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2022 Vol. 19, No. 15 Published: 2022-05-25

	4	Effects of insulin on glutathione peroxidase expression and its significance
		MA Jinhui1 LIU Jie1 LI Yuanyuan2 SONG Yankun3 ZHENG Lishuang4 TAN Yinghui4 XI Xin4
		Objective To explore the effects of insulin on glutathione peroxidase (GSH-Px) expression and its significance. Methods The differentiation of 3T3-L1 preadipocytes were induced by cocktail method and the degree of differentiation was identified by oil red O staining; after 3T3-L1 adipocytes were treated with 500 nmol/L insulin for 1 h, the mRNA expression levels of GSH-PX1, GSH-PX4, and GSH-PX7 were detected by real-time quantitative PCR; 3T3-L1 adipocytes were pretreated with GSH-Px inhibitor Mercaptosuccinate (MS, 10, 20 mmol/L) for 30 min and then stimulated with or without 500 nmol/L insulin for 4 h, the expression level of glucose transporter 4 (GLUT4) protein was detected by Western blot. Results 3T3-L1 preadipocytes were spindle-shaped; and the cells gradually became spheroid and small lipid droplets were observed in the cells on the 5th day after induced differentiation; the cells further became spherical and the number of intracellular lipid droplets increased significantly on the 8th day after induced differentiation. The mRNA relative expression levels of GSH-Px1，GSH-Px4, and GSH-Px7 in insulin group were lower than those in control group, and the differences were statistically significant (P < 0.05); with or without insulin, there was no significant in expression of GLUT4 protein between the 10 mmol/L MS treatment group and the MS untreated group (P ＞ 0.05); the level of GLUT4 protein in 20 mmol/L MS treated group was lower than that in MS untreated group, and the difference was statistically significant (P < 0.05). Conclusion Long-term insulin stimulation inhibited GSH-Px mRNA expression, and MS inhibition of GSH-Px activity negatively regulated GLUT4 protein expression.
		2022 Vol. 19 (15): 4-7 [Abstract] ( 93 ) HTML (1 KB) PDF (827 KB) ( 68 )

	8	Effect of akupotomye on stiffness and fibrosis of rectus femoris muscle in rabbits with knee osteoarthritis
		GONG Yurong1* LIN Qiaoxuan2* LIU Jing3 GUO Zexing4 LU Liming4 XIU Zhongbiao3
		Objective To explore the effect of akupotomye on stiffness and fibrosis of rectus femoris muscle in rabbits with knee osteoarthritis (KOA). Methods Twenty-four healthy male New Zealand rabbits were divided into blank group, model group, and akupotomye group by random number table method, with eight rabbits in each group. The KOA rabbit model was made by plaster fixation of left hind limb in straight position for six weeks by modified Videman method. The model success criteria was evaluated by the Lequesne MG score of knee joint behavior ≥4 points. Akupotomye group received akupotomye release treatment for “top of the cranium”, “upper of the external iliac”, and “lower of the internal iliac”, intervention once every seven days, a total of four interventions. The blank group and model group underwent the same grasping and fixation, but no akupotomye treatment. One week after the intervention, real-time tissue elastography was performed to measure the elastic strain rate ratio to evaluate the changes in tissue hardness of rectus femoris muscle. Masson staining was used to observe the changes of tissue morphology and collagen fiber content of rectus femoris muscle. Results Compared with the blank group, the elastic strain rate ratio and collagen volume fraction of rectus femoris muscle in the model group were all increased (P ＜ 0.05). Compared with the model group, the ratio of elastic strain rate and collagen volume fraction of rectus femoris in the akupotomye group decreased significantly (P ＜ 0.05). Conclusion Akupotomye intervention can improve the hardness of rectus femoris tissue in KOA rabbits and promote the restore of chronic injury fibrosis of rectus femoris. It can be one of the mechanisms of acupotomy in treating KOA.
		2022 Vol. 19 (15): 8-11 [Abstract] ( 157 ) HTML (1 KB) PDF (1175 KB) ( 54 )

	12	Study on the mechanism of Kushen Wumei Decoction against hepatitis B virus in HepG 2.2.15 cell model based on network pharmacology and metabolomics
		ZHENG Rui GUO Peng LIU Yu KONG Wei CHEN Yan
		Objective To explore the anti-hepatitis B virus (HBV) mechanism of Kushen Wumei Decoction on HepG 2.2.15 cell model by using network pharmacology and metabonomics technology. Methods Enzyme linked immunosorbent assay was used to evaluate the effect of Kushen Wumei Decoction on HepG 2.2.15 cell model. Metabolomics analysis method of UHPLC-LTQ-Orbitrap-MS was used, combined with principal component analysis method and orthogonal-partial least squares multiplicative analysis method were used for multivariate statistical analysis. In addition, the network pharmacology technology was used to predict the potential metabolic pathways of Kushen Wumei Decoction against HBV. Combining the metabolic pathways obtained from the two parts, the anti-HBV mechanism of Kushen Wumei Decoction was explored. Results Compared with blank group, the survival rates of 1250 μg/ml and 2500 μg/ml groups were lower (P ＜ 0.05); Compared with blank group, 2500 μg/ml group had lower HBVDNA content (P ＜ 0.05); 40 metabolites with significant differences between groups were screened, which mainly affected the biosynthesis of phenylalanine, tyrosine, and tryptophan, phenylalanine metabolism, sphinolipid metabolism, arginine and proline metabolism; the potential therapeutic targets of the candidate active ingredients of Kushen Wumei Decoction were 115, and the top five targets in degree value were protein kinase B, human epidermal growth factor receptor, proto-oncogene tyrosine protein kinase Src, tumor necrosis factor, and vascular endothelial growth factor A. A total of 679 genes were identified by gene ontology enrichment analysis, including 2162 biological processes, 56 cell components, and 133 molecular functions; Kyoto encyclopedia of genes and genomes pathway enrichment analysis showed that the top 20 P-value pathways mainly included PI3K-Akt, hepatitis B, Kaposi’s sarcoma associated herpes virus infection, and other signaling pathways. Conclusion Kushen Wumei Decoction can resist HBV. Metabolomics and network pharmacology found that the mechanism of its action may be related to the regulation of sphingolipid metabolism pathway, the biosynthesis of phenylalanine, tyrosine, and tryptophan, and phenylalanine metabolism pathway, and PI3K-Akt signaling pathway, which provides a basis for the mechanism of anti-HBV.
		2022 Vol. 19 (15): 12-18 [Abstract] ( 79 ) HTML (1 KB) PDF (2577 KB) ( 267 )

	19	Analysis on the medication rule of Professor Jiang Deyou in the treatment of heart pain based on data mining technology
		LI Qiushi1 ZHANG Jing2 YAO Ziyin2 JIANG Deyou2▲
		Objective To analyze the medication rule of Professor Jiang Deyou in the treatment of heart pain by using data mining technology. Methods Medical cases of heart pain treated by Professor Jiang in First Affiliated Hospital, Heilongjiang University of Chinese Medicine from January 2010 to December 2020 were collected. Excel 2019, IBM SPSS Modeler 18.0 and IBM SPSS Statistics 21.0 software were used to conduct medication frequency statistics, association rules, and high frequency drug cluster analysis of Professor Jiang’s prescription for treating heart pain. Results A total of 280 prescriptions involving 112 drugs were included. According to the statistics of medication frequency, the frequency of 19 medicines such as Salviae Miltiorrhizae Radix Et Rhizoma, Notoginseng Radix Et Rhizoma, and Eupolyphaga Steleophaga was higher. The property of 112 traditional Chinese medicines were mainly warm, cold, and plain, and their tastes were sweet, bitter, and pungent, which mainly belong to the liver, lung, spleen, heart, kidney, and stomach channels. Association rule analysis showed that Aurantii Fructus and Glycyrrhizae Radix Et Rhizoma were the couplet medicines with the highest correlation, while Salviae Miltiorrhizae Radix Et Rhizoma, Puerariae Lobatae Radix, Notoginseng Radix Et Rhizoma and Eupolyphaga Steleophaga were the drug groups with the highest correlation. High-frequency drug cluster analysis obtained four cluster groups, respectively for the treatment of heart pain caused by blood stasis, qi stagnation, phlegm-heat, deficiency of root cause of four causes. Conclusion Professor Jiang often uses the unblocked method and dredging method of activating blood circulation to dissipate blood stasis, activating qi to open depression, clearing heat and dissipating phlegm to treat heart pain.
		2022 Vol. 19 (15): 19-22,28 [Abstract] ( 67 ) HTML (1 KB) PDF (1576 KB) ( 33 )

	23	Analysis of research trends and hotspots of triptolide in recent ten years based on knowledge graph#br#
		YUAN Bo1 ZHI Kai2 CUI Weilu1 ZHANG Xieyu1 GE Lin1 CAO Wei3
		Objective To explore the development trend and hotspots of triptolide research in recent ten years in China through bibliometric visualization analysis. Methods The literatures related to triptolide included in Chinese National Knowledge Infrastructure from January 2011 to October 2021 were searched, and the included research institutions, authors and keywords were visually analyzed by CiteSpace software. Results The numbers of triptolide-related literature published was stable; the research institutions were mostly Chinese medicine universities and pharmacology-related laboratories, with less inter-institutional cooperation; the authors with the most number of articles were Liu Jianqun, Que Huiqing and Xu Wei, and no core team has been formed in China; the top three keywords in terms of frequency were “apoptosis”, “proliferation”, and “rheumatoid arthritis”, with 12 clusters of keywords and ten emergent words. Conclusion The number of triptolide-related articles issued in the past decade is stable, and the disease types involved in the research are constantly enriched, and preclinical research centered on anti-tumor and oxidative emergency is the hotspot of triptolide research in recent years.
		2022 Vol. 19 (15): 23-28 [Abstract] ( 68 ) HTML (1 KB) PDF (3104 KB) ( 59 )

