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2022 Vol. 19, No. 30 Published: 2022-10-25

	7	Establishment and test of reliability and validity of knowledge-attitude-practice scale for prevention of upper limb lymphedema in patients after breast cancer surgery
		SHI Bohui1 LIN Zihan2 MA Xiaoxia1 HAO Na1 QI Jing1 CHEN Yao1 WANG Lian3▲
		DOI: 10.20047/j.issn1673-7210.2022.30.01
		Objective To develop a scale of knowledge-attitude-practice of preventing the upper limb lymphedema for breast cancer patients after surgery and test its reliability and validity. Methods Based on the knowledge- attitude-practice theory, the first draft of the scale was constructed on the basis of evidence and combined with brainstorming method. The Delphi method was used to consult experts for further revision. After the pre-survey, a total of 200 breast cancer patients who were hospitalized in the First Affiliated Hospital of Xi’an Jiaotong University from September to November 2021 were selected by convenience sampling for questionnaire survey to test the reliability and validity of the scale. Results The knowledge-attitude-practice scale for preventing upper limb lymphedema in patients after breast cancer surgery includes three dimensions, knowledge-attitude-practice, with a total of 23 items. The positive coefficients of the two rounds of expert consultation were 1.00 and 0.93, the authoritative coefficients were 0.90 and 0.89, and the coordination coefficients were 0.387 and 0.287. Thirty valid questionnaires were collected in the pre-survey with an effective recovery rate of 100%. The recovered scale was revised again according to the patient’s feedback, and a total of four items were modified. A total of 162 valid questionnaires were recovered from the formal investigation, with an effective recovery rate of 81%. The correlation coefficient between the total scale and each item was 0.414-0.787, the content validity of the total scale was 0.938, the content validity index of each item level was 0.857-1.000, the Cronbach’s α coefficient of the scale was 0.931, the split half coefficient was 0.875, and the test-retest coefficient was 0.916. Exploratory factor analysis was used to extract three common factors, which could explain 62.843% of the total variables, and confirmatory factor analysis showed that the model had a good fit. Conclusion The knowledge-attitude-practice scale for preventing upper limb lymphedema in patients after breast cancer surgery has good reliability and validity, and can be used as an assessment tool for patients’ knowledge- attitude-practice of lymphedema prevention.
		2022 Vol. 19 (30): 7-11 [Abstract] ( 12 ) HTML (1 KB) PDF (923 KB) ( 58 )

	12	Knowledge indexing scheme and knowledge representation of Treatise on Cold Pathogenic and Miscellaneous Diseases based on knowledge element theory
		YANG Feng ZHONG Xianggen ZHOU Ranran HOU Jianchen LI Qianqian LI Ran LI Yiran TAO Xiaohua
		DOI: 10.20047/j.issn1673-7210.2022.30.02
		Objective To explore the knowledge indexing scheme and knowledge representation method of Treatise on Cold Pathogenic and Miscellaneous Diseases, to transform the natural language text into structured logical data, and to guide the development and utilization of ancient books of typhoid and golden chamber class. Methods The technologies of indexing and knowledge graph were used to extract and represent the knowledge in Treatise on Cold Pathogenic and Miscellaneous Diseases, based on knowledge element theory. Results After a deep indexing of Treatise on Febrile Diseases and Synopsis of Golden Chamber, 923 knowledge bodies, 6 204 knowledge elements, 10 607 semantics, and 3 690 semantic relationships were obtained totally, and an indexing scheme was formed. The knowledge graph of “disease-pulse-syndrome combined treatment” showed Zhang Zhongjing’s clinical diagnosis and treatment thinking mode, which was “disease differentiation→pulse analysis→syndrome analysis→treatment”. Conclusion By analyzing the knowledge structure and kernel of ancient traditional Chinese medicine books, the strategy of creating a suitable indexing template first and then indexing texts, helps in acquiring dynamic and static knowledge in ancient books in depth. And the form of logical data and knowledge graph facilitates the computer to make full use of the multi-grained and interrelated knowledge of ancient books.
		2022 Vol. 19 (30): 12-16,40 [Abstract] ( 12 ) HTML (1 KB) PDF (2063 KB) ( 112 )

	17	Effect of Fluoxetine on synaptic plasticity of optic cortical neuron cells in monocular deprived amblyopia rats and its related mechanism
		LUO Xianling WU Luoling
		DOI: 10.20047/j.issn1673-7210.2022.30.03
		Objective To investigate the effect of Fluoxetine on synaptic plasticity of optic cortical neuron cells in monocular deprived amblyopia rats and its related mechanism. Methods Ten of 60 SPF male SD rats were selected as the control group, and the other 50 rats were used to construct the monocular deprived amblyopia rat model. The 50 rats with successful modeling were divided into positive drug group, model group, low, medium, and high dose groups by random number table method, with 10 rats in each group. The low, medium, and high dose groups were intraperitoneally injected with 5, 10, and 20 mg/(kg·d) Fluoxetine; the positive drug group was intraperitoneally injected with 80 mg/(kg·d) Levodopa; and the model group and the control group were intraperitoneally injected with the same amount of normal saline. Each group was treated for 28 days. P100 latency and P100 amplitude in each group were measured; the ultrastructural changes of synapses of neurons in visual cortex in each group were observed; the ERK1/2, p-ERK1/2, CREB, and p-CREB protein in visual cortex in each group were detected. Results The P100 latency, synaptic gap, and synaptic density thickness in the model group were higher than those in the control group, and the P100 amplitude and p-ERK1/2/ERK1/2, and p-CREB/CREB in visual cortex were lower than those in the control group (P ＜ 0.05). The P100 latency, synaptic gap, and synaptic density thickness in the low, medium, and high dose groups were lower than those in the model group, and the P100 amplitude, p-ERK1/2/ERK1/2, and p-CREB/CREB in the visual cortex were higher than those in the model group; the P100 latency, synaptic space, and synaptic density thickness in the middle and high dose groups were lower than those in the low dose group, and the P100 amplitude, p-ERK1/2/ERK1/2, and p-CREB/CREB in the visual cortex were higher than those in the low dose group; the P100 latency, synaptic gap, and synaptic density thickness in the high-dose group were lower than those in the medium dose group, and the P100 amplitude, p-ERK1/2/ERK1/2, and p-CREB/CREB in the visual cortex were higher than those in the medium dose group (P ＜ 0.05). Compared with the model group, the synaptic structure of the visual cortex neurons in the low, medium, and high dose groups was slightly clear, and the myelin sheath lamellar structure was clear. Conclusion Fluoxetine can remodel the synaptic ultrastructure of visual cortex neurons in monocular deprived amblyopic rats, activate the structural plasticity of visual cortex, and improve the visual function of rats, which may be achieved by activating ERK/CREB pathway.
		2022 Vol. 19 (30): 17-20 [Abstract] ( 11 ) HTML (1 KB) PDF (966 KB) ( 26 )

	21	Visual analysis of traditional Chinese medicine treatment of tic disorder based on CiteSpace
		JING Chenyang1 WANG Xiaoyan2 KONG Lingxia2 ZHANG Yanmei2 YANG Yafeng2 ZHAO Li1
		DOI: 10.20047/j.issn1673-7210.2022.30.04
		Objective To analyze the research hotspots and trends of traditional Chinese medicine in the treatment of tic disorders in the past 20 years by visualization method. Methods With the theme of “tic disorders”, relevant Chinese journals and literatures from January 2001 to December 2021 were retrieved from CNKI, while the authors, institutions, and keywords were visually analyzed using VOSviewer and CiteSpace software. Results A total of 602 papers were included, and the number of papers published in the past 20 years had shown a trend of increasing year by year; the author with the most publications was Wang Sumei, and had formed a core research team represented by Wang Sumei, Ma Rong, and Wu Min; the research institutions were mainly universities and their affiliated hospitals, and the cooperation between institutions was quite different; research hotspots were clinical experience, external treatment of traditional Chinese medicine, and the mechanism of action of prescriptions. In addition, data mining was also a current research hotspot. Conclusion This study visually shows the research status of the treatment of tic disorders in the field of traditional Chinese medicine in the past 20 years, shows the relevant research teams and institutions, and preliminarily analyzes the current research hotspots and trends, in order to provide certain reference for relevant scholars to study this field.
		2022 Vol. 19 (30): 21-25 [Abstract] ( 14 ) HTML (1 KB) PDF (2007 KB) ( 31 )

