可逆性后部白质脑病综合征临床及影像学特点分析

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Abstract Objective To analyze the clinical and imaging characteristics of rever-sible posterior leukoencephalopathy syndrome. Methods The clinical features, imaging features, treatment and prognosis of 17 patients with rever-sible posterior leukoencephalopathy syndrome admitted in Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from May 2017 to June 2020 were retrospectively analyzed. Results All the 17 rever-sible posterior leukoencephalopathy syndrome patients were female with a mean age of (31.06±12.84) years. The most common clinical manifestations included epilepsy, disturbance of consciousness, headache and blurred vision, and epileptic persistence was rare. The vast majority of patients have elevated blood pressure at onset. Eclampsia / preeclampsia, puerperium, tyrosine kinase inhibitor use, systemic lupus erythematosus, blood transfusion reactions, and nephrotic syndrome were common causes of rever-sible posterior leukoencephalopathy syndrome. The white matter lesions were mainly parietal and occipital lobes, followed by frontal and temporal lobes, and a small number of lesions involved basal ganglia, cerebellum and brainstem. The signal of the lesion suggested vasogenic edema with rare enhancement. The overall prognosis of the patients was good. Within one week, the symptoms of most patients improved significantly, and most lesions were clearly absorbed. A total of 14 patients were followed up, and the longest follow-up time was 39 months after onset. There was no recurrence of rever-sible posterior leukoencephalopathy syndrome and no seizures. Conclusion Rever-sible posterior leukoencephalopathy syndrome can be associated with many diseases, and its clinical manifestations are diverse with imaging features. Timely treatment can obtain a better prognosis, and patients with rever-sible posterior leukoencephalopathy syndrome have a low probability of long-term epilepsy.

Key words： Rever-sible posterior leukoencephalopathy syndrome High blood pressure Eclampsia / preeclampsia Blood transfusion Seizure

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	HAN Lijuan1 LI Zheng2 HUANG Rong1 XU Yun1 CHEN Yanting1▲

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HAN Lijuan1 LI Zheng2 HUANG Rong1 XU Yun1 CHEN Yanting1▲. Analysis of clinical and imaging characteristics of rever-sible posterior leukoencephalopathy syndrome#br#[J]. 中国医药导报, 2022, 19(2): 117-120,125.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I2/117

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