抗米勒管激素联合体重指数检测在年龄≤35岁不孕症女性夫精人工授精妊娠结局中的预测价值

doi:10.20047/j.issn1673-7210.2023.21.25

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Abstract Objective To investigate the predictive value of anti-Mullerian hormone (AMH) combined with body mass index (BMI) in pregnancy outcome of infertile women aged ≤35 years old after artificial insemination by husband (AIH). Methods A retrospective analysis was performed on 261 cases with infertile women aged ≤35 years old (449 cycles) who received AIH treatment in Maanshan Maternal and Child Health Hospital, Anhui Province from January 2018 to December 2021. According to the clinical pregnancy outcome, they were divided into pregnant group (77 cycles) and non-pregnant group(372 cycles). The general information, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), progesterone (P), testosterone(T), and AMH levels of two groups were compared; the predictive value of AMH and BMI in AIH pregnancy outcome was analyzed by receiver operating characteristic curve. Results BMI of pregnant group was lower than that of non-pregnant group, and AMH was higher than that of non-pregnant group (P＜0.05). There were no significant differences in FSH, E2, P, PRL, LH, and T between two groups (P＞0.05). The area under the curve of AIH pregnancy outcome combined predicted by AHM and BMI was higher than that predicted by AMH and BMI alone (P＜0.05). Conclusion AMH combined with BMI has a certain predictive value for AIH pregnancy outcome in infertile women aged ≤35 years old.

Key words： Intrauterine insemination Anti-Mullerian hormone Body mass index Gestation

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	AI Fenglian ZHANG Yuanbao HUANG Cun XU Xiaolian PAN Weijun▲

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AI Fenglian ZHANG Yuanbao HUANG Cun XU Xiaolian PAN Weijun▲. Predictive value of anti-Müllerian hormone combined with body mass index in pregnancy outcome of infertile women aged ≤35 years old after artificial insemination by husband[J]. 中国医药导报, 2023, 20(21): 117-120.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.21.25 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I21/117

