TT、FIB、D-D用于二次创伤骨折术后深静脉栓塞风险评估的价值

doi:10.20047/j.issn1673-7210.2023.21.18

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Abstract Objective To analyze the value of thrombin time (TT), fibrinogen (FIB), and D-dimer (D-D) in the risk assessment of deep vein thrombosis (DVT) after secondary traumatic fracture. Methods A total of 100 patients with secondary traumatic fracture admitted to Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine from January 2019 to July 2022 were selected and divided into DVT group (41 cases) and non-DVT group (59 cases) according to whether DVT occurred after operation. Univariate and multivariate logistic regression analysis were used to analyze the independent risk factors of postoperative DVT, and receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of TT, FIB, and D-D in postoperative DVT. Results TT in DVT group was lower than that in non-DVT group, FIB and D-D were higher than those in non-DVT group, and the differences were statistically significant (P＜0.05). There was no significant difference in PT and APTT between the two groups (P＞0.05). logistic regression analysis results showed that, general anesthesia (OR[95%CI]=2.194[1.626-2.960]), intraoperative blood transfusion (OR[95%CI]=2.458[1.780-3.394]), FIB (OR[95%CI]=1.483[1.244-1.768]), and D-D (OR[95%CI]= 2.026[1.610-2.549]) were independent risk factors for DVT after secondary traumatic fracture (P＜0.05); TT (OR[95%CI]= 0.868[0.774-0.973]) was an independent protective factor for DVT after secondary traumatic fracture (P＜0.05). The area under the curve predicted by the combination of TT, FIB and D-D was 0.914, the sensitivity was 0.927, and the specificity was 0.878. Conclusion TT, FIB, and D-D are independent influencing factors for DVT after secondary traumatic fracture, and the combination of these three factors can be used as a sensitive predictor of postoperative DVT.

Key words： Thrombin time Fibrinogen D-dimer Secondary trauma fracture Deep vein thrombosis

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	WU Jihong1 OUYANG Guolin1 CHEN Tao2 SHAO Weigang2 RONG Xiangbin2▲

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WU Jihong1 OUYANG Guolin1 CHEN Tao2 SHAO Weigang2 RONG Xiangbin2▲. Value of TT, FIB, and D-D in risk assessment of deep vein embolism after secondary traumatic fracture[J]. 中国医药导报, 2023, 20(21): 84-87.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.21.18 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I21/84

