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2022 Vol. 19, No. 21 Published: 2022-07-25

	5	Effect of osteoporosis on the treatment effect of middle-aged and elderly patients with severe chronic periodontitis
		CHEN Changxing1 LIU Hong2 ZHANG Liping3 QIU Lihua4
		Objective To investigate the effect of osteoporosis on the treatment effect of middle-aged and elderly patients with severe chronic periodontitis. Methods Forty-eight middle-aged and elderly patients with severe chronic periodontitis who were treated in the Department of Periodontology, Yancheng Stomatological Hospital of Jiangsu Province from January 2017 to December 2020 were selected. According to whether they had osteoporosis or not, they were divided into observation group and control group, with 24 cases in each group. The periodontal clinical indicators (plaque index [PLI], sulcus bleeding index [SBI], periodontal pocket depth [PD]), inflammatory factor indicators (interleukin-1β [IL-1β], IL-6, tumor necrosis factor α [TNF-α]), and imaging indicators. Results After treatment, the PLI, SBI, and PD of the two groups were lower than those before treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, there was no significant difference in periodontal clinical indicators between the two groups (P ＞ 0.05). After treatment, the levels of inflammatory factors in the two groups were lower than those before treatment, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Osteoporosis affects the inflammatory factor levels and the effect of alveolar bone repair and regeneration after basic treatment for middle-aged and elderly patients with severe chronic periodontitis.
		2022 Vol. 19 (21): 5-8 [Abstract] ( 92 ) HTML (1 KB) PDF (768 KB) ( 100 )

	9	Research on mediation rule of external treatment of ecthyma with traditional Chinese medicine based on data mining#br#
		ZHANG Peng1 QU Jianhua2
		Objective To explore the medication rule of external treatment of ecthyma in traditional Chinese medicine. Methods The literatures in accordance with the external use of traditional Chinese medicine in the treatment of ecthyma were searched in CNKI, Wanfang, VIP and other databases from the establishment of the database to July, 2021. The herbs and their properties, tastes, and meridians were analyzed by frequency analysis, cluster analysis, and association rule analysis. Results In terms of herb efficacy, the frequencies of heat clearing herbs, blood activating, and stasis removing herbs, and deficiency tonifying herbs were the highest, which were 22.40%, 13.49% and 8.79%, respectively. In terms of herb taste, the proportion of spicy, sweet and bitter was the highest, which were 31.26%, 29.93% and 23.26%, respectively. In terms of herb distribution, cold, warm, and plain ranked among the top three, 56.42%, 25.68% and 17.90%, respectively. In terms of meridian distribution, heart, liver and spleen were the most critical, accounting for 21.03%, 20.63% and 17.34%, respectively. Cluster analysis was divided into three categories. Conclusion The external use of traditional Chinese medicine in the treatment of ecthyma starts with “dampness, heat, blood stasis and deficiency”, and pays attention to the treatment of clearing heat, promoting blood circulation, and removing blood stasis and tonifying deficiency. Most of the medicine tastes are spicy, sweet and bitter. Pay attention to the use of cold, warm and plain properties.
		2022 Vol. 19 (21): 9-12 [Abstract] ( 75 ) HTML (1 KB) PDF (835 KB) ( 80 )

	13	Study of the role and mechanism of C-terminal Src protein / focal adhesion kinase / E-cadherin pathway in invasion and metastasis of cervical cancer
		TANG Qunhua MU Xiaoqin HUANG Shilan TANG Zhikang LIAN Xiaoling▲
		Objective To study the role and mechanism of C-terminal Src protein (c-Src) / focal adhesion kinase (FAK) / E-cadherin (E-cad) pathway in invasion and metastasis of cervical cancer. Methods Thirty cervical squamous cell carcinoma (CSCC) tissue samples and 30 normal cervical (NC) tissue samples were collected from the First Affiliated Hospital of Hunan University of Medicine from January 2019 to December 2020. Immunohistochemical stain was used to detect the positive rate of E-cad in CSCC and NC tissue samples. The relationship between E-cad and clinicopathological features of CSCC patients was analyzed. Western blot was used to detect the protein expression levels of c-Src, FAK, and E-cad in CSCC and NC tissues. In addition, cervical cancer Caski cell lines were selected and divided into Caski group and Caski+ c-SRC inhibitor group. The Caski group was not treated, and the Caski+c-SRC inhibitor group was added with c-Src inhibitor (2.7 nmol/L). The migration, invasion, and apoptosis of the two groups were observed, and the protein expression levels of c-Src, FAK, and E-cad in the two groups were detected by Western blot. Results The positive rate of E-cad in CSCC tissue samples was lower than that in NC, the difference was statistically significant (P ＜ 0.05). E-cad expression was correlated with International Federation of Gynecology and Obstetrics staging, differentiation degree, and recurrence of CSCC patients (P ＜ 0.05). The expression levels of c-Src and FAK protein in CSCC tissue samples were higher than those in NC tissue samples, while the expression level of E-cad protein was lower than that in NCT, the differences were statistically significant (P ＜ 0.05). The count of invaded and migrated cells and the expression levels of c-Src and FAK protein in Caski+c-Src inhibitor group were lower than those in Caski group, and the apoptosis rate and expression level of E-cad protein were higher than those in Caski group, the differences were statistically significant (P ＜ 0.05). Conclusion C-src may lead to decreased invasion and migration ability of cervical cancer cells by up-regulating FAK and down-regulating E-cad, the mechanism may be related to increased apoptosis.
		2022 Vol. 19 (21): 13-16,25 [Abstract] ( 86 ) HTML (1 KB) PDF (1087 KB) ( 61 )

	17	Law of acupoint selection in acupuncture treatment of postoperative gastroparesis syndrome
		SUN Haojie1 WANG Zhou2 XIA Changjun2
		Objective To study the characteristics and rules of acupuncture for postsurgical gastroparesis syndrome（PGS）. Methods Wanfang, VIP, CNKI, China Biomedical Literature Database, Web of Science, Embase, PubMed, Cochrane Library were used as data sources to search clinical research literatures on acupuncture treatment of PGS collected from the database establishment to July 2021. Descriptive statistics, systematic cluster analysis, association rule analysis, and other methods were used to analyze the characteristics and rules of acupoint selection in acupuncture treatment of PGS. Results A total of 116 literatures were included, involving 118 acupuncture prescriptions and 62 acupoints. Zúsānlǐ was the most frequently used, followed by nèiguān, zhōngwǎn and so on; there were many acupoints on the limbs and abdomen; the commonly used meridians were stomach meridian, conception vessel and spleen meridian; the specific acupoints with more frequent use were lower he-sea points, five transport points, front-mu points. Through the analysis of association rules, 22 strong association rules were obtained, including nèiguān→zúsānlǐ, zhōngwǎn→zúsānlǐ, zhōngwǎn- nèiguān→zúsānlǐ, etc. Four cluster groups were obtained by cluster analysis. Conclusion Acupuncture treatment of PGS focuses on the use of specific points. “Acupoint selection along meridians” is the main method of acupoint selection for acupuncture treatment of PGS, which embodies the idea of “treating the disease according to the meridians”. The compatibility of acupoints embodies the principle of “giving consideration to both deficiency and excess, and regulating yin and yang”.
		2022 Vol. 19 (21): 17-20,35 [Abstract] ( 68 ) HTML (1 KB) PDF (1614 KB) ( 38 )

	21	Study on quality evaluation of Verbena officinalis L. based on ultra high performance liquid chromatography fingerprint and chemical pattern recognition
		ZHANG Zhipeng DENG Lihong WANG Shoufu HUANG Mengting LI Ling WEI Mei
		Objective To study the fingerprints differences of root, main stem, lateral branch, leaf, and flower of Verbena officinalis L. Methods Eleven batches of Verbena officinalis L. from different producing areas were collected. The fingerprints of medicinal material, root, main stem, lateral branch, leaf, and flower of Verbena officinalis L. were determined by ultra high performance liquid chromatography. Similarity evaluation, cluster analysis, principal component analysis, and partial least square discriminant analysis were used to analyze the chemical pattern recognition of fingerprints of different parts. Results The ultra high performance liquid chromatography fingerprints of medicinal material, root, main stem, lateral branch, leaf, and flower of Verbena officinalis L. were established, and 22, 14, 20, 20, 21, 22 common characteristic peaks were confirmed, respectively, and three components (5-hydroxyl verbenalin, verbenalin, and verbascoside) were identified. The higher similarity between medicinal material and its lateral branch, but lower similarity for root. Heat maps showed that the contents of chemical constituents in different parts were different, which mainly enriched in flower. Clustering analysis showed that the consistency between herbs and lateral branches was high. Combined with principal component analysis and partial least square discriminant analysis, 5-hydroxyl verbenalin was an important indexes of the formation of different parts of the difference. Conclusion The quality of Verbena officinalis L. can be improved by harvesting at flowering stage and removing root for medicinal application, which provided experimental reference for removing root for medicinal application.
		2022 Vol. 19 (21): 21-25 [Abstract] ( 66 ) HTML (1 KB) PDF (4148 KB) ( 176 )

