双嘧达莫联合IVIG及阿司匹林治疗儿童川崎病的效果及对T淋巴细胞亚群、凝血功能和炎症因子水平的影响

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Abstract Objective To investigate the effect of Dipyridamole combined with Intravenous Immunoglobulin (IVIG) and Aspirin in the treatment of children with Kawasaki disease (KD) and its effect on T lymphocyte subsets, coagulation function, and inflammatory factor levels. Methods A total of 80 children with KD admitted to Department of Pediatrics, Fuyang Women’s and Children’s Hospital of Anhui Province from January 2018 to January 2021 were selected, they were divided into observation group and control group, with 40 cases in each group. The control group was treated with Aspirin and IVIG, and observation group was treated with Dipyridamole on the basis of control group. The clinical efficacy of two groups was compared; T lymphocyte subsets, prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (Fbg) and the levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP) were compared between two groups before and after treatment; the occurrence of adverse reactions during treatment was recorded. Results The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P < 0.05). After treatment, CD4+ and CD4+/CD8+ in observation group were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05); CD8+ in both groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P < 0.05). After treatment, there were no significant differences in PT, TT, and APTT between two groups compared with before treatment (P > 0.05); the level of Fbg in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of TNF-α, IL-6, and CRP in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Dipyridamole combined with IVIG and Aspirin in the treatment of KD can effectively improve the immune function, coagulation function, and inflammation level of children, with high safety and significant effect, suggesting clinical application.

Key words： Kawasaki disease Dipyridamole Intravenous Immunoglobulin T lymphocyte subsets Coagulation function Inflammatory factor

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	LI Hongyuan ZHANG Hui ZHANG Jianming▲

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LI Hongyuan ZHANG Hui ZHANG Jianming▲. Effect of Dipyridamole combined with IVIG and Aspirin in the treatment of children with Kawasaki disease and its effect on T lymphocyte subsets, coagulation function and inflammatory factor levels#br#[J]. 中国医药导报, 2022, 19(2): 88-91.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I2/88

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