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2022 Vol. 19, No. 2 Published: 2022-01-15

	4	Effect of glucagon-like peptide-1 on cerebral ischemic-reperfusion injury in neonatal rats#br#
		LI Chengyan1 ZHOU Xuan2 TANG Lanfen1 MO Bo1 CHEN Yinhui1 CHEN Qiaomei1 YAN Xingyu1 AO Dang1
		Objective To study the neuroprotective effect and mechanism of glucagon-like peptide-1 (GLP-1) on cerebral ischemia-reperfusion injury in neonatal rats. Methods Eighteen 7-day-old SD neonatal rats were divided into control group, model group， and treatment group, with six rats in each group. After anesthesia, the left common carotid artery was dissected in the neck of neonatal rats, while only the left common carotid artery was exposed in the control group, the blood flow of model group and treatment group was recovered after clipping the left common carotid artery for 60 min. After operation, treatment group was given Liraglutide Injection intraperitoneal injection, and control group and model group were given the same amount of normal saline intraperitoneal injection. Longa method was used to score neurobehavioral disorder in neonatal rats; TUNEL assay was used to detect the number of apoptotic cells in hippocampal neurons; the number of nuclear factor κB(NF-κB) positive cells in hippocampus was detected by immunohistochemistry; the expressions of NF-κB, tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), and Caspase-3 protein in hippocampus tissues were detected by Western blot. Results The neurobehavioral disorder score, the number of apoptotic cells in hippocampal neurons, the number of NF-κB positive cells, and the levels of TNF-α, iNOS, and Caspase-3 protein in model group were higher than those in control group, the neurobehavioral disorder score, the number of apoptotic cells in hippocampal neurons, the number of NF-κB positive cells, and the levels of TNF-α, iNOS, and Caspase-3 protein in treatment group were lower than those in model group, and the differences were statistically significant (P < 0.05). In model group, the level of intranuclear p-NF-κB protein level was higher than that in cytoplasmic NF-κB protein level; and in treatment group, the intranuclear p-NF-κB p65 protein level was lower than the cytoplasmic NF-κB protein level, and the differences were statistically significant (P < 0.05). Conclusion GLP-1 can reduce apoptosis of hippocampal neurons in ischemia-reperfusion neonatal rats by inhibiting NF-κB mediated inflammatory response.
		2022 Vol. 19 (2): 4-7,12 [Abstract] ( 174 ) HTML (1 KB) PDF (1867 KB) ( 89 )

	8	Comparative study on authorial stance markers in English abstracts of Chinese and international medical journals#br#
		HU Liping ZHANG Cunyu WANG Shanshan
		Objective To analyze the features of use and academic discourse function of authorial stance markers in Chinese and international medical journals. Methods Chinese and foreign medical journals with high impact factors were randomly selected from China National Knowledge Infrastructure and Science Citation Index databases, English abstracts of papers published in 2018-2019 were extracted. Corpus of English abstracts of domestic medical journals and international medical journals were established. AntConc 3.5.8 software was used to retrieve the occurrence frequency of stance markers in these two corpora, and the differences in the use of stance markers in the two corpora were compared and analyzed. Results The frequencies of the use of hedges, boosters, attitude markers, and self-referencing in international journals were higher than those in domestic journals (P ＜ 0.05); the frequencies of verb, adverb, and adjective hedges in international journals were higher than those in domestic journals (P ＜ 0.05) ; the frequency of noun boosters in international journals was higher than that in domestic journals (P ＜ 0.05); the frequencies of attitude verb, adjective attitude markers in international journals were higher than those in domestic journals (P ＜ 0.05), and the frequencies of self-referencing "we" "our" were higher than those in domestic journals (P ＜ 0.05). The diction of authorial stance markers in international journals was relatively diversified, while that in domestic journals was relatively monotonous. Conclusion Chinese medical researchers could use appropriate stance markers to construct their academic stance and identity, enhance the discourse interaction with readers, so as to build up academic power and deliver the voice of the Chinese medical community to the world.
		2022 Vol. 19 (2): 8-12 [Abstract] ( 37 ) HTML (1 KB) PDF (568 KB) ( 83 )

	13	Effect of Bifidobacterium on invasion and metastasis of HCT116 colon cancer cells through IL-6 mediated EMT#br#
		DU Heng WU Anding▲ ZHANG Hongying YU Jie JIAN Hui
		Objective To investigate the effect of Bifidobacterium on invasion and metastasis of HCT116 colon cancer cells through interleukin-6 (IL-6) mediated epithelial-mesenchymal transition (EMT). Methods HCT116 colon cancer cells were cultured in vitro and divided into control group and Bifidobacterium group. The control group was cultured conventionarily, and the Bifidobacterium group was cultured with 80 μg/ml Bifidobacterium. After 48 hours, the expression levels of IL-6, E-cadherin, and N-cadherin in both groups were detected by Western blot, and the expression and localization of IL-6, E-cadherin, and N-cadherin were detected by immunofluorescence technique. Cell scratch test and Transwell chamber test were used to detect the cell metastasis and invasion ability of the two groups. Results The results of Western blot showed that the expression level of E-cadherin in the Bifidobacterium group was higher than that in the control group, while the expression level of IL-6 and N-cadherin was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). The results of immunofluorescence showed that IL-6, E-cadherin, and N-cadherin proteins were localized on cell membranes. Compared with the control group, the fluorescence of E-cadherin in Bifidobacterium group was obvious, while the fluorescence of IL-6 and N-cadherin was weak. The healing rate of cell scratches in Bifidobacterium group was lower than that in control group, and the difference was statistically significant (P ＜ 0.05). The results of crystal violet staining and quantitative analysis in Transwell chamber test showed that the number of invasive cells in Bifidobacterium group was less than that in control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Bifidobacterium can inhibit the EMT process mediated by inflammatory factor IL-6, and weaken the invasion and metastasis ability of HCT116 colon cancer cells.
		2022 Vol. 19 (2): 13-16 [Abstract] ( 87 ) HTML (1 KB) PDF (1620 KB) ( 47 )

	17	Effect of Apatinib on apoptosis of triple negative breast cancer cells#br#
		ZHANG Yifan1 TANG Xijun1 WANG Xinshuai2
		Objective To study the effect of Apatinib on apoptosis of triple negative breast cancer cells and its mechanism. Methods Triple negative breast cancer cell line MDA-MB-468 was cultured in vitro, and PBS group, 1, 5, 10, and 20 μg/ml Apatinib groups were set, and treated with PBS, 1, 5, 10, and 20 μg/ml Apatinib, respectively. MTT assay, flow cytometry, scratch assay and Transwell assay were used to detect the effects of Apatinib on cell proliferation, apoptosis, cycle, migration and invasion, and Western blot was used to detect the expression of apoptosis-related proteins. Results The cell survival rate of apatinib groups was lower than that of PBS group, and the difference was statistically significant (P ＜ 0.05). The apoptosis rate of 1 and 10 μg/ml Apatinib group was higher than that of PBS group, the difference was statistically significant (P ＜ 0.05). There was no significant difference in cell cycle distribution between PBS group and 1 and 10 μg/ml Apatinib group (P ＞ 0.05). The migration movement area of 1 and 10 μg/ml Apatinib group was lower than that of PBS group, and the difference was statistically significant (P ＜ 0.05). The number of cell invasion in 1 and 10 μg/ml Apatinib group was lower than that in PBS group, the difference was statistically significant (P ＜ 0.05). The expression levels of P65 and Bcl-2 in 5 and 10 μg/ml Apatinib groups were lower than those in PBS group, and the differences were statistically significant (P ＜ 0.05). Conclusion Apatinib can inhibit the proliferation and induces apoptosis of MDA-MB-468 breast cancer cells. At the meantime, the p65/Bcl-2 signaling pathways are also suppressed.
		2022 Vol. 19 (2): 17-20 [Abstract] ( 194 ) HTML (1 KB) PDF (2119 KB) ( 37 )

	21	Effect of Kujin Tablets on inflammatory response of macrophages induced by lipopolysaccharide#br#
		LIU Qing ZHU Chunxue LIU Chengyu WANG Yicheng HE Meijuan HE Yanjie HUANG Hanpeng▲
		Objective To investigate the effect of Kujin Tablets on the inflammatory response and its possible mechanism, the cell model of inflammatory response was established by lipopolysaccharide (LPS) stimulation of mononuclear macrophages in mice. Methods The cells were divided into control group, LPS group and Kujin Tablets group. The cells in LPS group were stimulated with LPS (final concentration of 1 μg/ml) for 12 h, and the Kujin Tablets group was stimulated with Kujin Tablets (1 mg/ml) for 4 h after LPS stimulation. The control group was not treated with special treatment. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), autophagy associated protein 5 (ATG5), microtubule-associated protein 1 light chain 3 Ⅱ(LC3 Ⅱ) mRNA and TNF-α, caspase-3, LC3 Ⅱ, p62 proteins were detected. Results Compared with the control group, the mRNA expression levels of IL-6, TNF-α, TGF-β, ATG5, and LC3 Ⅱ in LPS group were significantly increased, and the differences were statistically significant (P ＜ 0.05). Compared with the control group, the protein expression levels of TNF-α, LC3 Ⅱ, p62 and caspase-3 in LPS group were increased, and the differences were statistically significant (P ＜ 0.05). The mRNA expression levels of IL-6, TNF-α, TGF-β, ATG5, and LC3 Ⅱ in Kujin Tablets group were significantly lower than those in LPS group, the differences were statistically significant (P ＜ 0.05). The protein expression levels of TNF-α, LC3 Ⅱ, p62, and caspase-3 in Kujin Tablets group were significantly lower than those in LPS group, and the differences were statistically significant (P ＜ 0.05). Conclusion Kujin Tablets can significantly reduce LPS-induced cell inflammation, reduce apoptosis and improve cell viability. Autophagy is involved in the anti-inflammatory process of Kujin Tablets.
		2022 Vol. 19 (2): 21-24 [Abstract] ( 85 ) HTML (1 KB) PDF (529 KB) ( 62 )