	26	Analysis of research hotspots and changing trends of county medical community based on literature metrology
		XU Pingping ZHAO Jing SHEN Huihuang FU Yunxiang YANG Lijin MA Hanbin
		Objective To explore the progress, hotspots, development trends and changing trends of relevant policy research on county medical community in China, and to provide reference for further theoretical deepening and policy promotion research. Methods Literatures related to county medical communities published by CNKI, VIP database and Wanfang data knowledge service platform from January 2014 to February 2021 were selected to conduct summary coding and format conversion for the included literatures. CiteSpace and VOSviewer software were used to analyze and map the literatures. Results Wang Fang etc. were the core authors in this field. The keywords were county medical community, medical community, and graded diagnosis and treatment, with prominent hotspots in this field. Conclusion The number of related literatures of county medical community is increasing year by year; the cooperation between authors and institutions is not close; the research has formed three main research clusters and three main stages, and the research hotspots are concentrated. There are significant differences between regions.
		2022 Vol. 19 (21): 26-30 [Abstract] ( 68 ) HTML (1 KB) PDF (1635 KB) ( 49 )

	31	Protective effect and mechanism of ursodeoxycholic acid on cerebral ischemia-reperfusion injury in rats#br#
		YOU Meigui1 TIAN Hua1 ZENG Yun2
		Objective To study the protective effect and mechanism of ursodeoxycholic acid (UDCA) on cerebral ischemia-reperfusion injury in rats. Methods Forty male SD rats were divided into sham operation group, middle cerebral artery occlusion (MCAO) group, UDCA 60 mg/kg group, and UDCA 120 mg/kg group according to random number table method, with ten rats in each group. Rats were given prophylactic medicine for three days. MCAO model was established by thread bolt method. Reperfusion was realized after blocking for 1.5 hours. Rats continued to be given medicine for five days and half hour at the last administration, the neurological function score of rat was evaluated by Longa’s standard, 2,3,5-triphenyltetrazolium chloride staining was used to calculate the volume of cerebral infarction in rats. The contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in cerebral ischemic tissues of rats were measured. The expressions of PI3K and p-AKT proteins in rat hippocampus were detected. Results The neurological function score of MCAO group was higher than that of sham operation group (P ＜ 0.01). The neurological function scores of UDCA 60 mg/kg group and UDCA 120 mg/kg group were lower than those of MCAO group (P ＜ 0.05). In sham operation group, all brain tissues were rose red, and no infarct lesions were found; the cerebral infarction area of MCAO group showed obvious pale infarct area. The percentage of cerebral infarction in MCAO group was higher than that in sham operation group (P ＜ 0.01). The percentages of cerebral infarction tissue in UDCA 60 and 120 mg/kg groups were lower than those in MCAO group (P ＜ 0.05). The content of SOD in MCAO group was lower than that in sham operation group, and the content of MDA in MCAO group was higher than that in sham operation group (P ＜ 0.01). The contents of SOD in UDCA 60 and 120 mg/kg groups were higher than those in MCAO group, and the contents of MDA in UDCA 120 mg/kg groups were lower than those in MCAO group (P ＜ 0.05). The expressions of PI3K and p-AKT protein in hippocampus of MCAO group were lower than those of sham operation group (P ＜ 0.05). The expressions of PI3K and p-AKT protein in UDCA 60 and 120 mg/kg groups were higher than those in MCAO group (P ＜ 0.05). Conclusion UDCA has effects on the cerebral ischemia-reperfusion injury in rats, and its mechanism may be related to improvement of brain oxidative stress, regulating the AKT signaling pathway.
		2022 Vol. 19 (21): 31-35 [Abstract] ( 64 ) HTML (1 KB) PDF (1010 KB) ( 56 )

	36	Research progress on mechanism of senescence related pigmented dermatosis
		HU Shuanghai LEI Tiechi
		Senescence of human skin is a natural phenomenon and an important external manifestation of aging. Skin senescence may be related to DNA damage, up-regulation of cell cycle arresting protein, and senescence related secretion phenotype. Skin senescence can be divided into natural senescence and photosenescence, and its performance is thin epidermis, decline in elasticity, increase in wrinkles, and decline in skin barrier function. The changes of melanocytes during skin senescence have attracted more and more attention. Senescence is an important factor in the progress of pigmentation and hypopigmentation. Skin senescence is related to hypopigmentation, such as chloasmaidiopathic guttate hypomelanosis, vitiligo, skin aging can also cause pigmentation, such as sunspots and chloasma. The intervention of skin senescent cells is expected to become a new idea and new means for the clinical treatment of pigmented dermatosis. This review will review the latest progress in the mechanism of senescence related pigmented skin diseases.
		2022 Vol. 19 (21): 36-39 [Abstract] ( 68 ) HTML (1 KB) PDF (483 KB) ( 191 )

	40	Research progress of relationship between gastrointestinal tract microecology and biliary and pancreatic diseases
		XIA Shaoxuan1 LIU Hao1 LI Jialin1 ZHOU Yutong1 HAN Min2
		Gastrointestinal tract flora is involved in many physiological functions and is closely related to biliary and pancreatic diseases. Many factors, such as diet, drugs, and diseases can affect the abundance and distribution structure of gastrointestinal tract flora, and then cause the occurrence and development of related biliary and pancreatic diseases. The gastrointestinal tract microecological imbalance is often associated with biliary and pancreatic diseases such as biliary tract infection, biliary stones, pancreatitis, and biliary and pancreatic tumors. This paper discusses the relationship between gastrointestinal tract flora and biliary and pancreatic diseases.
		2022 Vol. 19 (21): 40-44 [Abstract] ( 74 ) HTML (1 KB) PDF (616 KB) ( 109 )

	45	Status quo and influencing factors of nursing needs of human immunodeficiency virus-infected patients with tuberculosis
		YANG Jing1,2 JI Yulin1 LIU Xiangmin1,2 ZHANG Huan1,2 CAO Xinyu1,2 XUE Miao1,2▲
		Objective To explore the current situation and influencing factors of nursing needs in patients with human immunodeficiency virus (HIV) infection complicated with tuberculosis. Methods A total of 150 HIV-infected patients with tuberculosis who visited West China Hospital of Sichuan University from June 2018 to June 2021 were selected as the research objects. The self-made nursing needs scale was used to evaluate the nursing needs of HIV-infected patients with tuberculosis, and analyze their current nursing needs. According to the median score of nursing needs scale, the patients were divided into high-needs group and low-needs group, 75 cases in each group, and the influencing factors of HIV infection complicated with tuberculosis needs were analyzed. Results The total score of nursing needs of HIV-infected patients with tuberculosis was (196.37±10.87) points. There were statistically significant differences in education, tuberculosis type, the scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS), and social support between the two groups (P ＜ 0.05). The results of logistic regression analysis showed that education (OR = 8.637), tuberculosis type (OR = 3.920), SAS scores (OR = 1.262), SDS scores (OR = 1.310), and social support scores (OR = 0.724) were the influencing factors for nursing needs of HIV-infected patients with tuberculosis (P ＜ 0.05). Conclusion The nursing needs of HIV-infected patients with tuberculosis are relatively high. There are differences in the nursing needs of HIV-infected patients with tuberculosis with different population characteristics. Education, tuberculosis type, SAS scores, SDS scores, and social support scores are the influencing factors of the nursing needs of HIV-infected patients with tuberculosis. This group of people should be focused on in clinical nursing work.
		2022 Vol. 19 (21): 45-48,61 [Abstract] ( 66 ) HTML (1 KB) PDF (689 KB) ( 36 )

	49	Analysis of risk factors for early seizures after endovascular therapy for acute ischemic stroke
		QIN Bailing LI Tong HU Minting WEI Chunyan
		Objective To investigate the risk factors for early seizures after endovascular therapy for acute ischemic stroke. Methods A retrospective summary was made of 184 patients with acute ischemic stroke who underwent endovascular treatment in the Department of Neurology, Nanning Second People’s Hospital from June 2019 to December 2021. The patients were divided into 36 cases in the epilepsy group and 148 cases in the non-epileptic group according to whether they were complicated with epilepsy. Neurological deficits were assessed using the National Institutes of Health stroke scale (NIHSS) score, and the Glasgow coma scale (GCS) were used to assess the degree of disturbance of consciousness. Logistic regression was used to analyze the possible risk factors of early seizures after endovascular therapy for acute ischemic stroke. Results The proportion of epilepsy group in age ≤65 years old, preoperative NIHSS score＞11 points, preoperative GCS≤8 points, diabetes, anterior circulation lesions, mechanical thrombectomy and aspiration, hemorrhagic transformation, and operation duration＞1 h were higher than those of the non-epilepsy group (P < 0.05). The results of multivariate logistic regression analysis showed that the preoperative NIHSS score＞11 points, preoperative GCS≤8 points, mechanical thrombectomy, hemorrhagic transformation and aspiration, operation time＞1 h were independent risk factors for acute ischemic stroke complicated with early epilepsy after endovascular treatment (P ＜ 0.05). Conclusion Disease severity, surgical method, hemorrhagic transformation and duration of surgery are risk factors for early seizures in patients undergoing endovascular interventional therapy in the acute phase, and it is worthy of clinical attention.
		2022 Vol. 19 (21): 49-52 [Abstract] ( 62 ) HTML (1 KB) PDF (478 KB) ( 35 )

