, 28 cases) and fasting plasma glucose (FPG) (＞10.0 mmol/L, 38 cases; ≤10.0 mmol/L, 45 cases) in diabetes mellitus group were compared. Results The maximum urine flow rate and average urine flow rate in the diabetes mellitus group were lower than those in the non-diabetes mellitus group, and the scores of IPSS, HRQL questionnaire, and urinary storage period were higher than those in the non-diabetes mellitus group, the differences were statistically significant (P＜0.05). The urine storage period score and HRQL questionnaire score of diabetic patients with disease course≥ five years were lower than those of patients with disease course ＜ five years, and the differences were statistically significant (P＜0.05). The average urine flow rate of diabetic patients with FPG＞10.0 mmol/L was higher than that of patients with FPG≤10.0 mmol/L, and the difference was statistically significant (P＜0.05). Conclusion In middle-aged and elderly men with diabetes, lower urinary tract symptoms are more severe, and their quality of life is also reduced.
2023 Vol. 20 (21): 76-79 [Abstract] ( 21 ) HTML (1 KB)  PDF (580 KB)  ( 46 )
80 Effect of Taohong Siwu Decoction on early postoperative cognitive dysfunction after femoral head replacement in elderly patients with hip fracture
WU Zhongqing1 WU Rong1 PAN Le2
DOI: 10.20047/j.issn1673-7210.2023.21.17
Objective To investigate the effect of Taohong Siwu Decoction on early postoperative cognitive dysfunction (POCD) after femoral head replacement in elderly patients with hip fracture. Methods Eighty elderly hip fracture patients with early POCD after femoral head replacement admitted to the First People’s Hospital of Huzhou of Zhejiang Province from June 2020 to May 2022 were selected and divided into control group and observation group by random number table method, with 40 cases in each group. The control group was given heparin treatment for one week, and the traditional Chinese medicine decoction placebo for one month; the observation group was given heparin treatment for one week, and the Taohong Siwu Decoction for one month. After treatment, the clinical efficacy of the two groups was compared, and the cognitive function scores and serological indexes of the two groups were compared before and after treatment, and the occurrence of adverse reactions during treatment was observed. Results After treatment, the score of mini mental status examination (MMSE), and levels of melatonin (MT), insulin-like growth factor 1 (IGF-1) in both groups were higher than those before treatment, the scores of National Institute of Health stroke scale (NIHSS) and levels of amyloid β(Aβ) were lower than those before treatment, and the score of MMSE and levels of MT, IGF-1 in the observation group were higher than those in the control group, scores of NIHSS and levels of Aβ were lower than those in control group, the differences were statistically significant (P＜0.05). The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Taohong Siwu Decoction has a remarkable effect in the treatment of early POCD after femoral head replacement, which can improve the cognitive level and nerve function of patients.
2023 Vol. 20 (21): 80-83 [Abstract] ( 24 ) HTML (1 KB)  PDF (611 KB)  ( 30 )
84 Value of TT, FIB, and D-D in risk assessment of deep vein embolism after secondary traumatic fracture
WU Jihong1 OUYANG Guolin1 CHEN Tao2 SHAO Weigang2 RONG Xiangbin2▲
DOI: 10.20047/j.issn1673-7210.2023.21.18
Objective To analyze the value of thrombin time (TT), fibrinogen (FIB), and D-dimer (D-D) in the risk assessment of deep vein thrombosis (DVT) after secondary traumatic fracture. Methods A total of 100 patients with secondary traumatic fracture admitted to Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine from January 2019 to July 2022 were selected and divided into DVT group (41 cases) and non-DVT group (59 cases) according to whether DVT occurred after operation. Univariate and multivariate logistic regression analysis were used to analyze the independent risk factors of postoperative DVT, and receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of TT, FIB, and D-D in postoperative DVT. Results TT in DVT group was lower than that in non-DVT group, FIB and D-D were higher than those in non-DVT group, and the differences were statistically significant (P＜0.05). There was no significant difference in PT and APTT between the two groups (P＞0.05). logistic regression analysis results showed that, general anesthesia (OR[95%CI]=2.194[1.626-2.960]), intraoperative blood transfusion (OR[95%CI]=2.458[1.780-3.394]), FIB (OR[95%CI]=1.483[1.244-1.768]), and D-D (OR[95%CI]= 2.026[1.610-2.549]) were independent risk factors for DVT after secondary traumatic fracture (P＜0.05); TT (OR[95%CI]= 0.868[0.774-0.973]) was an independent protective factor for DVT after secondary traumatic fracture (P＜0.05). The area under the curve predicted by the combination of TT, FIB and D-D was 0.914, the sensitivity was 0.927, and the specificity was 0.878. Conclusion TT, FIB, and D-D are independent influencing factors for DVT after secondary traumatic fracture, and the combination of these three factors can be used as a sensitive predictor of postoperative DVT.