	25	Predictive value of total bilirubin and its ratio to direct bilirubin in the prognosis of patients with extensive-stage small cell lung cancer#br#
		CAI Xueqin1 XU Mingjing2 MA Huan1 LU Donghui1
		Objective To evaluate the predictive value of total bilirubin to direct bilirubin and the ratio of the two in the prognosis of patients with extensive-stage small cell lung cancer (ES-SCLC). Methods A total of 83 ES-SCLC patients admitted to the 901st Hospital of the Joint Service Support Force of the Chinese People’s Liberation Army from January 2018 to July 2020 were selected as the research objects. Clinical data, biochemical tests, progression-free survival (PFS) and overall survival (OS) of patients upon admission were collected. Multivariate Cox regression was used to analyze the effect of bilirubin on the survival and prognosis of ES-SCLC patients, and the Kaplan-Meier method was used to evaluate the survival time. Results Total bilirubin and total bilirubin / direct bilirubin had predictive value for the survival and prognosis of ES-SCLC patients (P ＜ 0.05), and the best cut-off values were 12.3 μmol/L and 2.8, respectively; compared with patients in the low total bilirubin group (≤12.3 μmol/L), patients in the high total bilirubin group (＞12.3 μmol/L) had longer median PFS and OS (P ＜ 0.05); compared with patients in the low total bilirubin / direct bilirubin group (≤2.8), patients in the high total bilirubin / direct bilirubin group (＞2.8) had longer median PFS and OS (P ＜ 0.05); total bilirubin and total bilirubin / direct bilirubin were independent prognostic factors affecting ES-SCLC patients (P ＜ 0.05). Conclusion Total bilirubin level and total bilirubin / direct bilirubin level may be important prognostic factors of ES-SCLC, which can help determine the prognosis of patients.
		2022 Vol. 19 (2): 25-28,45 [Abstract] ( 176 ) HTML (1 KB) PDF (719 KB) ( 41 )

	29	Comparison of effects and mechanisms of acupoint injection at different tissue levels and research progress#br#
		REN Shanjie1 LU Hongxiu2 SU Fan2
		As a combination of traditional acupuncture and moxibustion with modern injection therapeutic method, acupoint injection has achieved remarkable curative effect. This article reviewed the PubMed, China National Knowledge Infrastructure, and Wanfang database about the acupoint injection level study, found acupoint points are mainly divided into three levels: intradermal, subcutaneous, and muscle layer, the effect of acupoint injection at different level and its physiological anatomy, the nerve distribution and targeting pathway is closely related to, this may be This may be the key to different clinical effects on the same disease at the same acupoint at different levels.
		2022 Vol. 19 (2): 29-32 [Abstract] ( 155 ) HTML (1 KB) PDF (651 KB) ( 260 )

	33	Research progress of teaching ability promotion strategies of clinical nursing teachers#br#
		WANG Xinran1 WANG Wenshuang2 ZHANG Xiaoxue1 JIN Jin1
		Clinical nursing teachers play a leading role in the process of practice teaching, teacher’s teaching ability directly affects the teaching behavior and teaching effect. This study summarizes the significance of clinical teachers’ teaching ability for teaching and nursing, and it reviewes the strategies to improve teaching ability. Firstly, it is showed that the selection of clinical nursing teachers should be paid attention, the selection standards should be improved, and multi-dimensional and whole-process evaluation should be carried out. Secondly, through improving the system for teaching and training, personalized management gives play to the advantages of different teachers. In addition, implementing teaching incentive mechanism and professional quality education, cultivating the dual identity of nursing, and teaching majors can provide guarantee to improve the teaching quality of clinical nursing.
		2022 Vol. 19 (2): 33-36，50 [Abstract] ( 113 ) HTML (1 KB) PDF (664 KB) ( 118 )

	37	Research progress of cystic brain metastasis of breast cancer#br#
		ZHANG Lei1 ZHANG Jing1 WAN Donggui2
		Brain metastasis of breast cancer is a complication of advanced breast cancer with serious symptoms and poor prognosis. Its incidence is low, but it has high mortality rate. Patients lack clinical specific manifestation that mianly symptoms are nervous system symptoms, and the diagnosis is mainly based on cranial CT and MRI. Due to the existence of blood-brain barrier and blood-brain tumor barrier, related drugs are not effective and the treatment means are limited, therefore, clinicians should pay attention to it. For high risk of recurrence, patients should periodic review. If the disease has occurred, radiotherapy and surgical treatment should be the main treatment methods, and combined with the patient’s condition to make individualized plan. This paper reviews the clinical characteristics, diagnostic points, treatment methods, and prognosis of the disease, in order to provide more reference for the clinic.
		2022 Vol. 19 (2): 37-40 [Abstract] ( 143 ) HTML (1 KB) PDF (510 KB) ( 68 )

	41	Investigation and analysis on the improvement of the autonomy of undergraduates of traditional Chinese medicine by master-appretice-education#br#
		WANG Yanjun1，2 SUN Mingxin2 LAN Xiangdong2 ZHANG Ying3 SUN Shijiang1
		Objective To discuss the influence of the five-in-one master-appretice education of traditional Chinese medicine model on students’ autonomy, in order to provide a reference for the training model of Chinese medicine talents. Methods A questionnaire was used to conduct research on 351 students receiving master-appretice education of traditional Chinese medicine. The questions involved three aspects, including the necessity of introducing master-appretice education of traditional Chinese medicine into the undergraduate class of Chinese medicine, and whether it would improve students’ interest in learning Chinese medicine, critical thinking, and independent learning ability after the master-appretice education of traditional Chinese medicine. Results 90.6% of students believed that it was necessary to introduce a master-appretice education of traditional Chinese medicine model at the undergraduate level, 91.2% of the students believed that the introduction of master-appretice education of traditional Chinese medicine in the undergraduate course could increase their interest in learning Chinese medicine, and 90.6% of students believed that master-appretice education of traditional Chinese medicine could enhance their independent learning ability. 91.5% of the students believed that the master-appretice education of traditional Chinese medicine model could improve their critical thinking skills, while 91.5% of the students believed that the master-appretice education of traditional Chinese medicine was conducive to the development of personality and teaching students in accordance with their aptitude. Conclusion The majority of students affirm the advantages of master-appretice education and believe that their autonomy could be improved through the teaching of the five-in-one master-appretice education model.
		2022 Vol. 19 (2): 41-45 [Abstract] ( 91 ) HTML (1 KB) PDF (963 KB) ( 19 )

	46	Investigation and analysis of children’s medication information in the drug instructions for intravenous drip medication in Maternal and Child Health Hospital of Tongling#br#
		ZHENG Chao SUN Ji
		Objective To investigate the information labeling conditions of children’s medication in the instructions for intravenous drip medicines in Maternal and Child Health Hospital of Tongling (“our hospital” for short), and to provide a reference for standardizing the information on the instructions. Methods The instructions for intravenous infusion medicines used in our hospital from January to April 2021 was collected, the medication information for children mentioned in ten items such as “usage and dosage” “adverse reactions” and “children’s medications” in the instructions into an Excel table were listed, and statistical analysis to relevant content was carried on. Results The labeling rate of children’s medication information in 104 intravenous drip drug inserts was generally low; the labeling rate of children’s drug information in the foreign-funded drug manuals was generally higher than that of domestic drugs; the labeling rate of children’s medication information in western medicine instructions was generally higher than that of Chinese patent medicines; “children’s medication” item of medication information labeling was seriously missing; the instruction manual was not revised in time; among them, the conversion of children’s drug dosage in the antibacterial drug instructions was not standardized; there were differences in the usage and dosage of the three groups of foreign and domestic intravenous antibacterial drugs in the instructions for children. Conclusion There are many problems in the labeling of children’s medication information in the instructions for intravenous infusion drugs, which need to be further improved and should be paid attention by the relevant national departments.
		2022 Vol. 19 (2): 46-50 [Abstract] ( 117 ) HTML (1 KB) PDF (667 KB) ( 47 )

	51	Influencing factors of visiting beliefs and attitudes of family members of patients in intensive care unit#br#
		QIAN Haiyong1 TANG Wenqi1 FENG Xiao2 ZHANG Zuoyan1 ZHANG Li1▲
		Objective To explore the influencing factors of visiting beliefs and attitudes of family members of patients in intensive care unit (ICU). Methods A total of 108 family members of ICU patients (one family member for each patient) in Shanghai Sixth People’s Hospital from December 2018 to December 2020 were selected. The beliefs and attitudes toward visitations in ICU questionnaire (BAVIQ) was used to evaluate the beliefs and attitudes of visiting of all family members of ICU patients, and related baseline data of family members of all patients were collected. BAVIQ scores of family members of patients with different data characteristics were compared, the related factors that might affect the visiting beliefs and attitudes of family members of ICU patients were analyzed. Results There were statistically significant differences in ICU of BAVIQ scores among the family members of patients with different education levels, satisfaction with visits, and self-rating anxiety scale scores (P ＜ 0.05). After multiple linear regression analysis, education level of high school or below, dissatisfaction with visits, and heavier anxiety were the general influencing factors of visiting beliefs and attitudes of ICU family members of patients (P ＜ 0.05). The regression equation was got: Y = 71.085+6.935X1+8.065X2+9.915X3. Conclusion Family members of ICU patients have general visiting beliefs and attitudes, which are affected by factors such as the lower education level of family members of patients, dissatisfaction with visiting and heavy anxiety.
		2022 Vol. 19 (2): 51-54 [Abstract] ( 190 ) HTML (1 KB) PDF (531 KB) ( 30 )