	53	The mediating effect of coping style on the needs and subjective well-being of patients with breast cancer after chemotherapy
		YU Ying WAN Yonghui TANG Yao
		Objective To explore the mediating effect of coping style in the influence of needs on subjective well-being in breast cancer patients undergoing chemotherapy, and to provide evidence for improving their subjective well-being. Methods From August to December 2020, a total of 300 breast cancer patients undergoing chemotherapy after breast cancer surgery were selected by convenience sampling method in Wuhan University People’s Hospital, Wuhan University Zhongnan Hospital, and Hubei Cancer Hospital. Taking stress theory as the theoretical framework, a questionnaire survey was conducted using the need assessment scale for female breast cancer patients, the medical coping style questionnaire, and the overall well-being scale. Results A total of 300 questionnaires were distributed in this survey, 300 questionnaires were recovered, and 282 were actually valid, with an effective recovery rate of 94%. The needs of patients after breast cancer surgery were negatively correlated with facing and subjective well-being, and positively correlated with avoidance and yielding; facing was negatively correlated with avoidance and yielding, and positively correlated with subjective well-being; avoidance was positively correlated with yielding, and negatively correlated with subjective well-being; Yield was negatively correlated with subjective well-being (P < 0.05). Facing coping and yielding coping played a partial mediating effect between the needs and subjective well-being of breast cancer patients undergoing chemotherapy after surgery (95%CI: -6.443 to -0.760, -4.251 to -0.837). Conclusion Needs can directly affect the subjective well-being of patients undergoing chemotherapy after breast cancer surgery, and can also indirectly affect their subjective well-being through confrontation and surrender.
		2022 Vol. 19 (21): 53-56,69 [Abstract] ( 53 ) HTML (1 KB) PDF (1039 KB) ( 141 )

	57	Survey on cognition of direct-to-consumer genetic testing among junior medical students in our school
		LIN Zhenkui1 QIU Lijia1 LIANG Shaoming2 CHEN Huiyi2 LIN Mengqin2 LI Jinhua2 LIU Wei3
		Objective To investigate the cognition of direct-to-consumer genetic testing (DTC) among college students in Zhaoqing Medical College (“our school” for short). Methods From September 2018 to June 2020, taking students of different grades in our school were taken as the research objects, the stratified random sampling survey method was used to conduct a questionnaire survey on the content of DTC genetic testing. Results In this survey, 2507 questionnaires were distributed, 1696 valid questionnaires were recovered, and the effective recovery rate was 67.65%. The medical students surveyed had a certain understanding of DTC genetic testing, and they had a high degree of confidence in it. More than 93% of students agreed that there was a relationship between genes and health. However, it could be seen from the specific cases and details that they did not have a deep understanding of this aspect. 63.33% of medical students accepted DTC genetic testing. There were no significant differences in the degree of confidence in DTC gene products among students of different genders, origins, grades, and majors (P ＞ 0.05). There were no significant differences in the acceptance of DTC gene products among students of different genders and origins (P ＞ 0.05); there were statistically significant differences in the acceptance of DTC gene products among students of different grades and majors (P ＜ 0.05). Conclusion Although the medical students who were surveyed have some knowledge of DTC genetic testing, the understanding and acceptance of it is still at a superficial stage. Knowledge composition and knowledge level affect medical students’ acceptance of DTC genetic testing. Medical students should actively understand the cutting-edge technologies and products of modern medicine and enrich their medical knowledge.
		2022 Vol. 19 (21): 57-60 [Abstract] ( 60 ) HTML (1 KB) PDF (1345 KB) ( 26 )

	62	Epidemiological investigation on malocclusion deformity and orthodontic treatment awareness among children in Shijiazhuang
		ZHANG Liming1 SONG Peng2▲ ZHAO Yue3 TIAN Man1 WANG Yu1
		Objective To understand the prevalence and composition ratio of malocclusion deformity in preschool children in Shijiazhuang, and to investigate the causes of malocclusion deformity and their awareness of orthodontic treatment. Methods A total of 2144 children with deciduous dentition aged three to six years old from ten kindergartens in eight districts of Shijiazhuang City from January to June 2021 were selected as clinical research samples by the principle of stratified random sampling. The development of deciduous teeth malocclusion deformity, understand the prevalence of malocclusion deformity and the ratio of various components were checked. At the same time, the cause of malocclusion deformity and the awareness of orthodontic treatment were understood in the form of self-made questionnaires. Results There was no statistical difference in the different genders of prevalence of deciduous dentition deformity among preschool children in Shijiazhuang (P ＞ 0.05); in different genders of malocclusion deformities, there was no statistical difference between different type (P ＞ 0.05); among the causes affecting the formation of deciduous dentition deformity, there was no significant difference in the prevalence of children of different genders (P ＞ 0.05). The proportion of male children with orthodontic awareness was lower than that of female children, and the difference was statistically significant (P ＜ 0.05); there was no significant difference in the proportion of children of different genders receiving orthodontic treatment (P ＞ 0.05). Conclusion The prevalence of deciduous malocclusion deformity in preschool children in Shijiazhuang is high, and the awareness of orthodontic treatment is insufficient. Early attention should be given and oral health education should be strengthened, effective use of oral public health policies for targeted prevention, and good oral health care for deciduous dentition.
		2022 Vol. 19 (21): 62-65 [Abstract] ( 56 ) HTML (1 KB) PDF (2390 KB) ( 31 )

	66	The current situation of scientific research ability training of professional postgraduate students in a hospital in Beijing under the dual-track integration mode
		WANG Ying1 ZHOU Zhe1 CHEN Jianjun2 WEI Wenge2▲
		Objective To discuss the current situation of scientific research ability training under the dual-track integration mode in a hospital in Beijing, and to provide countermeasures for improving the scientific research training system of specialization and master’s degree. Methods A cluster survey was used to conduct a questionnaire survey on 311 postgraduates under the dual-track integration mode who were jointly trained in Beijing Friendship Hospital Affiliated to Capital Medical University from January to June 2021. The questionnaire was consisted of general information questionnaire, scientific research ability training cognition, scientific research ability self-assessment, and scientific research ability training satisfaction. The self-assessment of scientific research ability and the satisfaction of scientific research ability training were designed in the form of Likert scale. The survey data were analyzed using descriptive statistical methods. Results 91.0% of the postgraduates believe that the cultivation of scientific research ability was important. The overall self-rating of the scientific research ability of the postgraduate and master students was (2.66±0.91) points, among which the score of the ability dimension of analyzing and summarizing research results was lower than the overall score (48.2%). In the research and training satisfaction survey, the overall satisfaction was (3.58±1.10) points, and 57.6% of the masters and masters had a lower satisfaction score for their tutors than the overall satisfaction. 74.3% of the postgraduates’ satisfaction scores with the hospital were lower than the overall satisfaction. Conclusion The scientific research ability of the combined postgraduates under the dual-track integration mode needs to be further improved. It is recommended to promote the combination of scientific research and clinical practice, strengthen the policy support of the hospital, and strengthen the guiding role of mentors to ensure the quality of scientific research ability training.
		2022 Vol. 19 (21): 66-69 [Abstract] ( 70 ) HTML (1 KB) PDF (568 KB) ( 36 )

	70	Analysis of clinical characteristics and risk factors in patients with nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus
		MA Hailin QUAN Li JIANG Sheng
		Objective To investigate the clinical characteristics and risk factors of nonalcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 349 NAFLD patients admitted to the First Affiliated Hospital of Xinjiang Medical University from August 2020 to August 2021 were retrospectively analyzed. According to the presence or absence of T2DM, the patients were divided into a simple NAFLD group (281 cases) and a NAFLD combined T2DM group (68 cases). The clinical data were collected to analyze the risk factors of NAFLD developing T2DM. Results The age, family history of diabetes, fasting blood glucose, and glycosylated hemoglobin in the NAFLD combined with T2DM group were higher than those in the simple NAFLD group, while the high-density lipoprotein was lower than that in the simple NAFLD group, and the differences were statistically significant (P ＜ 0.05). Spearson correlation analysis showed that NAFLD complicated with T2DM was positively correlated with age, fasting blood glucose, and glycosylated hemoglobin (r ＞ 0, P ＜ 0.05); it was negatively correlated with high-density lipoprotein (r ＜ 0, P ＜ 0.05). Logistic regression analysis showed that age (OR = 1.037), fasting blood glucose (OR = 1.420), high-density lipoprotein (OR = 0.301), and glycosylated hemoglobin (OR = 1.186) were independent risk factors for T2DM in NAFLD (P ＜ 0.05). Receiver operating characteristic curve analysis showed that fasting blood glucose, glycosylated hemoglobin, and high-density lipoprotein had diagnostic value for NAFLD-induced T2DM (P < 0.05). Conclusion Age, fasting blood glucose, high-density lipoprotein, and glycosylated hemoglobin were independent risk factors for NAFLD to develop T2DM.
		2022 Vol. 19 (21): 70-73,82 [Abstract] ( 63 ) HTML (1 KB) PDF (687 KB) ( 50 )

	74	Clinical effect of Yinhua Miyanling Tablets in treatment of cystitis glandularis
		YUAN Jincheng1 ZHANG Shirui1 QIU Jianhong1 ZHAO Xinhong1 BI Yuwang2
		Objective To investigate the effect of Yinhua Miyanling Tablets in the treatment of cystitis glandularis (CG). Methods A total of 82 male CG patients who underwent transurethral plasma vaporectomy and postoperative chemotherapy combined with bladder infusion were selected from January 2016 to March 2021 in the 980th Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army. They were divided into control group and observation group according to the random number table method, with 41 cases in each group. The control group was given Tamsulosin Hydrochloride Sustained-Release Capsules after operation, and the observation group was additionally given Yinhua Miyanling Tablets on this basis. The treatment lasted for six months, the clinical efficacy, urodynamics indexes (maximum flow rate, average flow rate, residual urine volume), serum levels of inflammatory cytokines (interleukin-8 [IL-8], IL-17 and tumor necrosis factor-α [TNF-α]) were compared between two groups. Results The total effective rate in observation group was higher than that in control group (P < 0.05). After treatment, the maximum flow rate and average flow rate of two groups were higher than those before treatment, while the residual urine volume was lower than that before treatment (P < 0.05); the maximum flow rate and average flow rate in observation group were higher than those in control group, while the residual urine volume was lower than that in control group (P < 0.05). After treatment, The levels of IL-8, IL-17, and TNF-α in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Conclusion Yinhua Miyanling Tablets plays a positive role in the treatment of CG, which may be related to its anti-inflammatory effect.
		2022 Vol. 19 (21): 74-77 [Abstract] ( 71 ) HTML (1 KB) PDF (600 KB) ( 43 )