2023 Vol. 20 (21): 84-87 [Abstract] ( 21 ) HTML (1 KB)  PDF (1276 KB)  ( 115 )
88 Influence of triple-tunnel Femoral-Intrafix fixed double bundle reconstruction on knee stability and function in patients with anterior cruciate ligament injury
FENG Zhiwei LIU Diankui CHANG Deyong LIANG Zhenxing YANG Hui▲
DOI: 10.20047/j.issn1673-7210.2023.21.19
Objective To investigate the influence of triple-tunnel Femoral-Intrafix fixed double bundle reconstruction on knee stability and function in patients with anterior cruciate ligament injury. Methods Fifty-four patients with anterior cruciate ligament injury of knee joint admitted to Huabeiyiliao Jiankangjituan Fengfeng Zongyiyuan from November 2019 to November 2020 were selected and divided into observation group and control group by random drawing method, with 27 cases in each group. Single-tunnel single bundle reconstruction was used in the control group, while triple-tunnel Femoral-Intrafix fixed double bundle reconstruction was used in the observation group, and both groups were followed up for 24 months after surgery. The operation and postoperative conditions of the two groups were compared, the differences in joint function and knee stability before operation and 24 months after operation between the two groups were compared, and the incidence of postoperative complications between the two groups was recorded. Results The time of hospitalization, weight bearing, and getting out of bed in the observation group were shorter than that in the control group (P＜0.05). At 24 months after operation, International Knee Documentation Committee score and Lysholm score of the two groups were higher than those before operation, and those of observation group were higher than those of control group (P＜0.05). At 24 months after operation, the positive rates of the front drawer test and Lachman test in the two groups were lower than those before operation, and the positive rate of the axial shift test in the observation group was lower than that before operation and control group (P＜0.05); there was no statistical significance in the positive rate of the axial shift test in the control group compared with that before operation (P＞0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). Conclusion Triple-tunnel Femoral-Intrafix fixed double bundle reconstruction can restore the function and rotational stability of the patient’s knee joint better, and is worthy of clinical promotion.
2023 Vol. 20 (21): 88-91 [Abstract] ( 23 ) HTML (1 KB)  PDF (578 KB)  ( 122 )
92 Causality between osteoporosis and lumbar disc herniation: a Mendelian randomized study
XU Jingwei1 WU Yadong2 WANG Jing3 DENG Wenjie4 YIN Shichang1▲
DOI: 10.20047/j.issn1673-7210.2023.21.20
Objective To study the causal relationship between osteoporosis (OP) and lumbar disc herniation (LDH) by Mendelian randomization analysis. Methods A genome-wide meta-analysis sample of calcaneal bone density was obtained through genome-wide association analysis, and a total of 17 166 350 single nucleotide polmorphism(SNPs) were collected. SNP mapping between OP and LDH outcomes was screened out, and instrumental variables SNP was obtained. The causal relationship between OP and LDH were analyzed by Mendelian randomization. Results A total of 203 SNPs, including rs10022648, rs10066763, rs10130587, as included as instrumental variables. The MR-Egger regression result P=0.442324 286, indicating no horizontal pleiotropy. IVW analysis showed that P＜0.05, OR=0.893 174 092 (OR_lci95, 0.823 290 84; OR_uci95, 0.968 989 231), the risk of LDH increased by 0.89 times for every one SD decrease in BMD, and the two were negatively correlated. The result of heterogeneity test was P=0.44 with no heterogeneity. Conclusion There is a causal relationship between OP represented by bone density and LDH.
2023 Vol. 20 (21): 92-96 [Abstract] ( 23 ) HTML (1 KB)  PDF (928 KB)  ( 254 )
97 Clinical effect of oblique lumbar interbody fusion and minimal invasive surgery-transforaminal lumbar interbody fusion for degenerative lumbar scoliosis combined with lumbar stenosis
LIN Jun’an HONG Ye CHEN Zhigang LYU Shujun
DOI: 10.20047/j.issn1673-7210.2023.21.21
Objective To investigate the effect of oblique lumbar interbody fusion (OLIF) and minimal invasive surgery-transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of degenerative lumbar scoliosis (DLS) combined with lumbar stenosis (LSS). Methods A total of 89 patients with DLS combined with LSS admitted to the Department of Orthopedics of Haian City People’s Hospital, Jiangsu Province from February 2019 to February 2021 were selected and divided into OLIF group (45 cases) and MIS-TLIF group (44 cases) according to the random number table method. The OLIF group was treated with OLIF, and the MIS-TLIF group was treated with MIS-TLIF. The operative blood loss, operation time, 3 d postoperative drainage volume, getting out of bed time, hospitalization time, and the effect at six months after operation were compared between the two groups. Lumbar function (Oswestry disability index [ODI] and Japanese Orthopaedic Association evaluation treatment [JOA] score) were evaluated before and six months after operation, and postoperative complications were counted. Results The operative blood loss and 3 d postoperative drainage volume in OLIF group were lower than those in MIS-TLIF group, and the operative time, getting out of bed time, and hospitalization time were shorter than those in MIS-TLIF group, and the operative effect was better than that in MIS-TLIF group (P＜0.05). At six months after operation, ODI was lower than that before operation, and JOA score was higher than that before operation, and ODI in OLIF group was lower than that in MIS-TLIF group, JOA score was higher than that in MIS-TLIF group (P＜0.05). The incidence of postoperative complications in OLIF group was lower than that in MIS-TLIF group (P＜0.05). Conclusion Compared with MIS-TLIF, OLIF in DLS patients with LSS can improve perioperative indexes, improve operative results, enhance lumbar function, and reduce postoperative complications.
2023 Vol. 20 (21): 97-100,145 [Abstract] ( 24 ) HTML (1 KB)  PDF (695 KB)  ( 49 )
101 Visual analysis of research trends of functional magnetic resonance imaging in gynecology based on CiteSpace
ZHENG Zheng1 YU Yue1 WANG Yuxing2 YANG Xuejiao3 LIU Xinmin1
DOI: 10.20047/j.issn1673-7210.2023.21.22
Objective To explore the research trend of functional magnetic resonance imaging (fMRI) in gynecology by bibliometrics. Methods Relevant literatures on fMRI in the field of gynecology were retrieved from CNKI and Web of Science core collection database from November 2012 to November 2022. CiteSpace 6.1.R2 was used to analyze the author, institution, key words, study content, fMRI type, and use of analysis methods. Results A total of 156 literatures were included. In the past ten years, the number of papers published by CNKI and Web of Science core collection database had been on the rise. Xie Hongwu, Wu Junchen, and Wang Ziwen were the most prolific authors on CNKI; Web of Science core collection database was LIU PENG. Chengdu University of Traditional Chinese Medicine published the most papers on CNKI; Web of Science core collection database was Xidian University. “Acupuncture” appeared most in CNKI; Web of Science core collection database was “Menstrual cycle”. Non-randomised controlled trials were the most common type of research in CNKI; Web of Science core collection database for case control studies. Primary dysmenorrhea was the most popular research hotspot in CNKI; Web of Science core collection database was physiological states. The literatures in CNKI and Web of Science core collection database were the most without intervention measures. The fMRI types of literatures in CNKI and Web of Science core collection database were most in resting state. In terms of functional differentiation, the data analysis of CNKI was mainly low-frequency amplitude, and the software analysis was mainly in Web of Science. In terms of functional differentiation, the data analysis of CNKI was mainly low-frequency amplitude, and the software analysis was mainly in Web of Science; in terms of functional integration, both CNKI and Web of Science core collection database were based on functional connection-seed point analysis. Various gynecological diseases involve abnormal activity in different brain regions. Conclusion fMRI is widely studied in the field of gynecology, and there are some differences at home and abroad.