	29	Analysis of research hotspots of clinical alarm management based on Web of Science
		SHI Leilei1 LIU Dan2▲ LUO Yu1 GAO Feng1
		Objective To analyze the the research status and hotspots of clinical alerm management, and provides reference for the research exploration and clinical work in this field in China. Methods Based on the Web of Science database, clinical alerm management literature was retrieved from the self-built database to June 2021, and the CiteSpace literature analysis software was used to map and analyze the scientific knowledge of the number of published articles, countries/institutions and keywords. Results A total of 171 articles were included. The number of papers published in the United States was the highest, and the university of Pennsylvania was the most prolific institution. Research focuses on: artificial intelligence, alarm safety, and alarm fatigue. Conclusion CiteSpace software was used to analyze the research status and hot spots of clinical alerm management to provide reference for future research.
		2022 Vol. 19 (15): 29-32,40 [Abstract] ( 65 ) HTML (1 KB) PDF (1888 KB) ( 61 )

	33	Research progress in etiology and pathogenesis and treatment of connective tissue disease-associated interstitial lung disease in traditional Chinese medicine
		LIANG Yanxia1 FAN Maorong1 WANG Bing1 ZHAO Yuan1 MA Hui2 ZHANG Ziran3 CONG Xiaodong1
		In this paper, traditional Chinese medicine treatment of connective tissue disease-associated interstitial lung disease was discussed from the perspective of etiology and pathogenesis and treatment principles. It is believed that internal injury and deficiency are the root of the disease, invasion of external evil is the inducement of the disease, and the blocking of phlegm, stasis, and toxin is throughout the disease. In terms of treatment, the acute exacerbation period is based on dispersing cold and removing dampness, dispelling wind and clearing ligaments, while the stabilization period is based on tonifying the internal organs and harmonizing qi, blood, yin, and yang, and the whole process of treatment focuses on resolving phlegm and eliminating stasis and clearing heat and toxins.
		2022 Vol. 19 (15): 33-36 [Abstract] ( 112 ) HTML (1 KB) PDF (619 KB) ( 98 )

	37	Research progress on traditional Chinese medicine acupoint selection for mild cognitive impairment of different syndrome types
		QIN Siqi AI Yating HU Hui ZOU Jingjie WANG Yuncui
		Mild cognitive impairment (MCI) has a high probability of conversion to dementia, which not only causes the elderly’s self-care ability and social adaptability to decline, but also brings heavy burden to the family and society. At present, there is no effective medication for MCI. External treatment of traditional Chinese medicine, such as acupuncture, massage and moxibustion, have the characteristics of simple operation, economic and practical, high acceptance by patients and so on, all of them can improve the cognitive function of patients, enhance the quality of life, and delay the development of dementia by acupoint stimulation. In this paper, combined with relevant traditional Chinese medicine acupoint selection theories, the clinical acupoints selection of different syndromes of MCI were reviewed in order to provide reference for preventing the occurrence and development of MCI.
		2022 Vol. 19 (15): 37-40 [Abstract] ( 81 ) HTML (1 KB) PDF (630 KB) ( 67 )

	41	Research progress of acupuncture in the treatment of migraine based on fMRI
		YANG Xu1 LI Xiaoling2 MA Cuisong1 GAO Shenglan1 WANG Peng3 SUN Xuchen1 YUAN Yuan1 ZHAO Pei1
		Migraine is a common idiopathic nervous system disease, which is highly prevalent and difficult to heal. Acupuncture is effective, safe, and economical for migraine, but its central mechanism is not clear. Functional magnetic resonance imaging (fMRI) can objectively and indirectly show the changes of brain activation areas and functional connections between different brain areas during acupuncture. Reviewing the research on acupuncture treatment of migraine based on fMRI in recent years, it is found that acupuncture treatment of migraine causes specific changes in brain functional structure, brain blood flow, and brain functional network, which may be the central mechanism of acupuncture treatment of migraine. This paper summarizes the application of real task fMRI, resting fMRI, and functional connection in acupuncture diagnosis and treatment of migraine, and discusses the research direction and prospect of the combination of fMRI and acupuncture in the treatment of migraine.
		2022 Vol. 19 (15): 41-44 [Abstract] ( 69 ) HTML (1 KB) PDF (498 KB) ( 189 )

	45	Research progress of end-stage renal disease complicated with renal cell carcinoma
		LIU Wei1 YU Chunzhao2 YANG Jian1 JIANG Rongjiang1
		The increase of the morbidity and mortality of end-stage renal disease is the focus of chronic disease prevention and treatment in China. Renal cell carcinoma associated with end-stage renal disease is the leading cause of death in patients with end-stage renal disease. The pathological types of end-stage renal disease associated renal cell carcinoma include conventional renal cell carcinoma histological subtypes and unique histological subtypes, such as acquired cystic kidney disease associated renal cell carcinoma and clear cell papillary renal cell carcinoma, which are difficult to diagnose and treat. This article reviews the etiology, incidence, pathogenesis, pathological classification, and prognosis of end-stage renal disease associated renal cell carcinoma, which is helpful to improve the understanding of end-stage renal disease associated renal cell carcinoma in urinary diseases.
		2022 Vol. 19 (15): 45-47,52 [Abstract] ( 107 ) HTML (1 KB) PDF (465 KB) ( 109 )

	48	Research progress of risk prediction model for pulmonary complications after esophageal cancer
		BI Cen1 JING Liwei2 ZOU Shengqiang1 XUE Qi3
		Pulmonary complications after esophageal cancer are the main cause of postoperative death and affect the long-term prognosis of patients. As an assessment tool for high-risk population, risk prediction model can help improve clinical decision making. This paper reviews the risk prediction models for postoperative pulmonary complications of esophageal cancer defined by different standards, introduces the evaluation content and prediction efficiency of the existing risk prediction models for postoperative pulmonary complications of esophageal cancer, and analyzes their scientificity and limitations. It is aiming at providing a reference for the development of simple，effective and highly targeted risk screening tools for pulmonary complications after postoperative esophageal cancer.
		2022 Vol. 19 (15): 48-52 [Abstract] ( 116 ) HTML (1 KB) PDF (612 KB) ( 25 )

	53	Progress in clinical application of event-related potentials in early onset schizophrenia
		LIU Zhiwei1 YAO Gaofeng1 YANG Rongchun1 LIU Yun1 LIU Huanzhong2
		Early onset schizophrenia (EOS) refers to schizophrenia that develops before 18 years of age, and its clinical severity and prognosis are different from adult schizophrenia. As an effective neuroelectrophysiological marker, event-related potentials (ERPs) show great application prospect in patients with schizophrenia. In this paper, P300, mismatch negativity (MMN), N100, and other common components of ERPs are reviewed to explore their clinical application value in EOS patients. It was found that ERPs can be an ideal biological marker for EOS patients, which can help provide appropriate personalized interventions for the early stage of the disease. It provides some reference value for clinical practice to improve the prognosis of this disease.
		2022 Vol. 19 (15): 53-56 [Abstract] ( 66 ) HTML (1 KB) PDF (417 KB) ( 66 )

	57	Secondary prevention medication use in patients with cardiovascular disease in Northwest China from 2015—2019
		ZHONG Hui YU Yanwu HE Wei WANG Yunfeng ZHU Zhihong ZHANG Lihua LI Xi LIU Jiamin
		Objective To investigate the secondary prevention drug use in patients with cardiovascular disease in the community population in Northwest China, and to explore its correlation with individual characteristics. Methods The participants aged 35-75 years from 43 communities in Northwest China were studied based on the “China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project” from 2015—2019. The self-reported history of ischemic heart disease or ischemic stroke and drug use were collected through questionnaires. Associations between individual characteristics and secondary prevention medication use were analyzed using multivariate mixed-effects models. Results Among 14 212 patients with ischemic heart disease and / or ischemic stroke, 22.6% reported the use of antiplatelet or statin drugs. The results of multivariate analysis showed that older age (55 to 65 and 65 to 75 years old), middle school and above, married, overweight or obese, and those with hypertension were more likely to use antiplatelet or statin drugs (P ＜ 0.05); while women, farmers, rural areas, and smokers were less likely to take antiplatelet or statin drugs (P ＜ 0.05). Conclusion In patients with ischemic heart disease and/or ischemic stroke in Northwest China, the application of antiplatelet drugs and statins is insufficient, and the status also varies across different population characteristics.
		2022 Vol. 19 (15): 57-60 [Abstract] ( 68 ) HTML (1 KB) PDF (927 KB) ( 77 )