	78	Comparison of percutaneous endoscopic lumbar discectomy in the treatment of secondary scoliosis and non-scoliosis lumbar disc herniation
		CHEN Baosheng1 TIAN Yafeng2 YANG Gang2 DONG Shaoyang1 YANG Mingshuai2 ZHANG Yili1 XUE Pengyu1 FAN Jinrui1
		Objective To study the clinical effect of percutaneous endoscopic lumbar discectomy for secondary scoliosis and non-scoliosis lumbar disc herniation. Methods From March 2018 to January 2020, 45 patients with lumbar disc herniation treated by percutaneous endoscopic lumbar discectomy in the First Affiliated Hospital of Hebei University of Chinese Medicine were selected as the research subjects. According to scoliosis, the patients were divided into the scoliosis group (21 cases) and the non-scoliosis group (24 cases). The operation time, intraoperative blood loss, and hospitalization days of the two groups were observed and compared, the incidence of adverse reactions in the two groups was recorded. Visual analogue scale (VAS) score and Oswestry disability index (ODI) were recorded and compared between the two groups before operation and two weeks and six months after operation, and changes of lumbar Cobb angle in scoliosis group were analyzed. Results There were no significant differences in operative time, intraoperative blood loss, and hospitalization days between the two groups (P ＞ 0.05). No serious complications such as neurovascular injury, dural tear, and intervertebral space infection occurred in both groups. VAS score and ODI of waist and leg in both groups at two weeks and six months after operation were lower than those before operation, and VAS score and ODI of waist and leg at six months after operation were lower than those at two weeks after operation, the differences were statistically significant (P ＜ 0.05). There were no significant differences in VAS score and ODI of waist and leg at each time point between the two groups (P ＞ 0.05). Cobb angle in the scoliosis group was lower than that before operation at two weeks and six months after operation, Cobb angle at six months after operation was lower than that at two weeks after operation, the differences were statistically significant (P ＜ 0.05). Conclusion Percutaneous endoscopic lumbar discectomy for the treatment of secondary scoliosis and non-scoliosis lumbar disc herniation has little trauma and fast postoperative recovery. From the short-term observation, similar clinical effects can be obtained, which is worthy of further study.
		2022 Vol. 19 (21): 78-82 [Abstract] ( 63 ) HTML (1 KB) PDF (691 KB) ( 41 )

	83	Clinical effect of phase Ⅰ closed reduction and external fixation sequential phase Ⅱ internal fixation in the treatment of C3 Pilon fracture
		YIN Ruofeng DING Ya’nan TIAN Congbin WANG Hui ZHANG Guoping▲
		Objective To explore the clinical effect of phase Ⅰ closed reduction and external fixation sequential phase Ⅱ internal fixation in the treatment of C3 Pilon fracture. Methods According to the random number table, 82 patients with C3 Pilon fracture of 904th Hospital of Chinese PLA Joint Logistics Support Force from January 2019 to June 2021 were selected and divided into control group (conventional incision reduction internal fixation) and observation group (phase Ⅰclosed reduction and external fixation sequential internal fixation), with 41 cases in each group. The perioperative indexes and therapeutic effects of the two groups were compared. Ankle function, visual analog scale (VAS), and quality of life questionnaire score were compared between the two groups before and three months after operation. The complications of the two groups were recorded. Results The amount of intraoperative blood loss in the observation group was lower than that in the control group, the fracture healing time was shorter than that in the control group, and the treatment effect was better than that in the control group (P ＜ 0.05). Three months after operation, ankle function and quality of life questionnaire scores in both groups were higher than those before operation, and the observation group was higher than the control group (P ＜ 0.05). Three months after operation, VAS scores in both groups were lower than those before operation, and the observation group was lower than the control group (P ＜ 0.05). There was no significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion Phase Ⅰ closed reduction and external fixation sequential phase Ⅱ internal fixation in the treatment of C3 Pilon fracture can reduce intraoperative blood loss, fracture healing time, improve ankle joint function, and improve the quality of life of patients, with high safety and worthy of clinical promotion.
		2022 Vol. 19 (21): 83-86 [Abstract] ( 54 ) HTML (1 KB) PDF (547 KB) ( 24 )

	87	Comparison of the application of “4” font position arthroscopic medial approach and conventional lateral approach for the preparation of femoral bone canal in anterior cruciate ligament reconstruction
		WANG Ling FENG Dehong GUO Yu HE Junshan DING Yujian ZHU Haoming LI Yaxin▲
		Objective To investigate the application effect of “4” font position arthroscopic medial approach and conventional lateral approach to prepare femoral bone canal in anterior cruciate ligament (ACL) reconstruction. Methods A total of 84 patients with ACL injury admitted to Wuxi People’s Hospital Affiliated to Nanjing Medical University from March 2017 to July 2020 were selected and divided into study group and control group, according to the random number table method, with 42 cases in each group. The study group adopted the “4” font position arthroscopic medial approach, and the control group adopted the conventional lateral approach. The operative time, intraoperative blood loss, the length of the femoral canal were compared between the two groups. Lysholm score, International Knee Documentation Committee (IKDC) score, and knee stability (Lachman test and axial displacement test) were compared between the two groups before and one year after operation. The complications of the two groups were recorded. Results There were no statistically significant differences in operative time and intraoperative blood loss between the two groups (P ＞ 0.05). The length of the femoral canal in the study group was longer than that in the control group, the difference was statistically significant (P ＜ 0.05). One year after operation, Lysholm score and IKDC score of two groups were higher than those before operation, and the study group was higher than the control group, the differences were statistically significant (P ＜ 0.05). One year after operation, Lachman test and axial displacement test in both groups were better than those before operation, and the differences were statistically significant (P ＜ 0.05). There were no significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion Compared with conventional lateral approach, “4” font position arthroscopic medial approach is more similar to anatomical reconstruction in ACL reconstruction, and can achieve better stability of postoperative knee function.
		2022 Vol. 19 (21): 87-90 [Abstract] ( 55 ) HTML (1 KB) PDF (554 KB) ( 196 )

	91	Clinical study of cavernostomy and sensitive antibiotics combined with fumigation and washing with Mudanye Decoction in the treatment of chronic osteomyelitis of lower limbs
		SHENG Kuisheng1 ZHANG Zhiguo2 XU Yanyan3 CHEN Xia3 WEI Yongli4 LI Keming5▲
		[Abstract] Objective To observe the clinical efficacy cavernostomy and sensitive antibiotics combined with fumigation and washing with Mudanye Decoction in the treatment of chronic osteomyelitis of lower limbs. Methods Eighty patients with chronic osteomyelitis of lower limbs admitted to Rizhao Hospital of Traditional Chinese Medicine, Shandong Province from January 2015 to June 2020 were selected and divided into control group and observation group by random number table method, with 40 cases in each group. The control group was treated with conventional surgical cavernostomy and sensitive antibiotic anti-infection treatment, while the observation group was treated with fumigation and washing with Mudanye Decoction on the basis of control group. After six weeks of treatment, the clinical efficacy of the two groups was compared. Visual analog scale (VAS) score, white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were compared between the two groups before and after treatment. The incidence of adverse reactions in the two groups was recorded. Results There was no significant difference in total clinical effective rate between the two groups (P ＞ 0.05). After treatment, VAS score, white blood cell count, erythrocyte sedimentation rate, and C-reactive protein in two groups were lower than those before treatment, and VAS score, erythrocyte sedimentation rate, and C-reactive protein of observation group were lower than those of control group, the differences were statistically significant (P ＜ 0.05). There were no serious adverse reactions in both groups. Conclusion The integration of traditional and Western medicine therapy of cavernostomy and sensitive antibiotics combined with fumigation and washing with Mudanye Decoction can effectively relieve pain and promote healing of local lesions of chronic osteomyelitis of lower limbs, which is a safe and effective measure.
		2022 Vol. 19 (21): 91-94 [Abstract] ( 49 ) HTML (1 KB) PDF (597 KB) ( 29 )