2023 Vol. 20 (21): 101-106,112 [Abstract] ( 23 ) HTML (1 KB)  PDF (2101 KB)  ( 123 )
107 Visual analysis of research status of previous cesarean scar defect based on CiteSpace
CHEN Weihong1 SHI Wenyin1 ZONG Minghui2 WANG Min2 WANG Yiqun1 LI Wei1
DOI: 10.20047/j.issn1673-7210.2023.21.23
Objective To visually analyze the research status of previous cesarean scar defect (PCSD) based on CiteSpace software, so as to provide reference for future research. Methods By searching the research literature related to PCSD from January 2000 to December 2021 in CNKI and Web of Science core collection database, CiteSpace software was used to visually analyze the number of publications, publishing countries, publishing institutions, authors, and keywords in this field. Results A total of 1 037 literatures were included, including 987 articles from CNKI and 111 articles from Web of Science core collection database. China had the largest number of publications. The number of domestic PCSD publications has experienced three different stages of development, with the highest number of publications in 2018. Compared with the intensive cooperation network structure at abroad, the cooperative relations among domestic institutions were loosely distributed. The team led by Professor Wang Xipeng published the most articles at home and abroad. The most centrality and most occurrence in China was “cesarean section”; foreign centrality was the strongest “risk factor”. “Uterine incision” was the strongest at home, and “management” was the strongest at abroad. Conclusion China is the core country in PCSD, and there may be some regional imbalance in domestic. The research hotspots at home and abroad are slightly different. The incidence of PCSD is likely to increase further in the future.
2023 Vol. 20 (21): 107-112 [Abstract] ( 25 ) HTML (1 KB)  PDF (2123 KB)  ( 17 )
113 Clinical effect of Acyclovir combined with Transfer Factor Oral Liquid in the treatment of children with infectious mononucleosis
SUN Pengling FU Bin SUN Yao
DOI: 10.20047/j.issn1673-7210.2023.21.24
Objective To explore the clinical effect of Acyclovir combined with Transfer Factor Oral Solution in the treatment of children with infectious mononucleosis (IM). Methods A total of 84 children with IM admitted to Nanjing Lishui District People’s Hospital from January 2017 to April 2022 were selected as the study subjects. They were divided into the control group and study group according to the randem number table method, with 42 cases in each group. The control group were treated with Acyclovir intravenously, and the study group was treated with Acyclovir combined with Transfer Factor Oral Liquid. One week after treatment, the clinical effective rate, the regression time of angina pectoris, the regression time of cervical lymphadenopathy, the regression time of fever, the levels of CD3+, CD4+, CD4+/CD8+, serum immunoglobulin G (IgG), IgA, IgM and the incidence of adverse reactions during treatment were compared between the two groups. Results The curative effect of the study group was higher than that of the control group (P＜0.05). The regression time of angina pectoris, the regression time of cervical lymphadenopathy and fever in the study group were shorter than those in the control group (P＜0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+, IgG, IgA and IgM were higher than those before treatment, the study group was higher than the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Acyclovir Transfer Factor Oral Liquid combined with in the treatment of children with infectious mononucleosis is more helpful to improve immune function, enhance clinical efficacy and good safety.
2023 Vol. 20 (21): 113-116 [Abstract] ( 21 ) HTML (1 KB)  PDF (635 KB)  ( 222 )
117 Predictive value of anti-Müllerian hormone combined with body mass index in pregnancy outcome of infertile women aged ≤35 years old after artificial insemination by husband
AI Fenglian ZHANG Yuanbao HUANG Cun XU Xiaolian PAN Weijun▲
DOI: 10.20047/j.issn1673-7210.2023.21.25
Objective To investigate the predictive value of anti-Mullerian hormone (AMH) combined with body mass index (BMI) in pregnancy outcome of infertile women aged ≤35 years old after artificial insemination by husband (AIH). Methods A retrospective analysis was performed on 261 cases with infertile women aged ≤35 years old (449 cycles) who received AIH treatment in Maanshan Maternal and Child Health Hospital, Anhui Province from January 2018 to December 2021. According to the clinical pregnancy outcome, they were divided into pregnant group (77 cycles) and non-pregnant group(372  cycles). The general information, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), progesterone (P), testosterone(T), and AMH levels of two groups were compared; the predictive value of AMH and BMI in AIH pregnancy outcome was analyzed by receiver operating characteristic curve. Results BMI of pregnant group was lower than that of non-pregnant group, and AMH was higher than that of non-pregnant group (P＜0.05). There were no significant differences in FSH, E2, P, PRL, LH, and T between two groups (P＞0.05). The area under the curve of AIH pregnancy outcome combined predicted by AHM and BMI was higher than that predicted by AMH and BMI alone (P＜0.05). Conclusion AMH combined with BMI has a certain predictive value for AIH pregnancy outcome in infertile women aged ≤35 years old.
