|
|
|
| Clinical study of cavernostomy and sensitive antibiotics combined with fumigation and washing with Mudanye Decoction in the treatment of chronic osteomyelitis of lower limbs |
| SHENG Kuisheng1 ZHANG Zhiguo2 XU Yanyan3 CHEN Xia3 WEI Yongli4 LI Keming5▲#br# |
1.Department of Microscopic Orthopaedic, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
2.Department of Orthopedics, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
3.Department of Nursing, Rizhao Hospital of Traditional Chinese Medicine, Shandong Province, Rizhao 276800, China;
4.Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250011, China;
5. Pharmacology Laboratory, Shandong Institute of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China |
|
|
|
Abstract
[Abstract] Objective To observe the clinical efficacy cavernostomy and sensitive antibiotics combined with fumigation and washing with Mudanye Decoction in the treatment of chronic osteomyelitis of lower limbs. Methods Eighty patients with chronic osteomyelitis of lower limbs admitted to Rizhao Hospital of Traditional Chinese Medicine, Shandong Province from January 2015 to June 2020 were selected and divided into control group and observation group by random number table method, with 40 cases in each group. The control group was treated with conventional surgical cavernostomy and sensitive antibiotic anti-infection treatment, while the observation group was treated with fumigation and washing with Mudanye Decoction on the basis of control group. After six weeks of treatment, the clinical efficacy of the two groups was compared. Visual analog scale (VAS) score, white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were compared between the two groups before and after treatment. The incidence of adverse reactions in the two groups was recorded. Results There was no significant difference in total clinical effective rate between the two groups (P ＞ 0.05). After treatment, VAS score, white blood cell count, erythrocyte sedimentation rate, and C-reactive protein in two groups were lower than those before treatment, and VAS score, erythrocyte sedimentation rate, and C-reactive protein of observation group were lower than those of control group, the differences were statistically significant (P ＜ 0.05). There were no serious adverse reactions in both groups. Conclusion The integration of traditional and Western medicine therapy of cavernostomy and sensitive antibiotics combined with fumigation and washing with Mudanye Decoction can effectively relieve pain and promote healing of local lesions of chronic osteomyelitis of lower limbs, which is a safe and effective measure.
|
|
|
|
|
|
[1] 胡秀年，刘辉.慢性骨髓炎诊断治疗研究进展[J].医学理论与实践，2017，30（15）：2215-2217.
[2] 李强，宋世锋，张伟，等.负压封闭引流联合负载万古霉素硫酸钙与自体骨治疗慢性骨髓炎的临床研究[J].中国骨伤，2017，30（11）：1059-1062.
[3] 顾玉彪，蒋国鹏，谢兴文，等.万古霉素骨水泥链珠配合中药治疗慢性骨髓炎疗效观察[J].中国中西医结合杂志，2017，37（3）：377-379.
[4] 纪建军，殷波，邓斌，等.不同外科治疗方案在胫骨慢性骨髓炎症感染及软组织缺损患者的疗效对比[J].中华医院感染学杂志，2017，27（13）：3036-3039.
[5] 黄凯，张展，刘亦杨，等.中西医结合治疗慢性创伤性股骨骨髓炎的临床疗效研究[J].中华中医药杂志，2017，32（1）：373-375.
[6] 国家中医药管理局.中医病症诊断疗效标准[M].南京：南京大学出版社，1994.
[7] 胥少汀，葛宝丰，徐印坎.实用骨科学[M].2版.北京：人民军医出版社，2006.
[8] 严广斌.视觉模拟评分法[J]．中华关节外科杂志（电子版），2014，9（2）：273.
[9] 卜凡玉，薛明宇，王进，等.改良诱导膜技术结合带蒂（肌）皮瓣治疗糖尿病患者胫骨慢性骨髓炎[J].中国修复重建外科杂志，2021，35（6）：716-721.
[10] 梁佳佳，廖涛，彭饶，等.病灶清除联合一期植入载万古霉素自固化磷酸钙骨水泥对Ⅲ/Ⅳ型慢性骨髓炎的疗效分析[J].中国医学前沿杂志（电子版），2021，13（1）：103-108.
[11] 郭保逢，赵巍，吴鸿飞，等.Ilizarov跖骨延长治疗糖尿病足溃疡并跖骨头慢性骨髓炎[J].中国修复重建外科杂志，2020，34（8）：1000-1004.
[12] 王栋，张永红，贺国宇，等.胫骨横向骨搬移技术结合抗生素骨水泥治疗下肢慢性缺血性疾病伴足踝部慢性感染[J].中国修复重建外科杂志，2020，34（8）：979-984.
[13] 朱庭标，李智，任静，等.病灶清除联合VSD及自体植骨治疗胫骨慢性骨髓炎[J].中国骨与关节损伤杂志，2019， 34（2）：205-207.
[14] 李强，宋世锋，张伟，等.负压封闭引流联合负载万古霉素硫酸钙与自体骨治疗慢性骨髓炎的临床研究[J].中国骨伤，2017，30（11）：1059-1062.
[15] 郑世维，徐浩，李黔春，等.基于中医理论探讨化脓性骨髓炎的病因病机[J].中华中医药杂志，2017，32（1）：80-83.
[16] 蒋国鹏，黄晋，李应福，等.慢性骨髓炎辨治体会[J].中医杂志，2016，57（16）：1426-1427.
[17] 段佳玉，段佳威.对附骨疽病因病机及诊治的探讨[J].北京中医药大学学报，2000，23（6）：63-64.
[18] 陈赟.牡丹叶湿敷对Ⅲ期压疮抗氧化机制研究[D].广州：广州中医药大学，2015.
[19] 郭凤，罗小勇.牡丹叶及其不同溶剂提取物对生菜等幼苗生长的抑制效应[J].杂草科学，2012，30（3）：21-26.
[20] 唐浩国，单方方，魏晓霞，等.牡丹叶总黄酮抑菌活性研究[J].时珍国医国药，2009，20（6）：1355-1357.
[21] 王玉梅，王珊珊，李付英，等.牡丹叶总苷对3T3-L1细胞葡萄糖和脂肪代谢的影响[J].药物分析杂志，2008， 28（11）：1888-1891.
[22] Jiang N，Qin CH，Hou YL，et al. Serum TNF-α，erythrocyte sedimentation rate and IL-6 are more valuable biomarkers for assisted di-agnosis of extremity chronic osteomyelitis [J]. Biomark Med，2017，11（8）：597-605.
[23] 梁宏伟，赵宝峰，张涛，等.骨炎方联合抗菌药物治疗慢性骨髓炎疗效及对患者血清炎症细胞因子影响观察[J].中国药师，2021，24（6）：1105-1108.
[24] 黄楠，齐明，张军，等.中药骨炎方治疗胫骨慢性骨髓炎的作用机制[J].中国药师，2019，22（5）：848-851.
[25] 刘念，陈伦.益气消疽方治疗慢性骨髓炎疗效观察[J].中医学报，2018，33（9）：1794-1797. |
|
|
|