	95	Effect of Mailuo Shutong Pills combined with Rivaroxaban on thrombosis after complex tibial plateau fracture operation
		WANG Aijun1 TAO Jianfeng2
		Objective To observe the effect of Mailuo Shutong Pills combined with Rivaroxaban on thrombosis after complex tibial plateau fracture operation. Methods A total of 115 postoperative patients with complex tibial plateau fractures admitted to the Second Department of Traumatology of the Second Hospital of Tangshan City, Hebei Province from January 2018 to December 2019 were selected, and they were divided into the control group (57 cases) and the observation group (58 cases) according to the random number table method. The control group was given Rivaroxaban orally, and the observation group was given Mailuo Shutong Pills on the basis of the control group, both groups were treated for 14 days. Numerical scoring method (NRS) was used to evaluate the pain of the two groups before operation and 1, 3, 7, 14 d after operation. The levels of prothrombin time (PT), thrombin coagulation time (TT), activated partial thrombin time (APTT), fibrinogen (FIB), fibrinolytic index D-dimer (D-D), and fibrinogen degradation product (FDP) were compared between the two groups before operation and 1, 3, 7 d after operation. The time of swelling subside, deep venous thrombosis (DVT), and adverse reactions were recorded. Results The NRS scores of both groups at 1, 3 d after operation were higher than those before operation, NRS scores of both groups at 7, 14 d after operation were lower than those before operation, NRS scores of both groups at 3, 7, 14 d after operation were lower than those at 1 d after operation, NRS scores of both groups at 7, 14 d after operation were lower than those at 3 d after operation, NRS scores of both groups at 14 d after operation were lower than those at 7 d after operation (P ＜ 0.05). NRS scores of observation group at 3, 7, 14 d after operation were lower than control group at the same time points (P ＜ 0.05). The FIB, D-D, and FDP of the two groups at 1, 3, 7 d after operation were higher than those before operation, and the FIB and D-D of the two groups at 3, 7 d after operation were lower than those at 1 d after operation, FDP of the control group at 3, 7 d after operation and FDP of the observation group at 7 d after operation were both lower than those at 1 d after operation, the FIB, D-D, and FDP of both groups at 7 d after operation were lower than those at 3 d after operation (P ＜ 0.05). The FIB, D-D, and FDP of observation group were lower than those of control group at 3, 7 d after operation (P ＜ 0.05). The time of swelling subside in observation group was shorter than that in control group (P ＜ 0.05). There were no significant differences in the incidence of DVT and total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Mailuo Shutong Pills could improve coagulation and fibrinolysis functions, and prevent the postoperative thrombus of complex tibial plateau fractures effectively.
		2022 Vol. 19 (21): 95-98,114 [Abstract] ( 57 ) HTML (1 KB) PDF (684 KB) ( 20 )

	99	Clinical effect of non-operative spinal decompression system combined with McKenzie therapy in the treatment for lumbar disc herniation
		LIU Xiaoyan1 ZHANG Ying2 WANG Chunfang2 SUN Changcheng2 WANG Zhonghan2
		Objective To observe the clinical effect of non-operative spinal decompression system combined with McKenzie therapy in the treatment for lumbar disc herniation. Methods A total of 95 patients with lumbar disc herniation admitted to the Department of Rehabilitation Medicine, Tianjin People’s Hospital from September 2020 to July 2021 were selected and divided into control group 1 (31 cases), control group 2 (32 cases), and combined group (32 cases) according to random number table method. The control group 1 was treated with non-operative spinal decompression system, and the control group 2 was treated with McKenzie therapy, the combined group was treated with non-operative spinal decompression system combined with McKenzie therapy. All of the three groups received four weeks of treatment, five days of continuous treatment per week. Visual analogue scale (VAS) score, Oswestry disability index (ODI), Japanese Orthopaedic Association (JOA) lumbar function score, root mean square (RMS) value of semg signal on erector spine surface, and flexion and extension ratio (FER) were compared between the two groups before and after treatment. The clinical efficacy of the two groups was compared. Results During the treatment, there were one case of detachment in control group 1, two cases in control group 2, and two cases in combined group, and 90 cases were eventually included in the study. After treatment, VAS score, ODI, and RMS in the three groups were lower than those before the treatment, JOA lumbar function score and FER were higher than those before the treatment, and VAS score, ODI, and RMS in the combined group were lower than those in the control group 1 and 2, while JOA lumbar function score and FER were higher than those in the control group 1 and 2, the differences were statistically significant (P ＜ 0.05). After treatment, the clinical efficacy of combined group was better than control group 1 and 2, the difference was statistically significant (P ＜ 0.05). Conclusion Non-operative spinal decompression system combined with McKenzie therapy can improve the strength of lumbodorsal muscles, strengthen the stability of spinal muscles and function, further reduce muscle tension, relieve clinical symptoms, and thus improve the function of lumbar spine and the ability of daily living.
		2022 Vol. 19 (21): 99-102,118 [Abstract] ( 58 ) HTML (1 KB) PDF (688 KB) ( 31 )

	103	Effect of electromyographic biofeedback complicated with resistance training on rehabilitation of elderly patients with knee osteoarthritis
		TANG Fengjuan1 WANG Jiao2
		Objective To analyze the effect of electromyographic biofeedback complicated with resistance training in elderly patients with knee osteoarthritis (KOA). Methods A total of 100 elderly patients with KOA admitted to West China Hospital, Sichuan University from July 2019 to January 2021 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 50 cases in each group. The control group received routine rehabilitation therapy and resistance training, and the observation group received routine rehabilitation therapy and electromyographic biofeedback combined with resistance training. The intervention lasted for 21 days. Visual analog scale (VAS), Western Ontario and McMaster University (WOMAC) osteoarthritis index scale, Lysholm knee score, and isokinetic muscle force parameters (peak moment [PT], total work [TW], work fatigue [WF]) were assessed before and after intervention. The incidence of adverse events in the two groups during intervention was analyzed. Results After intervention, Lysholm knee score in both groups was higher than before intervention, and the observation group was higher than the control group (P ＜ 0.05). After intervention, VAS and WOMAC osteoarthritis index scale scores of the two groups were lower than before intervention, and the observation group was lower than the control group (P ＜ 0.05). After intervention, PT, TW, and WF of knee extension in both groups were higher than before intervention, and the observation group was higher than the control group (P ＜ 0.05). There was no significant difference in the total incidence of adverse events between the two groups (P ＞ 0.05). Conclusion Electromyographic biofeedback combined with resistance training in elderly patients with KOA can effectively reduce pain, enhance anti-fatigue ability, and improve knee function, which is worthy of clinical promotion.
		2022 Vol. 19 (21): 103-106 [Abstract] ( 61 ) HTML (1 KB) PDF (591 KB) ( 28 )

	107	Clinical effect of Fufang Zilian Ointment combined with Hydrocortisone Butyrate Cream in the treatment of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome
		GONG Ke1 GUO Jianhui1 DU Kaiqing1 GUO Wen1 ZHANG Xianzhe1 ZHANG Man1 CUI Yaxin2 LIU Jiayao2
		Objective To observe the clinical effect of Fufang Zilian Ointment combined with Hydrocortisone Butyrate Cream in the treatment of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome. Methods A total of 100 cases of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome from December 2020 to July 2021 in Department of Dermatology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei University of Traditional Chinese Medicine were selected. They were divided into treatment group and control group, with 50 cases in each group. The control group was treated with Hydrocortisone Butyrate Cream, and treatment group was treated with Fufang Zilian Ointment on the basis of control group. After two weeks of treatment, the clinical efficacy of two groups was observed; eczema area and severity index (EASI) score, traditional Chinese medicine syndrome score, transepidermal waterloss (TEWL) and the occurrence of adverse reactions in two groups were compared; two weeks after the end of treatment, the recurrence rate was counted. Results After two weeks of treatment, EASI score, traditional Chinese medicine syndrome score and TEWL in two groups were lower than those before treatment, and treatment group was lower than control group, and the differences were statistically significant (P < 0.05). The clinical efficacy of treatment group was better than that of control group, and the difference was statistically significant (P < 0.05). The recurrence rate of treatment group was lower than that of control group, and the difference was statistically significant (P < 0.05). No obvious discomfort and no adverse events occurred in the two groups during treatment. Conclusion Fufang Zilian Ointment combined with Hydrocortisone Butyrate Cream can significantly improve the skin lesions and symptoms of subacute infantile eczema with spleen deficiency and dampness accumulation syndrome, with good clinical efficacy and low recurrence rate, which is worthy of clinical promotion and further research.
		2022 Vol. 19 (21): 107-110 [Abstract] ( 62 ) HTML (1 KB) PDF (549 KB) ( 83 )

	111	Relationship between ultrasound umbilical artery blood flow parameters and fetal distress at different gestational ages
		JIANG Xue1 LU Rui1 HE Xiao2
		Objective To analyze the relationship between ultrasound umbilical artery blood flow parameters and fetal distress at different gestational ages. Methods A total of 136 pregnant women who underwent prenatal examination in the Affiliate Shuyang Hospital, College of Medicine, Yangzhou University from October 2019 to March 2021 were selected as the research objects. According to the gestational age, they were divided into 4-12+ weeks group (38 pregnant), 13-27+ weeks group (41 pregnant), and 28-40 weeks group (57 pregnant). The incidence of fetal distress, parameters of umbilical artery (pulse index [PI], resistance index [RI], and peak systolic flow rate / end diastolic flow rate [S/D]) were compared among three groups; the correlation between umbilical artery blood flow parameters of different gestational ages and fetal distress was analyzed. Results There was statistical difference in the incidence of fetal distress among three groups (P < 0.05). PI, RI, and S/D values in 4-12+ weeks group were higher than those in 13-27+ weeks group and 28-40 weeks group, and PI, RI, and S/D values in 13-27+ weeks group were higher than those in 28-40 weeks group, and the differences were statistically significant (P < 0.05). The incidence of fetal distress was positively correlated with PI, RI, and S/D values at different gestational ages (r > 0, P < 0.05). Conclusion PI, RI, and S/D values of umbilical artery blood flow were different in different gestational ages, and PI, RI, and S/D values were positively correlated with the incidence of fetal distress.
		2022 Vol. 19 (21): 111-114 [Abstract] ( 54 ) HTML (1 KB) PDF (535 KB) ( 32 )