2023 Vol. 20 (21): 117-120 [Abstract] ( 23 ) HTML (1 KB)  PDF (666 KB)  ( 84 )
121 Effect of small incision combined with negative-pressure closed drainage in the treatment of mammary abscess during lactation
HU Chao LI Chao TIAN Tian LI Ming
DOI: 10.20047/j.issn1673-7210.2023.21.26
Objective To observe the clinical effect of small incision combined with negative-pressure closed drainage in the treatment of mammary abscess during lactation, and to provide reference for clinical treatment in primary hospitals. Methods A total of 146 patients with mammary abscess who were hospitalized in Beijing Luhe Hospital, Capital Medical University from June 2021 to June 2022 were selected as the research objects. According to the random odd and even number method, they were divided into observation group and control group, with 73 cases in each group. The control group was treated with small incision and drainage, and observation group was treated with small incision combined with negative-pressure closed drainage. Incision length, wound healing time, and pain score were compared between two groups; postoperative follow-up was three months, the recurrence and continued lactation rate of two groups were observed. Results There was no significant difference in incision length between two groups (P＞0.05); the wound healing time of observation group was shorter than that of control group, and numerical rating scale score was lower than that of control group (P＜0.05). The recurrence rate of postoperative abscess in observation group was lower than that in control group, and continued lactation rate was higher than that in control group (P＜0.05). Conclusion Small incision combined with negative-pressure closed drainage for mammary abscess during lactation can shorten the healing time of patients, reduce the pain of patients, reduce the recurrence of abscess, and enable more patients to continue breastfeeding. The clinical operation is simple and suitable for primary hospitals.
2023 Vol. 20 (21): 121-124 [Abstract] ( 27 ) HTML (1 KB)  PDF (657 KB)  ( 38 )
125 Effect of blasting mode of Nd: YAG laser on posterior capsulotomy
MA Yinghui1 JIA Luyao1 YANG Jie1 MA Linli2 TAN Xiaobo1▲ LIU Gang3
DOI: 10.20047/j.issn1673-7210.2023.21.27
Objective To investigate the effect of different neodymium-doped yttrium aluminum garnet (Nd: YAG) laser blasting modes on posterior capsulotomy. Methods A total of 59 patients (59 eyes) with posterior capsular opacification in the Affiliated Hospital of Chengde Medical University were selected from December 2017 to December 2019, and they were divided into monopulse group 29 cases and multi-pulse group 30 cases by random number table method. The best corrected visual acuity (BCVA), intraocular pressure (IOP), anterior chamber flash, and anterior chamber cell grade, central macular retinal thickness, and quality of life were compared between the two groups before and after operation. Results BCVA was higher in both groups at one week after operation than that before operation( P＜0.05). The IOP between the two groups at different time points was statistically significant(P＜0.05). At one week after operation, the grade of anterior chamber flash and anterior chamber cells in both groups were lower than that at one hour after operation(P＜0.05). The total energy of Nd: YAG laser in monopulse group was lower than that in multi-pulse group (P＜0.05). The central macular retinal thickness between the two groups at different time points was statistically significant(P＜0.05). Conclusion Nd:YAG laser with monopulse mode can save laser energy and reduce intraocular light injury in posterior capsulotomy, which is the first choice in clinic.
2023 Vol. 20 (21): 125-128,191 [Abstract] ( 25 ) HTML (1 KB)  PDF (1115 KB)  ( 74 )
129 Effect of high speed turbine drill combined with ultrasonic osteotome on extraction of mandibular impacted wisdom teeth
XU Jinwei1 ZHANG Qin2 CHEN Haisu2 YU Baojun2 YU Huiming1▲
DOI: 10.20047/j.issn1673-7210.2023.21.28
Objective To investigate the effect of high speed turbine drill combined with ultrasonic osteotome on extraction of mandibular impacted wisdom teeth. Methods From January 2021 to January 2022, 100 patients （100 teeth) with mandibular impacted wisdom teeth were selected from Huaian First Hospital Affiliated to Nanjing Medical University. The patients were divided into control group （high-speed turbine drill) and observation group （high-speed turbine drill combined with ultrasonic osteotome) by random number table method, with 50 cases in each group. Perioperative conditions, postoperative pain, swelling, restriction of mouth opening, levels of inflammatory factors, incidence of complications, and quality of life were compared between the two groups. Results The operation time in the observation group was shorter than that in the control group (P＜0.05); the intraoperative blood flow in the observation group was lower than that in the control group (P＜0.05). The grade of pain, swelling, and mouth opening limitation in the observation group were better than those in the control group (P＜0.05). After surgery, the levels of interleukin-6 and C-reactive protein in the two groups were higher than those before surgery, and the observation group were lower than those in the control group (P＜0.05). The score of postoperative symptom severity scale and the total incidence of complications in the observation group were lower than those in the control group (P＜0.05). Conclusion High speed turbine drill combined with ultrasonic osteotome can effectively shorten the operation time, reduce postoperative pain and stress reaction, improve the quality of life, and it is safe and reliable.
