|
|
|
| Causality between osteoporosis and lumbar disc herniation: a Mendelian randomized study |
| XU Jingwei1 WU Yadong2 WANG Jing3 DENG Wenjie4 YIN Shichang1▲ |
1.Department of Orthopedics Trauma, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
2.Department of Spinal Orthopedics, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
3.Department of Encephalopathy, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
4.Department of Microorthopedics, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China
|
|
|
|
Abstract Objective To study the causal relationship between osteoporosis (OP) and lumbar disc herniation (LDH) by Mendelian randomization analysis. Methods A genome-wide meta-analysis sample of calcaneal bone density was obtained through genome-wide association analysis, and a total of 17 166 350 single nucleotide polmorphism(SNPs) were collected. SNP mapping between OP and LDH outcomes was screened out, and instrumental variables SNP was obtained. The causal relationship between OP and LDH were analyzed by Mendelian randomization. Results A total of 203 SNPs, including rs10022648, rs10066763, rs10130587, as included as instrumental variables. The MR-Egger regression result P=0.442324 286, indicating no horizontal pleiotropy. IVW analysis showed that P＜0.05, OR=0.893 174 092 (OR_lci95, 0.823 290 84; OR_uci95, 0.968 989 231), the risk of LDH increased by 0.89 times for every one SD decrease in BMD, and the two were negatively correlated. The result of heterogeneity test was P=0.44 with no heterogeneity. Conclusion There is a causal relationship between OP represented by bone density and LDH.
|
|
|
|
|
|
[1] Yu XH，Wei YY，Zeng P，et al. Birth weight is positively associated with adult osteoporosis risk：observational and Mendelian randomization studies [J]. J Bone Mine Res，2021， 36（8）：1469-1480.
[2] Liu YQ，Liu Y，Chen ZY，et al. Rheumatoid arthritis and osteoporosis：a bi-directional Mendelian randomization st- udy [J]. Aging （Albany NY），2021，13（10）：14109-14130.
[3] Kou N，Zhou W，He Y，et al. A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data [J]. Frontiers Bioeng Biotechnol，2020，8.
[4] Shemory ST，Pfefferle KJ，Gradisar IJO. Modifiable Risk Factors in Patients With Low Back Pain [J]. Crthopedics，2016， 39（3）：e413- e416.
[5] Iwai K，Koyama K，Okada T，et al. Asymmetrical and smaller size of trunk muscles in combat sports athletes with lumbar intervertebral disc degeneration [J]. Springerplus，2016，5（1）： 1474.
[6] Keller Baruch J，Forgetta V，Manousaki D，et al. Genetically Decreased Circulating Vascular Endothelial Growth Factor and Osteoporosis Outcomes：A Mendelian Randomization Study [J]. J Bone Miner Res，2020，35（4）：649-656.
[7] Zheng HF，Forgetta V，Hsu YH，et al. Whole-genome sequ- encing identifies EN1 as a determinant of bone density and fracture [J]. Nature，2015，526（7571）：112-117.
[8] Liu Q，Wang X，Hua Y，et al. Estrogen Deficiency Exacer- bates Intervertebral Disc Degeneration Induced by Spinal Instability in Rats [J]. Spine，2019，44（9）：E510-E519.
[9] Ding Y，Chen JY，Yang JC，et al. Disc degeneration contri- butes to the denser bone in the subendplate but not in the vertebral body in patients with lumbar spinal stenosis or disc herniation [J]. Spine J，2023，23（1）：64-71.
[10] Liu FJ，Xie LY，Li HZ，et al. Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration [J]. Dis Markers，2021，2021：3532716.
[11] Teraguchi M，Yoshimura N，Hashizume H，et al. Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration：The Wakayama Spine Study [J]. PLoS One，2016，11（2）：e147565.
[12] Deng RY，Hong T，Li CY，et al. Long non-coding RNA zinc finger antisense 1 expression associates with increased disease risk，elevated disease severity and higher inflammatory cytokines levels in patients with lumbar disc degenera- tion [J]. Medicine （Baltimore），2019，98（52）：e18465.
[13] Xu J，Li S，Zeng Y，et al. Assessing the Association between Important Dietary Habits and Osteoporosis： A Genetic Correlation and Two-Sample Mendelian Randomization St- udy [J]. Nutrients，2022，14（13）：2656.
[14] Yang M，Wang N，Zhang W，et al. The Dual Effect of Abnormal Serum Uric Acid on Intervertebral Disc Degeneration [J]. Oxid Med Cell Longev，2021，2021：2362799.
[15] Doraisamy R，Ramaswami K，Shanmugam J，et al. Genetic risk factors for lumbar disc disease [J]. Clin Anat，2021，34（1）：51-56.
[16] Bjorland S，Roe C，Moen A，et al. Genetic predictors of recovery in low back and lumbar radicular pain [J]. Pain，2017，158（8）：1456-1460.
[17] Xu HW，Yi YY，Zhang SB，et al. Does vitamin D status influence lumbar disc degeneration and low back pain in postmenopausal women? A retrospective single-center study [J]. Menopause，2020，27（5）：586-592.
[18] Li R，Zhang W，Xu Y，et al. Vertebral endplate defects are associated with bone mineral density in lumbar degenerative disc disease [J]. Eur spin J，2022，31（11）：2935-2942.
[19] Zhuang C，Wang Z，Chen W，et al. Osteoporosis and Endplate Damage Correlation Using a Combined Approach of Hounsfield Unit Values and Total Endplate Scores：A Retrospective Cross-Sectional Study [J]. Clin Interv Aging， 2021， 16：1275-1283.
[20] Huang DY，Shen YJ，Wang F，et al. Correlative analysis of degenerative lumbar scoliosis and osteoporosis [J]. Zhonghuo Gu Shang，2019，32（3）：244-247.
[21] 梁旺全，杨卫保，王辉.肥胖及骨密度与腰椎间盘退变程度的相关性研究[J].颈腰痛杂志，2021，42（4）：508-511.
[22] Yuan J，Peng L，Luan F，et al. Causal Effects of Genetically Predicted Cystatin C on Osteoporosis：A Two-Sample Men- delian Randomization Study [J]. Front in Genet，2022， 13.
[23] Sun Q，Tian FM，Liu F，et al. Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats [J]. Arthritis Res Ther，2021，23（1）：152.
[24] Alanazi MH，Parent EC，Dennett E. Effect of stabilization exercise on back pain，disability and quality of life in adults with scoliosis：a systematic review [J]. Eur J Phys Rehabil Med，2018，54（5）：647-653. |
|
|
|