	115	Effect of batroxobin combined with citicoline sodium in the treatment of senile sudden deafness in elder
		YANG Yun1 LANG Yongyao1 LIU Qing1 SHI Jianhua2▲
		Objective To investigate the effect of batroxobin combined with citicoline sodium in the treatment of senile sudden deafness. Methods A total of 92 elderly patients with sudden deafness who were admitted to Jiangsu Shengze Hospital, Nanjing Medical University from July 2018 to July 2020 were selected and divided into combination group and control group according to random number table method, with 46 cases in each group. The control group was treated with citicoline sodium, while the combined group was treated with batroxobin combined with citicoline sodium. The disappearance time of clinical symptoms, clinical efficacy, coagulation function, microcirculation, and adverse drug reactions were compared between the two groups. Results There was no significant difference in the disappearance time of vertigo and tinnitus between the two groups (P ＞ 0.05); the disappearance time of ear fullness and hearing recovery time in the combined group were shorter than those in the control group (P ＜ 0.05). The clinical efficacy of the combination group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the prothrombin time and thrombin time of the two groups were higher than those before treatment, while the combined group was higher than the control group, and the differences were statistically significant (P ＜ 0.05); the levels of fibrinogen in the two groups were lower than those before treatment, while the combined group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The levels of endothelin in the two groups were lower than before treatment, while the combination group was lower than the control group, and the differences were statistically significant (P ＜ 0.05); the levels of nitric oxide in the two groups were higher than those before treatment, while the combined group was higher than the control group, with statistical significance (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Batroxobin combined with citicoline sodium for the treatment of senile sudden deafness can improve clinical symptoms, the effect is exact, and it can improve coagulation function and microcirculation index, and it is safe and reliable.
		2022 Vol. 19 (21): 115-118 [Abstract] ( 53 ) HTML (1 KB) PDF (561 KB) ( 44 )

	119	Effect of Tanreqing Injection on the treatment of stroke-associated pneumonia and its effect on bacterial clearance
		WANG Jingtao SHANG Bing▲
		Objective To explore the effect of Tanreqing Injection on the treatment of stroke-associated pneumonia (SAP) and its effect on bacterial clearance. Methods A total of 84 SAP patients admitted to Nanjing Tongren Hospital, Southeast University School of Medicine from July 2018 to April 2021 were selected as the research subjects. They were divided into the observation group and the control group according to the random number table method, with 42 cases in each group. The control group was treated with Cefoperazone / Sulbactam, the observation group was treated with Tanreqing Injection on the basis of the control group. Traditional Chinese medicine syndrome score, clinical efficacy, bacterial clearance, serum inflammatory factor level (tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6] and C-reaction protein [CRP]) and the occurrence of adverse drug reactions were evaluated after one week of treatment. Results After one week of treatment, traditional Chinese medicine syndrome scores of the two groups were lower than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (P < 0.05). The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P < 0.05). The total clearance rate of pathogens in the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After one week of treatment, the levels of TNF-α, IL-6, and CRP in the two groups were lower than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The treatment of Tanreqing Injection combined with Cefoperazone / Sulbactam for SAP patients can effectively improve the clinical treatment effect of patients, reduce traditional Chinese medicine syndrome scores, increase pathogen clearance, reduce inflammation, and have good safety.
		2022 Vol. 19 (21): 119-122 [Abstract] ( 74 ) HTML (1 KB) PDF (567 KB) ( 34 )

	123	The value of traditional Chinese medicine knowledge protection from the origin of traditional Chinese medicine#br#
		SHI Xueqin LIU Qian WANG Liuqing QIN Peijie AN Hong LI Yu WANG Shiheng LIU Jianfeng
		Traditional Chinese medicine has a long history and is in the stage of continuous development and progress. However, the current status of traditional Chinese medicine inheritance is not optimistic, and many excellent traditional Chinese medicine knowledge is on the verge of being lost. On the basis of facing up to the indelible historical value of traditional Chinese medicine and the current status of traditional Chinese medicine, it is urgent to do a good job in the protection of traditional Chinese medicine knowledge, which requires us to have a deeper understanding of traditional Chinese medicine knowledge and the connotation of it, and fully grasp the protection value of traditional Chinese medicine knowledge. The protection of traditional Chinese medicine knowledge is of great value, it can solve the “pain of not being passed on” of traditional Chinese medicine and improve the clinical service capacity of traditional Chinese medicine, “innovation” development of traditional Chinese medicine on the basis of “inheritance”, promote the modernization of traditional Chinese medicine, and can enhance public recognition of traditional Chinese medicine and cultivate confidence in traditional Chinese medicine culture.
		2022 Vol. 19 (21): 123-126 [Abstract] ( 62 ) HTML (1 KB) PDF (625 KB) ( 57 )

	131	Yuan Shaoying’s experience in treating female infertility based on the concept of “harmony, conservation, adjustment and integration”#br#
		YE Qiwen1 HUANG Ting2 WANG Youlian2 QIN Zhan2 HE Chaoba2 YUAN Shaoying2
		This article summarizes Professor Yuan Shaoying’s experience in the treatment of female infertility based on the concept of “harmony, conservation, adjustment and integration”, provides a clinical case which offers new references and thoughts in the treatment of this disease. Professor Yuan Shaoying believes that the causes of this disease are complex and varied, so its treatment should be fully analyzed and flexibly follow the treatment concept of “harmony, conservation, adjustment and integration”.“Harmony” refers to harmonizing yin and yang, regulating qi and blood, pleasure of modern, eating and living regularly, etc. “Conservation” refers to clinical adherence to the principle of syndrome differentiation and treatment, taking kidney as the root, coordinating liver and spleen, giving consideration to heart and lung. “Adjustment” refers to the flexible use of drugs according to the situation, people and time. “Integration” refers to the integration of internal treatment of traditional Chinese medicine therapy and modern medicine with traditional characteristic therapy to improve the curative effect.
		2022 Vol. 19 (21): 131-135 [Abstract] ( 56 ) HTML (1 KB) PDF (824 KB) ( 57 )

	136	Clinical effect of self-designed Xiaozhang Qingsu Decoction combined with lifting feet to pick up zúsānlǐ acupoints in the treatment of habitual constipation with yin deficiency and intestinal dryness type
		ZHANG Xiaoyu1 YANG Xin2 WANG Fenglin3 WANG Surui1 GAO Xue3 CAO Xueli4
		[Abstract] Objective To observe the clinical effect of self-designed Xiaozhang Qingsu Decoction combined with lifting feet to pick up zúsānlǐ acupoints in the treatment of habitual constipation with yin deficiency and intestinal dryness type. Methods Eighty patients with habitual constipation with yin deficiency and intestinal dryness type hospitalized in Sanhe Hospital of Hebei Province from September 2020 to March 2021 were selected as the research objects. They were divided into treatment group and control group according to random number table method, with 40 cases in each group. The treatment group was treated with self-designed Xiaozhang Qingsu Decoction combined with lifting feet to pick up zúsānlǐ acupoints. The control group was treated with self-designed Xiaozhang Qingsu Decoction. The levels of serum 5-hydroxytryptamine (5-HT), substance P (SP), somatostatin (SS), and the curative effect of traditional Chinese medicine were compared between the two groups. Results After treatment, the serum 5-HT levels in two groups were higher than those before treatment, and treatment group was higher than control group (P < 0.05). After treatment, the levels of serum SP in the two groups were higher than those before treatment, and the levels of serum SS in the two groups were lower than those before treatment, and the level of serum SP in treatment group was higher than that in control group, and the level of serum SS in treatment group was lower than that in control group (P < 0.05). The curative effect of traditional Chinese medicine in treatment group was better than that in control group (P < 0.05). Conclusion The effect of self-designed Xiaozhang Qingsu Decoction combined with lifting feet to pick up zúsānlǐ acupoints in the treatment of habitual constipation with yin deficiency and intestinal dryness type is remarkable. It can alleviate the constipation symptoms of patients. The operation is safe and quick effect. It is suitable for clinical application.
		2022 Vol. 19 (21): 136-139,152 [Abstract] ( 61 ) HTML (1 KB) PDF (737 KB) ( 40 )

	140	Discussion on Cui Jinhai’s experience in preventing the recurrence of ischemic stroke by regulating qi and dissipating phlegm method
		WANG Kaicheng1 WANG Xiufang2 LU Chengjie3 HAN Lijuan4 LI Hailin5 GENG Chunying6 FAN Zhizhong7 CUI Jinhai8
		[Abstract] This paper discusses Cui Jinhai’s experience in preventing the recurrence of ischemic stroke by regulating qi and dissipating phlegm method, discusses the etiology and disease mechanism of ischemic stroke, and analyzes the factors causing ischemic stroke. The method of regulating qi and dissipating phlegm has a good effect on the control of ischemic stroke. A comprehensive analysis of Cui Jinhai’s application of the method of regulating qi and dissipating phlegm can well master the medical knowledge applied by the prevention method, which is conducive to clinical workers to better understand the disease. At the same time, study on Cui Jinhai’s experience in preventing the recurrence of ischemic stroke by regulating qi and dissipating phlegm method is conducive to the clinical prevention of this disease and is of great significance to prevent the recurrence of ischemic stroke. Therefore, this paper mainly discusses Cui Jinhai’s experience in preventing the recurrence of ischemic stroke by regulating qi and dissipating phlegm method.
		2022 Vol. 19 (21): 140-143 [Abstract] ( 58 ) HTML (1 KB) PDF (581 KB) ( 54 )