	61	Cognitive investigation and enlightenment of postpartum depression among obstetric medical staff
		YAO Yao YANG Huaijie
		Objective To investigate the cognitive status of obstetric medical staff on postpartum depression, to analyze related influencing factors, and to provide a theoretical basis for the prevention and treatment of postpartum depression. Methods From January to February 2019, an online questionnaire survey was used to investigate the cognitive status of obstetric medical staff on postpartum depression by using the postpartum depression cognition questionnaire seven general hospitals and three maternal and child health care hospitals in Yichang area were selected. At the same time, the general information of medical staff was collected, and the factors affecting the cognition of postpartum depression of obstetric medical staff were analyzed. Results A total of 435 obstetric medical staff in ten hospitals were surveyed, of which 427 medical staff completed the questionnaire, and the effective rate of questionnaire recovery was 98.16%. The overall mean score of the postpartum depression cognitive questionnaire was 77.47 points. Comparing the cognitive scores of postpartum depression among medical staff in obstetrics department with different educational levels, positions and work units, and the differences were statistically significant (P ＜ 0.05). Multiple linear regression analysis showed that education level and position were important factors affecting the cognition of postpartum depression (P ＜ 0.05). Conclusion The overall level of cognitive status of postpartum depression among obstetric medical staff in this area is not high. Hospital management departments and obstetric medical staff should further increase the importance of postpartum depression. At the obstetrics management level, medical staff with different education levels and positions need to conduct regular stratified special training, especially training in postpartum depression assessment and diagnosis methods, to provide guarantee for the further implementation of postpartum depression prevention and treatment.
		2022 Vol. 19 (15): 61-64,74 [Abstract] ( 91 ) HTML (1 KB) PDF (644 KB) ( 42 )

	65	Analysis on the current situation and demand characteristics of nursing staff training in Southwest and East China
		CHEN Hefang1 WANG Qian1 ZANG Shuang1 WANG Qian2 QIU Guixing3
		Objective To understand the current situation and demand characteristics of nursing staff training in Southwest and East China, and to provide a basis for nursing staff training in nursing institutions. Methods From July to September 2020, a multi-stage stratified sampling method was used to investigate the general conditions, training status and needs of 201 elderly care workers in Southwest China and 369 in East China. Results There were statistically significant differences in the education level, previous work as an elderly care worker, employment method, working years, whether there was any relevant study or work experience before joining the job, whether you had participated in training before the job, whether you had participated in the assessment before the job, participated in training during work in Southwest and East China (P ＜ 0.05). There were statistically significant differences in the frequency of training, the desired duration of each training, and the practical operational requirements among elderly care workers in Southwest and East China (P ＜ 0.05). In Southwest and East China, the satisfaction rate of living care and nursing assistance was more than 90%. There were statistically significant differences in the living care needs of nursing staff with different ages, educational levels, previous work as nursing staff, and difficulty in caring for the elderly (P ＜ 0.05). There were statistically significant differences in the nursing assistance needs of nursing assistants of different ages, educational levels, previous jobs, and working years (P ＜ 0.05). There were statistically significant differences in the nursing assistance needs of nursing assistants with different educational levels, previous jobs, and working years (P ＜ 0.05). Age (OR = 0.643), education level (OR = 1.507), difficulty in caring for the elderly (OR = 1.341), and previous work as a nursing care worker (OR = 0.338) were the influencing factors of training needs for life care (P ＜ 0.05). Educational level (OR = 1.333), working years (OR = 0.734), and previous work as a nursing care worker (OR = 0.316) were the influencing factors of the need for nursing assistance training (P ＜ 0.05). Educational level (OR = 0.727), working years (OR = 0.557), and previous work as a nursing care worker (OR = 4.321) were the influencing factors of psychological support training needs (P ＜ 0.05). Conclusion Managers of elderly care institutions should standardize the entry and training system, pay attention to differences in regions and educational backgrounds, and adopt diversified training methods to comprehensively improve the nursing skills of elderly care workers.
		2022 Vol. 19 (15): 65-69 [Abstract] ( 78 ) HTML (1 KB) PDF (805 KB) ( 73 )

	70	Research on the current situation of hospital culture and youth work
		HU Bo DAI Fang YU Jinrui LU Shan NIE Xiaoying▲
		Objective To study the current situation of hospital culture and youth work, and to explore the effective ways of co-construction and mutual promotion between them. Methods In November 2020, a stratified sampling method was used and a self-made questionnaire was used to investigate 338 young hospital employees in a tertiary children’s hospital. At the same time, the cultural activities related to young medical staff carried out by the hospital from 2015 to 2020 were reviewed. Results A total of 338 questionnaires were sent out in this study, of which 337 questionnaires were valid, and the recovery rate was 99.11%. “You know the hospital motto and understand the specific definition” was positively correlated with working years (r = 0.111, P ＜ 0.05); “You will often pay attention to and read the relevant news information of the hospital”, “You will often participate in activities related to the hospital culture”, “You have a strong sense of happiness working in this hospital”, “You have never considered leaving the office” were negatively correlated with academic qualifications (r = -0.125, -0.165, -0.162, -0.117, P ＜ 0.05). In addition, “Frequently participating in activities related to hospital culture” was positively correlated with “Hospital culture improved ideological and moral level” (r = 0.596, P ＜ 0.01); “Under the training of the hospital, you have a clear career plan and your work ability has been improved” and “Will give suggestions to colleagues or superiors on work improvement” were positively correlated (r = 0.554, P ＜ 0.01); “Hospital culture conforms to its own ideals, beliefs and value pursuits” was positively correlated with “Frequently forwarded and publicized news information about hospitals” (r = 0.687, P ＜ 0.01); “Having a strong sense of well-being in this hospital” was positively correlated with “Never considering quitting” (r = 0.836, P ＜ 0.01). Conclusion The overall situation of young employees’ awareness of hospital culture is good, and hospital culture plays a driving role in improving the ideological and political level of young people, promoting the construction of young people’s medical ethics and medical style, and helping the growth of young talents; youth style and youth thinking have an impact on expanding hospital culture dissemination and promoting the innovation and development of hospital culture. At the same time, it is recommended to strengthen the participation of highly educated personnel in hospital culture-related work.
		2022 Vol. 19 (15): 70-74 [Abstract] ( 113 ) HTML (1 KB) PDF (705 KB) ( 53 )

	75	Investigation on knowledge, behavior, practice of emergency nurses in maternal and child specialty hospitals on intravenous infusion of high-alert drugs
		WU Jing LI Qianyun XU min▲
		Objective To investigate the status quo of knowledge, behavior, practice of nurses in the emergency department of a maternal and child hospital on intravenous infusion of high-alert drugs. Methods The cluster sampling method was adopted, and in April 2020, West China Second University Hospital, Sichuan Maternal and Child Health Hospital, Chengdu Women and Children’s Central Hospital, Chengdu Longquanyi District Maternal and Child Health Hospital, Chengdu Chenghua District Maternal and Child Health Hospital, and Pengzhou Maternal and Child Health Hospital were selected. A total of 171 emergency nurses from six maternity and children specialized hospitals Care were selected as the research subjects, and their knowledge, behaviors, practice about intravenous infusion of high-alert drugs were investigated by questionnaire. Results A total of 173 nurses were investigated in this study, 171 valid questionnaires were obtained, and the effective recovery rate was 98.84%. The total score of knowledge, behavior, practice of nurses in the emergency department of the women and children’s hospital for intravenous infusion of high-alert drugs was (245.67±12.69) points, the knowledge score rate was 77.69%, 91.82% of the nurses had a good attitude, and 8.77% of the nurses had a poor behavior. The univariate result analysis showed that there were statistically significant differences in the total score of emergency nurses’ knowledge in different professional titles, employment forms and monthly income (P ＜ 0.05); there was a statistically significant difference in the behavior scores of emergency nurses in maternal and child specialist hospitals with different professional titles (P ＜ 0.05). Conclusion The level of knowledge, behavior, practice of emergency nurses in specialized hospitals for intravenous infusion of high-alert drugs is above the middle level, but the knowledge level needs to be improved urgently. Managers should strengthen the training and management of emergency nurses in maternal and child specialist hospitals on the application of intravenous high-alert drugs to reduce the risk of drug use in pregnant and lying-in children.
		2022 Vol. 19 (15): 75-78,82 [Abstract] ( 107 ) HTML (1 KB) PDF (699 KB) ( 73 )

	79	Effect of Calcitriol combined with Olmesartan Medoxomil in the treatment of early type 2 diabetes nephropathy and its mechanism on nephrotic podocyte damage
		HUANG Cheng1 SHAO Yunxia1 WU Yan1 XING Changying2▲
		Objective To investigate the effect of Calcitriol combined with Olmesartan Medoxomil in treatment of early type 2 diabetic nephropathy (T2DN) and the mechanism of nephrotic podocyte damage. Methods A total of 82 early T2DN patients admitted to Wuhu Second People’s Hospital of Anhui Province from January 2018 to December 2019 were selected as the research objects, and they were divided into study group and control group by random number table method, with 41 cases in each group. The control group was treated with Olmesartan Medoxomil on the basis of conventional treatment, and the study group was treated with Calcitriol on the basis of the control group. The clinical efficacy and safety of the two groups were compared, and the levels of microRNA-30 (miR-30) and serum creatinine (Scr) of the two groups were compared before treatment (T0), at week 1 (T1), week 4 (T2) and week 8 (T3) after treatment. Results The curative effect of the study group was better than that of the control group (P ＜ 0.05). The overall analysis found that: the comparison of Scr, miR-30 between groups, time points, and interaction were statistically significant (P ＜ 0.05). Further pairwise comparison, intra-group comparison: at T1, T2, and T3, the levels of Scr and miR-30 in the two groups were lower than those at T0 (P ＜ 0.05). At T2 and T3, the levels of Scr and miR-30 in the two groups were lower than those at T1 (P ＜ 0.05). At T3, the levels of Scr and miR-30 in the two groups were lower than at T2 (P ＜ 0.05). Comparison between groups: At T1, T2, and T3, the levels of Scr and miR-30 in the study group were lower than those in the control group (P ＜ 0.05). During the treatment period, there was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Calcitriol combined with Olmesartan Medoxomil has a significant effect in the treatment of early T2DN and improves renal podocyte damage. The mechanism may be related to the inhibition of podocyte damage in miR-30 patients.
		2022 Vol. 19 (15): 79-82 [Abstract] ( 108 ) HTML (1 KB) PDF (558 KB) ( 62 )

