巴曲酶联合胞磷胆碱钠治疗老年突发性聋的效果

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Abstract Objective To investigate the effect of batroxobin combined with citicoline sodium in the treatment of senile sudden deafness. Methods A total of 92 elderly patients with sudden deafness who were admitted to Jiangsu Shengze Hospital, Nanjing Medical University from July 2018 to July 2020 were selected and divided into combination group and control group according to random number table method, with 46 cases in each group. The control group was treated with citicoline sodium, while the combined group was treated with batroxobin combined with citicoline sodium. The disappearance time of clinical symptoms, clinical efficacy, coagulation function, microcirculation, and adverse drug reactions were compared between the two groups. Results There was no significant difference in the disappearance time of vertigo and tinnitus between the two groups (P ＞ 0.05); the disappearance time of ear fullness and hearing recovery time in the combined group were shorter than those in the control group (P ＜ 0.05). The clinical efficacy of the combination group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the prothrombin time and thrombin time of the two groups were higher than those before treatment, while the combined group was higher than the control group, and the differences were statistically significant (P ＜ 0.05); the levels of fibrinogen in the two groups were lower than those before treatment, while the combined group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The levels of endothelin in the two groups were lower than before treatment, while the combination group was lower than the control group, and the differences were statistically significant (P ＜ 0.05); the levels of nitric oxide in the two groups were higher than those before treatment, while the combined group was higher than the control group, with statistical significance (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Batroxobin combined with citicoline sodium for the treatment of senile sudden deafness can improve clinical symptoms, the effect is exact, and it can improve coagulation function and microcirculation index, and it is safe and reliable.

Key words： Batroxobin Citicoline sodium Elderly Sudden deafness Blood coagulation Microcirculation

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	YANG Yun1 LANG Yongyao1 LIU Qing1 SHI Jianhua2▲

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YANG Yun1 LANG Yongyao1 LIU Qing1 SHI Jianhua2▲. Effect of batroxobin combined with citicoline sodium in the treatment of senile sudden deafness in elder[J]. 中国医药导报, 2022, 19(21): 115-118.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I21/115

[1] 冰丹，兰兰，关静，等.年龄对突发性耳聋的预后影响[J].中华耳科学杂志，2018，16（3）：312-318.
[2] 金凤，顾向阳，霍俊.长春西汀联合纤溶酶治疗突发性耳聋的临床研究[J].现代药物与临床，2019，34（5）：1440-1445.
[3] 谭凌翔，张玲.老年突发性耳聋的临床特点及影响治疗效果的因素分析[J].中国医师杂志，2018，20（4）：535-537，542
[4] 李欣，陈雯婧，伊海金，等.巴曲酶联合甲强龙对突发性聋患者听力和凝血功能，血流变学的影响[J].血栓与止血学，2020，26（3）：88-89.
[5] 同娟，马永红.高压氧联合胞磷胆碱钠对突发性耳聋患者听力水平的影响[J].山西医药杂志，2020，49（16）：2138-2140.
[6] 高晓燕，高晓星，王平.巴曲酶治疗对突发性耳聋患者凝血功能与纤维蛋白原变化分析[J].贵州医药，2020，44（6）：943-944.
[7] 张旻，韩学锋，韩淼淼，等.巴曲酶在全聋型突发性聋患者常规治疗无效后的疗效观察[J].中华耳科学杂志，2019， 17（2）：218-221.
[8] 江德胜.专家诊治耳鸣耳聋[M].上海：上海科学技术文献出版社，2012：105-108.
[9] 李姝娜，李越，杨军，等.突发性聋治疗的国际共识[J].听力学及言语疾病杂志，2018，26（4）：451-452.
[10] 王文涛，陈贤明，郭文玲.血脂及凝血功能与突发性耳聋的相关性研究[J].东南国防医药，2018，20（2）：138-141.
[11] 蒋中莉，钟时勋.耳后注射甲泼尼龙治疗低频下降型突发性耳聋的疗效研究[J].重庆医学，2020，49（2）：277-279，289.
[12] 唐慧玲，郭家亮，王园.耳聋胶囊联合甲泼尼龙治疗突发性耳聋的临床研究[J].现代药物与临床，2021，36（1）：130-134.
[13] 杨明，伏飞达，朱晓燕.突发性耳聋患者血清sVCAM-1水平变化及其意义[J].中国医药导报，2018，15（15）：119-122.
[14] 陈国辉，高天乐，郭志强，等.突发性耳聋患者椎-基底动脉及眼动脉血流动力学的研究[J].临床和实验医学杂志，2021，20（18）：2001-2005.
[15] 姜思媛，侯文珍，倪光夏，等.不同电针刺激参数对突发性耳聋临床疗效的影响[J].中国针灸，2021，41（10）：1103-1107.
[16] 徐瑾，薛鑫淼，陈学敏，等.高压氧治疗突发性耳聋的效果及不良反应[J].西北国防医学杂志，2020，41（1）：63-66，封三.
[17] 李娟，高志强，高俊风，等.胞磷胆碱联合美金刚治疗血管性痴呆的临床研究[J].现代药物与临床，2018，33（9）：2218-2221.
[18] 刘文婷，蔡克万.巴曲酶对中度以上突发性耳聋临床疗效分析[J].山西医药杂志，2019，48（12）：1450-1451.
[19] 闫一敏，巩红娟，陈子涵，等.巴曲酶+地塞米松对突发性耳聋患者血液流变学的影响[J].安徽医学，2021，42（4）：421-425.
[20] 蒋晨霞，奚广军.巴曲酶与血管扩张剂治疗突发性耳聋的疗效及对凝血指标的影响[J].临床输血与检验，2019， 21（6）：571-574.
[21] 张学红，梁小微，王鸿梅，等.巴曲酶联合银杏叶注射液治疗突发性耳聋的疗效及对患者凝血功能的影响[J].河北医学，2018，24（6）：979-983.
[22] 刘亚楠，张春和，王敬敬，等.突发性耳聋患者血清CysC、ET-1表达与血流动力学及听力预后的相关性研究[J].标记免疫分析与临床，2020，27（11）：1911-1914，1969.
[23] 张炜，贾国章，杨斌，等.红花黄色素联合长春西汀对突发性耳聋疗效及血清CRP和NO的影响[J].贵州医药，2018，42（7）：819-820.
[24] 王倩滢，钟时勋.巴曲酶在不同类型突发性耳聋治疗中的应用[J].中华耳科学杂志，2018，16（2）：239-243.
[25] 郑雁.巴曲酶或血管扩张剂治疗突发性耳聋的临床疗效观察[J].血栓与止血学，2018，24（6）：987-989.