	144	Summary of Professor Song Aili’s experience in treating menopausal-like syndrome in endocrine therapy of breast cancer
		LIU Bingwei1 SHI Guangxi2 LIU Xiaofei2 LI Jingwei2
		Professor Song Aili is a senior well-known traditional Chinese medicine physician, who has rich clinical experience. She considers that the deficiency of kidney essence is the root cause of menopausal-like syndrome in endocrine therapy of breast cancer. And the pathogenetic character is that deficiency of kidney is the root, phlegm and toxin is the manifestation. According to years of clinical experience, combined with the relationship between the five viscera, Professor Song Aili thinks the disease can be divided into three syndromes, such as the yin deficiency of liver and kidney, the yang deficiency of spleen and kidney, and the disharmony between heart and kidney. The general principle of treatment is focusing on nourishing kidney and tonifying kidney to treat its root, and removing dampness and dissipating phlegm, clearing heat and removing toxicity to treat its manifestation, in the deficiency while not forgetting to remove evil to inhibit the development of cancer. According to the difference between these syndromes, she uses treatments like dispersing stagnated liver qi for relieving qi stagnation, nourishing qi to invigorate spleen, clearing heart and removing trouble. Professor Song Aili pays attention to the function of spleen and stomach, and thinks that the prescription should be stopped as soon as the syndrome is cured in order not to harm spleen and stomach. The spleen being acquired foundation, the source of qi and blood biochemistry, tonifying kidney also needs to tonify spleen. Erxian Decoction, Erzhi Pills, Buzhong Yiqi Decoction and other prescriptions are often used in clinic, and the clinical effect is remarkable. Therefore, to summarize professor Song Aili’s clinical syndrome differentiation thinking, in order to provide experience for traditional Chinese medicine treatment of menopausal-like syndrome in endocrine therapy of breast cancer.
		2022 Vol. 19 (21): 144-147 [Abstract] ( 58 ) HTML (1 KB) PDF (606 KB) ( 42 )

	148	Wu Yuning’s experience in treating adenomyosis from “phlegm, blood stasis, toxin and heat intermingle”
		QI Jun ZHAO Wei WU Yuning
		Adenomyosis is a kind of gynecological disease that is difficult to treat. Its focus is progressive aggravation, which makes the uterus gradually increased. It is often accompanied by severe dysmenorrhea and excessive menstruation, so it is very difficult to treat. Wu Yuning, a famous medical teacher of capital state, has rich experience in the diagnosis and treatment of this disease. She believes that “phlegm, blood stasis, toxin and heat intermingle” is its basic pathogenesis, and the disease is located in the collaterals and uterus. Because the clinical symptoms of non menstrual period are not obvious, but the symptoms in menstrual period are serious, so she proposed to discuss the treatment in stages. For the treatment of non menstrual period, it is mainly to eliminate blood stasis and phlegm, remove toxicity for eliminating accumulation, and take into account the menstrual cycle. She is good at using insect medicine, and pays attention to strengthening righteousness, dispelling evil, and protecting stomach qi. Menstrual symptoms should be treated with “Tiaojing Decoction” to promote blood circulation and remove blood stasis, which is also used to relieve pain and regulate menstruation. She used the prescriptions flexibly to relieve the symptoms of dysmenorrhea and control the amount of menstruation. The drug is unique and the clinical effect is remarkable. In this paper, Wu Yuning’s clinical experience in the treatment of adenomyosis is summarized. Moreover, the academic experience of famous Chinese doctors can be learned, the level of treatment can also be improved. Last but not least, a typical medical case is attached for peer’s reference.
		2022 Vol. 19 (21): 148-152 [Abstract] ( 63 ) HTML (1 KB) PDF (800 KB) ( 87 )

	153	Study of the translation of medical classics of Chinese ethnic minorities Yinshan Zhengyao #br#
		WANG Shanshan1 ZHAO Xia1 WANG Tianfang2
		This paper probes into the problems and difficulties in translating the medical classics of Chinese ethnic minorities and further discusses the solutions through the study of the first English version of Yinshan Zhengyao. By analyzing the translation of its title, medical theory, traditional Chinese medicine terms, ingredients, diet names, health cultivation concepts and taboos, it puts forwards that the translators should overcome the difficulties in language and culture, be faithful to the original work, follow the principles of nationality and integrating various appropriate transtation strategies and methods for better translation on the basis of maintaining the characteristics of ethnic medicine culture so as to promote the international communication of the traditional Chinese medicine culture.
		2022 Vol. 19 (21): 153-156 [Abstract] ( 59 ) HTML (1 KB) PDF (685 KB) ( 89 )

	157	Effect of graded nursing mode guided by SOFA score on rehabilitation effect and discharge readiness of patients after lung transplantation
		CHEN Haixia1 WU Ting2▲
		Objective To investigate the effect of graded nursing mode on rehabilitation effect and discharge readiness after lung transplantation under sequential organ failure assessment (SOFA) score. Methods A total of 90 lung transplant patients were selected from Wuxi People’s Hospital of Jiangsu Province from January 2019 to May 2021, they were divided into control group and observation group according to odd or even order of admission, with 45 cases in each group. The control group was in routine nursing mode, and the observation group was in graded nursing mode under SOFA score. The incidence of complications was compared between the two groups; lung function indexes and discharge readiness were compared before and after four weeks of nursing. Results The incidence of total complications in observation group was lower than that in control group (P ＜ 0.05); after four weeks of nursing, total lung capacity, forced expiratory volume, and cardiac function indexes of forced expiratory volume in the first second in both groups were increased, and the observation group was higher than the control group (P ＜ 0.05). The scores of discharge readiness scale in both groups were increased, and the observation group was higher than the control group (P ＜ 0.05). Conclusion The graded nursing mode under SOFA score was applied to patients after lung transplantation to reduce the occurrence of postoperative complications, promote the recovery of lung function, and improve the patient’s discharge readiness.
		2022 Vol. 19 (21): 157-160 [Abstract] ( 63 ) HTML (1 KB) PDF (573 KB) ( 22 )

	161	Effect of path-based rehabilitation training on self-management ability and rehabilitation effect of patients with acute myocardial infarction after PCI
		ZHAI Wenting1 LU Fangfang1▲ DAI Lu2
		Objective To explore the effect of path-based rehabilitation training on self-management ability and rehabilitation effect of patients with acute myocardial infarction after percutaneous coronary intervention (PCI). Methods A total of 132 patients with acute myocardial infarction after PCI who were admitted to the Huaian First Hospital Affiliated Nanjing Medical University from July 2018 to June 2019 were selected, and they were divided into observation group (66 cases) and control group (66 cases) by random number table method. Routine nursing intervention and rehabilitation training guidance for the control group, and the observation group was combined with path-based rehabilitation training management on the basis of the control group. The patients were followed up for six months, self-management ability and cardiopulmonary function were compared between the two groups. Results After six months of follow-up, the scores of self-management ability in both groups were higher than before management, and the observation group was higher than the control group (P ＜ 0.05). Left ventricular ejection fraction, maximum metabolic equivalent, and maximum oxygen uptake in two groups were higher than before management, and observation group was higher than control group (P ＜ 0.05). Conclusion Path-based rehabilitation training can improve the self-management ability of patients with acute myocardial infarction after PCI and promote the recovery of cardiopulmonary function.
		2022 Vol. 19 (21): 161-164 [Abstract] ( 56 ) HTML (1 KB) PDF (541 KB) ( 32 )

	165	Application of nursing intervention based on protective motivation theory in patients with inflammatory bowel disease
		LI Yunfei LI Chunmei WANG Yan▲
		Objective To explore the effect of nursing intervention based on protective motivation theory in patients with inflammatory bowel disease. Methods A total of 200 patients with inflammatory bowel disease admitted to Department of Gastroenterology, Affiliated Hospital of Yangzhou University from October 2017 to October 2020 were selected, according to the random number table method, they were divided into control group (n = 100) and experimental group (n = 100). The control group received routine nursing, and the experimental group received nursing measures based on protective motivation theory. Both groups continued nursing for three months, self-management ability, quality of life, and treatment compliance were used to evaluate the effect of intervention. Results After intervention, the scores of self-management ability in both groups were higher than those before intervention, and those in experimental group were higher than those in control group (P ＜ 0.05). Scores of all life quality dimensions in experimental group were lower than those before intervention, and those in experimental group were lower than those in control group (P ＜ 0.05); the scores of medication compliance and life compliance in both groups were higher than those before intervention, and the experimental group was higher than the control group (P ＜ 0.05). Conclusion Nursing intervention based on protective motivation theory has a significant effect on inflammatory bowel disease patients.
		2022 Vol. 19 (21): 165-168 [Abstract] ( 67 ) HTML (1 KB) PDF (475 KB) ( 32 )