	83	Effect of anterior urethral wall reconstruction on urinary control after radical prostate cancer
		SONG Tianmou ZHENG Bing CHU Kaiyun
		Objective To explore the effect of anterior urethral wall reconstruction on urinary control after radical prostate cancer. Methods Clinical data of 80 prostate cancer patients admitted to Nantong First People’s Hospital of Jiangsu Province from May 2018 to August 2020 were retrospectively analyzed, according to the treatment methods, the patients were divided into observation group 34 cases (anterior wall strengthening method) and control group 46 cases (anterior and posterior wall strengthening method). The clinical data of the two groups were collected, and the prostate volume, pathological stage, Gleason score and pathological stage were evaluated. At the same time, the recovery of urinary control at 1, 3, 6, and 12 months after operation was followed up by telephone, and the difference of the above data between the two groups was analyzed. Results Operation time, intraoperative blood loss, urethral reconstruction time of urethral reconstruction time, and indwelling catheterizationin time in observation group were significantly shorter than those in control group, while prostate volume in observation group was significantly larger than control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of postoperative complications between the two groups (P ＞ 0.05); the recovery rate of urinary control one month after operation in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05), but there was no significant difference in the recovery rate of urinary control 3, 6 and 12 months after operation between the two groups (P ＞ 0.05). Conclusion Enhancing the anterior wall of the urethra under cystoscopy can improve the recovery of early postoperative urinary control, and may shorten the operation time and intraoperative bleeding. The choice of surgical procedure may be affected by the volume of the prostate.
		2022 Vol. 19 (15): 83-86 [Abstract] ( 69 ) HTML (1 KB) PDF (575 KB) ( 36 )

	87	Meta-analysis of postoperative outcomes of patients undergoing hip arthroplasty with transcutaneous electrical acupoint stimulation
		YANG Min1 YAN Chunwen2 XING Yehong1 PAN Li3
		Objective To systematically evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative regression of patients undergoing hip arthroplasty (HA). Methods Randomized controlled trials of TEAS in the treatment of HA were searched by computer in CNKI, Wanfang Data, VIP, CBM, PubMed, Embase, the Cochrane Library, Web of Science, Medline, and Ovid databases. The retrieval time limit was from the inception to July 2021. Meta-analysis of pain, inflammatory factors, cognitive function, related indicators of brain metabolism, and the incidence of adverse reactions after surgery were compared between the experimental group and control group by Revman 5.3 software. Results A total of 16 literatures were included, involving 1039 patients. The results of meta-analysis showed that VAS scores of experimental group at 12, 24, and 48 h after surgery were lower than those in control group (P ＜ 0.05). Interleukin (IL) -1β of experimental group at 24 and 72 h after surgery were lower than those in control group, tumor necrosis factor-α at 24 h after surgery was lower than that in control group, and IL-6 and IL-10 within 2 h after surgery, and at 24, 72 h after surgery were lower than those in control group (P ＜ 0.05). The mini mental status examination score of experimental group at 72 h after surgery was higher than that in control group, the incidence of cognitive dysfunction at 24 and 72 h after surgery were lower than those in control group, S100β protein after surgery was lower than that in control group, and the cervical venous oxygen contents at 20 and 40 min after hypotension and 20 min after hypotension stopped were higher than those in control group, arterio-mixed venous oxygen content differences at 20 min after hypotension was lower than that in control group (P ＜ 0.05). The incidence of nausea and vomiting, vertigo in experimental group was lower than that in control group (P ＜ 0.05). Funnel plot showed no publication bias. Conclusion TEAS can relieve postoperative pain in HA patients, control the level of inflammatory factors, improve cognitive function, reduce the incidence of postoperative nausea and vomiting, vertigo, and further promote clinical value.
		2022 Vol. 19 (15): 87-92,104 [Abstract] ( 136 ) HTML (1 KB) PDF (1885 KB) ( 41 )

	93	Effect of moderate resistance muscle strength training in the treatment of osteoporosis in postmenopausal elderly
		ZHU Dongmei LI Xiaoxia WANG Li▲
		Objective To explore and analyze the effect of moderate resistance muscle strength training in the treatment of osteoporosis in postmenopausal elderly. Methods A total of 110 postmenopausal elderly patients with osteoporosis admitted to Xinjiang Uygur Autonomous Region People’s Hospital from August 2019 to October 2020 were selected and divided into control group and observation group by random number table method, with 55 cases in each group. The control group was given routine intervention, and the observation group was given moderate resistance muscle strength training on the basis of the control group. Both groups were trained continuously for 16 weeks. The differences of pain degree, bone mineral density, balance function, and quality of life scores were compared between the two groups before and after intervention. Results Fifty-one cases in the control group and 48 cases in the observation group were included. After intervention, bone mineral density of lumbar spine（L2-L4）, hip joint, and neck of femur , and the scores of physical functioning, physical functioning, physical pain, general health, vitality, social functioning, emotional functioning, mental health were all higher than those before intervention, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05). After intervention, the values of standing on solid surface with eyes open, standing on solid surface with eyes closed, standing on pillows with eyes open, standing on pillows with eyes closed were all lower than those before intervention, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The pain degree in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Moderate resistance muscle strength training for postmenopausal elderly patients with osteoporosis can effectively improve bone density, relieve pain, improve joint function and promote quality of life.
		2022 Vol. 19 (15): 93-96,120 [Abstract] ( 98 ) HTML (1 KB) PDF (661 KB) ( 24 )

	97	Effect of deep muscle rehabilitation exercise combined with thumb-tack needle for subcutaneous embedding on lumbago and daily life of patients after minimally invasive lumbar surgery
		CHEN Lijuan1 MAO Zhijuan1 LU Fangqin1 SHENG Yuanyuan1 XIA Xiaopeng2▲
		Objective To explore the effect of deep muscle rehabilitation exercise combined with thumb-tack needle for subcutaneous embedding on lumbago and daily life of patients with lumbar disc herniation after percutaneous transforaminal endoscopic discectomy. Methods Ninety patients diagnosed with lumbar disc herniation (LDH) and underwent percutaneous foraminal endoscopic discectomy in Nantong Hospital of Traditional Chinese Medicine, Jiangsu Province from January 2018 to April 2021 were selected as subjects. They were divided into observation group (45 case) and control group (45 case) by random number table method. The control group was treated with deep muscle rehabilitation exercise (one month) combined with conventional acupuncture (two days), and the observation group was treated with deep muscle rehabilitation exercise (one month) combined with thumb-tack needle for subcutaneaus embedding (two days). The differences of visual analog scale (VAS), Japanese Orthopaedic Association (JOA), traditional Chinese medicine symptom score, and Oswestry disability index (ODI) before and after surgery were compared between the two groups. Results After treatment, VAS and traditional Chinese medicine symptom scores in two groups were lower than those before treatment, while JOA score was higher than that before treatment, VAS and traditional Chinese medicine symptom scores in observation group were lower than those in control group, while JOA score was higher than that in control group (P ＜ 0.05). After treatment, pain intensity, self-care ability, extract, walking, standing, sleep, social activity, travel, and total score in two groups were lower than those before treatment, and observation group was lower than that in control group (P ＜ 0.05). Conclusion Deep muscle rehabilitation exercise combined with thumb-tack needle for subcutaneaus embedding can significantly reduce the lumbago of patients after lumbar disc herniation, improve the range of motion of lumbar spine and the ability of daily living, which can be popularized in clinical application.
		2022 Vol. 19 (15): 97-100 [Abstract] ( 138 ) HTML (1 KB) PDF (607 KB) ( 276 )