2023 Vol. 20 (21): 129-132 [Abstract] ( 26 ) HTML (1 KB)  PDF (586 KB)  ( 23 )
133 Effect of machanical nickel-titanium file combined with ultrasonic irrigation on C-shaped root canal preparation and filling quality in patients with chronic pulpitis
CHEN Wenli1 ZHOU Zhou2 XIAO Ping3
DOI: 10.20047/j.issn1673-7210.2023.21.29
Objective To investigate the effect of mechanical nickel-titanium file combined with ultrasonic irrigation on the preparation and filling quality of C-shaped root canals in patient with chronic pulpitis (CP). Methods A total of 89 CP patients admitted to Suzhou Municipal Hospital from February 2019 to February 2022 were selected and they were divided into observation group (44 cases) and control group (45 cases) by random number table method. The observation group was given machine-made nickel-titanium file to prepare the root canal with ultrasonic irrigation, while the control group was given machine-made nickel-titanium file to prepare the root canal with a syringe irrigation. One week after the patients underwent root canal treatment, the preparation of the C-shaped root canal and the pain after root canal preparation were compared between the two groups. Results There was no significant difference in the effect of good shape between the observation group and the control group (P＞0.05). After root canal preparation, the pain response rate of the observation group was lower than that of the control group (P＜0.05). The time of root canal preparation, filling, and flushing in the observation group were shorter than those in the control group (P＜0.05). The filling success rate of the observation group was higher than that of the control group (P＜0.05). Conclusion The mechanical nickel-titanium file combined with ultrasonic irrigation can improve the good rate of preparation, improve the pain after preparation, shorten the treatment time of root canal, and improve the filling quality.
2023 Vol. 20 (21): 133-136 [Abstract] ( 26 ) HTML (1 KB)  PDF (548 KB)  ( 68 )
137 Simultaneous distillation-extraction of essential oil components of Radix Astragali seu Hedysari overground part and its gas chromatography-quadrupole time-of-flight tandem mass spectrometry analysis
FENG Xin1 TIAN Jiayi1 CHEN Lifang1 LIU Min1 WANG Linyan2 ZENG Weixin1
DOI: 10.20047/j.issn1673-7210.2023.21.30
Objective To provide the theoretical basis for the further development and utilization of Radix Astragali seu Hedysari, the volatile oil from Radix Astragali seu Hedysari overground part was extracted by simultaneous distillation-extraction method and its chemical constituents were determined by gas chromatography-quadrupole time-of-flight mass spectrometry(GC-Q/TOF MS). Methods The chemical components in volatile oils were detected by GC-Q/TOF-MS, and identified by NIST 14.L database. The relative contents of each component were determined by area normalization method. Results Sixty-six compounds were identified, which account for 93.62% of total flow area, mainly included Aliphatic compound (79.48%), Aromatic compound (6.71%), and Terpenoids compound (4.68%). The main constituents of the oil werePhytol(16.84%), 1-Octen-3-ol(15.42%), 3-Hexen-1-ol, (E)-(9.51%), Benzyl alcohol(2.68%)，Phenylethyl Alcohol (1.84%), and  Linalool(2.98%). Conclusion There are abundant chemical constituents in the volatile oil of Radix Astragali seu Hedysari ground part. GC-Q/TOF MS can get the information of its composition in accurate and rapid. This research provide a new idea for the development and utilization of Radix Astragali seu Hedysari.
2023 Vol. 20 (21): 137-140 [Abstract] ( 24 ) HTML (1 KB)  PDF (666 KB)  ( 131 )
141 Effects of different storage temperatures on aflatoxin B1 content of Semen Platycladi sold in Beijing
ZHANG Wentao1 SHI Qinjin2 GAO Chen2 TIAN Yue1 LUO Ming2 JIN Min2
DOI: 10.20047/j.issn1673-7210.2023.21.31
Objective To determine the content of aflatoxin B1 (AFB1) in Semen Platycladi sold in Beijing, and clarify the effect of different storage temperatures on the content of AFB1 in Semen Platycladi. Methods Ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was used in Acquity UPLC BEH C18 (2.1 mm×100 mm×1.7 μm) column with methanol-10 mmol/L ammonium acetate solution as mobile phase, gradient elution, electrospray ion source, and positive ion collection mode. The initial content of AFB1 in Chinese Cypress kernel samples was determined, and the content of AFB1 in different temperatures (28℃, 4℃, -18℃) was stored for 90 days. Results The initial content of AFB1 in eight batches of Semen Platycladi did not exceed the standard. The optimum storage temperature of Semen Platycladi was -18℃, followed by 4℃. When stored at -18℃ for 90 d, the content of AFB1 in the sample did not exceed the standard; when stored at 4℃ for 90 d, the unqualified rate was 25%. 28℃ was not suitable for the storage of Semen Platycladi, and at this temperature the unqualified rate of AFB1 was the highest. Conclusion Controlling the storage temperature at 4℃ and -18℃ can slow down the production of AFB1 in Semen Platycladi and ensure the safety of clinical medication.
2023 Vol. 20 (21): 141-145 [Abstract] ( 23 ) HTML (1 KB)  PDF (808 KB)  ( 27 )
146 Research hotspot and trend analysis of Curcumae Rhizoma based on CiteSapce knowledge graph
BI Jianing1 LI Zhihong1 WU Xiai2
DOI: 10.20047/j.issn1673-7210.2023.21.32
Objective To explore the research hotspot and trend of Curcumae Rhizoma based on CiteSapce knowledge graph in recent 20 years. Methods Literatures related to Curcumae Rhizoma from CNKI, Wanfang Date, and VIP from January 2002 to December 2022 were searched, and CiteSpace was used to obtain the knowledge graph of the annual number of publications, authors, institutions, and keywords of the included literatures. Results Finally, 1 622 literatures were included, and the annual number of publications showed a fluctuating upward trend. The team represented by Tang Dongxin and Yang Zhu was formed, and the institution with the highest number of publications was Nanjing University of Chinese Medicine. The key words with high frequency included Curcumae Rhizoma, data mining, medication rules, etc., forming ten clusters in total. The key words with high intensity that had persisted so far were medication rules, data mining, breast cancer. Conclusion Curcumae Rhizoma has made achievements in component analysis, treatment of tumor, and liver diseases, and the current research focuses on data mining, analysis of medication rules, elucidating molecular mechanisms, and breast cancer treatment. However, the combination, means of medication, and treatment of other diseases of Curcumae Rhizoma need to be supplemented.