	26	Effect of long screws in injured vertebrae pry reset in the treatment of AO classification type A thoracolumbar fracture
		LUO Yuancheng WANG Lizuo▲ ZHU Bin ZHU Qian
		DOI: 10.20047/j.issn1673-7210.2022.30.05
		Objective To investigate the clinical effect of long screws in injured vertebrae pry reset in the treatment of AO classification type A thoracolumbar fracture. Methods From April 2018 to December 2020, 46 patients with type A thoracolumbar fracture without neurological symptoms treated in Department of Orthopedics, Enshi Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Province were selected as the research objects. According to the random number table method, the patients were divided into two groups: the pry teset group (redution and fixation by prying with long screw of injured vertebra, 25 cases) and the indirect reset group (after the reduction of adjacent vertebrac distraction, the injured vertebral was fixed with short screw, 21 cases). The general operation conditions (wound length, operation time, intraoperative blood loss and related complications) of the two groups were observed and compared. Cobb angle and anterior height ratio of injured vertebrae were measured and compared between the two groups. Results Both groups were followed up 12-18 months (median, 14 months). There were no significant differences in incision length, operation time, and intraoperative blood loss between the two groups (P ＞ 0.05). No postoperative complications were observed in the two groups. Overall analysis showed that there were statistically significant differences in Cobb angle and vertebral height ratio between the two groups at different time points, between groups and interaction (P ＜ 0.05). Intra-group comparison showed that the vertebral height ratio increased and the lateral Cobb angle decreased between the two groups immediately after operation (P ＜ 0.05). In indirect reduction group, there was significant difference between the last follow-up and the immediate postoperative follow-up (P ＜ 0.05). There were statistically significant differences in Cobb angle and vertebral height between the two groups at immediate and last follow-up after operation (P ＜ 0.05). At the last follow-up, no screw loosening, fracture and kyphosis were found in both groups. Conclusion The treatment of type A thoracolumbar fracture with the long screw of injured vertebra is ideal, reliable, and can maintain the reduction. The clinical effect is satisfactory.
		2022 Vol. 19 (30): 26-29 [Abstract] ( 10 ) HTML (1 KB) PDF (923 KB) ( 16 )

	30	Visual analysis of knowledge map in clinical research of traditional Chinese medicine qigong based on CiteSpace
		ZHANG Tian ZHANG Haibo LI Xin ZHANG Xiaohao YANG Xiuming
		DOI: 10.20047/j.issn1673-7210.2022.30.06
		Objective To explore the hotspots and trends of clinical research on traditional Chinese medicine qigong since, visual analysis was carried based on CiteSpace software. Methods Using CNKI and Web of Science core collection database as data sources, the relevant literatures of traditional Chinese medicine qigong clinical research collected from January 2000 to December 2021 were retrieved, and CiteSpace 5.8.R3 was used for analysis. Results A total of 2 747 articles were included, with an upward trend. Taijiquan and Baduanjin were popular methods in this field. The elderly were the main objects, and cardiovascular diseases were preponderant in traditional Chinese medicine qigong treatment. Conclusion The knowledge map displays representative organizations and authors in this field, reveals the hotspots and points out the direction for future development.
		2022 Vol. 19 (30): 30-35 [Abstract] ( 11 ) HTML (1 KB) PDF (3074 KB) ( 46 )

	36	Research progress of electrocardiogram automatic diagnosis based on deep learning in multiple system diseases
		ZHANG Xiling WANG Xinkang
		DOI: 10.20047/j.issn1673-7210.2022.30.07
		Electrocardiogram is a non-invasive method for detection, which can reflect the cardiac electrophysiology. Clinical findings show that many diseases can be complicated with cardiovascular events or change the normal working state of the heart. These changes can be reflected in small changes in electrocardiogram, which are not easy to be recognized by manual or traditional machine algorithms. In recent years, as the core of artificial intelligence development, deep learning can find nonlinear and subtle changes in electrocardiogram, and its application in this field has become an inevitable trend. At present, screening, monitoring, classification, diagnosis, and prediction of a variety of diseases can be realized through deep learning models. This paper reviews the research progress of electrocardiogram automatic diagnosis based on deep learning in multiple system diseases, and analyzes its future development trend.
		2022 Vol. 19 (30): 36-40 [Abstract] ( 11 ) HTML (1 KB) PDF (628 KB) ( 258 )

	41	Research progress in switching to Aphercept in patients with refractory neovascular senile macular degeneration
		WEN Yan PENG Hui
		DOI: 10.20047/j.issn1673-7210.2022.30.08
		With the advent of anti-vascular endothelial growth factor drugs, the treatment of neovascular senile macular degeneration has been greatly developed. However, there are still some patients who have poor effect after long-term treatment with the same drug, which may be related to drug resistance and rapid drug resistance response. At this time, drug replacement is a feasible option. As a representative of fusion protein drugs, Aphercept has the advantages of high affinity binding to vascular endothelial growth factor and multiple targets. This article reviews the current research status of switching to Aphercept in patients with refractory neovascular senile macular degeneration, in order to provide ideas for the treatment of this disease.
		2022 Vol. 19 (30): 41-44,49 [Abstract] ( 11 ) HTML (1 KB) PDF (528 KB) ( 30 )

	45	Research progress on the mechanism of gasotransmitters in non-alcoholic fatty liver disease
		KONG Guangyao JIANG Feng LIU Liping CHEN Yingqing
		DOI: 10.20047/j.issn1673-7210.2022.30.09
		Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver injury caused by abnormal deposition of fat in hepatocytes in addition to alcohol. Gasotransmitters, including nitric monoxide, carbon monoxide, and hydrogen sulfide can improve NAFLD by regulating VEGF-eNOS, PERK-eIF2-ATF4, Nrf2/HO-1,SESN2/AMPK/mTOR, and other signaling axes. This article mainly reviews the regulatory effects and molecular mechanisms of gasotransmitters on NAFLD, so as to provide new ideas for the treatment of NAFLD by gas signaling molecules and their donors in the future.
		2022 Vol. 19 (30): 45-49 [Abstract] ( 13 ) HTML (1 KB) PDF (1139 KB) ( 44 )

	50	Research progress on the mechanism and assessment methods of increased arterial stiffness
		CAI Zichun LI Jiming
		DOI: 10.20047/j.issn1673-7210.2022.30.10
		Arterial stiffness is recognized as an independent factor for assessing cardiovascular events. A growing number of clinical studies have shown that the assessment of arterial stiffness can predict the risk of cardiovascular disease, neurodegenerative disease, and chronic kidney disease. However, changes in arterial stiffness are often mistakenly equated with the development of arteriosclerosis or atherosclerosis, and little is known about its pathogenesis, and its rationale and limitations are unknown when applying assessment methods. Therefore, this article aims to review the concept of increased arterial stiffness, describe the research progress of researchers on the mechanism of arterial stiffness in recent years, and evaluate the principles, limitations, and clinical applications of arterial stiffness methods.
		2022 Vol. 19 (30): 50-53,57 [Abstract] ( 11 ) HTML (1 KB) PDF (606 KB) ( 104 )

	54	Research progress of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease
		WANG Wei LONG Qi YUE Guolong WU Haiqiao
		DOI: 10.20047/j.issn1673-7210.2022.30.11
		Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high mortality and a heavy economic burden. Modern medical treatment of COPD has disadvantages such as high cost and large side effects. Traditional Chinese medicine has obvious advantages in the treatment of this disease. This article expounds the understanding of the pathogenesis of COPD by traditional Chinese medicine, and reviews the traditional Chinese medicine treatment in recent years from the aspects of lung, spleen, and kidney qi deficiency, yang deficiency, phlegm turbidity, blood stasis, etc., in order to provide more reference for clinical treatment.
		2022 Vol. 19 (30): 54-57 [Abstract] ( 9 ) HTML (1 KB) PDF (585 KB) ( 61 )

	58	Research progress on regulation of psoriasis related immune cells by traditional Chinese medicine
		ZHAO Jiusi1 YANG Suqing2 ZHANG Qing2
		DOI: 10.20047/j.issn1673-7210.2022.30.12
		Psoriasis, as a common chronic inflammatory disease in dermatology, has the characteristics of long duration and easy to recurrence. The traditional western medicine treatment effect is not good and the side effect is great. Traditional Chinese medicine treatment can not only treat the symptoms and root causes, effectively improve skin lesions, but also regulate the imbalance of the body’s internal environment. This review combined with the latest research, the traditional Chinese medicine treatment to improve under the abnormal state of T lymphocyte subsets, horniness cells, dendritic cells, mast cells, macrophages, and inhibition of peripheral blood related inflammatory cytokine secretion were systematically stated, provide theoretical basis for multiple targets for treatment of Chinese medicine psoriasis, in order to more accurately guide to clinical practice.
		2022 Vol. 19 (30): 58-61 [Abstract] ( 10 ) HTML (1 KB) PDF (598 KB) ( 36 )