	101	Effect of open reduction combined with universal locking plate on functional recovery and safety of elderly patients with acute foot lisfranc injury
		CHEN Dan ZHOU Qiang▲ LI Ningyuan QIANG Zhe ZHANG Jie
		Objective To explore the effect of open reduction combined with universal locking plate on the functional recovery and safety of elderly patients with acute foot lisfranc injury. Methods A total of 76 elderly patients with acute foot lisfranc injury admitted to 363 Hospital of General Medical from March 2018 to April 2020 were selected. The patients were divided into ordinary plate group (open reduction + ordinary plate) and universal locking plate group (open reduction + universal locking plate) by random number table method, 38 patients in each group. Operation time, intraoperative blood loss, total weight-bearing time were compared between the two groups. Visual analogue scale (VAS) scores were compared between the two groups before operation and one, three, and six months after operation, and American Orthopaedic Foot & Ankle Society (AOFAS) ankle hindfoot scale scores were compared between the two groups at three, six, and 12 months after operation. The incidence of postoperative complications was compared between the two groups. Results There were no significant differences in operative time, intraoperative blood loss, and complete weight-bearing time between the two groups (P ＞ 0.05). VAS scores at one, three, and six months after operation in both groups were lower than those before operation, VAS scores at three and six months after operation in both groups were lower than those at one month after operation, and VAS scores at six months after operation in both groups were lower than those at three months after operation (P ＜ 0.05). AOFAS ankle hindfoot scale scores of the two groups at six and 12 months after operation were higher than those at three months after operation, AOFAS ankle hindfoot scale scores of the two groups at 12 months after operation were higher than those at six months after operation, and AOFAS ankle hindfoot scale score of the universal locking plate group at 12 months after operation was higher than that of the ordinary plate group at the same time point (P ＜ 0.05). The total incidence of postoperative complications in the universal locking plate group was lower than that of the ordinary plate group (P ＜ 0.05). Conclusion Open reduction combined with universal locking plate is beneficial to the functional recovery of elderly patients with acute lisfranc injury, reducing the incidence of complications, and further promoting clinical practice.
		2022 Vol. 19 (15): 101-104 [Abstract] ( 55 ) HTML (1 KB) PDF (531 KB) ( 19 )

	105	Clinical effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide of the patients with vulvar lichen sclerosus
		LIU Nian1 ZHAO Junda1 LIU Ya2 MA Junqi1
		Objective To compare the effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide in the treatment of vulvar lichen sclerosus. Methods A total of 58 patients with vulvar lichen sclerosus in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to January 2020 were selected, they were divided into physical therapy group (21 cases) and drug therapy group (37 cases) according to follow-up conditions and wills. In physical therapy group, the vascular and lymphatic systems of the lower limbs and pelvic floor were treated with electrical stimulation, and drug therapy group was treated with Triamcinolone Acetonide Cream. Symptom and sign scores and quality of life index scores before treatment and 1, 3, 6, and 12 months after treatment were compared between two groups, and the occurrence of adverse reactions was observed. Results The symptom scores of physical therapy group were lower than those of drug therapy group at 12 months after treatment (P < 0.05). Sign scores of physical therapy group were higher than those of drug therapy group at 1 month after treatment (P < 0.05). The quality of life scores of physical therapy group were lower than those of drug therapy group at 1 and 6 months after treatment (P < 0.05). Sexual life scores of physical therapy group were lower than those of drug therapy group at 3,6, and 12 months after treatment (P < 0.05). The sleep anxiety scores of physical therapy group were lower than those of drug therapy group at 1, 6 and 12 months after treatment (P < 0.05). In the physical therapy group, one patient with diabetes developed vulvovaginal candidiasis, which was cured after treatment and continued treatment; in drug therapy group, two patients had local itching aggravation, prickling, redness, and swelling, and stopped taking the medicine. In the long-term medication follow-up, five patients showed unalleviated pruritus, local vascular dilation, pigmentation, and adverse drug reactions, and drug withdrawal. Conclusion Vascular smooth muscle electrical stimulation is safe and effective in the treatment of vulvar lichen sclerosus with few side effects. It has advantages in improving sexual life quality, skin pigment, and sleep anxiety recovery.
		2022 Vol. 19 (15): 105-108 [Abstract] ( 72 ) HTML (1 KB) PDF (539 KB) ( 204 )

	109	Relationship between serum vitamin A, D, and E levels with early-onset sepsis in preterm infants based on propensity score matching
		ZHANG Yinying1 JI Xiaoyi2 LI Ye1
		Objective To investigate the relationship between serum vitamin A (Vit A), Vit D and Vit E levels with early-onset sepsis (EOS) in preterm infants. Methods Fifty-four preterm infants diagnosed with EOS in Jiaxing Maternal and Child Health Hospital of Zhejiang Province from January 2019 to December 2020 were selected as the EOS group, 127 premature infants without sepsis during the same period were the control group. The 1∶1 propensity score matching (PSM) was used to balance the confounding factors between groups, Vit A, Vit D, and Vit E levels and deficiency rates were compared between groups, logistic regression analysis was used to evaluate the relationship between EOS and vitamin levels in premature infants. Results A total of 33 pairs of premature infants were successfully matched after PSM. There was no significant difference in serum Vit A and Vit E levels between the two groups (P > 0.05); the serum 25 (OH) Vit D level in EOS group was lower than that in control group, and the difference was statistically significant (P < 0.05). There was no significant difference in serum Vit A and Vit E deficiency rates between the two groups (P > 0.05); the serum 25 (OH) Vit D deficiency rate in EOS group was higher than that in control group, and the difference was statistically significant (P < 0.05). Logistic regression analysis showed that high level of 25 (OH) Vit D was an protective factor for the occurrence of EOS in premature infants (OR = 0.867, 95%CI:0.793-0.947, P ＜ 0.05). Conclusion Serum Vit D level was an important factor in the occurrence of EOS in premature infants, but Vit A and Vit E were not found to be associated with EOS in premature infants.
		2022 Vol. 19 (15): 109-112 [Abstract] ( 106 ) HTML (1 KB) PDF (460 KB) ( 16 )

	113	Changes of serum thyroid hormone level in pregnant women with subclinical hypothyroidism at different stages of pregnancy and its correlation with TPO-Ab
		LIU Guiying ZHOU Xiuyun
		Objective To explore the changes of serum thyroid hormone level in pregnant women with subclinical hypothyroidism (“hypothysis” for short) at different stages of pregnancy and its correlation with thyroid peroxidase antibody (TPO-Ab). Methods A retrospective analysis of 83 pregnant women with subclinical hypothysis admitted to Fuyang Women’s and Children’s Hospital of Anhui Province from March 2018 to March 2021 who underwent prenatal examination and delivered were enrolled as the observation group. According to gestational age, 26 patients were divided into the early gestational age (1-12 weeks), 29 patients in the middle gestational age (13-27 weeks), and 28 patients in the late gestational age (≥28 weeks); in addition, 83 pregnant women with normal thyroid function who underwent prenatal examination during the same period were selected as the control group. The serum thyroid hormones [thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4)] and TPO-Ab levels of all subjects were detected, TPO-Ab level > the upper limit of the reference value provided by the kit was considered TPO-Ab positive, and the correlation between TSH, FT4, FT3, and TPO-Ab positive was analyzed. Results The levels of TSH and TPO-Ab in the observation group were higher than those in the control group, the level of FT3 was lower than that in the control group, and the differences were statistically significant (P < 0.05); while there was no significant difference in FT4 between the two groups (P > 0.05). There were no significant differences in the levels of TSH, FT4, FT3, and TPO-Ab in the different pregnancy stages of the control group (P > 0.05). In the observation group， the levels of TSH and TPO-Ab in the third trimester of pregnancy were higher than those in the first and second trimesters of pregnancy, and the second trimester of pregnancy was higher than the first trimester of pregnancy; the level of FT3 in the third trimester of pregnancy was lower than that in the first and second trimesters of pregnancy, and the second trimester of pregnancy was lower than the first trimester of pregnancy, and the differences were statistically significant (P < 0.05); there were no significant differences in the levels of FT4 at different pregnancy stages (P > 0.05). There were statistically significant differences in the levels of TSH, FT4, FT3, and TPO-AB between the two groups during pregnancy (P < 0.05); there were no statistical significance differences in the levels of FT4 between the two groups during different pregnancy (P > 0.05). There was no statistically significant difference in the total incidence of pregnancy outcomes of mothers and infants with adverse pregnancy in the observation group (P > 0.05). Serum TSH was positively correlated with the positive rate of TPO-Ab (r = 0.513, P < 0.05); FT3 was negatively correlated with the positive rate of TPO-Ab (r = -0.245, P < 0.05). Conclusion The levels of serum TSH and FT3 in pregnant women with subclinical hypothysis were related to the positive rate of TPO-Ab, and strengthening the monitoring of TPO-Ab can timely judge the changes of thyroid related functional indexes.
		2022 Vol. 19 (15): 113-116 [Abstract] ( 72 ) HTML (1 KB) PDF (495 KB) ( 206 )

	117	Effect of self prepared Xuanfei Huatan Granules in the treatment of children with wind evil invading the lung syndrome cough variant asthma and its effect on immune function
		WANG Yunlan
		Objective To investigate the the effect of self prepared Xuanfei Huatan Granules in the treatment of children with wind evil invading the lung syndrome cough variant asthma and its effect on immune function. Methods A total of 80 children with wind evil invading the lung syndrome cough variant asthma admitted in Zhenjiang Hospital of Traditional Chinese Medicine of Jiangsu Province from March 2018 to May 2021 were selected as study objects, they were divided into observation group and control group according to the random number table method, with 40 cases in each group. The control group was given Budesonide Suspension on the basis of routine treatment, and the observation group was given self prepared Xuanfei Huatan Granules on the basis of control group. Both groups were treated for six weeks. The clinical efficacy, cough symptom scores, immunoglobulin (Ig) E, and eosinophils (EOS) before and after treatment. Results The clinical efficacy of observation group was better than control group (P < 0.05). After treatment, the daytime and nighttime cough symptom scores, IgE, and EOS in the two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Conclusion Self prepared Xuanfei Huatan Granules have obvious curative effect on cough variant asthma in children with wind evil invading the lung syndrome, and it’s beneficial to promote the recovery of immune function and has high clinical application value.
		2022 Vol. 19 (15): 117-120 [Abstract] ( 83 ) HTML (1 KB) PDF (619 KB) ( 32 )