2023 Vol. 20 (21): 146-150 [Abstract] ( 26 ) HTML (1 KB)  PDF (2217 KB)  ( 63 )
151 Wu Yu’s experience in treating liver cancer with Pinelliae Rhizoma Pra-eparatum Cum Alumine, Arisaematis Rhizoma Preparatum, and Fritillariae Thunbergii Bulbus as main prescriptions
LIANG Biyan1 DONG Xiaojia2 WANG Lianmei3 HAO Tengteng4 WU Jiao4 ZHOU Rui4 ZHAO Hanqing5 WU Yu4
DOI: 10.20047/j.issn1673-7210.2023.21.33
The occurrence of “phlegm” is related to congenital endowments and acquired multiple factors, as well as the resulting substances such as essence, blood, and body fluid, and the retained fluid caused by accumulation of body fluid. The process of phlegm formation affects the movement and excretion of body fluid due to the obstruction of the qi transformation function of the zang-fu viscera. Liver cancer is closely related to phlegm production. Professor Wu Yu believes that “phlegm” is an important pathogenic factor of liver cancer in Chinese medicine. “phlegm” is a necessary factor in the deve- lopment and metastasis of liver cancer and a participant from beginning to end. Eliminating phlegm method is a consistent principle in the treatment of liver cancer in traditional Chinese medicine. Liver cancer occurs with phlegm turbidities as evil, there is a strong lump in body, body fluid retention can form phlegm turbidities, phlegm turbidities stagnation, qi and blood operation is not smooth, a long time into the formation of cancer lumps, the treatment should dissipate phlegm and resolve masses and eliminate cancer lumps. Combining with the clinical treatment experience, the main prescription for the treatment of liver cancer is put forward, which includes Pinelliae Rhizoma Praeparatum Cum Alumine, Arisaematis Rhizoma Preparatum, and Fritillariae Thunbergii Bulbus. Among them, Pinelliae Rhizoma Praeparatum Cum Alumine, Arisaematis Rhizoma Preparatum eliminate dampness and phlegm, eliminate the visible cancer lumps, Fritillariae Thunbergii Bulbus dissipates phlegm and resolves masses, attack the visible cancer lumps.
2023 Vol. 20 (21): 151-153,196 [Abstract] ( 31 ) HTML (1 KB)  PDF (603 KB)  ( 35 )
154 Visual analysis of traditional Chinese medicine treatment of trigeminal neuralgia based on CiteSpace
GONG Zhiying MO Xueni MA Wei LIU Na LIU Jiao LAN Baixin PU Yanhua HUANG Chunlan
DOI: 10.20047/j.issn1673-7210.2023.21.34
Objective To quantitatively and visually analyze literatures related to traditional Chinese medicine treatment of trigeminal neuralgia, and explore the research hotspot and development trend in this field. Methods The relevant literatures on trigeminal neuralgia in the field of traditional Chinese medicine collected from CNKI, VIP, and Wanfang Data from January 2002 to May 2022 were searched as the research object, and the trend of publication, the cooperation of authors, the co-occurrence of keywords, clustering, and emergent situation were analyzed respectively, and the corresponding knowledge graph was drawn. Results A total of 991 literatures were included, and the annual publication volume in this field showed a curve rising trend. There were a total of 18 core authors with more than three literatures, and the authors with the most papers were Fang Jianqiao and Li Yaxue. The keywords with high frequency included Carbamazepine, electro-acupuncture, traditional Chinese medicine, and so on, and found 12 keyword clusters and 9 emergent keywords. Conclusion The Atlas intuitively shows that the main research directions are traditional Chinese medicine acupuncture and moxibustion, xiàguān point, warming needle moxibustion, acupuncture, etc. Traditional Chinese medicine treatment will become the future research trend in this field.
2023 Vol. 20 (21): 154-158 [Abstract] ( 28 ) HTML (1 KB)  PDF (1425 KB)  ( 218 )
159 Effect of JBI standardized drinking water guidance on renal function protection in patients after cardiovascular intervention surgery
WU Xixia HE Yula▲
DOI: 10.20047/j.issn1673-7210.2023.21.35
Objective To analyze the effect of JBI standardized drinking water guidance on renal function protection in patients after cardiovascular intervention surgery. Methods In the First Affiliated Hospital of Air Force Military Medical University of Chinese People’s Liberation Army from January 2019 to January 2021, 98 patients who received cardiovascular interventional surgery were included by convenience sampling method for study. According to random number table method, they were divided into JBI group and control group, with 49 cases in each group. After operation, JBI group was given the guidance of drinking water based on JBI, and control group was given the guidance of conventional drinking water standard. The incidence of contrast-induced nephropathy (CIN) and various renal function indexes before and after operation were compared between the two groups, and the incidence of postoperative complications except CIN was statistically compared. Results After operation, the incidence of CIN in the JBI group was lower than that in the control group (P＜0.05); 48 h after surgery, serum creatinine, glomerular filtration, creatinine clearance, serum uric acid and serum urea nitrogen levels in two groups were higher than those before surgery, but lower than those in JBI group (P＜0.05). The incidence of postoperative complications in JBI group was lower than that in control group (P＜0.05). Conclusion The implementation of JBI standardized drinking water guidance for patients after cardiovascular intervention can not only significantly reduce the damage of renal function caused by contrast agent, but also reduce the incidence of postoperative prognostic risk events to a certain extent.