	55	Investigation and analysis of the psychological resilience and mental health of postgraduates majoring in basic medicine and biology#br#
		JIANG Jinjin WU Xuezhong
		Objective To investigated and analyzed the psychological resilience and mental health of postgraduates majoring in basic medicine and biology. Methods In March 2021, a total of 100 postgraduates majoring in basic medicine and biology from a university in Anhui Province were randomly selected as the research objects, a general information questionnaire was made, and all the subjects were investigated using the symptom checklist 90 (SCL-90) and the Connor-Davidson resilience scale (CD-RISC). SCL-90 scale and CD-RISC scale were took as dependent variables, the factors affecting the above scales were assigned as independent variables for multiple linear regression analysis. Results There were statistically significant differences in mental unhealthy rates among different genders, family economic status, birthplaces, and only-child (P ＜ 0.05). Gender, only child, family economic status, and birthplace were the influencing factors of mental health status in basic medical and biological research (P ＜ 0.05). There were statistically significant differences in mental resilience score among different genders, marriage and relationship status, family economic status, student origin, internship experience, and student cadres (P ＜ 0.05). Gender, relationship status, student cadres, family economic status, internship experience, and source of origin were the factors affecting the psychological resilience of basic medical and biological research (P ＜ 0.05). Conclusion The mental health of postgraduates majoring in basic medicine and biology is not optimistic, mainly influencing factors such as gender, love and marriage, student leaders, only child, family economic status, internship experience, and the place of origin. Educators should pay attention to their mental health education and social support to improve their psychological stress resistance and improve their mental health.
		2022 Vol. 19 (2): 55-58,66 [Abstract] ( 156 ) HTML (1 KB) PDF (627 KB) ( 131 )

	59	Influencing factors of patients’ self-perceived burden after heart valve replacement#br#
		TANG Zhongfeng GUAN Yuzhen LU Zhen
		Objective To analyze the influencing factors of self perceived burden in patients after heart valve replacement. Methods A total of 100 patients after heart valve replacement (valvular heart disease) treated in Jiangsu Provincial Hospital from January 2018 to January 2021 were selected as the research subjects, the self perceived burden (self perceived burden scale [SPBS] score) of all patients on the 7th day after operation was evaluated, the statistical table of baseline data was designed, the baseline data of patients in the two groups were counted in detail, the SPBS scores of patients with different data characteristics after heart valve replacement were compared, the influencing factors of self perceived burden of patients after heart valve replacement were analyzed. Results On the 7th day after operation, the SPBS score of 100 patients after heart valve replacement was (29.25±5.16) points. There were statistically significant differences in family’s per capita monthly income, New York Heart Association classification, SPBS scores of main caregivers and social support patients in different families (P ＜ 0.05). Multivariate linear regression analysis showed that the family’s per capita monthly income was less than 5000 yuan, NYHA Ⅲ-Ⅳ, the main caregivers were children or others, and low social support were all influential factors for the mild to moderate self-experience burden of patients after heart valve replacement (P ＜ 0.05). The regression equation was as follows: Y = 40.338+2.742X1+6.586X2+6.022X3+2.470X4, where the regression model F = 63.410, R2 = 0.728, after adjustment, R2 = 0.716, P ＜ 0.001. Conclusion Most patients after heart valve replacement have mild to moderate self perceived burden, which may be related to the family’s per capita monthly income, NYHA classification, main caregivers and social support.
		2022 Vol. 19 (2): 59-62 [Abstract] ( 68 ) HTML (1 KB) PDF (532 KB) ( 40 )

	63	Effects of early intervention on the prognosis of patients with high risk non-ST -segment elevation acute coronary syndrome#br#
		WANG Wenbin YAN Mingcong CHENG Guojie
		Objective To explore the effect of different early interventional time on the prognosis of high risk patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods A total of 406 high-risk patients with NSTE-ACS admitted to the Department of Cardiology, Daxing District People’s Hospital of Beijing from January 2017 to December 2019 were enrolled. According to the different timing of percutaneous coronary intervention (PCI), the patients were divided into group A (incidence ＜12 hours) and group B (incidence 12-24 hours), and the incidence of major adverse cardiovascular events during hospitalization and one year after discharge were compared between the two groups. Results During hospitalization, and one year after discharge, the incidence of major adverse cardiovascular events in group A was significantly lower than group B (P ＜ 0.05). Conclusion For high-risk patients with NSTE-ACS, PCI therapy within 12 hours can significantly reduce the incidence of major adverse cardiovascular events during hospitalization and one year after discharge.
		2022 Vol. 19 (2): 63-66 [Abstract] ( 191 ) HTML (1 KB) PDF (502 KB) ( 41 )

	67	Diagnostic value of electrocardiogram combined with pro-brain natriuretic peptide precursor and cardiac troponin T in early acute myocardial infarction
		CAO Liangliang YAN Weiguo
		Objective To research the diagnostic value of electrocardiographic (ECG) combined with N-terminal pro brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in early acute myocardial infarction (AMI). Methods A total of 132 patients with chest pain and suspected early AMI admitted to the the First People’s Hospital of Anqing City, Anhui Province from January 2018 to September 2019 were selected as the research objects. According to the results of coronary angiography, they were divided into AMI group (85 cases) and non AMI group (47 cases). All patients underwent ECG, and their serum NT-proBNP and cTnT levels were measured. The ECG results, NT-proBNP and cTnT levels of the two groups were compared. The receiver operating characteristic curves of ECG + NT-proBNP, ECG + cTnT and ECG + NT-proBNP + cTnT in the diagnosis of early AMI were drawed, and their diagnostic efficacy were compared. Results There was no significant difference in the coincidence rate of ECG examination between the two groups (P ＞ 0.05). The levels of NT-proBNP and cTnT in AMI group were higher than those in non AMI group, the differences were statistically significant (P ＜ 0.05). The area under curve of ECG + NT-proBNP + cTnT in the diagnosis of early AMI (0.874) was higher than that of ECG + NT-proBNP and ECG + cTnT (0.817, 0.821, respectively), the differences were statistically significant (P ＜ 0.05). Conclusion ECG combined with serological indexes NT-proBNP and cTnT can significantly improve the diagnostic accuracy of early acute myocardial infarction, and has high clinical application value in early screening, diagnosis and treatment of acute myocardial infarction.
		2022 Vol. 19 (2): 67-70 [Abstract] ( 154 ) HTML (1 KB) PDF (679 KB) ( 50 )

	71	Predictive value of LP-PLA2 and transcranial Doppler ultrasound in the prognosis of acute ischemic stroke#br#
		YOU Wenjing1 LI Jing1 DONG Yanqing1 XU Yueyan1 LI Huizhen1 ZHENG Zhichao2▲
		Objective To explore the prognostic value of lipoprotein-related phospholipase A2 (LP-PLA2) and transcranial Doppler ultrasound (TCD) in the prognosis of acute ischemic stroke (AIS). Methods The clinical data of 171 AIS patients admitted to Nanhai Hospital of Guangdong Provincial People’s Hospital (“our Hospital” for short) from April 2017 to July 2019 were retrospectively analyzed as study group, and the physical examination data of 61 healthy volunteers who underwent physical examination in our hospital during the same period were retrospectively analyzed as control group. AIS patients were divided into mild, moderate and severe infarction patients according to the area of cerebral infarction, and LP-PLA2 and TCD parameters pulse index (PI), peak systolic flow rate (PSV) and mean blood flow velocity (MV) were compared. LP-PLA2, PI, PSV and MV were compared between the two groups. The influencing factors of poor prognosis in AIS patients were analyzed, and the predictive value of LP-PLA2, PI, PSV and the three on poor prognosis in ASI patients was analyzed. Results LP-PLA2 and PI in the study group were higher than those in the control group, while PSV and MV were lower than those in the control group (P ＜ 0.05). LP-PLA2 and PI in severe infarction patients were higher than those in mild and moderate infarction patients (P ＜ 0.05), while LP-PLA2 and PI in moderate infarction patients were higher than those in mild infarction patients (P ＜ 0.05). PSV and MV in patients with severe infarction were lower than those in patients with mild and moderate infarction (P ＜ 0.05), and PSV and MV in patients with moderate infarction were lower than those in patients with mild infarction (P ＜ 0.05). The proportion of LP-PLA2, PI and consciousness disorder in poor prognosis was higher than that in good prognosis, while PSV and MV were lower than that in good prognosis (P ＜ 0.05). LP-PLA2, PI, PSV and disturbance of consciousness were the influencing factors of poor prognosis in AIS patients (P ＜ 0.05). The area under curve values of LP-PLA2, PI, PSV and their combination in AIS patients with poor prognosis were 0.783, 0.785, 0.744, 0.915 (P ＜ 0.05). Conclusion LP-PLA2, TCD parameters PI, PSV can be used to predict the prognosis of AIS patients.
		2022 Vol. 19 (2): 71-74,79 [Abstract] ( 159 ) HTML (1 KB) PDF (717 KB) ( 38 )