	62	Research progress on the safety of Er:YAG laser-activated root canal irrigation
		ZHOU Yukun ZHANG Tingting ZHANG Fangqi LIU Xuejun
		DOI: 10.20047/j.issn1673-7210.2022.30.13
		The application of Er:YAG laser is a new method for treatment in stomatology in recent years. The derived photon-induced photoacoustic streaming technology and shock wave enhanced emission photoacoustic streaming technology have achieved ideal clinical results, but their safety still needs to be assessed. This article summarizes the potential safety problems of Er:YAG laser-activated root canal irrigation and its related researches. It is found that it has excellent performance in avoiding mechanical and thermal damage, reducing apical extrusion of irrigant, avoiding damage to periapical tissue, alleviating postoperative pain, and reducing aerosol production. Besides, the principle, parameter settings, and clinical operation of the technology are briefly introduced, in order to provide clinicians with new treatment options and improve laser treatment technology. It also provides a basis for the safety of the application of Er:YAG laser in root canal irrigation.
		2022 Vol. 19 (30): 62-66 [Abstract] ( 13 ) HTML (1 KB) PDF (506 KB) ( 20 )

	66	Analysis of the correlation between professional loyalty and willingness to stay in nursing nurses
		CHEN Weixian1 ZHOU Shu2 SUN Suya3 LIU Xiaohong4 BO Jin5 LIN Mengyue5 CHEN Yamei1▲
		DOI: 10.20047/j.issn1673-7210.2022.30.14
		Objective To explore the relationship between the professional loyalty of standardized training nurses and their willingness to stay on the job, so as to provide a reference for improving the willingness of standardized training nurses to stay on the job. Methods In June 2021, a convenience sample of 250 nurses in a tertiary-grade hospital in Shanghai was selected as the survey subjects. The survey was conducted using the general information questionnaire, the nurses’ occupational loyalty and willingness to stay on the job scale, and correlation analysis was carried out. Results A total of 250 questionnaires were distributed, and 247 valid questionnaires were recovered, with an effective recovery rate of 98.8%. The total score of occupational loyalty of nurses trained in a tertiary hospital in Shanghai was (64.96±13.71) points, and the total score of willingness to stay was (19.22±2.12) points. There were statistically significant differences in the scores of different professional choices, the degree of family support for nursing work, the influence of hospital examinations, and the willingness of nurses to stay on the job in department atmosphere training (P ＜ 0.05). Pearson correlation analysis showed that each dimension and total score of the professional loyalty scale of nursing nurses were positively correlated with each dimension and total score of willingness to stay (r ＞ 0, P ＜ 0.05). There was a positive correlation between the professional loyalty of nurses in regular training and the willingness to stay on the job (r ＞ 0, P ＜ 0.05). Conclusion The scores of occupational loyalty and willingness to stay of nurses in regular training are both at a moderate level. Nursing managers can pay attention to the professional loyalty of nurses in regular training, strengthen career guidance, improve the willingness of nurses in regular training to stay on the job, and strengthen the stability of the nursing team.
		2022 Vol. 19 (30): 66-69,74 [Abstract] ( 18 ) HTML (1 KB) PDF (624 KB) ( 104 )

	70	Investigation and research on clinical characteristics, diagnosis, and treatment status of chronic heart failure patients in tertiary and first-class hospitals in Xinjiang area
		Refukaiti Abuduhalike Kailibinuer Abuduhalike SUN Juan Ailiman Mahemuti
		DOI: 10.20047/j.issn1673-7210.2022.30.15
		Objective To investigate the demographic data, clinical characteristics, and management of inpatients with chronic heart failure (CHF) in a tertiary hospital in Xinjiang. Methods This study was a cross-sectional study. From January 2018 to September 2020, 1 500 patients with CHF who were continuously hospitalized in the provincial tertiary hospitals in Xinjiang (the First Affiliated Hospital of Xinjiang Medical University, the People’s Hospital of Xinjiang Uygur Autonomous Region, and the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region) and three municipal tertiary hospitals (the Second People’s Hospital of Kashgar, Yili Prefecture People’s Hospital, Changji Prefecture Traditional Chinese Medicine Hospital) were selected. The general information, risk factors, etiology of CHF, examination results, drug use, and other clinical data of the selected patients were collected. Results A total of 1 451 CHF patients were finally included, including 967 males; the age was (64.14±13.13) years; the median hospital stay was nine days. Patients with CHF with reduced ejection fraction (HFrEF) and class Ⅲ cardiac function accounted for the highest proportions. The rates of ACEI/ ARB/ARNI, β-blocker, and aldosterone receptor antagonist use in HFrEF patients were 87.2%, 89.5%, and 88.0%, respectively. The proportion of CHF patients hospitalized in provincial tertiary hospitals was higher than that of municipal tertiary hospitals, while the length of stay was shorter than that of century tertiary hospitals, and the differences were statistically significant (P ＜ 0.05). The rate of NT-Pro BNP/BNP examination in CHF patients in provincial tertiary hospitals, patients with HFrEF and cardiac function grade Ⅳ, patients undergoing pacing intervention, coronary intervention or bypass, and the proportion of hyperuricemia, anemia, and renal insufficiency in provincial tertiary hospitals were higher in the municipal tertiary hospital (P ＜ 0.05). The proportion of HFrEF patients in provincial tertiary hospitals were higher than that of municipal tertiary hospitals; the proportion of patients using aldosterone receptor antagonists was lower than that of municipal tertiary hospitals (P ＜ 0.05). Conclusion Coronary heart disease is the main cause of inpatient CHF in the top three hospitals in Xinjiang. CHF patients hospitalized in provincial tertiary hospitals were older and had worse cardiac function. There was no significant difference in the proportion of standardized drug use recommended by the guidelines for HFrEF patients hospitalized in provincial and municipal tertiary hospitals.
		2022 Vol. 19 (30): 70-74 [Abstract] ( 12 ) HTML (1 KB) PDF (608 KB) ( 22 )

	75	Analysis of differences of plasma glucose, insulin, and C-peptide levels in patients with type 2 diabetes mellitus after glucose load in Wuhan
		PENG Li TANG Ting LI Ling YANG Liu
		DOI: 10.20047/j.issn1673-7210.2022.30.16
		Objective To investigate the differences in serum levels of plasma glucose (PG), insulin (INS), and C-peptide (CP) in patients with type 2 diabetes mellitus (T2DM) after glucose load in Wuhan. Methods A total of 191 patients with T2DM admitted to Hubei Provincial Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from November 2020 to October 2021 were selected as the study group, and 74 non-diabetic patients admitted to our hospital during the same period were selected as the control group. After fasting for 8-10 h, 75 g glucose was orally administered within five minutes in both groups. The levels of PG, INS, and CP at fasting and 0.5, 1, 2, and 3 h after glucose load were collected and compared. According to the different progression of T2DM, patients in the study group were divided into T2DM uncomplicated group (144 cases) and T2DM with complications group (47 cases). At the same time, 21 patients diagnosed with prediabetes in the control group were selected as the prediabetes group. The differences of each detection index among the three groups were compared. In addition, according to the different complications of T2DM, the patients in T2DM with complications group were divided into peripheral neuropathy group (11 cases), retinopathy group (9 cases), ketoacidosis group (8 cases), macrovascular disease group (9 cases), and diabetic nephropathy group (10 cases). The differences of each detection index among the five groups were compared. Results Fasting PG, 0.5hPG, 1hPG, 2hPG, 3hPG in the study group were higher than those in the control group, and 0.5hINS, 1hINS, 2hINS, 0.5hCP, 1hCP, 2hCP were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Fasting PG, 0.5hPG, 1hPG, 2hPG, and 3hPG in T2DM uncomplicated group and T2DM with complications group were higher than those in prediabetes group; 0.5hINS, 1hINS, 0.5hCP, 1hCP, and 2hCP were lower than those in prediabetes group; 2hINS in T2DM with complications group were lower than those in prediabetes group, the differences were statistically significant (P ＜ 0.05). The 1hPG of retinopathy group was lower than that of ketoacidosis group, and the 1hCP and 2hCP of retinopathy group were lower than those of macrovascular disease group; the 2hPG of macrovascular disease group was lower than that of ketoacidosis group; fasting PG, 0.5hPG, 2hPG, and 3hPG in peripheral neuropathy group were higher than those in macrovascular disease group, and the differences were statistically significant (P ＜ 0.05). Conclusion The secretion of CP in T2DM patients after glucose load is different among different complications. In the early stage of diabetes, the secretion of INS and CP are delayed and the compensatory secretion is increased.
		2022 Vol. 19 (30): 75-78,87 [Abstract] ( 11 ) HTML (1 KB) PDF (586 KB) ( 20 )