	121	Analysis of influencing factors on the integration effect of oral implant
		HUANG Yunsheng QI Xiaofeng LI Yong
		Objective To analyze the relevant factors affecting the integration effect of oral implants. Methods The clinical data of 130 patients treated with dental implant repair who were admitted to the Second Affiliated Hospital of Soochow University from January 2019 to January 2020 were retrospectively analyzed. The postoperative implant integration effect was analyzed, and general data such as age, gender, inflammatory factor level and periodontal index were counted, and multivariate logistic regression analysis was used to analyze the independent risk factors affecting the implant integration effect after oral implant restoration. Results A total of 130 patients after oral implant repair were divided into good group (77 cases) and poor group (53 cases) according to the integration effect. Age, oral hygiene, oblique implant placement, proportion of vertical bone profile, interleukin (IL)-1, IL-6, IL-8, C-reactive protein (CRP), and the levels of tumor necrosis factor-α (TNF-α), plaque index (PLI), sulcus bleeding index (SBI), and probing depth (PD) in poor group were higher than those in the good group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that age, oral hygiene, IL-1, IL-6, IL-8, CRP, TNF-α, SBI, PLI, PD, implantation direction, and vertical bone profile were risk factors for implant integration after dental implant restoration (OR ＞ 1, P ＜ 0.05). Conclusion In addition to age, oral hygiene status, implantation direction, and vertical bone profile, the postoperative implant integration effect of patients with oral implant restoration is also related to inflammatory factors and periodontal index.
		2022 Vol. 19 (15): 121-124 [Abstract] ( 139 ) HTML (1 KB) PDF (540 KB) ( 144 )

	125	Study on the relationship between sleep quality, itching degree, and severity of psoriasis vulgaris patients with different traditional Chinese medicine syndromes
		TAN Meng GAO Yuexuan XU Jing DUAN Xingwu
		Objective To investigate the correlation between sleep quality, itching degree, and severity of psoriasis vulgaris patients with different traditional Chinese medicine syndromes. Methods From February to September 2021, 112 patients with psoriasis vulgaris were selected from the outpatient department of Dongzhimen Hospital of Beijing University of Chinese Medicine, they were divided into blood heat group, blood stasis group, and blood dryness group according to the dialectical classification of traditional Chinese medicine. They were investigated by sleep quality index (PSQI), insomnia severity index (ISI), visual analogue scales (VAS), and psoriasis area and severity index (PASI). Another 112 healthy volunteers were selected as the control group. Results Compared with blood heat group, ISI, and VAS scores were lower in blood stasis group, PSQI, PASI, and VAS scores were lower in blood dryness group (P ＜ 0.05). Compared with blood stasis group, PASI score in blood dryness group was lower (P ＜ 0.05). The subjective sleep quality, sleep time, and sleep efficiency scores of blood heat group were higher than those of control group (P ＜ 0.05). The sleep time scores of blood heat group, blood stasis group, and blood dryness group were higher than those of control group (P ＜ 0.05). The sleep disturbance score of blood heat group was higher than that of blood stasis group and control group (P ＜ 0.05). The daytime dysfunction score of blood heat group was higher than that of blood stasis group and control group, and the daytime dysfunction score of blood dryness group was lower than that of blood heat group and control group (P ＜ 0.05). PSQI, VAS scores were positively correlated with PASI scores in blood heat group (P ＜ 0.05). Conclusion Different traditional Chinese medicine syndromes have different sleep quality, pruritus degree, and severity of disease. Blood dryness syndrome mainly to improve sleep quality, blood heat syndrome mainly to relieve pruritus, blood stasis syndrome mainly to treat the primary disease, could achieve better curative effect.
		2022 Vol. 19 (15): 125-128 [Abstract] ( 132 ) HTML (1 KB) PDF (550 KB) ( 45 )

	129	Discussion on the scientificity of traditional Chinese medicine from cognitive mode
		YAN Huiqian1 GE Haitao2 SUN Lingzhi3▲
		[Abstract] At each stage of science development, there are overlapping of different cognitive methods. The vagueness of terminology leads to the limitation of cognition. The separate research fields have their own emphasis and lead to the tilt of evaluation. Human beings often respond to the scientific problems of traditional Chinese medicine based on the value, but ignored the medical culture. There is a philosophical dialectic between “comparative state” and double-blind testing, neither of which is invulnerable. The defenders themselves are also factors that create prejudice in traditional Chinese medicine. The education system of traditional Chinese medicine that has never kept pace with the times has delayed its scientific modernization. Traditional Chinese medicine was once a science because it conformed to the cognition and interpretation of science at that time, and it stayes in the pre-scientific era because of the contemporary definition of science.
		2022 Vol. 19 (15): 129-132,147 [Abstract] ( 72 ) HTML (1 KB) PDF (813 KB) ( 240 )

	133	Application of “treating upper jiao is like a feather” in the treatment of otorhinolaryngology disease
		SUN Hong LIU Jianhua YAN Zhanfeng JIAO Lulu ZHU Yajing LIU Lili HUANG Xiaorui ZHANG Linjing
		Wu Jutong, a warm disease epidemiologist, proposes that “treating upper jiao is like a feather”, that is for the warm disease in the disease of upper jiao disease with “light” drugs should be applied. Ears, nose, and throat on the head and neck of the human body, are clear orifices, in the upper jiao, if the medicine is not light, they can not reach the upper jiao. Clinical treatment of the disease of this part often selects the light texture of the product. At the same time, with the flavoring and channel ushering drugs to help medicine to reach the disease site, belongs to the category of “treating upper jiao is like a feather”. This article is based on “treating upper jiao is like a feather” of the common diseases in otorhinolaryngology, in particular, the specific application in the initial treatment of diseases is discussed, in order to guide clinical treatment better.
		2022 Vol. 19 (15): 133-135 [Abstract] ( 76 ) HTML (1 KB) PDF (524 KB) ( 65 )

	136	Application comparison of electroacupuncture dilatational wave, electroacupuncture intermittent wave, and electroacupuncture continuous wave on knee osteoarthritis with syndrome of blood stasis obstruction and stagnation
		LUO Fangfang LIN Munan HUANG Dong’e HUANG Saiju LI Wei▲
		Objective To compare the therapeutic effects of electroacupuncture therapy with different waveforms on knee osteoarthritis with syndrome of blood stasis obstruction and stagnation. Methods A total of 90 patients on knee osteoarthritis with syndrome of blood stasis obstruction and stagnation admitted to NO.900 Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army from July 2018 to December 2020 were studied. According to the random number table method, they were divided into intermittent electric wave group, continuous electric wave group, and dense electric wave group, with 30 cases in each group. The knee function, inflammatory factors, and clinical efficacy of the three groups were compared. Results After treatment, the knee function scores of the three groups were higher than those before treatment, and those of the continuous electric wave group and the dense electric wave group were higher than those of the intermittent electric wave group (P ＜ 0.05). After treatment, the levels of interleukin-1 in the three groups were lower than those before treatment, and the levels of transforming growth factor -β1 in the three groups were higher than those before treatment, and the level of interleukin-1 in the density electric wave group was lower than that in the intermittent electric wave group and continuous electric wave group, and the level of transforming growth factor -β1 in the density electric wave group was higher than that in the intermittent electric wave group and continuous electric wave group (P ＜ 0.05). The clinical efficacy of density electric wave group was better than that of intermittent electric wave group and continuous electric wave group (P ＜ 0.05). Conclusion The use of density electric wave in the treatment of knee osteoarthritis with syndrome of blood stasis obstruction and stagnation can improve the function of knee joint, and regulate inflammatory factors with significantly effective.
		2022 Vol. 19 (15): 136-139 [Abstract] ( 144 ) HTML (1 KB) PDF (594 KB) ( 32 )

	140	Effect of Yishen Zhuyu Decoction on patients with benign prostatic hyperplasia with syndrome of kidney deficiency and stagnation and obstruction
		YANG Cheng LI Bibo BAO Qingbing▲
		Objective To explore the clinical efficacy of Yishen Zhuyu Decoction in the treatment of benign prostatic hyperplasia with syndrome of kidney deficiency and stagnation and obstruction and its influence on inflammatory factors and sex hormones. Methods A total of 92 patients with benign prostatic hyperplasia admitted to Taizhou Hospital of Traditional Chinese Medicine of Jiangsu Province from December 2018 to December 2020 were selected, they were divided into two groups according to random number table method, with 46 cases in each group. The control group was treated with Qianlie Shutong Capsules, and the study group was treated with Yishen Zhuyu Decoction on the basis of the control group. The scores of traditional Chinese medicine symptoms, clinical efficacy, inflammatory factors level, sex hormones level, and complications were compared between the two groups before and after treatment. Results After treatment, the scores of traditional Chinese medicine symptoms in both groups were lower than those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05). After treatment, the clinical efficacy of the study group was better than that of the control group (P ＜ 0.05). After treatment, the levels of interferon-γ and interleukin-6 in both groups were lower than those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05). After treatment, luteinizing hormone level in both groups were lower than those before treatment, and that in the study group was lower than that in the control group, while testosterone level in both groups were higher than those before treatment, and that in the study group was higher than that in the control group (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (corrected χ2=0.261, P = 0.609). Conclusion Yishen Zhuyu Decoction in the treatment of benign prostatic hyperplasia with syndrome of kidney deficiency and stagnation and obstruction can improve the clinical symptoms, have significant curative effects, and it can reduce inflammation and regulate the level of sex hormones.
		2022 Vol. 19 (15): 140-143 [Abstract] ( 131 ) HTML (1 KB) PDF (531 KB) ( 30 )