	75	Effect of directional drug penetration combined with Fuke Qianjin Capsules in the treatment of pelvic inflammatory disease with damp heat stasis type#br#
		WANG Qun1 LUO Mingyan2
		Objective To investigate the effect of directional drug penetration combined with Fuke Qianjin Capsules in the treatment of pelvic inflammatory disease (PID) with damp heat stasis type. Methods A total of 91 PID patients with damp heat stasis type who were admitted to Xindu Hospital of Traditional Chinese Medicine from January 2019 to October 2020 were selected. They were divided into control group (45 cases, Fuke Qianjin Capsules + conventional treatment) and study group (46 cases, directional drug penetration + Fuke Qianjin Capsules + conventional treatment) by random number table method. The clinical efficacy, traditional Chinese medicine symptom score, serum inflammatory factors (interleukin-6[IL-6], IL-2, tumor necrosis factor-α [TNF-α], and high-sensitivity C-reactive protein [hs-CRP]), hemorheology index (plasma viscosity, low shear whole blood viscosity, fibrinogen, high shear whole blood viscosity, and hematocrit), pelvic effusion depth, pelvic inflammatory mass diameter were compared between two groups; the incidence of adverse reactions during treatment was observed. Results The total effective rate of study group was higher than that of control group (P < 0.05). After treatment, the scores of lower abdominal pain, lumbosacral pain, prolonged menstrual period, increased menstrual volume, and mental fatigue in two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). After treatment, the levels of serum IL-6, IL-2, TNF-α, and hs-CRP of two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). After treatment, the plasma viscosity, low shear whole blood viscosity, fibrinogen, high shear whole blood viscosity, and hematocrit of two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). After treatment, the pelvic effusion depth and pelvic inflammatory mass diameter in two groups were lower than those before treatment, and study group was lower than control group (P < 0.05). There were no serious adverse reactions in two groups during treatment. Conclusion Directional drug penetration combined with Fuke Qianjin Capsules has good clinical efficacy in the treatment of PID with damp heat stasis type patients, which can reduce inflammatory reaction, improve hemorheology, relieve clinical symptoms with high safety.
		2022 Vol. 19 (2): 75-79 [Abstract] ( 74 ) HTML (1 KB) PDF (720 KB) ( 58 )

	80	Clinical characteristics of adenovirus pneumonia and respiratory syncytial virus pneumonia in children#br#
		YANG Yan1 ZHANG Yang2 HUANG Juan1 ZHAN Xiaoyun1 ZHAO Alan1 WU Bei1 LU Yinghong1▲
		Objective To analyze the clinical characteristics of adenovirus (ADV) and respiratory syncytial virus (RSV) infection in hospitalized children with pneumonia, and to provide reference for clinical diagnosis and treatment. Methods Retrospective analysis from January to December 2019, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology of the clinical data of children with simple ADV pneumonia and simple RSV pneumonia, including general situation, clinical manifestations, early course of laboratory examination and imaging examination, severe or very severe pneumonia, respiratory support, and hospital stay. Results Among 102 cases of pneumonia, 36 cases were simple ADV pneumonia and 66 cases were simple RSV pneumonia. There was no significant difference in gender between two groups (P > 0.05). The age of onset in ADV group was significantly higher than that in RSV group (P < 0.05). There was statistical significance in onset seasons between two groups (P < 0.05). The course of heat of ADV group was longer than that of RSV group, the proportion of fever ≥39.0℃ was higher than that of RSV group, the incidence of expectoration, moist rale, and wheezing sound were lower than those of RSV group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of gasping and inspiratory three concave sign between two groups (P > 0.05). There was no significant difference in white blood cell count between two groups (P > 0.05). The percentage of neutrophil, C-reactive protein level, and the proportion of procalcitonin > 0.1 ng/ml in ADV group were higher than those in RSV group; the percentage of lymphocytes was lower than that in RSV group, and the differences were statistically significant (P < 0.05). There were no significant differences in lung imaging and imaging improvement rate after treatment between two groups (P > 0.05). There were no extremely severe pneumonia in both groups; there were no significant differences in the incidence of severe pneumonia between two groups (P > 0.05). There were no significant differences in oxygen rate, non-invasive respiratory support rate and hospital stay between two groups (P > 0.05). Conclusion ADV pneumonia should be considered in infants and preschool children with high fever, lung auscultation with only moist rale, neutrophil percentage, C-reactive protein and procalcitonin significantly increased, while RSV pneumonia should be considered in infants with obvious wheezing sound.
		2022 Vol. 19 (2): 80-83,103 [Abstract] ( 152 ) HTML (1 KB) PDF (691 KB) ( 119 )

	84	Clinical analysis of uterine artery embolization combined with Ethacridine and Mifepristone for induction of mid-term pregnancy in placental predisposition #br#
		YANG Xiaorong1 JIN Xuan1 DING Juan1 LI Junqiang2▲
		Objective To investigate the application effect of uterine artery embolization combined with Ethacridine and Mifepristone for induction of mid-term pregnancy in placental predisposition. Methods From January 2018 to September 2020, 97 cases with placental predisposition admitted to Department of Gynecology and Obstetrics, Sichuan Jinxin Women & Children’s Hospital were selected. Uterine artery embolization was performed after admission for all patients, they were divided into experimental group (51 cases) and control group (46 cases) according to random number table method after embolization. Experimental group received Mifepristone oral administration combined with Ethacridine amniotic cavity injection for labor induction; and control group received Ethacridine amniotic cavity injection to induce labor. The effect of induced labor, time from intervention to delivery, the amount of blood loss, residual placenta membrane, length of stay, and total hospitalization cost were compared between two groups. Results All 97 patients were successfully induced labor without using other methods. The time from intervention to delivery in experimental group was shorter than that in control group, and the amount of blood loss, and residual placenta membrane rate were lower than those in control group, with statistical significances (P < 0.05). There were no significant differences in length of stay and total hospitalization cost between two groups (P > 0.05). Conclusion For the patients with placental predisposition in mid-term pregnancy and no history of cesarean section or placental implantation, the labor induction with Ethacridine combined with Mifepristone after uterine artery embolization is satisfactory, safe and reliable, and worthy of clinical reference.
		2022 Vol. 19 (2): 84-87 [Abstract] ( 76 ) HTML (1 KB) PDF (578 KB) ( 38 )

	88	Effect of Dipyridamole combined with IVIG and Aspirin in the treatment of children with Kawasaki disease and its effect on T lymphocyte subsets, coagulation function and inflammatory factor levels#br#
		LI Hongyuan ZHANG Hui ZHANG Jianming▲
		Objective To investigate the effect of Dipyridamole combined with Intravenous Immunoglobulin (IVIG) and Aspirin in the treatment of children with Kawasaki disease (KD) and its effect on T lymphocyte subsets, coagulation function, and inflammatory factor levels. Methods A total of 80 children with KD admitted to Department of Pediatrics, Fuyang Women’s and Children’s Hospital of Anhui Province from January 2018 to January 2021 were selected, they were divided into observation group and control group, with 40 cases in each group. The control group was treated with Aspirin and IVIG, and observation group was treated with Dipyridamole on the basis of control group. The clinical efficacy of two groups was compared; T lymphocyte subsets, prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (Fbg) and the levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP) were compared between two groups before and after treatment; the occurrence of adverse reactions during treatment was recorded. Results The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P < 0.05). After treatment, CD4+ and CD4+/CD8+ in observation group were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05); CD8+ in both groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P < 0.05). After treatment, there were no significant differences in PT, TT, and APTT between two groups compared with before treatment (P > 0.05); the level of Fbg in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of TNF-α, IL-6, and CRP in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Dipyridamole combined with IVIG and Aspirin in the treatment of KD can effectively improve the immune function, coagulation function, and inflammation level of children, with high safety and significant effect, suggesting clinical application.
		2022 Vol. 19 (2): 88-91 [Abstract] ( 203 ) HTML (1 KB) PDF (551 KB) ( 35 )

	92	Analysis of factors affecting the prognosis of patients with non-small cell lung cancer after treatment with epidermal growth factor receptor tyrosine kinase inhibitors#br#
		YU Miao1 CHEN Xiaoling2 ZHANG Yingdan1 LI Xiaoqi1 Ulantuya1 ZHANG Binbin1 MEN Tonglin3
		Objective To investigate the factors affecting the prognosis of patients with non-small cell lung cancer (NSCLC) after treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Methods A total of 161 NSCLC patients admitted to Shenyang Tenth People’s Hospital from January 2018 to September 2019 were selected, all of whom received first-line EGFR-TKIs treatment. According to their prognosis, they were divided into poor prognosis group (32 cases) and good prognosis group (129 cases). Clinical data, laboratory indicators, and imaging data of the two groups were collected and compared, and the influencing factors of prognosis of patients were analyzed by logistic regression model. Results The levels of programmed death-ligand 1 (PD-L1) and serum carcinoembryonic antigen (CEA) in the poor prognosis group were higher than those in the good prognosis group. The level of serum albumin, mean lung density ratio of expiration / inspiration (MLD E/I), change in lung volume as a percentage of total lung volume with a respiratory bipolar voxel index between -850 HU and -950 HU (VI-850/-950E-I) in poor prognosis group were lower than those in the good prognosis group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that PD-L1, serum CEA, and serum albumin were influential factors for the prognosis of NSCLC patients after EGFR-TKIs treatment (P ＜ 0.05). Conclusion PD-L1, serum CEA, and serum albumin are closely related to the prognosis of NSCLC patients after EGFR-TKIs treatment.
		2022 Vol. 19 (2): 92-95,111 [Abstract] ( 55 ) HTML (1 KB) PDF (677 KB) ( 23 )