	79	Efficacy and safety of Risenatide in the treatment of mild cognitive impairment in elderly patients with type 2 diabetes mellitus
		ZHU Ping WU Xinhua MA Liming YAN Yan SHI Wen YU Tao HUANG Yujie ZHOU Jie▲
		DOI: 10.20047/j.issn1673-7210.2022.30.17
		Objective To explore the efficacy and safety of Risenatide in the treatment of mild cognitive impairment in elderly patients with type 2 diabetes mellitus. Methods A total of 82 elderly patients with type 2 diabetes mellitus and mild cognitive impairment admitted to Huaian Cancer Hospital, Jiangsu Province from April 2019 to April 2021 were selected and divided into experimental group and control group according to the treatment plan. The control group (41 cases) was treated with insulin injection, and the experimental group (41 cases) was treated with Risenatide on the basis of the control group. The blood glucose, cognitive function, and neurological function index were compared between the two groups after 12 weeks of treatment, and the incidence of adverse reactions was recorded. Results The levels of glycosylated hemoglobin, fasting blood glucose before breakfast, and 2 h postprandial blood glucose in the two groups after treatment were lower than those before treatment, and those in the experimental group were lower than those in the control group (P ＜ 0.05). After treatment, the scores of Montreal cognitive assessment scale in the two groups were higher than those before treatment, the scores of National Institutes of Health stroke scale in the two groups were lower than those before treatment, and the scores of Montreal cognitive assessment scale in the experimental group were higher than those in the control group, and the scores of National Institutes of Health stroke scale were lower than those in the control group (P ＜ 0.05). After treatment, the levels of serum central nervous specific protein (S100β) and plasma β-amyloid protein-42 in the two groups were lower than those before treatment, and the experimental group was lower than the control group (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The application of Risenatide in the treatment of mild cognitive impairment in elderly patients with type 2 diabetes mellitus can contribute to lower blood glucose level and improve cognitive function with good safety.
		2022 Vol. 19 (30): 79-82 [Abstract] ( 13 ) HTML (1 KB) PDF (570 KB) ( 18 )

	83	Clinical analysis of spontaneous intraspinal hemorrhage in adults
		ZHANG Youqiang1 YAN Ling1 LIAO Wei1 WANG Guang1 CHEN Xiaoheng1 DENG Jiang1 SHEN Yuguang2
		DOI: 10.20047/j.issn1673-7210.2022.30.18
		Objective To investigate the clinical features, treatment options, and prognosis of spontaneous intraspinal hemorrhage in adults. Methods The clinical symptoms, signs, imaging data, causes of hemorrhage, treatment methods, and follow-up of 35 patients with spontaneous intraspinal hemorrhage who were admitted from January 2012 to May 2021 in the Department of Spinal Surgery, the First Affiliated Hospital of Zunyi Medical University and the Third Affiliated Hospital of Zunyi Medical University were retrospectively analyzed. Results There were 30 cases of dural hemorrhage and 5 cases of intramedullary hemorrhage. Hematoma was located in cervical vertebrae in 10 cases, thoracic vertebrae in 14 cases, lumbar vertebrae in 3 cases, cervical thoracic vertebrae in 3 cases, and thoracolumbar vertebrae in 5 cases. Surgical treatment was performed in 23 cases, conservative treatment in 9 cases, and refusal of surgery in 3 cases. All cases were followed up, and the improvement rate of neurological function was 87.5% at the last follow-up. The postoperative improvement rate of 8 patients with American Spinal Injury Association (ASIA) grade A was 50%. Conclusion ASIA grade A to C is recommended for emergency decompression, and conservative treatment is recommended for mild or progressive improvement of nerve injury. The more severe the neurological dysfunction, the worse the prognosis.
		2022 Vol. 19 (30): 83-87 [Abstract] ( 13 ) HTML (1 KB) PDF (775 KB) ( 17 )

	88	Curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis
		ZENG Li1 WANG Yongcai1 XING Gengyan2 YAN Bing1
		DOI: 10.20047/j.issn1673-7210.2022.30.19
		Objective To study the curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle knee osteoarthritis. Methods A total of 40 postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis patients in the Department of Joint Surgery, Leshan People’s Hospital of Sichuan Province were selected from December 2019 to December 2020. They were divided into experimental group and control group by random number table method, with 20 cases in each group. The control group was treated with Zoledronate and Caltrate, and the experimental group was treated with Diacerein on the basis of control group. The scores of Western Ontario and McMaster University osteoarthritis index (WOMAC), Lequesne, and visual analogue scale (VAS) were compared between two groups before treatment and 1, 6, and 12 months after treatment. Results There were significant differences in WOMAC score, Lequesne score, and VAS score between two groups at different time points (P < 0.05). At 1, 6, and 12 months of treatment, the scores of WOMAC and VAS of two groups were significantly different (P < 0.05); there was no significant difference in Lequesne score between two groups (P > 0.05). Conclusion Zoledronate combined with Diacerein can significantly relieve knee joint pain and improve knee joint function in the treatment of postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis.
		2022 Vol. 19 (30): 88-91 [Abstract] ( 13 ) HTML (1 KB) PDF (488 KB) ( 24 )

	92	Clinical effect of Wu Men Medical school plastic splint and plate internal fixation in the treatment of Robinson type ⅡB middle clavicle fractures
		ZHU Xingtao1 SUN Yitao1 JIANG Hong2 LIU Jintao2
		DOI: 10.20047/j.issn1673-7210.2022.30.20
		Objective To compare the clinical effect of Wu Men Medical school’s plastic splint and plate internal fixation in the treatment of Robinson ⅡB middle clavicle fractures. Methods A retrospective analysis was performed on 67 patients with Robinson ⅡB middle clavicle fractures admitted to Suzhou Traditional Chinese Medicine Hospital from October 2019 to November 2020. The patients were divided into Robinson ⅡB1 and Robinson ⅡB2, and the number of patients with the two types of fractures was comprehensively compared. A total of 35 cases of Robinson ⅡB1 and 32 cases of Robinson ⅡB2 were selected according to the proportion, and the patients were divided into plastic splint group and plate internal fixation group by drawing lots. The plastic splint group of 32 cases was treated with manual reduction and plastic splint; the plate internal fixation group of 35 cases was treated with open reduction and internal fixation. The Constant-Murley shoulder joint score, appearance satisfaction, and complication rate were compared between the two groups after 1, 3, and 9 months of treatment, and the efficacy was evaluated. Results All patients were followed up for 9 to 12 months, with an average of (10.82±2.06) months. There was no significant difference in the treatment effect between the two groups (P ＞ 0.05). There were statistically significant differences of the Constant-Murley shoulder joint score between the two groups, time point comparison and interaction comparison (P ＜ 0.05). Further pair-wise comparison: within-group comparison, the Constant-Murley shoulder joint scores of the two groups after 1, 3, and 9 months of treatment were higher than those before treatment, and the differences were statistically significant (P ＜ 0.05). Compared between groups, the Constant-Murley shoulder joint scores in the plate internal fixation group were higher than those in the plastic splint group after 1 and 3 months of treatment, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the Constant-Murley shoulder joint score between the two groups after 9 months of treatment (P ＞ 0.05). The appearance satisfaction of the plastic splint group was better than that of the steel plate internal fixation group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion Wu Men Medical school plastic splint has certain advantages over plate internal fixation in the treatment of Robinson ⅡB middle clavicle fractures compared with plate internal fixation, and can be used as a clinical treatment option. The use of internal fixation therapy should be based on the patient’s own conditions and wishes to comprehensively formulate standards.
		2022 Vol. 19 (30): 92-95,111 [Abstract] ( 9 ) HTML (1 KB) PDF (864 KB) ( 31 )

	96	Effect of motivational behavior transformation to construct postoperative rehabilitation strategy for patients with tibiofibular fracture
		WANG Yan WANG Zhumin▲
		DOI: 10.20047/j.issn1673-7210.2022.30.21
		Objective To explore the application effect of motivation behavior transformation on construct postoperative rehabilitation strategy for patients with tibiofibular fracture. Methods From April 2020 to February 2021, 110 patients with tibiofibular fractures who underwent surgical treatment in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine were selected. They were divided into control group (55 cases) and observation group (55 cases) by random number table method. The control group was given routine rehabilitation intervention and observation group received rehabilitation strategy intervention constructed by motivation behavior transformation. Both groups were intervened for three months. The knee function, psychological status of two groups before intervention and three months after intervention were compared, and the exercise compliance of two groups was observed. Results After three months of intervention, the dimensions and total scores of Oxford knee scale in both groups were decreased than those before intervention, and those in observation group were lower than those in control group (P < 0.05); the scores of self-rating depression scale and self-rating anxiety scale in both groups were decreased than those before intervention, and those in observation group were lower than those in control group (P < 0.05). The exercise compliance score of observation group was higher than that of control group (P < 0.05). Conclusion The rehabilitation strategy of motivation behavior transformation can increase the postoperative knee function, improve the psychological state, and enhance the exercise compliance of patients with tibiofibular fracture.
		2022 Vol. 19 (30): 96-99 [Abstract] ( 16 ) HTML (1 KB) PDF (565 KB) ( 16 )