[1] Dou C，Li T，Yang S，et al. Epidemiological status and risk factors of deep vein thrombosis in patients with femoral neck fracture [J]. J Orthop Surg Res，2022，17（1）：41-49.
[2] Zhu Y，Meng H，Ma J，et al. Prevalence of preoperative lower extremity deep vein thrombosis in bilateral calcaneal fractures [J]. J Foot Ankle Surg，2021，60（5）：950-955.
[3] 张堃，王鹏飞.下肢骨折患者深静脉血栓形成的发生时间与部位规律研究及药物防治效果评价[J].中华创伤骨科杂志，2022，24（3）：185-189.
[4] 岳睿，李晓玉，杨明辉，等.高龄老年髋部骨折患者术前下肢深静脉血栓形成的危险因素[J].首都医科大学学报，2020，41（3）：458-463.
[5] Walusimbi M，Dossa AY，Faryar K，et al. Upper extremity deep venous thrombosis risk factors，associated morbidity and mortality in trauma patients [J]. World J Surg，2022，46（3）：561-567.
[6] 杨超，张旭，李潭，等.创伤严重程度评分对多发创伤患者深静脉血栓形成的预测价值[J].实用医学杂志，2021， 37（18）：2371-2374.
[7] Zhang K，Zhu Y，Tian Y，et al. Role of a new age-adjusted D-dimer cutoff value for preoperative deep venous thrombosis exclusion in elderly patients with hip fractures [J]. J Orthop Surg Res，2021，16（1）：649-657.
[8] 中华医学会外科学分会血管外科学组.深静脉血栓形成的诊断和治疗指南（第三版）[J].中华普通外科杂志，2017，32（9）：807-812.
[9] 窦晨浩，李天华，杨淑红，等.股骨骨折患者下肢深静脉血栓形成的流行病学特征研究[J].中华创伤骨科杂志，2022，24（3）：262-266.
[10] 徐荣良，刘林，许铁，等. 血常规参数对骨折术后深静脉血栓形成的预测价值[J].中华实验外科杂志，2020，37（2）：363-365.
[11] Fei C，Wang PF，Qu SW，et al. Deep vein thrombosis in patients with intertrochanteric fracture：a retrospective study [J]. Indian J Orthop，2020，54（1）：101-108.
[12] Bengoa F，Vicencio G，Schweitzer D，et al. High prevalence of deep vein thrombosis in elderly hip fracture patients with delayed hospital admission [J]. Eur J Trauma Emerg Surg，2020，46（4）：913-917.
[13] 蔡明建，王虎，尚昆，等.髋部骨折患者急性下肢深静脉血栓的转归及其影响因素[J].山东医药，2021，61（3）：75-77.
[14] 陈颖，秦贤，王敬东，等.三级医院危重症患者下肢深静脉血栓形成的危险因素分析[J].中国中西医结合急救杂志，2021，28（2）：189-193.
[15] 李斌，石岩，黄承，等.胸腰段脊柱骨折合并急性创伤性脊髓损伤患者术后深静脉血栓的危险因素分析[J].中国脊柱脊髓杂志，2022，32（8）：713-719.
[16] Ma J，Du P，Qin J，et al. Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures [J]. Sci Rep，2021，11（1）：2441-2448.
[17] 刘延荣，吕亚娟.血栓弹力图评估重型颅脑创伤术后深静脉血栓形成的价值[J].血栓与止血学，2020，26（6）：951-952.
[18] Song K，Zhu B，Yao Y，et al. Incidence and risk factors of preoperative deep vein thrombosis in patients with intertrochanteric fractures：a retrospective study [J]. J Orthop Surg Res，2022，17（1）：375-380.
[19] 黄伟，钱锦锋，姜叶飞.老年胫骨平台骨折患者围手术期发生下肢深静脉血栓形成的危险因素分析[J].重庆医学，2021，50（S1）：219-221.
[20] 祁亚宁，王利新，刘辉，等.血清TM、P-selectin、HDL-C以及凝血功能指标与创伤性骨折患者术后深静脉血栓形成的关系研究[J].现代生物医学进展，2021，21（16）：3131-3135.
[21] 刘平，叶勇军，朱宁，等.髋部骨折患者术前发生下肢深静脉血栓的影响因素[J].中国当代医药，2023，30（2）：81-84.
[22] 王秀秀.下肢静脉曲张患者术后并发深静脉血栓的危险因素[J].中国医学创新，2022，19（12）：100-103.
[23] Wu L，Cheng B. Analysis of perioperative risk factors for deep vein thrombosis in patients with femoral and pelvic fractures [J]. J Orthop Surg Res，2020，15（1）：597-609.
[24] 王振群，章文洁，吴俊. 血栓分子标志物联合Caprini评分预测创伤性下肢骨折后深静脉血栓形成风险[J].中华检验医学杂志，2021，44（12）：1170-1175.
[25] 郝君霞，胡金花，夏群，等.2D-B/W、CDFI联合血浆Fib、D-D检测对DVT的诊断价值[J].中国医药导报，2022， 19（7）：104-107.
[26] 范鑫超，鲍文娟，张凯，等.D-二聚体、红细胞沉降率和C-反应蛋白在髋、膝关节置换后下肢深静脉血栓形成中的诊断价值[J].中国组织工程研究，2021，25（33）：5324-5328.
[27] 徐燕军，黄江山，陈智阳.常用血常规指标、血浆D-D、Fib监测对下肢创伤发生深静脉血栓的诊断价值[J].中国医药科学，2021，11（15）：142-146.
[28] 伍广，章芹，宋倩.FIB、D-D、PLT对妊娠期高血压疾病患者下肢深静脉血栓的预测价值[J].中外医学研究，2022，20（34）：76-79.
[29] 白树财，陈晓英，祝春霞，等.胫骨平台骨折术前下肢深静脉血栓形成的危险因素分析[J].中华骨科杂志，2021， 41（15）：1052-1058.