	96	Effect comparison of thoracoscopic lobectomy and segmentectomy in the treatment of aged patients with early stage non-small cell lung cancer#br#
		QIAN Hairong YIN Dongming MAO Kai
		Objective To study the intervention effect of different thoracoscopic surgical resection scope on aged patients with early stage non-small cell lung cancer. Methods A total of 86 aged patients with early stage non-small cell lung cancer admitted to Rugao Hospital Affiliated to Nantong University from July 2016 to July 2018 were divided into observation group and control group by random number table method, with 43 cases in each group. The control group underwent thoracoscopic lobectomy, and the observation group underwent thoracoscopic segmentectomy. The operative time, intraoperative blood loss, number of lymph node resection, postoperative visual analogue scale (VAS) score, drainage time, and hospitalization time between the two groups were compared. The levels of C-reactive protein (CRP), proalbumin (PA), and blood glucose were compared between the two groups before and after operation, and the incidence of complications during hospitalization was recorded. Results The operation time of the observation group was longer than that of the control group, and the drainage time and hospitalization time were shorter than those of the control group, the differences were statistically significant(P ＜ 0.05). There was no significant difference in the number of lymph node resection and postoperative VAS score between the two groups (P ＞ 0.05). The levels of CRP and blood glucose in the two groups were higher than those before operation, while PA was lower than that before operation, and CRP and blood glucose levels in the observation group were lower than those in the control group, while PA levels were higher than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion Compared with thoracoscopic lobectomy, thoracoscopic segmental lung resection in the treatment of aged patients with early stage non-small cell lung cancer can shorten the drainage time and hospital stay, which should be paid attention to.
		2022 Vol. 19 (2): 96-99 [Abstract] ( 132 ) HTML (1 KB) PDF (535 KB) ( 43 )

	100	Influencing factors of stigma after modified radical mastectomy in patients with breast cancer#br#
		HU Linlin ZHOU Xiaofeng WANG Yebei ZHOU Yuan REN Huihui YAO Feng▲
		Objective To analyze the influencing factors of stigma after modified radical mastectomy in patients with breast cancer. Methods A total of 240 breast cancer patients who received modified radical mastectomy in Renmin Hospital of Wuhan University from January 2018 to January 2021 were selected as research subjects. All patients received social impact scale (SIS) to assess stigma, and basic information of patients and their families was questioned and recorded. SIS scores of patients with different data characteristics were compared to analyze the related factors that may affect the stigma of patients after modified radical mastectomy. Results Two hundred and fourty patients with different degrees of stigma after modified radical mastectomy had an average SIS score of (61.89±8.41) points. The SIS score of patients with junior high school education or below, average monthly income ≤ 2000 yuan, on-the-job, postoperative time > two years were higher than those of patients with senior high school, technical secondary school education or above, average monthly income > 2000 yuan, no occupation, postoperative time ≤ two years, the difference was statistically significant (P ＜ 0.05). Multiple linear regression analysis showed that education level (X1), average monthly income (X2), postoperative time (X3), and work status (X4) were all influential factors leading to stigma of patients after modified radical mastectomy, and the equation: Y = 58.776+4.444X1+5.688X2+6.537X3+4.000X4 (F = 194.543, R2 = 0.871, adjusted R2 = 0.867, P ＜ 0.05). Conclusion The stigma of patients after modified radical mastectomy is affected by many factors, so early intervention of patients with these factors should be paid attention to in order to reduce the stigma of them.
		2022 Vol. 19 (2): 100-103 [Abstract] ( 168 ) HTML (1 KB) PDF (573 KB) ( 32 )

	104	Influencing factors of post-traumatic growth in patients with endometrial carcinoma after total hysterectomy#br#
		HONG Lihua1 WANG Bingqian1 WANG Jing2 HOU Yanwen1▲
		Objective To investigate the level of post-traumatic growth (PTG) in patients with endometrial carcinoma (EMC) after total hysterectomy, and to analyze the related factors of PTG of patients after operation. Methods The data of 120 EMC patients who received total hysterectomy treatment in the First Maternal and Child Health Hospital Affiliated to Tongji University from August 2014 to August 2018 was collectted, retrospectively. According to the score of PTG inventory after discharge, they were divided into normal level PTG group (score of PTG inventory ≥ 70 points, 75 cases) and low PTG level group (score of PTG inventory ＜ 70 points, 45 cases). The baseline data of the two groups were compared, and logistic regression model was used to analyze the influencing factors of PTG in EMC patients after total hysterectomy. Results The proportions of the International Federation of Gynecology and Obstetrics (FIGO) stage Ⅱ, self-rating anxiety scale (SAS) score ≥50, self-rating depression scale (SDS) score ≥53, and the scores of perceived stress scale (PSS) in the low PTG level group were higher than those in the normal level PTG group, and the social support scale (SSRS) score was lower than that of normal PTG group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that FIGO stage Ⅱ, SAS score ≥ 50, SDS score ≥53 and high PSS score were independent risk factors for low PTG level after total hysterectomy in EMC patients (OR ＞ 1, P ＜ 0.05), while high SSRS score was protective factor (OR ＜ 1, P ＜ 0.05). Conclusion The level of PTG in EMC patients after total hysterectomy is affected by social support, stress perception, negative psychological emotions, FIGO stage, and other factors.
		2022 Vol. 19 (2): 104-107 [Abstract] ( 110 ) HTML (1 KB) PDF (521 KB) ( 117 )

	108	Influencing factors of ruminative meditation in patients with hepatocellular carcinoma#br#
		WEI Mingfang SHEN Ming REN Hongfei ZHANG Mingguang
		Objective To analyze the influencing factors of ruminative meditation in patients with hepatocellular carcinoma. Methods A total of 153 patients with hepatocellular carcinoma admitted to West China Hospital, Sichuan University from August 2019 to December 2020 were selected as subjects to evaluate ruminative meditation. According to the two dimensions of ruminative meditation, they were divided into invasive ruminative meditation group (invasive ruminative meditation score ≥ purposive ruminative meditation score, 108 cases) and the purposive ruminative meditation group (invasive ruminative meditation ＜ purposive ruminative meditation score, 45 cases). Baseline data of the two groups were recorded, and the influencing factors of invasive ruminative meditation in hepatocellular carcinoma patients were analyzed by univariate and multivariate analysis. Results The recovery rate of 153 hepatocellular carcinoma patients was 100.00%, and the ruminative meditation score was in the middle level. The proportion of female, patients of primary school education or below, patients of family monthly income ＜ 3000 yuan, and visual analogue scale (VAS) score of the invasive ruminative meditation group were higher than those of the purposive ruminative meditation, and the proportion of Barcelona clinical liver cancer stage A in group was lower than that in purposive ruminative meditation, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that female, low family monthly income, high Barcelona clinical liver cancer stage, and high VAS score were independent risk factors for the development of invasive ruminative meditation in hepatocellular carcinoma patients (OR ＞ 1, P ＜ 0.05). High education level was a protective factor (OR ＜ 1, P ＜ 0.05). Conclusion Patients with hepatocellular carcinoma are prone to intrusive rumination, which is closely related to gender, family monthly income, Barcelona clinical liver cancer stage, and VAS score.
		2022 Vol. 19 (2): 108-111 [Abstract] ( 73 ) HTML (1 KB) PDF (554 KB) ( 51 )

	112	Clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients#br#
		WANG Yinglin1 LIU Jianzhong1 XIAO Mingzhong1 NI Wei1 CHEN Yao1 YU Xiaoli2 YUN Fan3 KE Jingwen3
		Objective To observe the clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients. Methods A total of 32 acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney in Wuhan Infectious Disease Hospital from January 2017 to December 2020 were selected as research subjects, and they were divided into treatment group and control group according to random number table method, with 16 cases in each group. Sixteen patients in the treatment group were treated with highly active anti-retroviral therapy (HAART) + Jianpi Bushen Mianjian Granules, and sixteen patients in the control group were treated with HAART+Jianpi Bushen Mianjian Granule Simulation Agents. Both groups were treated for 48 weeks. The liver and kidney function, traditional Chinese medicine symptom and sign score, Karofsky score and immunological indexes of the two groups were observed before and after treatment. Results There was no significant difference in liver and kidney function between the two groups after treatment and before treatment (P ＞ 0.05). After treatment, the scores of traditional Chinese medicine symptoms and signs in the two groups were lower than those before treatment, and which in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the Karofsky score in the treatment group was higher than that before treatment, and that in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the proportion of CD4+CD45RA+T cells and the ratio value of CD4+CD45RA+T cells to CD4+CD45RO+T cells in the treatment group were higher than those before treatment, and those in the treatment group were higher than those in the control group (P ＜ 0.05). After treatment, the proportion of CD4+CD45RO+T cells in the treatment group was lower than that before treatment, and that in the treatment group were higher than the control group (P ＜ 0.05). Conclusion Invigorating spleen and tonifying kidney method has a good safety in the treatment of acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney, improving the quality of life of patients, improving the immune function of the body, showing a good synergistic effect.
		2022 Vol. 19 (2): 112-116 [Abstract] ( 63 ) HTML (1 KB) PDF (695 KB) ( 55 )