	144	Effect of acupoint application combined with fire-dragon moxibustion in patients with lumbar intervertebral disc prolapse
		ZHU Jing SUN Jinglin
		Objective To investigate the effect of acupoint application combined with fire-dragon moxibustion in patients with lumbar intervertebral disc prolapse. Methods A total of 80 patients with lumbar intervertebral disc prolapse who were treated at the Bozhou Hospital of Traditional Chinese Medicine, Anhui Province from March 2017 to March 2020 were selected as the research objects. According to the random number table method, they were divided in to control group and combined group, each group were divided into 40 cases. The control group was treated with acupoint application, and the combination group was treated with fire-dragon moxibustion on the basis of the control group. After 30 days of treatment, the clinical efficacy, Japanese orthopaedic association (JOA) scores, numerical rating scale (NRS) score, median frequency slope (MFs), and flexure elongation ratio (FER) were compared between the two groups. Results The total effective rate in the combined group was higher than that in the control group (P ＜ 0.05). After treatment, the JOA scores of the two groups were higher than those before treatment, and the NRS score of the combined group was lower than that of the control group (P ＜ 0.05). After treatment, MFs in the two groups were higher than those before treatment, FER in the two groups were lower than those before treatment, MFs in the combined group was higher than that in the control group, FER in the combined group was lower than that in the control group (P ＜ 0.05). Conclusion Acupoint application combined with fire-dragon moxibustion in patients with lumbar intervertebral disc prolapse can improve the curative effect and low back pain, at the same time, can improve the function of the lumbar spine.
		2022 Vol. 19 (15): 144-147 [Abstract] ( 140 ) HTML (1 KB) PDF (580 KB) ( 60 )

	148	Literature study on measuring nursing workload based on working hour measurement method
		DING Xiangyun1 LIAO Wenli1 WANG Caocao2 ZHANG Yuhong1 MA Yanlan4
		Objective The literature of nursing workload measurement by working hour measurement method was systematically sorted out, and the research status, influencing factors and development trend of nursing workload measurement by working hour measurement method were discussed, so as to provide reference for nursing workload measurement by working hour measurement method in China. Methods PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, CBM and other databases were selected, and the retrieval time was from the establishment of the database to April 2020. Research literature on the measurement of nursing workload by working hour measurement method were selected, and summarized the distribution of research hospitals summarized, research objects and measurement methods, and the average time required for single nursing operation items in the included literature were summarized. Results A total of 12 Chinese and English literatures were included, most of which were from China. The literatures were published from January 2005 to April 2020, and the research objects were mainly Grade 3, Class A hospital. Working hour measurement method includes observation method and self-recording method. This study included 53 items, focusing on direct nursing and indirect nursing. Conclusion Working hour measurement method has a good guidance and reference function for hospitals to measure nursing workload and nursing personnel allocation. The research objects are mainly Grade 3, Class A hospital, and the content and quantity of research projects have not been unified, and there are many influencing factors.
		2022 Vol. 19 (15): 148-151 [Abstract] ( 58 ) HTML (1 KB) PDF (727 KB) ( 62 )

	152	Effect of PDCA cycle management on the treatment effect and prognosis of children with mycoplasma pneumoniae
		ZHANG LI REN Meiling▲
		Objective To explore the effect of PDCA cycle management on the treatment effect and prognosis of children with mycoplasma pneumoniae. Methods A total of 80 children with mycoplasma pneumonia who had received treatment in 904th Hospital of the Joint Logistic Support Force of the People’s Liberation Army from March 2019 to March 2020 were selected, and according to the random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group was given routine care for intervention, whereas the observation group was given both routine care and PDCA cycle management. The therapeutic effect, adverse reactions, time for the remission of clinical symptoms and parental satisfaction to nursing were compared. Results The total effective rate in the observation group was higher than that in the control group, the total incidence of adverse reactions was lower than that in the control group, cough disappearance time, antipyretic time, and hospitalization time were shorter than those in the control group, and the total satisfaction of parents’ satisfaction was shown to be higher than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion For children with mycoplasma pneumoniae, based on routine treatment and care intervention, the additional application of PDCA cycle management is good for the improvement of nursing service, and the remission of clinical symptoms. Besides, it is with fewer adverse reactions induced, with significant clinical nursing effects, and the prognosis effect is more significant.
		2022 Vol. 19 (15): 152-155 [Abstract] ( 74 ) HTML (1 KB) PDF (612 KB) ( 39 )

	156	Influence of quality control feedback combined with hierarchical management on the service quality of special needs ward
		LU Nan1 XU Lihong1 ZHAO Li2▲
		Objective To explore the influence of quality control feedback combined with hierarchical management on the service quality of special needs ward. Methods From January 2019 to December 2020, 90 nurses in the Special Need Ward, Xiaoshan District First People’s Hospital of Hangzhou City, Zhejiang Province were selected as the research objects. The traditional nursing mode was continued before implementation, and the hierarchical management and quality control feedback mode was adopted after implementation. The results of nurses’ operation and theory assessment, nursing quality, psychological state, and patient satisfaction were compared before and after implementation. Results The operational an theoretical scores after implementation were higher than before implementation, and the differences were statistically significant (P ＜ 0.05); the psychological state score of nurses after implementation was lower than before, and the difference was statistically significant (P ＜ 0.05); nursing quality score and satisfaction score after implementation were higher than before implementation, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of quality control feedback combined with hierarchical nursing management mode in the special need ward can significantly improve the quality of nurses, improve their psychological state and improve their nursing quality, which is worth clinical promotion and application.
		2022 Vol. 19 (15): 156-159 [Abstract] ( 112 ) HTML (1 KB) PDF (527 KB) ( 29 )

	160	Clinical effect of comprehensive nursing combined with total hip arthroplasty in the treatment of femoral neck fracture in the elderly
		ZHANG Min1 HE Peng1 LYU Xue2▲ ZHANG Mengnan1 ZHANG Jing1
		Objective To explore the clinical effect of comprehensive nursing combined with total hip arthroplasty in the treatment of femoral neck fracture in the elderly. Methods A total of 74 elderly patients with femoral neck fracture treated in Xidian Group Hospital from July 2019 to January 2021 were divided into observation group and control group by random number table method, with 37 cases in each group. They were treated with total hip arthroplasty. The control group was treated with routine nursing intervention and the observation group was treated with comprehensive nursing intervention. The clinical effects and pain degree of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05). The Harris score and Barthel index of the observation group after nursing were higher than those of the control group (P ＜ 0.05). The pain score after intervention was lower than that before intervention, and the observation group was significantly lower than that of the control group (P ＜ 0.05). Conclusion Comprehensive nursing combined with total hip arthroplasty can improve the clinical effect and relieve the pain of elderly patients with femoral neck fracture.
		2022 Vol. 19 (15): 160-162,174 [Abstract] ( 103 ) HTML (1 KB) PDF (571 KB) ( 213 )

	163	Effect of cognitive behavioral intervention on postoperative pain self-efficacy, rehabilitation training behavior, and recovery quality of patients with lumbar disc herniation
		ZHANG Cun YUE Huiling▲
		Objective To observe the effect of cognitive behavioral intervention on postoperative pain self-efficacy, rehabilitation training behavior, and recovery quality of patients with lumbar disc herniation (LDH). Methods A total of 150 LDH patients admitted to Shanghai Sixth People’s Hospital from January 2016 to January 2018 who underwent posterior lumbar decompression and internal fixation were divided into two groups according to the random number table method, with 75 cases in each group. The control group received routine intervention, and the observation group received cognitive behavioral intervention on the basis of control group, followed up for three months. The scores of chronic pain self-efficacy scale (CPSS), rehabilitation training compliance behavior scale, and lumbar Japanese Orthopaedic Society (JOA) were compared between the two groups before and after intervention, and the rehabilitation effects of the two groups were observed three months after surgery. Results The excellent and good rate of rehabilitation in observation group was higher than that in control group (P ＜ 0.05). After intervention, CPSS score and lumbar JOA score in both groups were higher than those before intervention, and the observation group was higher than the control group (P ＜ 0.05). The scores of compliance behaviors in the observation group were higher than those in the control group (P ＜ 0.05). Conclusion Cognitive behavioral intervention can improve postoperative pain self-efficacy and rehabilitation training compliance of patients with LDH, and promote the recovery of lumbar function.
		2022 Vol. 19 (15): 163-166 [Abstract] ( 136 ) HTML (1 KB) PDF (573 KB) ( 112 )