[1] 张孝东，邓成艳，黄学锋，等.中华医学会生殖医学分会：2019年辅助生殖技术数据报告[J].生殖医学杂志，2022，31（8）：1015-1021.
[2] 李医，孟晓楠，罗宇.血清FSH、IGF-Ⅰ及BMI对夫精人工授精助孕结局的影响[J].分子诊断与治疗杂志，2021， 13（2）：267-270，275.
[3] 郭小芹，李露，高郁森.夫精宫腔内人工授精早期妊娠丢失的多因素分析[J].生殖医学杂志，2022，31（11）：1588- 1591.
[4] Green KA，Zolton JR，Schermerhorn SM，et al. Progesterone luteal support after ovulation induction and intrauterine insemination：an updated systematic review and meta-analysis [J]. Fertil Steril，2017，107（4）：924-933.e5.
[5] Qiao J，Zhang Y，Liang X，et al. A randomised controlled trial to clinically validate follitropin delta in its individualised dosing regimen for ovarian stimulation in Asian IVF/ICSI patients [J]. Hum Reprod，2021，36（9）：2452-2462.
[6] Zarek SM，Mitchell EM，Sjaarda LA，et al. Is Anti-Müllerian Hormone Associated With Fecundability? Findings From the EAGeR Trial [J]. Clin Endocrinol Metab，2015，100（11）： 4215-4221.
[7] 李铮，张忠平，黄翼然，等.世界卫生组织不育夫妇标准检查与诊断手册[M].北京：人民卫生出版杜，2007.
[8] 谷翊群，陈振文，卢文红.世界卫生组织人类精液检查与处理实验室手册（第五版）[M].北京：人民出版社，2011.
[9] 琳莉，黄国宁，孙海翔，等.辅助生殖技术临床关键指标质控专家共识[J].生殖医学杂志，2018，27（9）：828-835．
[10] 戴善军，杨杰，王芳，等.抗苗勒管激素水平及促性腺激素剂量与体外受精胚胎移植妊娠结局的关系[J].郑州大学学报（医学版），2021，56（1）：42-46.
[11] 廖会姝，杨学妞.抗苗勒管激素预测多囊卵巢综合征促排卵治疗后卵巢反应性价值[J].中国计划生育学杂志，2022，30（1）：126-128，134.
[12] 高海彦，李永红，苗生虎.孕前基础性激素与抗苗勒式管激素对高龄育龄女性卵巢储备功能筛查价值[J].中国计划生育学杂志，2022，30（10）：2349-2352.
[13] 张妍，周玲，王莉，等.基于孕前BMI差异的妊娠早期增重正常孕妇的妊娠结局研究[J].中国实验诊断学，2022，26（11）：1620-1623.
[14] Ahmad R，Haque M. Obesity：A Doorway to a Molecular Path Leading to Infertility [J]. Cureus，2022，14（10）：e30770.
[15] 温晶，符爱贞.189例不孕患者试管婴儿助孕妊娠结局的影响因素分析[J].中南医学科学杂志，2022，50（3）：446-448.
[16] 涂文娇，许世艳，林晓谭，等.女性超重对宫腔内夫精人工授精妊娠结局的影响[J].中国计划生育和妇产科，2022，14（7）：45-49.
[17] 王瑜，张少静，张少娣，等.宫内病变、年龄与不孕症患者妊娠结局的相关性分析[J].中国临床医生杂志，2019， 47（3）：351-353.
[18] Wang JX，Warnes GW，Davies MJ，et al. Overweight infertile patients have a higher fecundity than normal-weight women undergoing controlled ovarian hyperstimulation with intrauterine insemination [J]. Fertil Steril，2004，81（6）：1710-1712.
[19] 加孜热亚·再依拿提，张凯迪，马福慧，等.乌鲁木齐育龄期健康女性AMH参考范围的建立及AMH与心血管危险因素的相关性研究[J].中国全科医学，2022，25（22）：2740-2745.
[20] 周杨，王晓琳，贺永艳，等.PCOS患者AMH水平与性激素及胰岛素抵抗的相关性研究[J].中国妇幼健康研究，2022，33（1）：49-54.
[21] Michalakis K，Mintziori G，Kaprara A，et al. The complex interaction between obesity，metabolic syndrome and reproductive axis：A narrative review [J]. Metabolism，2013，62（4）：457-478.
[22] Obradovic M，Sudar-Milovanovic E，Soskic S，et al. Leptin and Obesity：Role and Clinical Implication[J]. Front Endocrinol（Lausanne），2021，12：585887.
[23] Darcy E，Broughton，Kelle H，et al. Obesity and female infertility：potential mediators of obesity’s impact [J]. Fertil Steril，2017，107（4）：840-847.
[24] 章远谋，韩康，夏瑞，等.胰高血糖素样肽-1受体激动剂治疗多囊卵巢综合征的研究进展[J].中国临床研究，2021，34（10）：1413-1416.
[25] 黄兰，陈赛琼.“调冲任、固肾元”针刺法配合益宫养泡汤治疗小卵泡排卵不孕症疗效及对下丘脑-垂体-卵巢轴功能的影响[J].现代中西医结合杂志，2021，30（2）：160-163，203.
[26] 姜雪，李梦萦，林芳旭，等.卵巢储备功能对夫精宫腔内人工授精妊娠结局的影响[J].生殖医学杂志，2022，31（7）：911-917.
[27] 崔金秀.腹腔镜联合GnRH-a治疗对EMS伴不孕症性激素、CA125水平及妊娠率的影响[J].中国医药科学，2023，13（1）：123-126.
[28] 朱素婧，崔艳萍，黄文静，等.卵巢子宫内膜异位囊肿不孕症患者腹腔镜术后联合GnRH-a治疗的有效性分析[J].中外医学研究，2021，19（11）：38-41.