平滑肌电刺激与曲安奈德治疗外阴硬化性苔藓的临床效果

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Abstract Objective To compare the effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide in the treatment of vulvar lichen sclerosus. Methods A total of 58 patients with vulvar lichen sclerosus in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to January 2020 were selected, they were divided into physical therapy group (21 cases) and drug therapy group (37 cases) according to follow-up conditions and wills. In physical therapy group, the vascular and lymphatic systems of the lower limbs and pelvic floor were treated with electrical stimulation, and drug therapy group was treated with Triamcinolone Acetonide Cream. Symptom and sign scores and quality of life index scores before treatment and 1, 3, 6, and 12 months after treatment were compared between two groups, and the occurrence of adverse reactions was observed. Results The symptom scores of physical therapy group were lower than those of drug therapy group at 12 months after treatment (P < 0.05). Sign scores of physical therapy group were higher than those of drug therapy group at 1 month after treatment (P < 0.05). The quality of life scores of physical therapy group were lower than those of drug therapy group at 1 and 6 months after treatment (P < 0.05). Sexual life scores of physical therapy group were lower than those of drug therapy group at 3,6, and 12 months after treatment (P < 0.05). The sleep anxiety scores of physical therapy group were lower than those of drug therapy group at 1, 6 and 12 months after treatment (P < 0.05). In the physical therapy group, one patient with diabetes developed vulvovaginal candidiasis, which was cured after treatment and continued treatment; in drug therapy group, two patients had local itching aggravation, prickling, redness, and swelling, and stopped taking the medicine. In the long-term medication follow-up, five patients showed unalleviated pruritus, local vascular dilation, pigmentation, and adverse drug reactions, and drug withdrawal. Conclusion Vascular smooth muscle electrical stimulation is safe and effective in the treatment of vulvar lichen sclerosus with few side effects. It has advantages in improving sexual life quality, skin pigment, and sleep anxiety recovery.

Key words： Vascular smooth muscle electrical stimulation Triamcinolone acetonide Vulvar lichen sclerosus Quality of life

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	LIU Nian1 ZHAO Junda1 LIU Ya2 MA Junqi1

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LIU Nian1 ZHAO Junda1 LIU Ya2 MA Junqi1. Clinical effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide of the patients with vulvar lichen sclerosus[J]. 中国医药导报, 2022, 19(15): 105-108.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I15/105

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