	100	Correlation between sleep and emotional disorders and ocular surface status in patients with conjunctival laxa
		LIU Jiang1 WEN Hang2 SHA Yongyi1 ZHANG Wei1 XIANG Minhong1
		DOI: 10.20047/j.issn1673-7210.2022.30.22
		Objective To observe the sleep and emotional state of patients with conjunctival laxa and analyze its correlation with and ocular surface symptoms. Methods A total of 46 patients with conjunctival laxa admitted to the Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from October 2020 to May 2021 were collected as the conjunctival laxa group, and 27 healthy people who underwent physical examination during the same period in our hospital were selected as the normal control group. Pittsburgh sleep quality index (PSQI) was used to evaluate the sleep status of the two groups. Patient health questionnaire (PHQ-9) and general anxiety disorder scale (GAD-7) were used to evaluate the depression and anxiety status of the two groups. At the same time, the ocular surface disease index (OSDI), tear film rupture time (BUT), Schirmer Ⅰtest (SⅠT), and corneal fluorescein staining (FL) were examined in the two groups to further analyze the correlation between sleep and emotional disorders and ocular surface status in patients with conjunctival laxa. Results The PSQI and the scores of PHQ-9, GAD-7, corneal FL in the conjunctival laxa group were higher than those in the normal control group, and SⅠT and BUT were lower than those in the normal control group, and the differences were statistically significant (P ＜ 0.05). The results of correlation analysis showed that PSQI and the scores of PHQ-9 and GAD-7 were positively correlated with OSDI (rs ＞ 0, P ＜ 0.05), and negatively correlated with BUT and SⅠT (rs ＜ 0, P ＜ 0.05). Conclusion Patients with conjunctival laxa have poor sleep quality, depression, and ocular surface lacrimal abnormalities. Therefore, comprehensive management of sleep and emotion should be paid attention to while local treatment, and specialized treatment should be sought for patients with severe depression and anxiety.
		2022 Vol. 19 (30): 100-103 [Abstract] ( 13 ) HTML (1 KB) PDF (528 KB) ( 17 )

	104	Effect of Xiangju Capsules combined with Rhinocort on the recovery of mucosal function and olfactory function after operation of chronic sinusitis#br#
		SHENG Yingying1 SHAN Chunyan2 ZHENG Yi1 XIA Binghua1
		DOI: 10.20047/j.issn1673-7210.2022.30.23
		Objective To investigate the effect of Xiangju Capsules combined with Rhinocort on the recovery of mucosal function and olfactory function after operation of chronic sinusitis. Methods From September 2018 to September 2021, 82 patients with chronic sinusitis treated with sinus endoscopy and surgical dynamic system in Suzhou Ninth People’s Hospital, Jiangsu Province were selected and divided into control group (41 cases) and observation group (41 cases) by random number table method. The control group was treated with Rhinocort, and the observation group was treated with Xiangju Capsules on the basis of the control group. Four weeks were a course of treatment, and both groups were treated with two courses of treatment. The efficacy of the two groups was compared, and the traditional Chinese medicine symptom score, mucosal function, and olfactory function before and after treatment were compared between the two groups. The incidence of adverse reactions in the two groups was recorded. Results The total effective rate of observation group was higher than that of control group (P ＜ 0.05). After treatment, the scores of main symptoms, secondary symptoms, and total scores of traditional Chinese medicine symptom in the two groups were lower than those before treatment, and the observation group was lower than that of the control group (P ＜ 0.05). After treatment, the mucosal function scores of the two groups were lower than those before treatment, and the observation group was lower than that of the control group (P ＜ 0.05). The olfactory function scores of the two groups at 1, 3, and 5 weeks after treatment were lower than those before treatment, and the olfactory function scores of the observation group at 1, 3, and 5 weeks after treatment were lower than those of the control group (P ＜ 0.05). Conclusion Xiangju Capsules combined with Rhinocort can improve the mucosal function and olfactory function of patients with chronic sinusitis. It has significant curative effect and good safety.
		2022 Vol. 19 (30): 104-107 [Abstract] ( 12 ) HTML (1 KB) PDF (540 KB) ( 14 )

	108	Dissolution determination of Iron Polysaccharide Complex Capsules
		WANG Yaoxia1 KONG Fanqiang2 CHENG Hongxia2 FAN Qianye2 ZHU Bin2 DING Haiyan1▲
		DOI: 10.20047/j.issn1673-7210.2022.30.24
		Objective To establish a method for determination of Iron Polysaccharide Complex Capsules and to evaluate the practical application of the method. Methods Under heating conditions, the Iron Polysaccharide Complex solution was digested by hydrochloric acid. The free Fe3+ in the solution was reduced to Fe2+ by hydroxylamine hydrochloride, and Fe2+ reacts with 1,10-phenanthroline to form a chemically stable red complex. Based on this principle, the iron content was indirectly determined by UV-Vis spectrophotometry, and the dissolution of Iron Polysaccharide Complex Capsules was evaluated. Results The specificity, reproducibility, and stability of the method in this research were good. At the same time, the Fe2+ concentration has a good linear relationship in the range of 0.1-2.0 μg/ml (r2 = 0.999 9), and the average recovery rate was 99.3% (RSD = 1.03%). The results of actual sample measurement showed that the results of this study are basically consistent with those of the methods in the literature. Conclusion The method is simple, convenient, and suitable for determining the dissolution of Iron Polysaccharide Complex Capsules.
		2022 Vol. 19 (30): 108-111 [Abstract] ( 12 ) HTML (1 KB) PDF (660 KB) ( 38 )

	112	Discussion on Professor Wu Rongzu’s academic thought in the treatment of liver cancer based on the qi movement circular movement theory
		QIU Xiangyu HU Yamin GUAN Donglong XIONG Guofen HUANG Dan WU Shiguo
		DOI: 10.20047/j.issn1673-7210.2022.30.25
		Professor Wu Rongzu is a descendant of Yunnan School of the Fire God. Based on the in-depth study of Zheng Qinan’s fuyang thought and Peng Ziyi’s circular movement theory, Professor Wu Rongzu believes that the circular movement of human qi movement takes middle-earth as the axis，and the four images of water, fire, metal, and wood as the wheel, which together constitute the circular movement of the wheel axis. The three yin（Shaoyin, Taiyin, and Jueyin）yang qi deficiency and failure is the key pathogenesis of dysfunction of circular movement in transportation. Liver cancer is the result of the three yin yang qi unable to rise, abnormal circular movement of human qi movement, immobility of cold and dampness, phlegm coagulated by fluid，disharmony of qi and blood，blood stasis, phlegm and stasis coagulating with lump forming. In the treatment, Wuyu Sini Decoction and Linggui Zhugan Decoction are used to warm the cold of kidney water, dry the wet of spleen soil, warm the depression of liver wood. Kidney yang of Shaoyin is warmly lifted to warm the spleen yang, the axis works to change the phlegm and dampness of liver cancer; liver yang of Jueyin is warmly raised to run the outer wheel to regulate qi and blood, except the blood stasis caused by liver cancer.
		2022 Vol. 19 (30): 112-115,136 [Abstract] ( 14 ) HTML (1 KB) PDF (1094 KB) ( 90 )

	116	Clinical application of classical prescriptions in the treatment of heart failure
		GUO Yuna1 CHEN Liming2 LIU Kun1
		DOI: 10.20047/j.issn1673-7210.2022.30.26
		Heart failure is the terminal stage of the progression of various heart diseases, and its pathological mechanisms mainly include oxidative stress, inflammatory response, mitochondrial dysfunction, and abnormal calcium cycle. At present, western medicines for the treatment of heart failure mainly include angiotensin receptor enkephalinase inhibitor, angiotensin-converting enzyme inhibitor, angiotensin Ⅱ receptor blocker, β-receptor blocker blockers, aldosterone receptor antagonists, and sodium-glucose cotransporter 2 inhibitors. However, long-term use can lead to adverse reactions such as hypotension, electrolyte imbalance, and even increase the readmission rate. Reducing the fatality rate and readmission rate of heart failure and improving the quality of life of patients are clinical difficulties to be solved urgently. Traditional Chinese medicine has a long history of treating heart failure. Through long-term clinical observation, it has been found that traditional Chinese medicine has obvious advantages in improving the clinical symptoms of heart failure patients and reducing the recurrence rate. Based on the analysis of prescriptions related to heart failure in treatise on cold pathogenic diseases and synopsis of the golden chamber, this paper expounds the effects of Lingguizhugan Decoction, Zhenwu Decoction, Fuling Gancao Decoction, Xiaoqinglong Decoction, Guizhi Qushaoyao Decoction and Shenqi Pills in the development of heart failure. Different stages of application, explore the application of traditional Chinese medicine in the treatment of heart failure, in order to better guide the clinical.
		2022 Vol. 19 (30): 116-119 [Abstract] ( 13 ) HTML (1 KB) PDF (621 KB) ( 32 )

