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| Curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis |
| ZENG Li1 WANG Yongcai1 XING Gengyan2 YAN Bing1 |
1.Department of Joint Surgery, Leshan People’s Hospital, Sichuan Province, Leshan 614000, China;
2.Orthopaedic Center, the Third Medical Center of the Chinese People’s Liberation Army General Hospital, Beijing 100039, China |
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Abstract Objective To study the curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle knee osteoarthritis. Methods A total of 40 postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis patients in the Department of Joint Surgery, Leshan People’s Hospital of Sichuan Province were selected from December 2019 to December 2020. They were divided into experimental group and control group by random number table method, with 20 cases in each group. The control group was treated with Zoledronate and Caltrate, and the experimental group was treated with Diacerein on the basis of control group. The scores of Western Ontario and McMaster University osteoarthritis index (WOMAC), Lequesne, and visual analogue scale (VAS) were compared between two groups before treatment and 1, 6, and 12 months after treatment. Results There were significant differences in WOMAC score, Lequesne score, and VAS score between two groups at different time points (P < 0.05). At 1, 6, and 12 months of treatment, the scores of WOMAC and VAS of two groups were significantly different (P < 0.05); there was no significant difference in Lequesne score between two groups (P > 0.05). Conclusion Zoledronate combined with Diacerein can significantly relieve knee joint pain and improve knee joint function in the treatment of postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis.
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