2023 Vol. 20 (21): 159-162 [Abstract] ( 23 ) HTML (1 KB)  PDF (598 KB)  ( 53 )
163 Effect of positive psychological measures under health assessment on quality of life, self-care ability, and mental state of rectal cancer patients
ZHU Shu LIU Hui WANG Xiaojuan LIU Zheng
DOI: 10.20047/j.issn1673-7210.2023.21.36
Objective To explore the effect of positive psychological measures on quality of life, self-care ability and mental state of rectal cancer patients under the concept of health assessment. Methods A retrospective analysis method was used to select 41 patients with rectal cancer ostomy who received positive psychological intervention under health assessment from Fuyang People's Hospital in Anhui Province from March 2020 to December 2021 as the observation group, and 41 patients with rectal cancer ostomy who received routine nursing intervention during the same period as the control group. The psychological status of the two groups (health questionnaire depression scale-9 item [PHQ-9], generalized anxiety disorder-7 [GAD-7], exercise self care ability [ESCA] and generic quality of life inventory-74) of the two groups were compared. Results After intervention, the scores of PHQ-9 and GAD-7 in the two groups were lower than before intervention, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the health knowledge level, self-concept, self-responsibility, and self-skill scores of the two groups were higher than before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the scores of psychological function, social function, material life, and physical function of the two groups were higher than before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion The implementation of positive psychological measures under the health assessment can improve the mental state of rectal cancer patients, improve their self-care ability and quality of life, and have a positive effect.
2023 Vol. 20 (21): 163-166 [Abstract] ( 23 ) HTML (1 KB)  PDF (595 KB)  ( 146 )
167 Effect and mechanism of cognitive behavioral therapy combined with Mirtazapine on patients with functional dyspepsia
ZHANG Hongyan1 HAO Xiuqing2 LI Duo3 BIAN Rui1 ZHANG Yuping4 YANG Xiaojing5 ZHANG Haiyan5
DOI: 10.20047/j.issn1673-7210.2023.21.37
Objective To observe the effect and mechanism of cognitive behavioral therapy combined with Mirtazapine on patients with functional dyspepsia. Methods A total of 120 patients with functional dyspepsia admitted to the psychological clinic of the First Affiliated Hospital of Hebei North University from May 2019 to May 2021 were selected. They were divided into control group and experimental group according to the random table method, with 60 cases in each group. The control group was treated with Mirtazapine, and the experimental group was treated with Mirtazapine combined with cognitive behavior therapy. The clinical efficacy, safety, patient health questionnaire (PHQ-15), 5-hydroxytryptamine (5-HT), gastrin (GAS) and motilin (MTL) were compared between the two groups after eight weeks of treatment. Results In the control group, six patients were lost during follow-up, two patients were lost because of worrying about the side effects of antidepressants. And two patients were lost during follow-up in the experimental group. The clinical efficacy of the experimental group was higher than that of the control group after eight weeks of treatment(P＜0.05) . There was no significant difference in total incidence of adverse reactions between the two groups (P＞0.05). After treatment, PHQ-15 and 5-HT in two groups were lower than before treatment, and experimental group was lower than control group (P＜0.05). After treatment, GAS and MTL of the two groups were higher than those before treatment, and experimental group was higher than control group (P＜0.05). Conclusion In the treatment of functional dyspepsia, cognitive behavioral therapy combined with Mirtazapine is superior to Mirtazapine alone, which can not only improve a variety of somatic discomfort symptoms, but also better improve the related indexes of gastrointestinal dynamics, it is worthy of clinical application.
2023 Vol. 20 (21): 167-170 [Abstract] ( 27 ) HTML (1 KB)  PDF (585 KB)  ( 13 )
171 Application of mind mapping nursing process based on feedforward control in perioperative period of SAH patients undergoing embolization
SHEN Yan DENG Ruming
DOI: 10.20047/j.issn1673-7210.2023.21.38
Objective To explore the effect of mind mapping nursing process based on feedforward control in perioperative embolization of patients with subarachnoid hemorrhage (SAH). Methods A total of 80 SAH patients who received treatment in Bozhou People’s Hospital in Anhui Province from August 2019 to August 2022 were selected for interventional embolization surgery. They were divided into study group (40 cases) and control group (40 cases) according to random number table method. The control group was given routine nursing, and the study group was given mind mapping nursing intervention based on feedforward control. The recovery of neurological function and activities of daily living, the incidence of postoperative complications and the satisfaction with nursing were compared between the two groups. Results At discharge, the neurological function score of the two groups was lower than that at admission, and the study group was lower than the control group; the scores of activities of daily living in the two groups were higher than those in the admission, and the study group was higher than the control group, and the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The satisfaction of the study group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of mind map nursing process based on feedforward control in perioperative period of SAH patients with embolization is significant and worthy of promotion.
2023 Vol. 20 (21): 171-174 [Abstract] ( 21 ) HTML (1 KB)  PDF (775 KB)  ( 45 )
175 Effects of attention and interpretation therapy on the symptoms, mental resilience and quality of life of patients with lung cancer
FANG Zhen LI Guanlan SUN Shanzhi
DOI: 10.20047/j.issn1673-7210.2023.21.39
Objective To explore the effects of attention and interpretation therapy on the symptoms, mental resilience, and quality of life of patients with lung cancer. Methods A total of 80 patients with lung cancer admitted to Xuancheng People’s Hospital in Anhui Province from January 2020 to December 2022 were selected, they were divided into observation group and control group according to random number table method, with 40 cases in each group. The control group received routine nursing intervention, the observation group received combined attention and interpretation therapy intervention on the basis of routine care. The changes of symptoms, mental resilience, and quality of life due to cancer fatigue were compared between the two groups. Results After intervention, the scores of cancer fatigue assessment scale in both groups were lower than those of before intervention, and the observation group was lower than the control group (P＜0.05); after the intervention, the psychological resilience scores and Karnofsky performance status scores of both groups were higher than those of before the intervention, and the observation group was higher than the control group (P＜0.05). Conclusion Atention and interpretation therapy can effectively alleviate cancer-related fatigue symptoms, improve psychological resilience levels, and enhance the quality of life for patients with lung cancer.