	117	Analysis of clinical and imaging characteristics of rever-sible posterior leukoencephalopathy syndrome#br#
		HAN Lijuan1 LI Zheng2 HUANG Rong1 XU Yun1 CHEN Yanting1▲
		Objective To analyze the clinical and imaging characteristics of rever-sible posterior leukoencephalopathy syndrome. Methods The clinical features, imaging features, treatment and prognosis of 17 patients with rever-sible posterior leukoencephalopathy syndrome admitted in Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from May 2017 to June 2020 were retrospectively analyzed. Results All the 17 rever-sible posterior leukoencephalopathy syndrome patients were female with a mean age of (31.06±12.84) years. The most common clinical manifestations included epilepsy, disturbance of consciousness, headache and blurred vision, and epileptic persistence was rare. The vast majority of patients have elevated blood pressure at onset. Eclampsia / preeclampsia, puerperium, tyrosine kinase inhibitor use, systemic lupus erythematosus, blood transfusion reactions, and nephrotic syndrome were common causes of rever-sible posterior leukoencephalopathy syndrome. The white matter lesions were mainly parietal and occipital lobes, followed by frontal and temporal lobes, and a small number of lesions involved basal ganglia, cerebellum and brainstem. The signal of the lesion suggested vasogenic edema with rare enhancement. The overall prognosis of the patients was good. Within one week, the symptoms of most patients improved significantly, and most lesions were clearly absorbed. A total of 14 patients were followed up, and the longest follow-up time was 39 months after onset. There was no recurrence of rever-sible posterior leukoencephalopathy syndrome and no seizures. Conclusion Rever-sible posterior leukoencephalopathy syndrome can be associated with many diseases, and its clinical manifestations are diverse with imaging features. Timely treatment can obtain a better prognosis, and patients with rever-sible posterior leukoencephalopathy syndrome have a low probability of long-term epilepsy.
		2022 Vol. 19 (2): 117-120,125 [Abstract] ( 38 ) HTML (1 KB) PDF (901 KB) ( 26 )

	121	Citespace based visual analysis of spirituality research at home and abroad#br#
		TANG Ling1 GONG Ting1 LUO Lei2
		Objective To analyze the similarities and differences of the development trend and research hotspots of spirituality research at home and abroad by using visual analysis software, and to provide reference for spirituality research at home. Methods In this study, 4126 spiritual research articles included in Web of Science and 177 spiritual research articles included in China National Knowledge Infrastructure were selected as research objects. “Spirituality”, “Nursing”, “spirituality” and “care” were the key words in the search; the search dates were from January 2000 to December 2020. The annual publication quantity, journal distribution and document type were analyzed by bibliometrics, and knowledge map was drawn by CiteSpace V software. Results The number of spiritual literature at home and abroad was increasing. There were 858 English literature journals, mainly covering nursing, health care, oncology and internal medicine. There were 84 Chinese literature journals, and the research fields were mainly in the field of nursing. Experimental studies were the main types of literature published in English, while non-experimental studies were the main types of Chinese literature published. English literature research hotspots included: quality of life, cancer, social support, intervention, end of life, breast cancer, women, children, acquired immunodeficiency syndrome and so on. Chinese literature research hotspots included: spiritual care, spirituality, spiritual needs, nurses, the elderly, cancer patients and so on. Conclusion Chinese spirituality research is in the stage of rapid development, but the scope and depth of research are not enough. On the basis of learning from foreign spirituality research, China should construct spirituality assessment methods and intervention models suitable for China’s national conditions to promote the development of spirituality research in China.
		2022 Vol. 19 (2): 121-125 [Abstract] ( 266 ) HTML (1 KB) PDF (1830 KB) ( 30 )

	126	Clinical effect of acupuncture combined with rehabilitation therapy in the treatment of shoulder-hand syndrome after ischemic stroke#br#
		CHEN Honglin1 GUAN Fang2▲
		Objective To explore and analyze the clinical effect of acupuncture combined with rehabilitation in the treatment of shoulder - hand syndrome after ischemic stroke. Methods A total of 120 cases of ischemic stroke admitted to First Affiliated Hospital, Heilongjiang University of Chinese Medicine from April 2019 to April 2021 were selected and divided into control group and observation group by random number table method, with 60 cases in each group. The control group was given routine rehabilitation treatment, and the observation group was additionally given acupuncture treatment on the basis of the control group. Both groups were given four courses of treatment continuously for one course per week. The clinical efficacy, visual analogue scale (VAS) score, swelling degree score, simplified upper limb Fugl-Meyer motor scale (FMA) score, serum calcitonin generelated peptide (CGRP) content and substance P (SP) content before and after treatment were compared between the two groups, and the safety grade during treatment was observed. Results The cure effective rate of observation group was higher than control group, the difference was statistically significant (P ＜ 0.05). After treatment, VAS and swelling degree score in both groups were lower than before treatment, FMA score was higher than before treatment, serum CGRP and SP contents were lower than before treatment, VAS and swelling degree scores of observation group were lower than control group, FMA score was higher than control group, serum CGRP and SP contents were lower than control group, the differences were statistically significant (P ＜ 0.05). The safety rating of both groups during treatment was grade one, 60 cases in each group, accounting for 100.00%. Conclusion Acupuncture combined with rehabilitation in the treatment of shoulder-hand syndrome after ischemic stroke has a significant clinical effect, which can improve the pain and swelling, promote the improvement of upper limb motor function, and inhibit the release of serum CGRP and SP, with high safety during the treatment.
		2022 Vol. 19 (2): 126-129,142 [Abstract] ( 156 ) HTML (1 KB) PDF (733 KB) ( 42 )

	130	Professor Lei Genping’s experience in the treatment of esophageal cancer with pair medicine and horn medicine#br#
		ZHANG Ruiqing1 ZHAO Weihan2 LEI Genping3 DONG Sheng3
		Professor Lei Genping has been engaged in clinical practice of traditional Chinese medicine for a long time and has rich clinical experience in the treatment of esophageal cancer. He creatively puts forward the pathogenesis of “reciprocal causation of deficiency and excess” of esophageal cancer, which is interacted as both cause and effect, moving in circles, and he cleverly uses pair medicine and horn medicine, with outstanding curative effect. This paper summarizes the commonly used for pair medicine and horn medicine, summarizes the drug compatibility characteristics of Sparganii Rhizoma-Curcumae Rhizoma, Scorpio-Scolopendra, Trichosanthis Fructus-Pinelliae Rhizoma-Gleditsiae Spina, Smilacis Glabrae Rhizoma-Dioscoreae Spongiosae Rhizoma-Clematidis Radix et Rhizoma, Os Draconis-Ostreae Concha-Magnetitum, Arecae Semen-Arecae Pericarpium-Aucklandiae Radix, Lycii Fructus-Psoraleae Fructus-Epimedii Folium. And this paper analyzes the basis of drug selection and matching of Professor Lei Genping in the treatment of esophageal cancer, so as to guide the specialized drug use and improve clinical curative effect.
		2022 Vol. 19 (2): 130-133 [Abstract] ( 188 ) HTML (1 KB) PDF (715 KB) ( 19 )

	134	Wang Leting’s experience summary in treating paraplegia#br#
		SHI Zhixia1，2 WANG Rui2 ZHOU Mengyuan2 ZHAO Yin1 WANG Guiling1
		Wang Leting has formed his own unique treatment system for paraplegia. He believes that falling and flapping trauma or exogenous pathogens and poisons damage the governor channel and lead to paraplegia. This paper expounds Wang Leting’s experience in the treatment of paraplegia, and emphasizes taking the governor channel first. It also summarizes the “eleven methods for treating paralysis”, such as the method of treating governor channel, the method of treating jiájǐ, the method of treating back-shu, the method of treating bladder, the method of treating conception channel, the method of treating spleen and stomach, the method of treating liver and gallbladder, the method of treating three yin of foot, the method of treating three yang of hand, the method of treating three yin of hand and the method of treating hand and foot twelve needles. It puts forward the combination of local and overall, and selects the “eleven methods for treating paralysis” according to the injury location and accompanying symptoms.
		2022 Vol. 19 (2): 134-137 [Abstract] ( 123 ) HTML (1 KB) PDF (595 KB) ( 31 )

	138	Yang Hongzhi’s experience in treating severe chronic obstructive pulmonary disease from the theory of hidden pathogen #br#
		BAO Xiaolong1 YANG Hongzhi2，3
		Chronic obstructive pulmonary disease is a common disease that seriously endangers human health. And severe chronic obstructive pulmonary disease has a higher rate of death and disability, and acute exacerbation is more frequent. It has been a key difficulty in clinical treatment. Through long-term clinical practice and based on the theory of hidden pathogen, Yang Hongzhi believes that severe chronic obstructive pulmonary disease is lingering and repeated, and cough and asthma are difficult to be resolved, which should be blamed for the deficiency of the three organs of lung, spleen and kidney. Lung collateral qi deficiency and yang weak, phlegm and fluid retention, static blood can be deeply embedded in the deficiency of collateral, cementation is difficult to remove, consumption of vital qi, and the accumulation of hidden pathogen gradually gathered, brewed on the roots, repeatedly caused by his pathogenic attack. The key pathogenesis is accumulation of pathogen and damage, collaterals deficiency and pathogenic latent. And the basic pathological characteristics is manifestation deficiency and root excess, intermingled deficiency with excess. The treatment should follow the principle of reinforcing deficiency and reducing real pathogenic, removing and reinforcing, and should be treated in stages and sequential, with different stages having their own priorities. In the acute aggravation stage, the main purpose is to relieve acute cough and asthma by removing phlegm, removing static blood, and clearing colligals; in the remission period is to fill the deficiency and dredge collaterals, taking kidney qi to break the source of hidden pathogen, so as to achieve the effect of dispelling and reinforcing deficiency of lung collaterals, and dispelling the hidden pathogen spirits of lung collaterals. An empirical case is provided for evidence.
		2022 Vol. 19 (2): 138-142 [Abstract] ( 129 ) HTML (1 KB) PDF (837 KB) ( 53 )

