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| Research progress on the mechanism of gasotransmitters in non-alcoholic fatty liver disease |
| KONG Guangyao JIANG Feng LIU Liping CHEN Yingqing |
| Dalian Key Laboratory of Chronic Disease Research Center Dalian University, Liaoning Province, Dalian 116622, China |
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Abstract Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver injury caused by abnormal deposition of fat in hepatocytes in addition to alcohol. Gasotransmitters, including nitric monoxide, carbon monoxide, and hydrogen sulfide can improve NAFLD by regulating VEGF-eNOS, PERK-eIF2-ATF4, Nrf2/HO-1,SESN2/AMPK/mTOR, and other signaling axes. This article mainly reviews the regulatory effects and molecular mechanisms of gasotransmitters on NAFLD, so as to provide new ideas for the treatment of NAFLD by gas signaling molecules and their donors in the future.
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[1] Neuschwander-Tetri BA. Non-alcoholic fatty liver disease [J]. BMC Med，2017，15（1）：45.
[2] 迟骁玮.非酒精性脂肪肝病的发病机制和药物研发进展[J].中国药师，2021，24（7）：338-343.
[3] 程雅欣，李佳.非酒精性脂肪肝与常见内分泌代谢性疾病关系及临床治疗综述[J].解放军医学院学报，2021,42（9）：963-969.
[4] 刘思伽，陈潇凡，胡必成，等.非酒精性脂肪肝病的发病机制及治疗研究进展[J].湖北中医药大学学报，2019，21（2）：126-129.
[5] 李冬娟，钟继昌，谢少康，等.非酒精性脂肪肝病的发病机制及药物治疗研究进展[J].名医，2020（10）：71-72.
[6] Li S，Liao R，Sheng X，et al. Hydrogen Gas in Cancer Treatment [J]. Front Oncol，2019，9：696.
[7] Wu DD，Wang DY，Li HM，et al. Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease [J]. Oxid Med Cell Longev，2019，2019：3831713.
[8] Kim HJ，Joe Y，Kim SK，et al. Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway [J]. Free Radic Biol Med，2017，110：81-91.
[9] Maria ATJ，Rozier P，Fonteneau G，et al. iNOS Activity Is Required for the Therapeutic Effect of Mesenchymal Stem Cells in Experimental Systemic Sclerosis [J]. Front Immunol，2018，9：3056.
[10] Chen Y，Yuan S，Cao Y，et al. Gasotransmitters：Potential Therapeutic Molecules of Fibrotic Diseases [J]. Oxid Med Cell Longev，2021，2021：3206982
[11] Bravo M，Raurell I，Barberá A，et al. Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH [J]. Dis Model Mech，2021，14（5）：dmm048884.
[12] Lu J，Zhao YL，Zhang XQ，et al. The vascular endothelial growth factor signaling pathway regulates liver sinusoidal endothelial cells during liver regeneration after partial hepatectomy [J]. Expert Rev Gastroenterol Hepatol，2021，15（2）：139-147.
[13] Yang T，Zelikin AN，Chandrawati R. Progress and Promise of Nitric Oxide-Releasing Platforms [J]. Adv Sci（Weinh），2018，5（6）：1701043.
[14] Hammoutene A，Rautou PE. Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease [J]. J Hepatol，2019，70（6）：1278-1291.
[15] Sheldon RD，Meers GM，Morris EM，et al. eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH [J]. Am J Physiol Endocrinol Metab，2019，317（4）：E605-E616.
[16] Ahsan F，Oliveri F，Goud HK，et al. Pleiotropic Effects of Statins in the Light of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis [J]. Cureus，2020，12（9）：e10446.
[17] Becerril S，Rodríguez A，Catalán V，et al. iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice [J]. Genes（Basel），2019，10（3）：184-200.
[18] Zhang Y，Higgins CB，Fortune HM，et al. Hepatic arginase 2 （Arg2） is sufficient to convey the therapeutic metabolic effects of fasting [J]. Nat Commun，2019，10（1）：1587.
[19] Asosingh K，Lauruschkat CD，Alemagno M，et al. Arginine metabolic control of airway inflammation [J]. JCI Insight，2020，5（2）：e127801.
[20] Almeida AS，Soares NL，Sequeira CO，et al. Improvement of neuronal differentiation by carbon monoxide：Role of pentose phosphate pathway [J]. Redox Biol，2018，17：338-347.
[21] Chen Y，Park HJ，Park J，et al. Carbon monoxide ameliorates acetaminophen-induced liver injury by increasing hepatic HO-1 and Parkin expression [J]. Faseb J，2019，33（12）：13905-13919.
[22] Upadhyay KK，Jadeja RN，Vyas HS，et al. Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function [J]. Redox Biol，2020，28：101314.
[23] Hashimoto T，Sugihara T，Kanda T，et al. 5-Aminolevulinic Acid Attenuates Glucose-Regulated Protein 78 Expression and Hepatocyte Lipoapoptosis via Heme Oxygenase-1 Induction [J]. Int J Mol Sci，2021，22（21）：11405-11414.
[24] Joe Y，Kim S，Kim H J，et al. FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway [J]. Faseb J，2018，32（5）：2630-2643.
[25] Lu W，Li X，Luo Y. FGF21 in obesity and cancer：New insights [J]. Cancer Lett，2021，499：5-13.
[26] Tillman EJ，Rolph T. FGF21：An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases [J]. Front Endocrinol（Lausanne），2020， 11：601290.
[27] 李祖寅，周志杰，晏滨，等.内质网应激在非酒精性脂肪肝病中的作用[J].中华肥胖与代谢病电子杂志，2020，6（2）：122-126.
[28] Sun HJ，Wu ZY，Nie XW，et al. Implications of hydrogen sulfide in liver pathophysiology：Mechanistic insights and therapeutic potential [J]. J Adv Res，2021，27：127-135.
[29] Yu Y，Ye SM，Liu DY，et al. AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment [J]. Exp Anim，2021，70（4）：553-562.
[30] Wu D，Zhong P，Wang Y，et al. Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway [J]. Front Pharmacol，2020，11：585860.
[31] Kim JH，Sim HA，Jung DY，et al. Poria cocus Wolf Extract Ameliorates Hepatic Steatosis through Regulation of Lipid Metabolism，Inhibition of ER Stress，and Activation of Autophagy via AMPK Activation [J]. Int J Mol Sci，2019，20（19）：4801-4817. |
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