	120	Clinical study of Qigui Huoxue Decoction combined with acupuncture in the treatment of blood stasis due to qi deficiency type diabetic peripheral neuropathy
		YUAN Yi ZHAO Jing XU Zihan LU Junfeng
		DOI: 10.20047/j.issn1673-7210.2022.30.27
		Objective To investigate the effect of Qigui Huoxue Decoction combined with acupuncture in the treatment of blood stasis due to qi deficiency type diabetic peripheral neuropathy (DPN). Methods A total of 99 patients with DPN admitted to Lu’an Hospital of Traditional Chinese Medicine from January 2019 to October 2021 were selected and they were divided into three groups according to the random number table method, with 33 cases in each group. Control group 1 was treated with acupuncture, control group 2 was treated with Qigui Huoxue Decoction, and observation group was treated with Qigui Huoxue Decoction combined with acupuncture for four weeks. The clinical efficacy, traditional Chinese medicine syndrome score, Toronto clinical scoring system (TCSS), common peroneal nerve conduction velocity and visual analogue scale (VAS) were compared among the three groups, and the incidence of adverse reactions was recorded. Results The clinical efficacy of observation group was better than that of control group 1 and control group 2 (P ＜ 0.05). After treatment, the traditional Chinese medicine syndrome scores, TCSS scores, and VAS scores of the three groups were lower than those before treatment, and the sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of the common peroneal nerve were higher than those before treatment (P ＜ 0.05). After treatment, the traditional Chinese medicine syndrome score, TCSS score, and VAS score of the observation group were lower than those of the control group 1 and 2, SNCV and MNCV were higher than those in control group 1 and 2 (P ＜ 0.05). There were no obvious adverse reactions in the three groups during treatment. Conclusion Qigui Huoxue Decoction combined with acupuncture is effective in the treatment of blood stasis due to qi deficiency type DPN, which can improve nerve conduction velocity and relieve pain.
		2022 Vol. 19 (30): 120-123,149 [Abstract] ( 14 ) HTML (1 KB) PDF (690 KB) ( 11 )

	124	Professor Li Fazhi’s treatment experience of acquired immunodeficiency syndrome based on the spleen and stomach is the foundation of the five viscera
		YANG Ruihan1 MA Xiuxia2 MENG Pengfei2 LI Liangping2 DING Xue2 SONG Xiyuan2 CUI Weifeng3 XU Liran2
		DOI: 10.20047/j.issn1673-7210.2022.30.28
		Acquired immunodeficiency syndrome has always been one of the major infectious diseases threatening the safety of human life, and its prevention and treatment is the key and difficult problem to be solved clinically. Through many years of clinical practice, Professor Li Fazhi believes that the disease manifestation of acquired immunodeficiency syndrome is similar to the “consumption disease” of traditional Chinese medicine. Professor Li Fazhi pays attention to the theoretical idea that the spleen and stomach is the foundation of the five viscera, and emphasizes the nursing effect of the spleen and stomach on the five viscera. He points out that acquired immunodeficiency syndrome attacks people. First of all, acquired immunodeficiency syndrome damages the spleen and stomach. Gradually, acquired immunodeficiency syndrome leads to the loss of the heart, lung, kidney, and liver. Finally, acquired immunodeficiency syndrome causes the weakness of qi and blood, yin and yang of the five viscera. And it also causes the accumulation of pathological products such as blood stasis and phlegm, thus leading to a variety of concomitant diseases. The key to the pathogenesis is that the human immunodeficiency virus damages the primordial qi, spleen and stomach deficiency accompanied by internal dampness, loss of nourishment of the five viscera, weakness of qi and blood, and yin and yang loss. The change of the pathogenesis throughout the whole process of acquired immunodeficiency syndrome. Professor Li Fazhi emphasizes the importance of strengthening the spleen and stomach and caring for the middle soil in the treatment to correct the deficiency of the five viscera and various complications caused by human immunodeficiency virus. At the same time, he attaches great importance to distinguishing between deficiency and excess to achieve the effect of dispelling the evils of acquired immunodeficiency syndrome and nourishing primordial qi. The case is attached here to support the theory.
		2022 Vol. 19 (30): 124-127 [Abstract] ( 15 ) HTML (1 KB) PDF (613 KB) ( 16 )

	128	Questions and explanations in the protection of living traditional knowledge of traditional Chinese medicine
		LI Yu1 LIU Qian1 GUO Hua2 AN Hong1 ZHAO Zhupei1 SHI Xueqin1 ZHANG Fengxia1 LIU Jianfeng1
		DOI: 10.20047/j.issn1673-7210.2022.30.29
		In the collection and sorting of living traditional knowledge of traditional Chinese medicine, the personnel of project responsible units, grass-roots medical and health units, participating investigators and holders of traditional Chinese medicine knowledge in provinces, cities, districts and counties raised many questions in the process of project participation, and put forward many constructive opinions and suggestions on the protection of traditional Chinese medicine knowledge. Problems related to the knowledge holders in the process of carrying out the work of traditional Chinese medicine in 15 regions are sorted out, and explained from four aspects: the concept of live traditional Chinese medicine knowledge, the effectiveness of traditional Chinese medicine knowledge protection, the use of living traditional knowledge of traditional Chinese medicine database and the problems existing in the holders themselves. It is expected to provide reference and help for the follow-up collection and sorting of traditional Chinese medicine knowledge.
		2022 Vol. 19 (30): 128-131 [Abstract] ( 11 ) HTML (1 KB) PDF (544 KB) ( 31 )

	132	Treatment of chronic heart failure by Professor Zhou Yabin on the “Four-Dimensional theory”
		SUN Jing1 CAI Rui2 MAO Qichao2
		DOI: 10.20047/j.issn1673-7210.2022.30.30
		With the gradual aging of the population, the incidence rate of chronic heart failure is increasing, and the mortality of heart failure is also on the rise. Chronic heart failure is a common clinical syndrome in cardiology, which is mainly caused by insufficient cardiac output due to ventricular filling and / or impaired ejection function. This article summarizes Professor Zhou Yabin’s clinical experience in the treatment of chronic heart failure, and believes that the pathogenesis of this disease is complex and the treatment methods are changeable. Paying attention to the changing characteristics of a single disease pathogen, it is also necessary to grasp the overall disease situation, and integrate and understand it according to the overall syndrome differentiation concept of traditional Chinese medicine, so as to control the changes of the disease more profoundly.
		2022 Vol. 19 (30): 132-136 [Abstract] ( 14 ) HTML (1 KB) PDF (820 KB) ( 48 )

	137	Professor Wan Donggui’s experience in treatment of breast cancer related lymph-edema from the theory of “Quyu Chencuo ”
		ZHANG Chenyang1 CHEN Hongyang1 CHEN Dongmei2 SU Fei2 WAN Donggui2
		DOI: 10.20047/j.issn1673-7210.2022.30.31
		Professor Wan Donggui analyzes breast cancer related lymph-edema and proposes that the disease is located in the collaterals, which is the disease of deficiency in origin and excess in superficiality, which is caused by original deficiency. The key pathological factors of breast cancer related lymph-edema are fluid retention and blood stasis. The key pathological basis of breast cancer related lymph-edema is the deficiency of viscera. The key pathogenesis of breast cancer related lymph-edema is the accumulation of fluid retention and blood stasis and the obstruction of collaterals. In prodromal phase of the disease, the key pathogenesis is the deficiency of qi and blood and the newly produced fluid retention and blood stasis. In the symptomatic period, the key pathogenesis is the weakness of viscera and the gradual filling of fluid retention and blood stasis, and at the vesting period of the disease, the key pathogenesis is the adhesion of fluid retention and blood stasis. The principle of treatment should be “Quyu Chencuo”. The method is to remove fluid retention and blood stasis while filling the deficiency of viscera to eliminate the cause of blood stasis and water stasis. In the prodromal phase, invigorating the spleen and kidney, nourishing qi and blood is critical. In the symptomatic period, it is quite important to combine dredging method with tonifying method and to resolve fluid retention and invigorate the circulation of blood. In the vesting period, the key treatment are dissolving blood stasis, and expelling excessive fluid. This paper is intended to elaborate the academic thought and treatment experience of the “theory of Quyu Chencuo” on breast cancer related lymph-edema in order to broaden our mind on the treatment of this disease.
		2022 Vol. 19 (30): 137-140 [Abstract] ( 14 ) HTML (1 KB) PDF (704 KB) ( 22 )

	141	Experience of Zibo Wang’s gynecology in the treatment of infertility caused by luteinized unruptured follicle syndrome
		LI Ke1 ZHANG Dengshan2 LIU Hui3
		DOI: 10.20047/j.issn1673-7210.2022.30.32
		The main clinical manifestation of luteinized unruptured follicle syndrome is ovulation disorder, which is an important cause of infertility. As one of the famous schools of traditional Chinese medicine gynecology in Shandong, Zibo Wang’s gynecology believes that the fundamental pathogenesis of the disease is kidney deficiency and blood stasis, combined with liver depression and spleen deficiency, in terms of treatment, it puts forward the treatment method by stages, and draws up its own empirical formula, moreover, it pays attention to the combination of Chinese and western medicine, integration of disease and syndrome, and treating both inside and outside, with remarkable curative effect. This paper summaries and analyzes the clinical experience of Zibo Wang’s gynecological treatment of infertility with luteinized unruptured follicle syndrome, and analyzes the typical clinical medical record for reference.
		2022 Vol. 19 (30): 141-144 [Abstract] ( 13 ) HTML (1 KB) PDF (660 KB) ( 35 )

