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| Reasearch progress of signaling pathways and related therapies in neurogenesis after ischemic stroke |
| CHEN Yanxi1 XU Zhidong2 SUN Fangling1 WANG Wen1 |
1.Experimental Animal Center, Xuanwu Hospital, Capital Medical University Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China; 2.School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Hebei Province, Shijiazhuang 050018, China
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Abstract Ischemic stroke is a cerebrovascular disease that seriously reduces people’s quality of life. The effective therapeutic drug of this disease, Alteplase, has a narrow thrombolytic time window, which limits the application of patients. Wnt/β-catenin, Notch, PI3K/Akt, MAPK, and Eph-ephrin pathways play important roles in the development of central nervous system and are involved in cell growth, migration, and adhesion. Since adult nerve cells growth have been stopped, reactivation of these pathways may bring hope for endogenous regeneration and repair of brain injury. Finding mechanisms and drugs targeting these pathways involved in neurogenesis will be beneficial to stroke rehabilitation. This article reviews the key processes and drug development of these pathways involved in neurogenesis.
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