	143	Experience characteristics of the school of press combined with action massage manipulation in the treatment of tendon injury#br#
		ZHI Zhaolin LI Bing WANG Zheng ZHOU Xiaobo WANG Youren SHI Ruihua
		The press combined with action massage school which was founded in 1958 when Beijing Massage Hospital was established. It is a school of massage characterized by dynamic and static combination formed by doctors represented by Zhang Zhen in the Beijing Massage Hospital through long-term clinical practice. Press combined with action therapy is the characteristic massage technique of Beijing Massage hospital. It has distinct academic characteristics in the treatment of tendon injury and has remarkable curative effect. Press combined with action therapy pays attention to three aspects on the manipulation in the treatment of tendon injury: idea, qi, power, loose, smooth, bonesetting; press combined with action, balance yin and yang; doctor-patient cooperation, press combined with action coordination. This paper introduces the experience characteristics of the school of press combined with action massage manipulation in the treatment of tendon injury through the above three aspects with clinical cases, in order to provide a reference for the clinical workers of traditional Chinese medicine.
		2022 Vol. 19 (2): 143-147 [Abstract] ( 45 ) HTML (1 KB) PDF (757 KB) ( 122 )

	148	Prevention and treatment of adolescent polycystic ovary syndrome based on the theory of “preventive treatment of disease”#br#
		CUI Chen1 KANG Zhiyuan2
		At present, the etiology of polycystic ovary syndrome is unknown, and it may be closely related to genetics and environment. It is still incurable, and it is very harmful to the endocrine and metabolic system of women throughout their life. Polycystic ovary syndrome mostly starts in adolescence, so it is crucial to develop a correct prevention and treatment plan during adolescence to stop the progression of the disease. In order to reduce the incidence of polycystic ovary syndrome, the intervention is carried out at different stages, such as before disease onset, disease onset, after disease onset, under the guidance of the thought of “preventive treatment of disease” of traditional Chinese medicine. Specifically speaking, before disease onset, pay attention to health preserving with adjustment, from daily life, diet, exercise and emotion to establish a healthy lifestyle; in the stage of disease onset, the timely conditioning of the constitution to prevent the progress of the disease; at the time of after disease onset, strict lifestyle regulation and medicine treatment of traditional Chinese and Western medicine are adopted to promote the reversal of the disease; in the stable improvement stage, it is necessary to check erroneous ideas at the outset, make careful adjustments in life in order to the disease does not recur.
		2022 Vol. 19 (2): 148-151,179 [Abstract] ( 92 ) HTML (1 KB) PDF (839 KB) ( 51 )

	152	Essence derived from the experience in treating gastroesophageal reflux disease based on the core pathogenesis view by Wang Yangang#br#
		ZHAO Yuejia1 WANG Yangang1,2 ZHOU Pingping1 SHEN Pengpeng1 YANG Yuhan1 MA Liya1
		Professor Wang Yangang believes that the core pathogenesis of gastroesophageal reflux disease is stagnated heat and yin injury, which plays a leading role in the occurrence and development of the disease. This disease involves liver, lung and spleen and stomach, so it can be divided into two basic types: stagnated heat and yin injury in liver and stomach and stagnated heat and yin injury in lung and stomach, so that the treatment based on syndrome differentiation is more targeted. In the course of disease development, damp-heat, blood stasis and other pathogenesis may be involved. Therefore, the core treatment of the disease is to clear stagnated heat, nourish yin and protect fluid. Clearing heat and eliminating dampness, promoting blood circulation for removing blood stasis are the main treatment methods for combined pathogenesis, and the clinical effect is satisfactory. Clinical Professor Wang Yangang paid attention to the comprehensive analysis of data gained by four diagnostic methods, add and subtract of syndrome differentiation, and definite curative effect.
		2022 Vol. 19 (2): 152-155 [Abstract] ( 120 ) HTML (1 KB) PDF (667 KB) ( 33 )

	156	Application of narrative therapy based on nostalgia theme in psychological intervention of patients with advanced cancer#br#
		ZHONG Zhaodi MA Yu▲
		Objective To explore the application of narrative therapy based on nostalgia theme in psychological intervention of patients with advanced cancer. Methods A total of 140 patients with advanced cancer admitted to Huaian First Hospital Affiliated to Nanjing Medical University from May 2018 to August 2019 were selected. According to the random number table method, they were divided into 70 cases in the intervention group and 70 cases in the control group. The control group was given regular health education and psychological intervention, and the intervention group was combined with narrative therapy based on the theme of nostalgia. After eight weeks of intervention, the self-rating anxiety scale (SAS), self-rating depression scale (SDS), state self-esteem scale (SSES), and the Chinese version of Herth hope scale (HHI) were used to assess mental state, and levels of self-esteem and hope. Results After eight weeks of intervention, two cases fell off in the intervention group and six cases fell off in the control group, and the SAS and SDS scores of the two groups were lower than those before the intervention, and the SAS and SDS scores of the intervention group were lower than those of the control group (P ＜ 0.05); the SSES scores of the two groups were higher than those before the intervention; the total scores of appearance self-esteem, behavioral self-esteem, and SSES of the intervention group were higher than those of the control group (P ＜ 0.05); the HHI scores of the two groups were higher than those before the intervention, and the HHI scores of the intervention group were higher than those of the control group (P ＜ 0.05). Conclusion Narrative therapy based on nostalgia theme can help relieve the negative emotions of patients with advanced cancer, awaken their sense of self-esteem, and improve the level of life hope.
		2022 Vol. 19 (2): 156-159 [Abstract] ( 140 ) HTML (1 KB) PDF (566 KB) ( 114 )

	160	Influence of perceived social support and self-health management level in patients with obstructive sleep apnea hypopnea syndrome after UPPP#br#
		QI Xiao HUANG Meili CHEN Qinfen
		Objective To analyze the influence between perceived social support and self-health management level in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) after uvulopalatopharyngoplasty (UPPP). Methods A total of 104 patients with OSAHS admitted to Sir Run Run Shaw Hospital, Zhejiang University School of Medicine from December 2018 to December 2020 were selected as the research subjects, all patients were treated with UPPP, the perceived social support scale (PSPP) and adult health self-management self-rating scale (AHSMSRS) were used to assess the perceived social support and self-health management level of patients one month after operation, and the baseline data of patients were collected, the self-health management ability of patients with different data characteristics was analyzed, the relationship between perceived social support and self-health management level of OSAHS patients after UPPP was mainly analyzed. Results In the PSPP score of 104 OSAHS patients after UPPP, the score of family support dimension was (16.05±4.55) points; the score of friends support dimension was (13.86±3.72) points; and the score of other support dimensions was (15.65±4.08) points; the self-health management level of 104 OSAHS patients after UPPP was general, the average score of AHSMSRS was (115.87±12.41) points, the AHSMSRS score of OSAHS patients with positive coping was higher than that of OSAHS patients with negative coping after UPPP (P ＜ 0.05). Through multiple linear regression analysis, three factors [family support (X1), friend support (X2) and other support (X3)] may be the influencing factors leading to the average self-health management level of OSAHS patients after UPPP (P ＜ 0.05). The equation was as follows: Y = 80.218+0.792X1+0.973X2+0.605X3 (F = 13.078, R2 = 0.282, adjusted R2 = 0.260). Conclusion The perceived social support of OSAHS patients after UPPP may have some influence on their self-health management level.
		2022 Vol. 19 (2): 160-163 [Abstract] ( 119 ) HTML (1 KB) PDF (561 KB) ( 60 )

	164	Influence of meaning of life oriented spiritual care on the level of hope and social support in patients with advanced lung cancer#br#
		ZHAO Baofang1 QIAN Aiyun2▲ KANG Congying1 YAN Qi2 LI Suting1
		Objective To explore influence of meaning of life oriented spiritual care on the level of hope and social support in patients with advanced lung cancer. Methods A total of 120 patients with advanced lung cancer admitted to the Sixth People’s Hospital of Nantong City, Jiangsu Province from February 2019 to June 2020 were selected. The patients were divided into observation group and control group by random number table method, with 60 cases in each group. The control group received routine nursing intervention, and the observation group received combined spiritual care based on meaning of life. Three months after intervention, hope level and social support level were compared between the two groups. Results Three months after intervention, two cases in the observation group and four cases in the control group were fell off. The scores of hope level in both groups were higher than before intervention, and the total scores of intimacy, positive action, positive attitude, and hope level in observation group were higher than those in control group (P ＜ 0.05). The scores of social support level in both groups were higher than before intervention, and the total scores of objective support, subjective support, support utilization, and social support level in observation group were higher than those in control group (P ＜ 0.05). Conclusion Spiritual care based on the meaning of life is helpful to promote the development of the level of hope and improve the level of social support of patients with advanced lung cancer.
		2022 Vol. 19 (2): 164-167 [Abstract] ( 52 ) HTML (1 KB) PDF (577 KB) ( 68 )

