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| Effect and mechanism of cognitive behavioral therapy combined with Mirtazapine on patients with functional dyspepsia |
| ZHANG Hongyan1 HAO Xiuqing2 LI Duo3 BIAN Rui1 ZHANG Yuping4 YANG Xiaojing5 ZHANG Haiyan5 |
1.The Third Department of Neurology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Pathology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
3.Department of Gastroenterology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
4.Department of Pathophysiology, College of Basic Medicine, Hebei North University, Hebei Province, Zhangjiakou 075000, China;
5.Department of Outpatient, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
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Abstract Objective To observe the effect and mechanism of cognitive behavioral therapy combined with Mirtazapine on patients with functional dyspepsia. Methods A total of 120 patients with functional dyspepsia admitted to the psychological clinic of the First Affiliated Hospital of Hebei North University from May 2019 to May 2021 were selected. They were divided into control group and experimental group according to the random table method, with 60 cases in each group. The control group was treated with Mirtazapine, and the experimental group was treated with Mirtazapine combined with cognitive behavior therapy. The clinical efficacy, safety, patient health questionnaire (PHQ-15), 5-hydroxytryptamine (5-HT), gastrin (GAS) and motilin (MTL) were compared between the two groups after eight weeks of treatment. Results In the control group, six patients were lost during follow-up, two patients were lost because of worrying about the side effects of antidepressants. And two patients were lost during follow-up in the experimental group. The clinical efficacy of the experimental group was higher than that of the control group after eight weeks of treatment(P＜0.05) . There was no significant difference in total incidence of adverse reactions between the two groups (P＞0.05). After treatment, PHQ-15 and 5-HT in two groups were lower than before treatment, and experimental group was lower than control group (P＜0.05). After treatment, GAS and MTL of the two groups were higher than those before treatment, and experimental group was higher than control group (P＜0.05). Conclusion In the treatment of functional dyspepsia, cognitive behavioral therapy combined with Mirtazapine is superior to Mirtazapine alone, which can not only improve a variety of somatic discomfort symptoms, but also better improve the related indexes of gastrointestinal dynamics, it is worthy of clinical application.
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