	169	Clinical effect and value of evidence-based nursing in children with pertussis
		YI Man LIANG Juan HE Jinxiao LI Jingjing ZHU Yaqiong▲
		Objective To explore the effect of evidence-based nursing on children with pertussis. Methods A total of 46 children with pertussis treated in Xijing Hospital, the First Affiliated Hospital of Air Force Military Medical University from March 2019 to April 2020 were selected and they were divided into control group and observation group by random number table method, with 23 cases in each group. Routine nursing was given in the control group, and then evidence-based nursing was given in the observation group. Both groups were intervened for two weeks. The duration of related symptoms, length of hospital stay, occurrence of complications, and improvement of psychological state of family members were observed. Results After intervention, the time of vomiting caused by cough, the time of bluish complexion, the time of hearing lung rales, the time of crowing echo, spasmodic cough, and hospital stay in the observation group were shorter than those in the control group (P ＜ 0.05). After intervention, the scores of Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) in the families of the two groups were decreased, and the knowledge cognition scores were increased, and the HAMD and HAMA scores in the observation group were lower than those in the control group, while the knowledge cognition scores were higher than those in the control group (P ＜ 0.05). The total efficacy of observation group was better than control group, and the total incidence of complications was lower than control group (P ＜ 0.05). Conclusion Evidence based nursing in the nursing of children with pertussis can effectively accelerate the relief time of symptoms and signs of children, improve the psychological state of family members, improve their disease knowledge and cognition, and significantly reduce complications.
		2022 Vol. 19 (21): 169-172 [Abstract] ( 61 ) HTML (1 KB) PDF (625 KB) ( 30 )

	173	Application effect of predictive nursing care intervention in patients with chronic cervicitis
		ZHANG Ying SU Xiaohua LI Chunchun▲
		Objective To explore the predictive intervention measures and effect in nursing care of patients with chronic cervicitis. Methods A total of 90 patients with chronic cervicitis treated in the Department of Obstetrics and Gynecology of Tangdu Hospital, Air Force Military Medical University from May 2020 to August 2021. According to random number table method, they were divided into routine group and intervention group. The routine group (45 cases) received routine nursing intervention, and the intervention group (45 cases) received predictive nursing intervention on the basis of routine nursing. The intervention time of both groups was two weeks. The knowledge of disease, the improvement of negative emotion, the clinical effect, and the occurrence of complications were observed. Results After the interwention, the score of disease knowledge in both groups were higher than before intervention, and the score of intervention group was higher than that of routine group, the differences were statistically significant (P ＜ 0.05); the scores of self-rating depression scale and self-rating anxiety scale in the two groups were lower than those before the intervention, and the scores of the intervention group were lower than those of the routine group, the differences were statistically significant (P ＜ 0.05); the total clinical effective rate of the intervention group was higher than that of the routine group, and the total incidence of complications was lower than that of the routine group, the differences were statistically significant (P ＜ 0.05). Conclusion Predictive nursing intervention during drug and physical therapy for patients with chronic cervicitis, can help patients improve their awareness of disease knowledge, alleviate their negative emotions, contribute to the overall effect of disease treatment and reduce complications.
		2022 Vol. 19 (21): 173-176 [Abstract] ( 64 ) HTML (1 KB) PDF (575 KB) ( 39 )

	177	Evaluation and analysis of psychological and health education status of nurses in infectious diseases ward
		HE Caiyu YAN Dingyan ZHU Yuzhu LI Er▲
		Objective To explore the psychological and health education status of nursing staff in infectious disease ward of Hangzhou Xixi Hospital, and to provide basis for taking targeted measures. Methods A total of 86 nurses working in the Department of Infectious Diseases, Hangzhou Xixi Hospital, from January 2021 to May 2021 were selected as the study subjects. The self-rating depression scale (SDS), self-rating anxiety scale (SAS) and self-rating psychiatric symptom scale (SCL-90) were used to evaluate the psychological status of nursing staff, and the evaluation results were compared with the domestic norm consistent with baseline; and the knowledge-attitude-belief-behavior (KABP) questionnaire was used to evaluate the health education status of nursing staff. Results The SDS and SAS scores of nurses in infectious disease wards were higher than the domestic norm, the differences were statistically significant (P ＜ 0.05); the SCL-90 scores of nurses in infectious disease wards were higher than the domestic norm, the differences were statistically significant (P ＜ 0.05); knowledge: the correct answer rate of nurses was 88.37%; attitudes and beliefs: 98.84% of nurses hoped to master more knowledge about infectious diseases, 97.67% of nurses thought it was necessary to carry out health education on infectious diseases for all medical staff and were obliged to carry out health education on infectious diseases for patients, 77.91% of nurses that knowing the transmission route and preventive measures of infectious diseases could reduce the fear of nursing; behavior: 95.35% of nurses wear gloves when injecting and collecting blood for infectious disease patients, 93.02% of nurses wash hands with soap before and after operation, 96.51% of nurses can use disinfectant to disinfect the table with blood of infectious disease patients and then clean it. Conclusion The psychological condition of nurses in infectious disease ward is not good, the hospital and all walks of life should give infectious disease ward nurses psychological counseling, psychological care, and social support, and further strengthen the targeted health education, so as to enhance the awareness of protection.
		2022 Vol. 19 (21): 177-180 [Abstract] ( 65 ) HTML (1 KB) PDF (572 KB) ( 48 )

	181	Effect of nursing intervention based on hope theory on symptom distress and quality of life of patients with breast cancer after chemotherapy
		SUN Xiuxia PENG Yongqiang WANG Xiaodong
		Objective To explore the effect of intervention plan based on hope theory applied to breast cancer patients during chemotherapy. Methods A total of 80 breast cancer patients undergoing chemotherapy were selected from the Department of Nail and Breast Surgery, Bozhou People’s Hospital from January 2020 to Jun 2021, and they were divided into hope nursing group (40 cases, nursing intervention based on hope theory) and routine group (40 cases, routine nursing only) by random number table method. The incidence of chemotherapy toxicity, symptom distress, hope level and quality of life were compared between the two groups. Results The incidence of nausea vomiting and diarrhea in nursing group was lower than that in conventional group (P ＜ 0.05). After intervention, symptom distress in the hope nursing group was lower than before intervention, symptom distress in the conventional group was higher than before intervention, and symptom distress in the hope nursing group was lower than the conventional group (P ＜ 0.05). After intervention, Herth hope index (HHI) scores in both groups were higher than those before intervention, functional assessment cancerthrapy (FACT-G) scale scores in hope nursing group were higher than those before intervention, HHI and FACt-G scale scores in hope nursing group were higher than those in conventional group (P ＜ 0.05). Conclusion The intervention plan based on hope theory can relieve the symptoms caused by chemotherapy and improve the quality of life of breast cancer patients.
		2022 Vol. 19 (21): 181-184 [Abstract] ( 64 ) HTML (1 KB) PDF (585 KB) ( 43 )

	185	A case report and literature review prostatic adenocarcinoma transformed into neuroendocrine tumor of the prostate
		YIN Zhucheng LIANG Xinjun
		Neuroendocrine tumor of the prostate is a rare malignant tumor. In order to improve the understanding of neuroendocrine tumor of the prostate, this study retrospectively analyzed the data of one case of prostate adenocarcinoma transformed into neuroendocrine tumor of the prostate in Hubei Cancer Hospital. The clinical and pathological features, diagnosis, and treatment and prognosis of neuroendocrine tumor of the prostate were reviewed in combination with relevant literature. Neuroendocrine tumor of the prostate is rare, and some of them are prostate adenocarcinoma transformed into neuroendocrine tumor after androgen deprivation therapy. The diagnosis is based on clinical and pathological diagnosis. Neuroendocrine tumor of the prostate has a high degree of malignancy. The treatment is mainly chemotherapy, and the prognosis is poor.
		2022 Vol. 19 (21): 185-188 [Abstract] ( 63 ) HTML (1 KB) PDF (701 KB) ( 71 )

	189	A case report and literature review treatment of squamous cell lung cancer combined with pulmonary sarcomatoid carcinoma
		LONG Yunzhi1 ZHANG Xiangyan2▲ SHAO Songjun2 WANG Guoyu2
		Squamous cell lung cancer is a unique histological subtype of non-small cell lung cancer, its special clinicopathological features and molecular background determine the limitation of its treatment, pulmonary sarcomatoid canceration is a type of non-small cell lung cancer, contains elements of sarcoma or sarcomatoid differentiation. A malignant tumor of mixed epithelial and mesenchymal tissue, represents a whole continuum of epithelial and mesenchymal differentiation. It is a kind of poorly differentiated lung malignant tumor with rapid clinical progress and rare occurrence. It is rare to have both, treatment is also tricky. Combined with relevant literature review, the clinical data of a patient diagnosed with squamous cell lung cancer complicated with pulmonary sarcomatoid canceration recently admitted to the Department of Respiratory and Critical Medicine of the Affiliated People’s Hospital of Guizhou Medical University were analyzed, in order to improve clinicians’ understanding of the disease.
		2022 Vol. 19 (21): 189-192 [Abstract] ( 81 ) HTML (1 KB) PDF (1186 KB) ( 48 )

	193	Exploration and practice of cultivation of innovation ability of undergraduates majoring in basic medical sciences
		XU Qi Dilinaer Bolati GAO Fanfan Gulibahaer Ainiding BAI Shengbin
		The cultivation of top talents in basic medical science is not only the cornerstone of modern medical progress, but also the urgent need to implement the strategy of “Healthy China”. According to the professional training goal and the need of the academic career planning, Xinjiang Medical University cultivate students’ innovative ability by stages through the whole-course tutorial system. Meanwhile, the three-dimensional teaching and research platform is constructed by promoting curriculum construction, and based on project, the innovation ability of scientific research is integrated into the whole process of undergraduate education. The cultivation of top talents in basic medical science has been explored and practiced, and good results have been achieved. It is hoped to provide practice reference for the cultivation of top-notch talents in basic medical sciences.
		2022 Vol. 19 (21): 193-196 [Abstract] ( 62 ) HTML (1 KB) PDF (741 KB) ( 94 )

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