	168	Effect of improved early warning score combined with predictive nursing on incidence of adverse events in patients with heart failure#br#
		FAN Wenjia
		Objective To explore the effect of improved early warning score combined with predictive nursing on incidence of adverse events in patients with heart failure (hereinafter referred to as “heart failure”). Methods A total of 84 patients with heart failure admitted to the Department of Cardiovascular Medicine of Beijing Shijitan Hospital from September 2017 to September 2019 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 42 cases in each group. The control group received routine nursing care, and the observation group implemented improved early warning scoring combined with predictive nursing on the basis of the control group. The psychological status, adverse events, and quality of life before and after nursing were compared between the two groups. Results After nursing, the psychological state score of the two groups was lower than that before nursing, and the quality of life score of the observation group was higher than that of the control group, and the psychological state score of the observation group was lower than those of control group, the differences were statistically significant (P ＜ 0.05); the incidence of adverse events in observation group was lower than control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The combined application of improved early warning scoring and predictive care can alleviate the unhealthy mood of patients with heart failure, prevent adverse reactions and improve the quality of life.
		2022 Vol. 19 (2): 168-171 [Abstract] ( 205 ) HTML (1 KB) PDF (604 KB) ( 29 )

	172	Application of quality control nursing based on FMEA model in operating room nursing of patients undergoing gastrointestinal surgery#br#
		SHI Hongling XIA Taoxian DENG Lili
		Objective To explore the application effect of failure mode and effect analysis (FMEA) model of quality control nursing in the operation room nursing of patients with gastrointestinal surgery. Methods In April 2019, the Affiliated Hospital of West Anhui Health Vocational College applied the quality control nursing based on FMEA model to the operating room nursing of patients undergoing gastrointestinal surgery. Apply FMEA theory to find out the failure mode that may exist in the nursing process, formulate corrective measures, and assist and guide clinical medical staff to implement. A total of (65 cases) of FMEA model based quality control nursing before implementation (January 2018 to March 2019) were selected as the control group and (120 cases) of patients undergoing gastrointestinal surgery after implementation (April 2019 to March 2021) were selected as the study group. The related surgical indicators, postoperative complication rate and nursing satisfaction were compared between the two groups. Results The risk priority index was calculated, five failure modes were determined to be rectified, and the corresponding quality care rectification measures were proposed based on the FMEA model. The operative time, postoperative first exhaust time, and hospitalization time in the study group were significantly shorter than those in the control group, the differences were statistically significant (P ＜ 0.05). The incidence of postoperative complications in the study group was significantly lower than that in the control group, and nursing satisfaction was significantly higher than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The quality control nursing based on FMEA model standardizes the operating room nursing system and process of patients with gastrointestinal surgery, reduces the incidence of postoperative complications and improves patient satisfaction, which is worthy of clinical promotion.
		2022 Vol. 19 (2): 172-175 [Abstract] ( 149 ) HTML (1 KB) PDF (533 KB) ( 27 )

	176	Psychological and physiological value of psychological crisis combined with expectant therapy in pregnant women with premature rupture of membranes#br#
		GU Ying1 ZOU Weiwei2▲
		Objective To analyze the psychological and physiological value of psychological crisis combined with expectation therapy in pregnant women with premature rupture of membranes. Methods A total of 80 pregnant women with premature rupture of membranes were selected from September 2017 to August 2020 in Wuxi Maternal and Child Health Hospital of Jiangsu Province, they were divided into study group and control group according to random number table method, with 40 cases in each group. The control group was treated with routine expectant therapy, on the basis, the study group combined the psychological crisis therapy. The effects of the psychological and physiological intervention were compared between the two groups after receiving different intervention modes. Results After intervention, the scores of Hamilton depression scale and Hamilton anxiety scale in the study group were lower than those in the admission, and which of the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05), the incidence of cesarean section, postpartum hemorrhage, and neonatal asphyxia in the study group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05), the study group had longer fetal protection time than the control group, and the difference was statistically significant (P ＜ 0.05), the nursing satisfaction in the study group was significantly higher than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The application of psychological crisis combined with expectation therapy can improve and alleviate the negative psychological emotion of parturients, prolong the delivery time of parturients, reduce the occurrence of complications such as cesarean section, neonatal asphyxia, and postpartum hemorrhage, and ensure the safety of maternal and infant delivery outcomes.
		2022 Vol. 19 (2): 176-179 [Abstract] ( 72 ) HTML (1 KB) PDF (626 KB) ( 35 )

	180	Research on the developement problems of social services about psychology for the elderly#br#
		YAO Wenqi ZHU Qian
		Objective To investigate existing problems and influenceing factors of social services about psychology for the elderly from the perspective of the elderly psychological service practitioners, and put forward suggestions for the effective development of social services about psychology for the elderly. Methods From September to November 2020, in-depth interviews were conducted with the employees of providing social services about psychology for the elderly in Taiyuan Shantou pension institution by snowball sampling method, based on grounded theory research method, the interview content was analyzed, and the development problems of social services about psychology for the elderly were summarized. Results After three-level coding, 364 original concepts, 75 concepts, 17 categories, and 4 axialcoding were sorted out, and finally a story line was formed: the implementation of psychosocial services about psychology plays an important role in improving the mental health level for the elderly, but there were many dilemmas in the actual development process. The development of its services was affected by factors such as the cognition of social services about psychology, service capacity of each organization, and guarantee mechanism. Among them, service organization construction was the key, service cognition and behavior were the premise, service guarantee mechanism was the external support. Conclusion Social services about psychology for the elderly need to solve the dilemma, improve the cognition and behavior of social services about psychology for the elderly, strengthen the organization and construction of psychosocial service for the elderly, and perfect the security system of social services about psychology for the elderly.
		2022 Vol. 19 (2): 180-183,196 [Abstract] ( 168 ) HTML (1 KB) PDF (851 KB) ( 23 )

	184	SWOT analysis of senior health professional title accreditation in the Xiyuan Hospital of China Academy of Chinese Medical Sciences#br#
		CAI Xiaoqing1 XIE Pengcheng1 LI Qi2 XIANG Guoliang1 HAO Tengteng1 CUI Xiaochun1 LIU Longtao1
		With the continuous deepening of medical system reform and the gradual intensification of competition in the medical market, the development of hospitals encountering unprecedented challenges. Professional title accreditation, as an important system of talent evaluation, plays an important role in promoting the construction of hospital health team and optimizing the team structure. This paper takes the Xiyuan Hospital of China Academy of Chinese Medical Sciences as the research object, combined with the distribution situation of the number of senior titles, age structure, title structure, and professional classification, SWOT analysis is used to comprehensively analyze the four dimensions about strengths, weaknesses, opportunities, and threats of the professional title accreditation in the Chinese medicine hospital. Finally, measures and suggestions are put forward from the aspects of improving standards, revising systems, policy orientation, improving the level of information technology, and so on, aiming at strengthening the scientific and objective of professional title accreditation, stimulating the initiative and creativity of medical personnels and continuously promoting the hospital strategic development.
		2022 Vol. 19 (2): 184-187 [Abstract] ( 82 ) HTML (1 KB) PDF (604 KB) ( 48 )

	188	Research on the countermeasures of international cooperation in colleges of traditional Chinese medicine based on the concept of a community with a shared future for mankind#br#
		BAI Yu1 ZHOU Donglei2 YANG Yuhe1 LIU Hongyu1 CHE Zhiyuan4
		Traditional Chinese medicine is regarded as a “bridge” to build a community with a shared future for mankind through international exchanges. In recent years, Chinese medicine colleges and universities have successively established international cooperation projects represented by overseas centers of traditional Chinese medicine and Confucius Institutes of Chinese medicine in various countries, which give full play to its remarkable advantages in teaching and scientific research, talents, and culture platform, in order to promote the international development of traditional Chinese medicine. However, there are still some shortcomings in the international cooperation of traditional Chinese medicine colleges and universities, it is necessary to strengthen the understanding of the concept of a community with a shared future for mankind and deepen the effectiveness of international exchanges and cooperation in traditional Chinese medicine. Combined with the current situation of the internationalization of traditional Chinese medicine, this paper elaborates on the optimization of strategic layout, construction of innovation system, dissemination of excellent culture, promotion of talent training, improvement of management services and other aspects, and discusses the countermeasures of international cooperation of traditional Chinese medicine colleges and universities, so as to contribute to the buliding of a community with a shared future for human health.
		2022 Vol. 19 (2): 188-191 [Abstract] ( 154 ) HTML (1 KB) PDF (596 KB) ( 160 )

	192	Thinking and practice of improving the budget management level of public institution based on project database construction#br#
		JIA Chunyan1 LI Huijuan2 YAO Ye3▲
		With the continuous and deepening development of financial system reform, the construction of budget project database plays a more important role in budget management. Accelerating the effective integration of information technology and project database construction plays a positive role in optimizing budget management and improving the fund use performance. This paper sorts out the relevant systems of national budget management in recent years, takes the central public institutions as the reference, focuses on the current situation of unit budget management, and analyzes the problems existing in the budget management work and their causes. Based on the construction of project database, this paper puts forward the triune budget management mechanism of “plan-budget-performance” under information technology, expounds the principles, construction framework and ideas of project database construction, explores the innovative mode of budget management of public institutions, in order to enhance the level of budget management of public institutions.
		2022 Vol. 19 (2): 192-196 [Abstract] ( 80 ) HTML (1 KB) PDF (1492 KB) ( 25 )

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