	167	Effect of professional nursing group mode on blood gas index and complications in patients with acute pulmonary thromboembolism
		WANG Sumei WANG Ruihong ZHANG Jiajia▲
		Objective To explore the effect of specialized nursing group mode on blood gas index and complications of patients with acute pulmonary thromboembolism. Methods A total of 167 patients with acute pulmonary thromboembolism admitted to the East Hospital of Qingdao Municipal Hospital from January 2017 to January 2021 were selected as the study subjects. All 167 patients received conventional anticoagulant and thrombolytic therapy during hospitalization, and they were divided into study group (83 cases) and control group (84 cases) according to random number table method. The control group received routine nursing means for daily nursing, the study group received full-time nursing group mode for nursing, intervention of both groups for four weeks. The arterial oxygen partial pressure (PaO2), arterial carbon dioxide partial pressure (PaCO2), alveolar gas-arterial oxygen partial pressure difference (P [A-a] O2), clinical indicators (respiratory rate, heart rate, systolic blood pressure, diastolic blood pressure), complications and the satisfaction of patients’ family members with two different nursing modes were compared between the two groups before and after intervention. Results Before intervention, there were no significant differences in PaO2, PaCO2, P (A-a) O2, respiratiory rate, heart rate, systolic blood pressure, and diastolic blood pressure between the two groups (P > 0.05). After intervention, PaO2 values of the two groups were higher than those before intervention, and the study group was higher than that in the control group, while PaCO2 and P (A-a) O2 values were lower than those before intervention, and the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05). After intervention, respiratiory rate and heart rate of the two groups were lower than before intervention, and the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05), systolic and diastolic blood pressure were higher than before intervention, and the study group was higher than the control group, the differences were statistically significant (P ＜ 0.05). After intervention, the incidence of adverse reactions in the study group was lower than that in the control group (P ＜ 0.05). After intervention, nursing satisfaction in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The professional nursing group mode for patients with acute pulmonary thromboembolism can effectively improve the clinical symptoms of patients, reduce the incidence of complications, but also contribute to improve the nursing satisfaction of patients’ family members.
		2022 Vol. 19 (15): 167-170,178 [Abstract] ( 96 ) HTML (1 KB) PDF (622 KB) ( 46 )

	171	Diagnosis of two cases of critical chlamydia psittaci pneumonia by metagenomic next-generation sequencing
		WANG Jiali1 LIU Jian2 CAO Huidan1
		Chlamydia psittaci pneumonia is a long-neglected pulmonary infection caused by chlamydia psittaci infection. This paper reports two cases of critical chlamydia psittaci pneumonia diagnosed by metagenomic next-generation sequencing in Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. The clinical manifestations of this disease are lack of specificity, and the misdiagnosis rate is high, in serious cases, it may cause systemic multiple organ failure and other critical manifestations. Metagenomic next-generation sequencing technology is highly sensitive and can detect pathogens that cannot be detected by other traditional methods, which brings significant changes to the accurate diagnosis and treatment of respiratory tract infection, effectively shortening the course of disease and improving the prognosis of patients to the greatest extent.
		2022 Vol. 19 (15): 171-174 [Abstract] ( 109 ) HTML (1 KB) PDF (969 KB) ( 59 )

	175	A case report of acquired factor Ⅴ deficiency
		CHEN Danxia ZHANG Yuyi ZHANG Xiaogang ZHAI Xiaobo
		A case of abnormal coagulation function after laparoscopic cholecystectomy is reported, had two major abdominal bleeds, the coagulation factor test of the second abdominal hemorrhage showed that the activity of coagulation factor Ⅴ was 0.7%, and the Ⅴ antibody was 8.0 BU, and was diagnosed acquired clotting factor Ⅴ deficiency. After reviewing the literature, we analyzed the cause of acquired factor Ⅴ deficiency in this patient, which may be related to infection, plasma transfusion, and antibiotic use. After plasmapheresis and immunosuppression, the coagulation function gradually returned to normal. In this paper, literature review was conducted on the treatment of acquired factor Ⅴ deficiency in order to provide ideas for the diagnosis and management of clinicians.
		2022 Vol. 19 (15): 175-178 [Abstract] ( 105 ) HTML (1 KB) PDF (532 KB) ( 43 )

	179	Study on symptom monitoring module construction and design of infectious disease surveillance system
		CHEN Chongde GAO Xing WANG Yan HU Hongpu▲
		Infectious diseases have been one of the most important threats to mankind for a long time, its prevention and control is of great importance. However, the early warning ability of the direct reporting system of infectious diseases in China is not comprehensive at present, and it still needs to be upgraded and improved. In this study, based on the literature review, taking the symptom assignment matrix of infectious diseases established according to the principle of symptom monitoring as the core, a symptom monitoring module model of infectious disease surveillance system is constructed, which is composed of four parts of information input and human-computer interaction, symptom recognition and semantic standardization, disease judgment matrix based on patients’ symptoms, and output and subsequent decision-making and disposal, including the functions of symptom semantic standardization, disease identification according to symptoms, epidemiological data collection, automatic information reporting and comprehensive intelligent judgment. The model can simulate the expert clinical diagnosis and treatment judgment, and perform auxiliary differential diagnosis for similar diseases according to the symptoms of patients, so as to strengthen the probability of infectious disease identification by grass-roots health personnel, and further reduce the layout depth of infectious disease identification to the bottom of the national health coverage network, so as to improve the efficiency of infectious disease monitoring and response system.
		2022 Vol. 19 (15): 179-182,196 [Abstract] ( 70 ) HTML (1 KB) PDF (1304 KB) ( 135 )

	183	Construction of evaluation index system of Yunnan traditional Chinese medicine industry competitiveness based on diamond model
		ZHANG Xiong1 CHANG Haojuan1 ZHANG Difan1 LIU Xiaojing1 XIN Wenfeng2 MENG Qionghong3
		As an important industry of Yunnan’s economic development, the traditional Chinese medicine industry plays an important role in the implementation of strategies such as ecological protection, poverty alleviation and rural revitalization. Scientific evaluation of the competitiveness of the traditional Chinese medicine industry is of great significance to clarify the advantages and disadvantages of the development of the traditional Chinese medicine industry in various regions, consolidate the competitive advantages and formulate the future development strategy of the industry. However, how to analyze and evaluate the advantages and disadvantages and competitiveness of the development of the traditional Chinese medicine industry in domestic and provincial regions rich in traditional Chinese medicine resources is lack a corresponding structure and evaluation index system. In reference based on existing research results, this paper uses the diamond model analysis framework, the development of Wenshan Notoginseng Radix Et Rhizoma industry as the research object, from the production factors, demand conditions, related and supporting industries, enterprise organizations, opportunities, and government, six primary indexes of Wenshan Notoginseng Radix Et Rhizoma industry development is analyzed, combining with the field survey data, build 13 secondary indicators, 27 tertiary indicators, Thus, taking Wenshan Notoginseng Radix Et Rhizoma industry as an example, the evaluation index system of Yunnan traditional Chinese medicine industry competitiveness is constructed to provide decision-making basis for the development of Yunnan traditional Chinese medicine industry.
		2022 Vol. 19 (15): 183-187 [Abstract] ( 74 ) HTML (1 KB) PDF (866 KB) ( 50 )

	188	Analysis of Chinese medicine health service policy based on policy tools
		XIA Fang ZHANG Bing HE Yufang
		Objective To analyze the problems in the health service policy of traditional Chinese medicine from the perspective of policy tools and put forward suggestions for the follow-up improvement of the policy. Methods Based on the two dimensions of policy tools and traditional Chinese medicine health service system, a two-dimensional analysis framework was constructed and 443 content units of 15 policy texts published from January 2013 to March 2021 were analyzed by content analysis method. Results The structure of policy tools was not coordinated, with supply-oriented policy tools accounting for 47.6%, demand-oriented policy tools accounting for 20.53% and environment-oriented policy tools accounting for 31.87%; the traditional Chinese medicine health service system was unbalanced, with 40.41% improving service capacity, 19.86% innovating service technology, 12.87% enriching service products and 26.86% optimizing service environment. Conclusion It is suggested to optimize the internal structure of supply-oriented and environment-oriented policy tools, increase the use of demand tools, and adjust the distribution of policy tools to give full play to policy synergy. Pay attention to the coupling effect of policy tools and traditional Chinese medicine health service system.
		2022 Vol. 19 (15): 188-191 [Abstract] ( 64 ) HTML (1 KB) PDF (793 KB) ( 85 )

	192	Thoughts and explorations on the construction of clean government culture in medical colleges and universities from the perspective of traditional Chinese medicine culture
		HU Zhongxi
		The construction of clean government culture is the key link of “ensuring full and strict governance over the Party” and the important guarantee of the sustainable development of the school. Traditional Chinese medicine culture is closely related to the theory of clean government culture, how to rely on traditional Chinese medicine culture to improve the level of clean government culture construction, is an urgent need to solve the realistic subject. The current situation of clean government culture construction in medical colleges and universities is analyzed through questionnaire survey: “clean government spirit is vague, supervision mechanism is lacking, and education carrier is backward.” Based on the theory of traditional Chinese medicine culture, this paper puts forward the construction path of clean government culture: “Awakening the moral consciousness of clean government among teachers and students, perfecting the norms of clean government culture system, and enriching the expression forms of clean government culture.” In order to provide theoretical reference for the construction of clean government culture in medical colleges and universities.
		2022 Vol. 19 (15): 192-196 [Abstract] ( 67 ) HTML (1 KB) PDF (872 KB) ( 98 )

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