2023 Vol. 20 (21): 175-178 [Abstract] ( 21 ) HTML (1 KB)  PDF (646 KB)  ( 84 )
179 Treatment of pneumatosis cystoids intestinalis aerocele with traditional Chinese and Western medicine: a case report
SHEN Yaocun1 HUANG Can1 LIU Shenfan1 ZHU Jie1 LIU Yuyue2 WANG Zhibin3▲
DOI: 10.20047/j.issn1673-7210.2023.21.40
Pneumatosis cystoides intestinalis are gas cysts occurring in the submucosa or subserous membrane of the digestive tract, with low incidence and easy misdiagnosis. This paper describes a case of pneumatosis cystoides intestinalis with persistent abdominal distension as the main symptom. After admission, colon endoscopy, endoscopic ultrasound, pathology, and CT examination were completed to confirm the diagnosis of pneumatosis cystoides intestinalis. After the treatment of integrated Chinese and Western medicine during hospitalization and oral treatment of traditional Chinese medicine after discharge, the clinical symptoms disappeared and there was no abnormality in colonoscopy review, and the overall effect was good. Pneumatosis cystoides intestinalis is a rare disease, easily confused with intestinal tuberculosis, intestinal polyps, inflammatory enteritis, intestinal tumors, and other diseases, improper treatment can lead to pneumoperitoneum, intestinal obstruction, intestinal ischemia, and other serious complications. The diagnosis and treatment of this case is detailed, the pathological results are clear, and the treatment effect of integrated Chinese and western medicine is very good, which can provide clinical reference.
2023 Vol. 20 (21): 179-182 [Abstract] ( 26 ) HTML (1 KB)  PDF (1401 KB)  ( 39 )
183 Diagnosis and treatment of a cases with influenza-associated acute necrotizing encephalopathy and review of relevant literature and review of relevant literature
SUN Wenqiang1 ZHU Xueping1 FU Changchang1 LI Ying2 SHENG Mao3
DOI: 10.20047/j.issn1673-7210.2023.21.41
influenza-associated acute necrotizing encephalopathy (IANE) is one of the most critical subtypes of an acute encephalopathy, progressing rapidly, with fever, convulsions, and rapid onset of consciousness the most common, and with a poor prognosis. In order to improve clinicians’ ability to recognize and diagnose IANE at an early stage, ensure timely treatment of patients and improve their prognosis. In this paper, analyze and discuss a patient with IANE who was seen in the Children’s Hospital of Soochow University. The child started with a high fever and showed symptoms of neurological involvement within two days. The brain MRI showed bilateral symmetrical brain damage, and the diagnosis of IANE was considered in combination with relevant laboratory tests. The child was discharged after aggressive treatment but was left with mild cognitive impairment. Through a retrospective analysis of the national and international literature, it is mainly believed that early use of intravenous glucocorticoid shock combined with Oseltamivir antiviral, as well as the use of appropriate antibiotics against infection, is the best treatment regimen for IANE.
2023 Vol. 20 (21): 183-186 [Abstract] ( 23 ) HTML (1 KB)  PDF (1043 KB)  ( 160 )
187 A report of three cases and literature analysis clinical pharmacist participated in high dose Methotrexate therapy in children
JIA Chenhong LI Ruihong QIN Yabin DING Xiangyu
DOI: 10.20047/j.issn1673-7210.2023.21.42
High dose Methotrexate is an important means in the treatment of blood tumors in children, which greatly improves the remission rate of the disease. However, its severe toxic and side effects bring great harm to children. In this paper, clinical pharmacists participated in the treatment of three children with high dose Methotrexate, and individualized pharmaceutical care was carried out according to the different conditions of the children. For children with high Methotrexate concentration or delayed elimination, timely and appropriate calcium folinate rescue strategy and symptomatic treatment can reduce the toxic reaction of Methotrexate. To ensure the efficacy of Methotrexate while minimizing the occurrence of serious adverse reactions. Finally, combined with the treatment process and literature analysis, the method of individualized treatment and pharmaceutical care for children with high dose Methotrexate by clinical pharmacists based on blood concentration monitoring was discussed.
2023 Vol. 20 (21): 187-191 [Abstract] ( 25 ) HTML (1 KB)  PDF (691 KB)  ( 162 )
192 Pulmonary artery intimal sarcoma as a rare cause of pulmonary hypertension: a case report
CAI Bin1 AI Juan1 LI Xiangyu1 ZHENG Yuan2 LING Qiong1 YANG Manmei3▲
DOI: 10.20047/j.issn1673-7210.2023.21.43
Pulmonary artery intimal sarcoma (PAIS) is a rare disease with a high misdiagnosis rate. Because the onset is easy to be confused with other cardiovascular diseases, once misdiagnosed or missed diagnosis, resulting in further development of the disease, miss the best treatment opportunity. In order to improve the level of clinical diagnosis and treatment of this disease and make correct diagnosis and treatment plan, a case of PAIS was reported and analyzed in Guangdong Provincial Hospital of Chinese Medicine. The first symptoms of the patient were progressive chest tightness and asthma. The patient was considered to be PAIS through preoperative physical examination, imaging examination, and combined with previous medical history. The pulmonary artery tumor was excised under cardiopulmonary bypass, during which gray and white masses were found to invade the whole layer of blood vessels along the main pulmonary artery. The tumor was completely resected, and PAIS was confirmed by postoperative pathological examination. The patient died of multiple organ failure one month after surgery. Through retrospective analysis of domestic and foreign literature, most of them believe that once PAIS is diagnosed, surgery and concurrent chemorotherapy should be actively treated; at the same time, literature review was carried out on the symptoms, clinical manifestations, imaging features of the disease to improve the understanding of the disease, so as to reduce misdiagnosis or missed diagnosis.
2023 Vol. 20 (21): 192-196 [Abstract] ( 18 ) HTML (1 KB)  PDF (1873 KB)  ( 251 )
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