	145	Treatment of tourette syndrome based on Lu Zhizheng’s “hold the center and move around” method
		WANG Bo1 ZHANG Huadong2
		DOI: 10.20047/j.issn1673-7210.2022.30.33
		The etiology of tourette syndrome is complex and the pathogenesis is diverse, although the main symptoms can be quickly alleviated by treating only one viscera, it is often easy to relapse and the curative effect is poor. Based on the spleen and stomach, it can take into account the five zang viscera, six fu viscera and all limbs, which is more in line with the etiology and pathogenesis of tourette syndrome, meanwhile, based on the characteristics of the spleen and stomach, the medicine is light and does not hurt the viscera. It is also more in line with the characteristics of children’s long-term physical function weakening and children’s tender yin and yang elements. It can achieve better curative effect in the clinical treatment of tourette syndrome. This method is not only suitable for the etiology and pathogenesis of tic, but also suitable for the physical characteristics of children.
		2022 Vol. 19 (30): 145-149 [Abstract] ( 18 ) HTML (1 KB) PDF (753 KB) ( 26 )

	150	Effect of psychological cognitive behavior nursing patterns on psychological status of patients with prostatic hyperplasia undergoing surgery
		ZHOU Ling
		DOI: 10.20047/j.issn1673-7210.2022.30.34
		Objective To discuss the effect of psychological cognitive behavior nursing patterns on psychological status of patients with prostatic hyperplasia undergoing surgery. Methods From January 2020 to August 2021, 90 prostatic hyperplasia patients treated in Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing University of Chinese Medicine were selected as research subjects. According to the random number table method, they were divided into control group (45 cases) and study group (45 cases). The control group was served with routine nursing interventions, the study group was served with psychological cognitive behavioral nursing on the basis of control group. Intervention was continued in both groups until discharge. Behavior compliance and psychological status before and after intervention were compared between two groups. Results The behavior compliance of study group was better than that of control group, and the difference was statistically significant (P < 0.05). After intervention, the self-rating anxiety scale and self-rating depression scale scores of two groups were lower than those before intervention, and study group was lower than control group, and the differences were statistically significant (P < 0.05). Conclusion The psychological cognitive behavior nursing patterns can eliminate the patients’ bad mood and play an important role in postoperative recovery.
		2022 Vol. 19 (30): 150-153 [Abstract] ( 15 ) HTML (1 KB) PDF (575 KB) ( 40 )

	154	Effects of Gubenqiangji exercises on pain, cervical function, and sleep quality in patients with cervical spondylosis
		XU Jia1 XU Xiaoxia2▲
		DOI: 10.20047/j.issn1673-7210.2022.30.35
		Objective To explore the effect of Gubenqiangji exercises on pain, cervical function, and sleep quality in patients with cervical spondylosis. Methods A total of 108 patients with cervical spondylosis who were admitted to Changzhou Hospital of Traditional Chinese Medicine from July 2018 to June 2020 were selected and divided into the experimental group and the control group by random number table method, with 54 cases in each. The control group was given cervical traction, while the experimental group was given the exercise of Gubenqiangji exercises. After three months of intervention, the clinical efficacy, pain degree, cervical spine function, and sleep quality were compared between the two groups. Results After three months of intervention, 53 cases in the experimental group and 51 cases in the control group were completed. The effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After three months of intervention, the visual analog score, and cervical spine dysfunction index score in the two groups were lower than those before the intervention, while those in the experimental group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After three months of intervention, the scores of Pittsburgh sleep quality index (PSQI) in both groups were lower than those before intervention, while the total score of sleep quality, sleep onset time, sleep time, sleep efficiency, sleep disorder, hypnotic drugs, and PSQI in the experimental group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Gubenqiangji exercises can help relieve the pain of patients with cervical spondylosis, promote the recovery of cervical vertebra function, and improve the sleep quality of patients.
		2022 Vol. 19 (30): 154-157,162 [Abstract] ( 13 ) HTML (1 KB) PDF (693 KB) ( 59 )

	158	Effect of continuing care program on subjective happiness and self-management ability of elderly patients with chronic obstructive pulmonary disease
		ZHU Lin1 TANG Tianjuan2 XU Juan3 BIAN Xiaonian4
		DOI: 10.20047/j.issn1673-7210.2022.30.36
		Objective To explore the application of continuing care program on subjective happiness and self-management in elderly patients with chronic obstructive pulmonary disease (hereinafter referred to as “chronic obstructive lung”). Methods A total of 94 elderly patients with COPD who were selected in the 904th Hospital of the People’s Liberation Army Joint Logistic Support Force from August 2020 to October 2021 were selected as the research objects, according to the random sampling method, they were divided into control group and observation group, with 47 cases in each group. The control group was given routine nursing, and the observation group was given continuous care on the basis of the control group. The subjective happiness, self-management score, and pulmonary function improvement before and after intervention were compared between the two groups. Results After intervention, the pulmonary function indexes of the two groups were higher than those before intervention, and the observation group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05); the subjective happiness scores of the two groups were higher than those before intervention, and the observation group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05); the self-management scores of the two groups were higher than those before intervention, and the observation group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of continuous care program for elderly COPD patients can improve the subjective sense of happiness of patients, improve self-management ability, improve pulmonary function indicators, and facilitate the rapid prognosis of patients, which is worthy of reference and adoption by various departments.
		2022 Vol. 19 (30): 158-162 [Abstract] ( 14 ) HTML (1 KB) PDF (690 KB) ( 27 )

	163	Influence of supportive psychological intervention on social support and care burden of family members of patients with coronary heart disease undergoing percutaneous coronary intervention
		LI Fengye1 JIAO Ningji2 ZHU Suhua3 GUO Kun4
		DOI: 10.20047/j.issn1673-7210.2022.30.37
		Objective To analyze the application effect of supportive psychological intervention in family members of patients with coronary heart disease undergoing percutaneous coronary intervention (PCI). Methods A total of 110 family members of patients with coronary heart disease who underwent PCI in Lishui District People’s Hospital of Nanjing from January 2019 to December 2020 were selected, and according to the admission time, the patients were divided into control group (from January to December 2019) with 52 cases and observation group (from January to December 2020) with 58 cases. The family members of the control group were given routine education, and the family members of the observation group were given supportive psychological intervention. The negative emotions, social support, and care burden of the family members of the two groups were compared. Results After three months of intervention, the scores of self-rating anxiety scale and self-rating depression scale of family members in the observation group were lower than those before intervention, and the scores of the observation group were lower than those of the control group (P ＜ 0.05). The scores of objective support, subjective support and total scores of social support of family members in the observation group were higher than those before intervention, and the observation group was higher than the control group (P ＜ 0.05); the scores of time-dependent burden, developmental restriction burden, social burden, affective burden and total scores of care burden of family members in the observation group were lower than those before intervention, and those scores of the observation group were lower than those in the control group (P ＜ 0.05). Conclusion Supportive psychological intervention can help relieve the negative emotions of family members of patients with coronary heart disease after PCI, improve the level of social support, and reduce the care burden of patients’ family members.
		2022 Vol. 19 (30): 163-166 [Abstract] ( 11 ) HTML (1 KB) PDF (528 KB) ( 31 )

	167	Influence of whole-process quantitative nursing on rehabilitation effect of patients after orthopaedic surgery
		ZHANG Dan WANG Duo GUI Ping▲
		DOI: 10.20047/j.issn1673-7210.2022.30.38
		Objective To explore the influence of whole-process quantitative nursing on the rehabilitation effect of patients after orthopaedic surgery. Methods From January 2020 to January 2022, a total of 92 fracture patients who received surgical treatment in the Ward Five, Department of Orthopedics of the Second Affiliated Hospital of Air Force Military Medical University were prospectively selected as the research subjects, and they were divided into group A (52 case) and group B (40 cases). Group A was used whole-process quantitative nursing intervention, group B was used routine nursing intervention, and both groups were treated for two months. The recovery situation and the changes of the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and Barthel index before nursing and two months after nursing were compared between the two groups, and the nursing satisfaction of the two groups was compared. Results There was no significant difference in the malunion rate, complete functional recovery rate, and fracture end dislocation rate between the two groups (P ＞ 0.05). The bone union rate of group A was higher than that of group B, and the difference was statistically significant (P ＜ 0.05). After two months of nursing, the SAS and SDS of the two groups were lower than those before nursing, while those of the group A were lower than those of the group B, and the differences were statistically significant (P ＜ 0.05). After two months of nursing, the Barthel index of the two groups was higher than that before nursing, while those of the group A were higher than those of the group B, and the differences were statistically significant (P ＜ 0.05). The nursing quality, nursing attitude, nursing professional type, nursing procedure, and total score of group A were higher than those of group B, and the differences were statistically significant (P ＜ 0.05). Conclusion Taking whole-process quantitative nursing for fracture patients can promote postoperative recovery, improve negative emotions, and significantly improve functional levels and nursing satisfaction.
		2022 Vol. 19 (30): 167-170 [Abstract] ( 14 ) HTML (1 KB) PDF (541 KB) ( 25 )

	171	Analysis of research hotspots of venous infusion port nursing in China based on bibliometrics
		CHEN Li1 HAN Ling2 REN Yuyan1▲
		DOI: 10.20047/j.issn1673-7210.2022.30.39
		Objective To analyze the hotspots of nursing research related to intravenous infusion ports by bibliometrics in China. Methods Using “infusion port” and “nursing” as the search terms, the database was searched in CNKI, Wanfang, VIP, and other databases, and the period was set from the establishment of the database to December 2021. The data was exported in RefWorks format, and the CNKI literature visualization analysis system, Excel, and other software were used to draw the total number of papers published, the statistics of the number of published papers per unit, the distribution map of fund support, the co-occurrence map of keywords, the map of author cooperation network, and the map of literature mutual citation network. Results From 1998 to 2021, there were a total of 1 424 related literatures, of which 71 were funded by various levels of funds. The institution with the largest number of publications was the Fourth Hospital of Hebei Medical University, and the word with the highest frequency of keyword co-occurrence was “internal jugular vein”. The most active author of collaborative papers was Zhou Yingfeng (Fudan University), and the most frequently cited document was the “Code of Practice for Intravenous Treatment Nursing Techniques” led by the former National Health Commission in 2013. Conclusion This study analyzes the current status and hotspots in the field of VAP nursing research in China, and has certain reference significance for related nursing staff.
		2022 Vol. 19 (30): 171-175 [Abstract] ( 11 ) HTML (1 KB) PDF (1910 KB) ( 47 )

	176	Application of lifestyle nursing combined with mindfulness behavior training in patients with gestational diabetes mellitus
		ZHANG Shanshan YANG Haiying SONG Jingjia
		DOI: 10.20047/j.issn1673-7210.2022.30.40
		Objective To explore the application effect of lifestyle nursing combined with mindfulness behavior training in patients with gestational diabetes mellitus (GDM). Methods A total of 120 GDM patients admitted to Deyang People’s Hospital from February 2019 to April 2021 were selected as the research objects, and divided into the control group (60 cases) and the observation group (60 cases) according to the random number table method. The control group was given lifestyle nursing, while the observation group was given lifestyle nursing combined with mindfulness behavior training. Both groups were intervened until delivery. The blood glucose levels and psychological status before intervention and one day before delivery were compared between the two groups, and the occurrence of adverse pregnancy outcomes in the two groups was observed. Results The levels of fasting blood glucose and two hours postprandial blood glucose in the two groups before delivery were lower than those before intervention, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The scores of the anxiety self-rating scale and depression self-rating scale a day before delivery in the two groups were lower than those before the intervention, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of fetal distress and macrosomia in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the incidence of dystocia and neonatal hypoglycemia between the two groups (P ＞ 0.05). Conclusion Lifestyle nursing combined with mindfulness behavior training can help GDM patients control blood sugar levels, improve psychological status, and reduce the risk of adverse pregnancy outcomes to a certain extent.
		2022 Vol. 19 (30): 176-179,196 [Abstract] ( 11 ) HTML (1 KB) PDF (698 KB) ( 41 )

	180	Effect of extended nursing mode of case management on self-care ability and self-efficacy of patients after percutaneous nephrolithotomy
		ZHAI Luxuan YANG Xilan▲
		DOI: 10.20047/j.issn1673-7210.2022.30.41
		Objective To explore the effect of extended nursing mode of case management on self-care ability and self-efficacy of patients after percutaneous nephrolithotomy. Methods From September 2020 to September 2021, 126 patients after percutaneous nephrolithotomy treated in Department of Urology, Nanjing First Hospital were selected. They were divided into observation group and control group by random number table method, with 63 cases in each group. The control group was given the routine nursing mode, and the observation group added the extended nursing mode of case management based on the control group. Both groups were intervened for three months. The self-care ability, self-efficacy, and compliance during treatment were compared between the two groups before and three months of intervention. Results Three months of intervention, the scores of each dimension of self-care ability scale in the two groups were higher than those before intervention, and the observation group was higher than the control group (P ＜ 0.05); the scores of general self-efficacy scale in the two groups were higher than those before intervention, and the observation group was higher than the control group (P ＜ 0.05). The compliance of observation group was better than that of control group (P ＜ 0.05). Conclusion The extended nursing mode of case management can improve the self-care ability and self-efficacy of patients after percutaneous nephrolithotomy, and the compliance of patients is better.
		2022 Vol. 19 (30): 180-183 [Abstract] ( 12 ) HTML (1 KB) PDF (522 KB) ( 19 )

	184	Influence of emotional nursing of traditional Chinese medicine on self-efficacy and mental resilience of patients with chloasma
		GUO Yufeng XIAO Qian LI Li▲
		DOI: 10.20047/j.issn1673-7210.2022.30.42
		Objective To explore the influence of emotional nursing of traditional Chinese medicine on self-efficacy and psychological resilience of patients with chloasma, and provide theoretical reference for clinical practice. Methods A total of 200 cases of chloasma patients admitted to the Department of Dermatology of the First Affiliated Hospital of Chinese People’s Liberation Army Air Force Medical University Air Force Military Medical University from July 2020 to June 2021 were selected, and they were divided into control group and observation group by random number table method, with 100 cases in each group. The control group adopted focused solution mode, and the observation group implemented traditional Chinese medicine emotional nursing on the basis of the control group. The scores of general self-efficacy scale (GSES), connor-davidson resilience scale (CDRISC), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were compared between the two groups. Results One week after intervention, GSES and CDRISC scores of the two groups were higher than those before intervention, and the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). SAS and SDS scores of the two groups were lower than before those intervention, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of traditional Chinese medicine emotional nursing in chloasma patients can enhance patients’ sense of self-efficacy, improve patients’ psychological resilience, relieve patients’ anxiety and depression symptoms, and enhance patients’ nursing satisfaction, which is worthy of widespread clinical promotion and application.
		2022 Vol. 19 (30): 184-187 [Abstract] ( 17 ) HTML (1 KB) PDF (572 KB) ( 39 )

	188	A case of severe pneumonia caused by Chlamydia psittaci and literature analysis
		LIU Ruyue1 YAN Yanyu1 QI Menglei1 LIU Weiying2
		DOI: 10.20047/j.issn1673-7210.2022.30.43
		Psittacosis is an infectious disease caused by chlamydia psittaci infection. Due to the nonspecificity of its clinical symptoms and the limitations of detection methods, it is easy to miss diagnosis and misdiagnosis in clinical work. This paper reports a case, male, 67 years old, who was admitted to the first hospital of Lanzhou University on June 25, 2021. The main reason was “chest tightness and shortness of breath with fever for five days”. The empirical anti-infection effect was not good and worsened progressively, chlamydia psittaci infection was confirmed by macrogene next-generation sequencing, and antibiotics were adjusted to give effective anti-infection treatment, the patient’s condition improved and was discharged. This paper sortes out the medical records and analyzes the related literature, the clinical manifestations, diagnosis and treatment of psittacosis infection are reviewed, to improve clinicians’ awareness of the disease.
		2022 Vol. 19 (30): 188-191 [Abstract] ( 13 ) HTML (1 KB) PDF (1224 KB) ( 26 )

	192	Establishment and application of single disease model clinical biobank
		WANG Huan ZHANG Tian QIN Lingsha HU Yao QI Ling
		DOI: 10.20047/j.issn1673-7210.2022.30.44
		The urgent demand for clinical biobank resources is increasing day by day, which puts forward higher requirements for the construction of biobank and sample quality. Although the national standards have been released, the specific measures are not uniform, and the construction of biobank in different regions is uneven, and the operation mode is also very different. The clinical biobank of Qingyuan People’s Hospital of Guangdong Province (hereinafter referred to as “our hospital”) combined with the development characteristics of our hospital, explored a set of single disease sample management mode with its own characteristics. This paper summarizes the management experience of clinical biobank in our hospital, so as to provide reference for the standardized construction and specific implementation mode of the biobank, in order to promote the rapid development of medical research to a certain extent.
		2022 Vol. 19 (30): 192-196 [Abstract] ( 11 ) HTML (1 KB) PDF (1214 KB) ( 63 )

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